Abstract: In order to provide a method for producing easily a probe array with probes arranged in the hollow portion of a tubular member, the present invention provides a method for producing a probe array comprising a step of forming a flexible sheet member 11 having a probe-immobilizing surface 110 into a tubular member in such a way that the probe-immobilizing surface 110 constitutes the inner face of the tubular member.

Abstract: To provide a laser oscillation method and a laser device, which use a laser medium such as an Nd:GdVO4 crystal to which neodymium is doped in high concentration exceeding 1% in atomicity ratio, the laser medium comprised of the gadolinium-vanadate crystal to which neodymium as laser active ion is doped by a floating zone method such that concentration becomes exceeding 1% in atomicity ratio.

Abstract: A method of evaluating a non-linear optical crystal used for non-linear wavelength conversion of laser beam which enables the non-linear optical crystal to be evaluated before the crystal is actually used as a wavelength conversion element in order for the crystal to be constantly used for an extended time with a high conversion efficiency retained and without lowering in output when non-linear optical crystals for various non-linear wavelength conversions such as a CLBO crystal are used to convert laser beams, wherein the non-linear optical crystal is moved to changed a laser beam incident position to detect the output of a laser beam emitted from the non-linear optical crystal for each changing position.

Abstract: This invention provides a kit used for fabricating an integrated biomolecule sensor. The kit includes an optical fiber bundle unit, which holds the proximal ends of the plurality of optical fibers together with the end-face arranged substantially in the same plane and oriented substantially in the same direction, a plate with wells for holding solutions containing probe polymers with different base sequences, and an auxiliary plate having holes, which corresponds to the wells of the plate respectively. According to this invention, researchers and other people can easily fabricate the integrated biomolecule under individual requirements without need of expensive equipment.

Abstract: (A) V-CAD data of an object (1) is prepared. (B) A processed surface shape after NC processing is predicted by simulation using the V-CAD data. (C) The object is subjected to NC processing by a predetermined NC program, and a processed surface shape after NC processing is measured, and (D) processing correction data is obtained from a difference between the processed surface shapes acquired by simulation and measurement, and the NC program is corrected based on the processing correction data. As a result, the ultra-precise processing is enabled even if a workpiece or a tool has low rigidity and an inconstant quantity of deformation.

Abstract: V-CAD data is prepared by dividing external data 12 consisting of boundary data of an object into rectangular parallelepiped cells 13 having boundary planes orthogonal to each other in accordance with octree division and separating the respective divided cells into internal cells 13a positioned on the inner side of the object and boundary cells 13b including a boundary face, and a modeling unit quantity of a prototyping material 7 is changed in accordance with sizes of the internal cell 13a and the boundary cell 13b of a modeling portion. The prototyping material 7 is a resin, lumber powder, a low-fusing-point metal, metal powder, ceramics powder or a mixture of a binder and one of these materials, and its modeling unit quantity is set in such a manner that the modeling unit quantity is smaller than a capacity of a corresponding cell and does not protrude from the boundary plane of the cell.

Abstract: An integrated biomolecule sensor comprising a plurality of optical fibers whose proximal ends are held together with the end-faces arranged substantially in the same plane and oriented substantially in the same direction and which have probe polymers with different base sequences bound to the core end-face at their distal ends. The method and apparatus for fabricating the integrated biomolecule sensor, and the method and apparatus for detecting biomolecules using the integrated biomolecule sensor are also disclosed. Researchers can make their own sensors best suited for individual requirements, and detect the presence of target biomolecules quickly, without need of expensive equipment.

Abstract: There is prepared V-CAD data obtained by dividing external data 12 consisting of boundary data of an object into rectangular parallelepiped cells 13 having boundary planes orthogonal to each other in accordance with octree division and separating the respective divided cells into internal cells 13a positioned on the inner side of the object and boundary cells 13b including a boundary face, and mold data and mold processing data used to manufacture the object are generated from data of a reference plane which at least partially comes into contact with the object 1 and the V-CAD data. Further, in the mold processing data, a plurality of the processing tools 2 are selected in descending order of a size in accordance with sizes of the internal cells 13a of a processing portion, and the processing tool 2 is moved in a plane of the mold and in the thickness direction, thereby processing the mold.

Abstract: A Raman probe that does not produce Raman scattering that interferes with measurement, and a Raman spectrum measuring apparatus utilizing the Raman probe. The Raman probe comprises a hollow wave-guide path 10 with a light-transmitting medium (core) that is evacuated or filled with a gas that does not produce Raman scattering, such as air.

Abstract: An integrated biomolecule sensor comprising a plurality of optical fibers whose proximal ends are held together with the end-faces arranged substantially in the same plane and oriented substantially in the same direction and which have probe polymers with different base sequences bound to the core end-face at their distal ends. The method and apparatus for fabricating the integrated biomolecule sensor, and the method and apparatus for detecting biomolecules using the integrated biomolecule sensor are also disclosed. Researchers can make their own sensors best suited for individual requirements, and detect the presence of target biomolecules quickly, without need of expensive equipment.

