Patents by Inventor Hideki Yoshikawa
Hideki Yoshikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190175894Abstract: The object of the present invention is to provide a test method using a novel administration method of an extract from inflamed tissues inoculated with vaccinia virus or a preparation containing the extract. It has been demonstrated that by sustainedly administering an extract from inflamed tissues inoculated with vaccinia virus or a preparation containing the extract by using a continuous administration device according to the present invention, a comparable effect is exerted at a very low dose compared with conventional administration methods such as oral administration. Therefore, the present invention can provide a test method using animals requiring less burden on a researcher, a treatment of patient at a low dose, and the like.Type: ApplicationFiled: February 24, 2017Publication date: June 13, 2019Applicants: OSAKA UNIVERSITY, NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Hiroyuki TANAKA, Tsuyoshi MURASE, Hideki YOSHIKAWA, Mitsuru NAIKI, Tomonori MATSUMOTO
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Publication number: 20190083415Abstract: Provided is a sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet comprising a non-woven fabric that is formed from nanofibers each containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.Type: ApplicationFiled: March 6, 2017Publication date: March 21, 2019Applicants: OSAKA UNIVERSITY, NATIONAL INSTITUTE FOR MATERIALS SCIENCE, NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Hiroyuki TANAKA, Kiyoshi OKADA, Hideki YOSHIKAWA, Koji SUZUKI, Mitsuhiro EBARA
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Publication number: 20190059842Abstract: An X-ray imaging apparatus receives mode selection using a mode selection receiving unit including a mode setting unit and an operation display. When a CT mode is selected by the mode selection receiving unit, an X-ray beam shape adjuster shapes an X-ray beam into an X-ray cone beam in which a center beam that is a center of the X-ray beam is orthogonally incident on a body axis of a head. When a panoramic mode is selected, the X-ray beam shape adjuster shapes the X-ray beam into an X-ray narrow beam in which the center beam is incident on the body axis from obliquely below to obliquely above, the X-ray narrow beam having a length in a direction of the body axis.Type: ApplicationFiled: August 22, 2018Publication date: February 28, 2019Inventors: Yoshito SUGIHARA, Tomoyuki SADAKANE, Hideki YOSHIKAWA
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Publication number: 20190053775Abstract: A first position setting unit receives an operation to designate a position in a mesiodistal on a panoramic tomographic image displayed on a display, and sets a first position on a curved section based on the designation operation. The fluoroscopic imaging information providing unit provides information irradiating a subject with an X-ray beam along a direction having a component of a tangential direction at the first position of the curved section to execute fluoroscopic imaging acquiring a fluoroscopic image to a main body. A second position setting unit receives an operation to designate a position in a buccolingual direction on the fluoroscopic image displayed on the display, and sets a second position in the buccolingual direction based on the designation operation.Type: ApplicationFiled: August 20, 2018Publication date: February 21, 2019Inventors: Yoshinori ARAI, Hideki YOSHIKAWA
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Publication number: 20180353242Abstract: A treatment plan in which a position of a heat source and a treatment order are optimized is presented. A treatment support apparatus includes a processor, and a storage device connected to the processor, in which the storage device holds image information of tissue in a living body of a treatment target, and the processor extracts a blood vessel structure of the inside of the living body from the image information, calculates positions of one or more heat sources for thermal treatment on a treatment scheduled region including at least a part of the extracted blood vessel structure on the basis of the extracted blood vessel structure, and outputs data for displaying an image including the calculated positions of the one or more heat sources.Type: ApplicationFiled: April 26, 2018Publication date: December 13, 2018Inventors: Hideki YOSHIKAWA, Shigeo SUMINO
