Abstract: A biochip is described having a substrate that has disposed on a surface at least one spot containing a complex between a solid carrier modified by a reactive group and a substance to be immobilized that has been modified via a spacer by a group that reacts with the reactive group. A method for producing the biochip and a method for detecting a target substance using the biochip are also described.

Abstract: The purpose of the present invention is to provide a substrate for a biochip, a biochip, a method for manufacturing a biochip, and a method for preserving a biochip. The present invention pertains to a biochip having: a substrate having a hydrophilic reaction area; and a spot for a substance to be fixed that includes a biomaterial, the spot being disposed in the reaction area; the reaction area being enclosed by boundaries capable of retaining a liquid on the inner sides, and the spot furthermore including a thickening agent and/or a surfactant. The present invention also pertains to a method for manufacturing said biochip.

Abstract: In one embodiment of the present invention, provided are novel biomaterial immobilizing method having excellent immobilization ability and uses thereof, the method being characterized in that: an immobilization carrier having a surface modification specific to the biomaterial to be immobilized is used; the material to be immobilized is pre-immobilized to the surface of the immobilization carrier; a surface layer for maintaining the immobilization carrier on a biomaterial immobilizing substrate is provided; and the immobilization carrier is stamped in the shape of a spot on the surface layer.

Abstract: The present invention relates to a substance-immobilizing substrate for immobilizing a substance to be detected by chemiluminescence. The substance-immobilizing substrate of the present invention comprises a metal portion composed of at least one metal selected from the group consisting of chromium and molybdenum, or an alloy of the metal on at least a portion of a surface of the substrate. The present invention further relates to a substance-immobilized substrate wherein a substance is immobilized on the substance-immobilizing substrate. The substance is immobilized on the metal portion and the substrate is used for detecting the immobilized substance by chemiluminescence. The present invention further relates to an analysis method comprising directly or indirectly detecting by chemiluminescence a substance that is immobilized on a substrate.

Abstract: The device of testing interaction between biomolecules comprising a biomolecule microarray in which a biomolecule is immobilized on a substrate and a transparent electrode (opposite electrode) positioned so as to face the surface of the substrate of the microarray on which the bimolecule is immobilized. The device comprises a nonconductive spacer between the microarray and the opposite electrode, and a cavity is formed by the microarray, spacer and opposite electrode, and the microarray comprises a conductive material surface on at least a portion of the surface on which the biomolecule is immobilized, as well as comprises two through-holes communicating with the cavity, one of which is a hole for introducing a solution into the cavity, and the other of which is a hole for discharging a solution from the cavity.

Abstract: The substrate for biomolecule microarray has one or more spots for immobilizing a biomolecule. The spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, at least the surface of the substrate around the protruding spot part, the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance. Alternatively, the spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, the protruding spot parts adjacent each other border through the lateral surface of the protruding spot part, and at least the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance.

Abstract: A method of evaluating a non-linear optical crystal used for non-linear wavelength conversion of laser beam which enables the non-linear optical crystal to be evaluated before the crystal is actually used as a wavelength conversion element in order for the crystal to be constantly used for an extended time with a high conversion efficiency retained and without lowering in output when non-linear optical crystals for various non-linear wavelength conversions such as a CLBO crystal are used to convert laser beams, wherein the non-linear optical crystal is moved to changed a laser beam incident position to detect the output of a laser beam emitted from the non-linear optical crystal for each changing position.

Abstract: V-CAD data is prepared by dividing external data 12 consisting of boundary data of an object into rectangular parallelepiped cells 13 having boundary planes orthogonal to each other in accordance with octree division and separating the respective divided cells into internal cells 13a positioned on the inner side of the object and boundary cells 13b including a boundary face, and a modeling unit quantity of a prototyping material 7 is changed in accordance with sizes of the internal cell 13a and the boundary cell 13b of a modeling portion. The prototyping material 7 is a resin, lumber powder, a low-fusing-point metal, metal powder, ceramics powder or a mixture of a binder and one of these materials, and its modeling unit quantity is set in such a manner that the modeling unit quantity is smaller than a capacity of a corresponding cell and does not protrude from the boundary plane of the cell.

Abstract: A method of evaluating a non-linear optical crystal used for non-linear wavelength conversion of laser beam which enables the non-linear optical crystal to be evaluated before the crystal is actually used as a wavelength conversion element in order for the crystal to be constantly used for an extended time with a high conversion efficiency retained and without lowering in output when non-linear optical crystals for various non-linear wavelength conversions such as a CLBO crystal are used to convert laser beams, wherein the non-linear optical crystal is moved to changed a laser beam incident position to detect the output of a laser beam emitted from the non-linear optical crystal for each changing position.

Abstract: In order to provide a member for producing a probe array that allows producing desired probe arrays immediately once the probe arrangement is established, and to provide a probe array producing method that uses this member for producing a probe array, the pieces F1, F2 . . . Fn are produced by cutting the members M1, M2 . . . Mn for producing a probe array, and a predetermined number of pieces F1, F2 . . . Fn are detached from a release sheet 13 and are attached via the adhesive layer 12 onto the supporting member 2a at predetermined locations.