Abstract: For the sake of no needing to provide a mechanically actuating section such as a rotating mechanism thereby to be capable of realizing stable ultrashort pulse laser oscillation, an ultrashort pulse laser oscillator comprises a laser resonator composed of a mirror on outgoing side, and a total reflection mirror; a continuous wave oscillation laser for inputting excitation laser beam; a tunable laser medium capable of laser oscillation; a photoacoustic optical crystal having birefringent property as a crystal for selecting wavelength to which is input outgoing light from the tunable laser medium; a piezoelectric element inputting an acoustic wave having a frequency in response to a distortion upon application of voltage; a power source for applying the voltage; and a control means for controlling a frequency of voltage to be applied to the piezoelectric element by the power source wherein a frequency of voltage to be applied to the piezoelectric element by the power source is controlled by means of the control

Abstract: (A) The surface shape of an object (1) is measured by varying the position and/or direction of measurement, and a plurality of sets of partially measured data (2) including the common parts (2a) are acquired, (B) for all the partially measured data (2), the overlapped ranges (3a) of the adjacent common parts (2a) are determined within the measurement error ranges (3), (C) when there are no superposition ranges (3a), it is decided that a combination is not possible, and (D) when there are overlapped ranges (3a), the common parts of each set of partially measured data are combined within the ranges. Thus, combined data can be created at a high accuracy from a plurality of sets of partially measured data based on a small number of repeated calculations.

Abstract: A present micro array manufacturing apparatus includes a substrate placement portion 11 on which a plurality of substrates can be arranged, a tighter plate 12 for storing a solution including a living body sample, a solution storing member 52 for taking in the solution from the tighter plate 12 and storing the solution therein, and a needle 51 which can be inserted into the solution storing member 52 to allow the solution stored in the solution storing member 52 to adhere onto each of the substrates by a given quantity, wherein the solution storing member 52 and needle 51 are moved in directions where they approach and part away from the substrates to thereby form spots on the substrates. And, the individual operations of the solution storing member 52 and needle 51 are carried out by single drive means 32.

Abstract: To provide a laser oscillation method and a laser device, which use a laser medium such as an Nd:GdVO4 crystal to which neodymium is doped in high concentration exceeding 1% in atomicity ratio, the laser medium comprised of the gadolinium-vanadate crystal to which neodymium as laser active ion is doped by a floating zone method such that concentration becomes exceeding 1% in atomicity ratio.

Abstract: A method of stirring a reaction solution in a micro reaction vessel by imparting magnetic field fluctuation from the exterior of said reaction vessel to magnetic beads contained in said reaction solution. The reaction solution in a micro reaction vessel can be efficiently stirred.

Abstract: A laser device which has an excellent characteristic originally exerted by an yttrium-aluminum-garnet crystal doped with neodymium and is entirely reduced in size by using an entirely downsized laser medium is provided. The laser device is constituted such that a laser medium is disposed in a resonator, excited light is incident upon the laser medium so as to cause laser oscillation in the resonator, and laser light is emitted from the resonator. An yttrium-aluminum-garnet single crystal is used as the laser medium, in which neodymium is added at a concentration exceeding an atomicity ratio of 1.3%.

Abstract: The present invention provides a novel detecting reagent for double-stranded nucleic acid, and a method of using it to detect double-stranded nucleic acid formed by hybridization with a probe, with absolutely no labeling of the target nucleic acid. The detecting reagent for double-stranded nucleic acid of the invention is characterized by comprising, in the same molecule, a naphthalenediimide group which is intercalatable into double-stranded nucleic acid and a &bgr;-diketone group capable of forming a lanthanoid metal complex.

Abstract: The present invention provides a novel detecting reagent for double-stranded nucleic acid, and a method of using it to detect double-stranded nucleic acid formed by hybridization with a probe, with absolutely no labeling of the target nucleic acid.

Abstract: There is disclosed a method of storing substantial data integrating shape and physical properties comprising an external data input step (A) for inputting external data 12 consisting of boundary data of an object 1, an Octree division step (B) for dividing, by Octree division, the external data into cubical cells 13 which boundary surfaces are orthogonal to each other, and a cell data storage step (C) for storing the values of various physical properties for each of the cells. Furthermore, in the Octree division step (B), each of the divided cells 13 is classified to internal cells 13a located in the interior of the object, external cells 13b in the exterior thereof and boundary cells 13c including boundary surfaces.

Abstract: A method for controlling an index of refraction of silica glass, and in particular quartz glass, is disclosed. The method for controlling the index of refraction of silica glass includes the use of a vacuum ultraviolet laser beam having the same or shorter wavelength absorbable by the silica glass. The vacuum ultraviolet laser beam is irradiated to the silica glass to cause photodissociation of a Si—O bond at the point of irradiation. An index of refraction may also be altered using a vacuum ultraviolet laser beam having a longer wavelength absorbable by the silica glass.