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Publication number: 20180271480Abstract: An ultrasonic imaging device according to the present invention includes: a container provided with an opening for inserting a target region of a subject; and a transmission/reception unit that transmits ultrasound to the target region inserted into the container filled with a liquid and receives the ultrasound that penetrates the target region or is reflected from the target region. The container has a pressure reducing unit that holds the target region in the container by reducing a pressure in the container of which the opening is covered with the target region. According to the present invention, since it is possible to maintain a shape close to a predetermined shape when the target region of a breast or the like is inserted into a container filled with the liquid, it is possible to measure the target region with high accuracy by transmitting and receiving ultrasound.Type: ApplicationFiled: April 28, 2016Publication date: September 27, 2018Inventors: Kenichi KAWABATA, Hideki YOSHIKAWA, Rei ASAMI, Takahide TERADA, Kazuhiro YAMANAKA, Yushi TSUBOTA, Wenjing WU
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Patent number: 10076291Abstract: The present invention has an object of providing an X-ray CT imaging device which can direct X-ray to an area of interest appropriately even when, for example, the height of the area of interest with respect to the X-ray detector, which is revolving, varies with respect to the revolution direction, and thus can reduce the amount of unnecessary exposure to the X-ray and can perform X-ray imaging of the area of interest with certainty. In an X-ray CT imaging device for performing X-ray CT imaging of a CT imaging area of a subject, during the X-ray CT imaging when a revolving arm is revolving, the expansion in a length direction of an X-ray cone beam, which is to be restricted by length direction blocking plates, is adapted to the shape of the CT imaging area in accordance with the revolution position of the revolving arm.Type: GrantFiled: November 30, 2012Date of Patent: September 18, 2018Assignees: Nihon University, J. Morita Manufacturing CorporationInventors: Yoshinori Arai, Makoto Honjo, Masakazu Suzuki, Susumu Kirimura, Hideki Yoshikawa
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Patent number: 9962131Abstract: An X-ray generator generating an X-ray cone beam and a two-dimensional X-ray detector detecting the X-ray cone beam are supported by a support arm while facing each other, and the X-ray generator and the two-dimensional X-ray detector are turned with an object interposed therebetween. A filter constitution body is disposed between the two-dimensional X-ray detector and the object. Filters having X-ray beam energy distribution conversion characteristics different from each other are arrayed in the filter constitution body. In X-ray photography, a filter constitution body moving mechanism is moved in a direction along a detection surface of the two-dimensional X-ray detector such that the filter constitution body traverses the X-ray cone beam in turning the support arm.Type: GrantFiled: November 25, 2015Date of Patent: May 8, 2018Assignee: J. Morita Manufacturing CorporationInventors: Hideki Yoshikawa, Tomoyuki Sadakane, Yoshito Sugihara
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Patent number: 9895137Abstract: There is provided an ultrasonic diagnostic apparatus capable of measuring hardness information of a subject with high time resolution and spatial resolution. The apparatus is provided with a ultrasonic probe 1 and a displacement generation unit 10 configured to displace an inside of a subject and is configured to transmit an ultrasonic beam for displacement detection to a plurality of detection positions of the subject from the ultrasonic probe 1, and to detect a shear wave velocity based on the displacement at the plurality of detection positions in a control unit 3 by using a reflection signal detected in a detection unit 20, thereby outputting hardness information of the subject. The ultrasonic beam for displacement detection is transmitted to one of the plurality of detection positions.Type: GrantFiled: January 29, 2014Date of Patent: February 20, 2018Assignee: HITACHI, LTD.Inventors: Marie Tabaru, Hideki Yoshikawa, Rei Asami, Kunio Hashiba, Hiroshi Masuzawa
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Publication number: 20170333004Abstract: Provided is an ultrasound diagnostic device having an elasticity evaluation function with which high accuracy and high reproducibility can be achieved while avoiding the influence of internal stresses.Type: ApplicationFiled: November 17, 2015Publication date: November 23, 2017Inventor: Hideki YOSHIKAWA