Abstract: The invention provides a substrate for biopolymer hybridization, a biopolymer hybridization device, and a biopolymer hybridization method capable of: speeding up hybridization of a biopolymer, by means of dielectrophoresis or electrophoresis by applying an alternating voltage or a direct voltage to a planar electrode, so as to generate an electric field; and reading the hybridized biopolymer by means of a laser or the like.

Abstract: A Raman probe for measuring Raman spectrum includes an exciting-end light guiding path for guiding excitation light from a light source to a sample; a receiving light-guide path for guiding a light signal from said sample to a detector; a band-pass filter for passing said excitation light and blocking Raman-scattered light produced from said exciting-end light guiding path; a pipe for securing said band-pass filter inside said pipe, said pipe being mounted on a light-outgoing end of said exciting-end light guiding path; and an edge filter mounted on a light-incident end of said receiving light-guide path, said edge filter passing Raman-scattered light from said sample while blocking the excitation light. The edge filter is a short-wavelength transmitting filter that permits passage of wavelengths shorter than the excitation wavelength.

Abstract: The substrate for biomolecule microarray has one or more spots for immobilizing a biomolecule. The spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, at least the surface of the substrate around the protruding spot part, the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance. Alternatively, the spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, the protruding spot parts adjacent each other border through the lateral surface of the protruding spot part, and at least the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance.

Abstract: (A) V-CAD data of an object (1) is prepared. (B) A processed surface shape after NC processing is predicted by simulation using the V-CAD data. (C) The object is subjected to NC processing by a predetermined NC program, and a processed surface shape after NC processing is measured, and (D) processing correction data is obtained from a difference between the processed surface shapes acquired by simulation and measurement, and the NC program is corrected based on the processing correction data. As a result, the ultra-precise processing is enabled even if a workpiece or a tool has low rigidity and an inconstant quantity of deformation.

Abstract: A spectral probe for blood vessel diagnosis that can be used for diagnosing blood vessels with high reliability, without imposing an excessive burden on patients. A Raman spectrum measuring probe and either an endoscope or an ultrasonic probe are integrated. A mechanism is provided for bringing the tip of the Raman probe into contact with an affected area so as to eliminate the influence of blood when measuring. An endoscope has a forward-looking view in the blood vessel, while the Raman probe is of the lateral-view type for facilitating the measurement of blood vessel walls. A fixing balloon is provided at the probe tip portion that is inserted into a blood vessel, and a window for the Raman probe is provided on the opposite side of the balloon. As the fixing balloon is inflated, part of it comes into contact with the internal wall of a blood vessel and fixes the probe, while leaving a gap between the internal wall of the blood vessel and the probe. The window comes into contact with the affected area.

Abstract: There is prepared V-CAD data obtained by dividing external data 12 consisting of boundary data of an object into rectangular parallelepiped cells 13 having boundary planes orthogonal to each other in accordance with octree division and separating the respective divided cells into internal cells 13a positioned on the inner side of the object and boundary cells 13b including a boundary face, and mold data and mold processing data used to manufacture the object are generated from data of a reference plane which at least partially comes into contact with the object 1 and the V-CAD data. Further, in the mold processing data, a plurality of the processing tools 2 are selected in descending order of a size in accordance with sizes of the internal cells 13a of a processing portion, and the processing tool 2 is moved in a plane of the mold and in the thickness direction, thereby processing the mold.

Abstract: A method of storing substantial data integrating shape and physical properties comprising (A) inputting external data 12 consisting of boundary data of an object 1, (B) dividing, by modified Octree division, the external data into cubical cells 13 which boundary surfaces are orthogonal to each other, and (C) storing the values of various physical properties for each of the cells. Furthermore, in step (B), each of the divided cells 13 is classified to non-boundary cells 13a located in the interior of the object or in a region outside of the object, and boundary cells 13b including boundary surfaces. Thereby, substantial data integrating shape and physical properties can be stored in small storage capacity, thus enabling the integration of CAD and simulation.

Abstract: A Raman probe that can be used with high-intensity excitation light without producing light that interferes with the measurement of Raman scattering. A receiving-end filter is doughnut-shaped, with an exciting-end filter disposed at the center thereof. A light-blocking structure is provided between the exciting-end filter and the receiving-end filter such that the excitation end and the receiving end are completely separated.

Abstract: A biomolecular microarray substrate having a spot for fixing a biomolecular probe on a surface thereof. The spot of light-reflecting layer is present between the biomolecular probe-fixing spot and the substrate surface. A method of manufacturing the biomolecular microarray substrate. A biomolecular microarray having a biomolecular probe-fixing spot in which a biomolecular probe is fixed by a biomolecular probe-fixing spot having the biomolecular microarray substrate. A data collection method for biomolecular arrays.

Abstract: In order to provide a member for producing a probe array that allows producing desired probe arrays immediately once the probe arrangement is established, and to provide a probe array producing method that uses this member for producing a probe array, the pieces F1, F2 . . . Fn are produced by cutting the members M1, M2 . . . Mn for producing a probe array, and a predetermined number of pieces F1, F2 . . . Fn are detached from a release sheet 13 and are attached via the adhesive layer 12 onto the supporting member 2a at predetermined locations.