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Patent number: 9730653Abstract: An X-ray CT apparatus including an X-ray generator, an X-ray detector, a support part, and a base that rotatably supports the support part. The support part includes an exterior part made of carbon fiber reinforced plastic, and the X-ray generator and the X-ray detector are supported by the exterior part while being opposed to each other. The base rotatably supports the support part such that the X-ray generator and the X-ray detector turn about a turning axis.Type: GrantFiled: December 17, 2014Date of Patent: August 15, 2017Assignee: J. MORITA MANUFACTRING CORPORATIONInventors: Ryuichiro Niizeki, Hideki Yoshikawa, Susumu Kirimura
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Patent number: 9694107Abstract: The present invention can be used for actual implantation surgery without a scaffold. The present invention provides a synthetic tissue or complex which can be produced by culture and has a high level of differentiation ability. The present invention also provides a therapy and medicament for repairing and/or regenerating tissue using replacement and covering. By culturing cells under specific culture conditions such that medium contains an extracellular matrix synthesis promoting agent, the cells are organized and are easily detached from a culture dish. The present invention was achieved by finding such a phenomenon. In addition, the self contraction of the tissue can be regulated by culturing the tissue in a suspended manner. Therefore, it is possible to regulate the three-dimensional shape of the tissue.Type: GrantFiled: May 26, 2016Date of Patent: July 4, 2017Assignee: Two Cells, Co., Ltd.Inventors: Norimasa Nakamura, Hideki Yoshikawa, Wataru Ando
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Patent number: 9496492Abstract: A resistance switching device having a high resistance variation ratio, an excellent response characteristic, an excellent resistance memory characteristic (retention characteristics) and an excellent repeat resistance. The resistance switching device comprises an n-type oxide semiconductor and first and second electrodes which are disposed so as to interpose at least a part of the n-type oxide semiconductor therebetween wherein a Schottky junction which provides resistance variation/memory characteristics by the application of voltage having different polarities between the first and second electrodes is formed at an interface between the n-type oxide semiconductor and the first electrode; and the first electrode is positioned such that it is in contact with the n-type oxide semiconductor, and has a lower layer which is formed from Au oxide or a Pt oxide or Au or Pt containing oxygen having the thickness of 1-50 nm.Type: GrantFiled: August 13, 2014Date of Patent: November 15, 2016Assignees: MURATA MANUFACTURING CO., LTD., NATIONAL INSTITUTE FOR MATERIALS SCIENCEInventors: Sakyo Hirose, Naoki Ohashi, Hideki Yoshikawa
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Patent number: 9439620Abstract: When multiple tissues having differing speeds of sound are intermixed in the viewing field of a measured subject such as a living body, the invention measures hardness, such as modulus of elasticity or viscosity, with high precision.Type: GrantFiled: December 1, 2011Date of Patent: September 13, 2016Assignee: Hitachi, Ltd.Inventors: Marie Tabaru, Takashi Azuma, Hideki Yoshikawa, Kunio Hashiba
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Publication number: 20160256608Abstract: The present invention can be used for actual implantation surgery without a scaffold. The present invention provides a synthetic tissue or complex which can be produced by culture and has a high level of differentiation ability. The present invention also provides a therapy and medicament for repairing and/or regenerating tissue using replacement and covering. By culturing cells under specific culture conditions such that medium contains an extracellular matrix synthesis promoting agent, the cells are organized and are easily detached from a culture dish. The present invention was achieved by finding such a phenomenon. In addition, the self contraction of the tissue can be regulated by culturing the tissue in a suspended manner. Therefore, it is possible to regulate the three-dimensional shape of the tissue.Type: ApplicationFiled: May 26, 2016Publication date: September 8, 2016Inventors: Norimasa Nakamura, Hideki Yoshikawa, Wataru Ando
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Publication number: 20160183926Abstract: Disclosed is a technique capable of reducing deterioration of measurement accuracy and reproducibility due to a long measurement time and acquiring an ultrasound image with high diagnostic performance in measurement of a shear wave velocity of radiation pressure elastography. In the radiation pressure elastography, information relating to a motion (fluctuation) in a measurement region is extracted while detecting a shear wave from echo signals due to irradiation of tracking pulses, and is provided to a user as reliability information indicating the reliability of a measurement result. Further, a factor of the fluctuation is specified from the extracted information, and is presented to the user. Furthermore, when arithmetically averaging plural times of measurement results, weighting is performed using the reliability information.Type: ApplicationFiled: July 23, 2014Publication date: June 30, 2016Inventors: Rei ASAMI, Hideki YOSHIKAWA, Marie TABARU
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Patent number: 9370606Abstract: The present invention can be used for actual implantation surgery without a scaffold. The present invention provides a synthetic tissue or complex which can be produced by culture and has a high level of differentiation ability. The present invention also provides a therapy and medicament for repairing and/or regenerating tissue using replacement and covering. By culturing cells under specific culture conditions such that medium contains an extracellular matrix synthesis promoting agent, the cells are organized and are easily detached from a culture dish. The present invention was achieved by finding such a phenomenon. In addition, the self contraction of the tissue can be regulated by culturing the tissue in a suspended manner. Therefore, it is possible to regulate the three-dimensional shape of the tissue.Type: GrantFiled: February 16, 2007Date of Patent: June 21, 2016Assignee: Two Cells, Co., Ltd.Inventors: Norimasa Nakamura, Hideki Yoshikawa, Wataru Ando
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Patent number: 9370338Abstract: Disclosed is an ultrasound diagnosis device for creating an ultrasound image with a high contrast-to-tissue ratio. Said device sends a transmission pulse to the subject, uses an ultrasound probe to receive echoes reflected from an ultrasound contrast agent injected into the subject, and forms an image. The transmission pulse is sent such that nonlinear interactions between the constituent frequency components of said transmission pulse, as a result of the acoustic nonlinearity of the subject, do not produce sum and difference components in the frequency sensitivity range of the ultrasonic probe as the transmission pulse propagates across the subject.Type: GrantFiled: May 25, 2011Date of Patent: June 21, 2016Assignee: HITACHI MEDICAL CORPORATIONInventors: Kunio Hashiba, Hideki Yoshikawa, Tatsuya Hayashi
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Patent number: 9357971Abstract: An X-ray CT photographic apparatus including: a beam shaping mechanism that regulates an irradiation range of an X-ray generated from an X-ray generator and shapes the X-ray into an X-ray cone beam; and a main body controller that changes a read region, where an X-ray detection signal is read in the X-ray detector, according to the irradiation range of the X-ray cone beam. The main body controller changes the irradiation range of the X-ray cone beam to an x-axis direction during an X-ray CT photography such that only a set CT photographic region is irradiated with the X-ray cone beam according to the set CT photographic region input through a CT photographic region setting unit. The main body controller changes a read region in an X-ray detector with respect to the x-axis direction in a detection surface of the X-ray detector during the X-ray CT photography.Type: GrantFiled: May 1, 2013Date of Patent: June 7, 2016Assignee: J. MORITA MANUFACTURING CORPORATIONInventors: Hideki Yoshikawa, Masakazu Suzuki
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Publication number: 20160151027Abstract: An X-ray generator generating an X-ray cone beam and a two-dimensional X-ray detector detecting the X-ray cone beam are supported by a support arm while facing each other, and the X-ray generator and the two-dimensional X-ray detector are turned with an object interposed therebetween. A filter constitution body is disposed between the two-dimensional X-ray detector and the object. Filters having X-ray beam energy distribution conversion characteristics different from each other are arrayed in the filter constitution body. In X-ray photography, a filter constitution body moving mechanism is moved in a direction along a detection surface of the two-dimensional X-ray detector such that the filter constitution body traverses the X-ray cone beam in turning the support arm.Type: ApplicationFiled: November 25, 2015Publication date: June 2, 2016Applicant: J. Morita Manufacturing CorporationInventors: Hideki YOSHIKAWA, Tomoyuki SADAKANE, Yoshito SUGIHARA