Abstract: A discharge device is provided with a pressurized product filling and sealing the concentrate and the pressurizing agent P inside the container, and a discharge member discharging the concentrate by breaking through the pressurized product. The discharge member is provided with a valve which becomes a discharge passage of the concentrate, and a cap which covers the valve and is detachably mounted to the pressurized product. The discharge device is provided with a suppressing means (a maintaining mechanism, a movable lid, pressing to the bottom of the recessed part of the projecting part, a part releasing mechanism, a ratchet mechanism, a thin part and a plurality of coupling parts) for suppressing the leakage of the concentrate caused by removing the valve.

Abstract: A method for manufacturing a discharge product includes the steps of: preparing the double pressurized container including an outer container; an inner container stored inside the outer container and having flexibility; and a plug for sealing both of the outer container and the inner container; charging a concentrate inside the inner container; contracting the inner container before or after charging the concentrate; tightly mounting the plug to a mouth of the inner container; charging the pressurizing agent between the outer container and the inner container through a space between a mouth of the outer container and the mouth of the inner container; and tightly closing the space between the mouth of the outer container and the mouth of the inner container by the plug.

Abstract: A double pressurized container 11, 31 includes an outer container 13, 33; an inner container 14, 34 stored inside the outer container 13, 33 and having flexibility; and a plug 15, 35 welded to the outer container 13, 33 and the inner container 14, 34 and sealing both of the outer container 13, 33 and the inner container 14, 34. An inside of the inner container 14, 34 is a concentrate chamber for charging a concentrate C, and a space between the outer container 13, 33 and the inner container 14, 34 is a pressurizing agent chamber for charging a pressurizing agent P, and the plug 15, 35 is provided with an openable seal part 15d, 44 to open the concentrate chamber. A discharge product 11a, 31a has the double pressurized container 11 filled with the concentrate C and the pressurizing agent P.

Abstract: This content-accommodating container comprises: a container body having an opening at the top end; and a valve-accommodating part for closing the opening, the valve-accommodating part being fixed to the container body. The valve-accommodating part is provided with: a cylindrical housing part accommodated inside the container body; a tube part extending downward from the housing part, the lower end thereof being disposed near the bottom side of the container body; and a first sealing part for closing the bottom end of the tube part.

Abstract: A discharge device is provided with a pressurized product filling and sealing the concentrate and the pressurizing agent P inside the container, and a discharge member discharging the concentrate by breaking through the pressurized product. The discharge member is provided with a valve which becomes a discharge passage of the concentrate, and a cap which covers the valve and is detachably mounted to the pressurized product. The discharge device is provided with a suppressing means (a maintaining mechanism, a movable lid, pressing to the bottom of the recessed part of the projecting part, a part releasing mechanism, a ratchet mechanism, a thin part and a plurality of coupling parts) for suppressing the leakage of the concentrate caused by removing the valve.

Abstract: Provided is a crystal of a novel pyrido[3, 4-d]pyrimidine derivative having excellent CDK 4/6 inhibitory activity. A crystal of a compound represented by formula (I). In the formula, R1 represents a hydrogen atom or a C1-3 alkyl group; R2 represents a hydrogen atom or an oxo group; L represents a single bond or a C1-3 alkylene group; and X represents CH or N.

Abstract: A double pressurized container 11, 31 includes an outer container 13, 33; an inner container 14, 34 stored inside the outer container 13, 33 and having flexibility; and a plug 15, 35 welded to the outer container 13, 33 and the inner container 14, 34 and sealing both of the outer container 13, 33 and the inner container 14, 34. An inside of the inner container 14, 34 is a concentrate chamber for charging a concentrate C, and a space between the outer container 13, 33 and the inner container 14, 34 is a pressurizing agent chamber for charging a pressurizing agent P, and the plug 15, 35 is provided with an openable seal part 15d, 44 to open the concentrate chamber. A discharge product 11a, 31a has the double pressurized container 11 filled with the concentrate C and the pressurizing agent P.

Abstract: Provided is a crystal of a novel pyrido[3, 4-d]pyrimidine derivative having excellent CDK 4/6 inhibitory activity. A crystal of a compound represented by formula (I). In the formula, R1 represents a hydrogen atom or a C1-3 alkyl group; R2 represents a hydrogen atom or an oxo group; L represents a single bond or a C1-3 alkylene group; and X represents CH or N.

Abstract: This content-accommodating container comprises: a container body having an opening at the top end; and a valve-accommodating part for closing the opening, the valve-accommodating part being fixed to the container body. The valve-accommodating part is provided with: a cylindrical housing part accommodated inside the container body; a tube part extending downward from the housing part, the lower end thereof being disposed near the bottom side of the container body; and a first sealing part for closing the bottom end of the tube part.

Abstract: Provided are an ejection member and an aerosol product using the same capable of obtaining a desired shape of an ejection material by suppressing adhesion of the ejection ejection materials to each other. An ejection member to be connected to an aerosol container filled with a foaming content is provided with an expansion chamber for promoting foaming of the foaming content from the aerosol container and a plurality of nozzles for ejecting the foaming content in the expansion chamber to the outside. The expansion chamber is provided with an introduction port for introducing the foaming content from the aerosol container and a delivery port for delivering the foaming content to the nozzle side. The nozzles each have a slit-shaped ejection port. The communication path that communicates the ejection port and the delivery port has a slit-shaped slit portion. A length of the slit portion in the ejection direction is greater than a slit width of the ejection port.

Abstract: This content-accommodating container comprises: a container body having an opening at the top end; and a valve-accommodating part for closing the opening, the valve-accommodating part being fixed to the container body. The valve-accommodating part is provided with: a cylindrical housing part accommodated inside the container body; a tube part extending downward from the housing part, the lower end thereof being disposed near the bottom side of the container body; and a first sealing part for closing the bottom end of the tube part.

Abstract: This content-accommodating container comprises: a container body having an opening at the top end; and a valve-accommodating part for closing the opening, the valve-accommodating part being fixed to the container body. The valve-accommodating part is provided with: a cylindrical housing part accommodated inside the container body; a tube part extending downward from the housing part, the lower end thereof being disposed near the bottom side of the container body; and a first sealing part for closing the bottom end of the tube part.

Abstract: Provided is a cell adhesion inhibitor which exhibits low cytotoxicity and an excellent cell adhesion prevention effect; a tool and an apparatus each having a surface modified through application of the cell adhesion inhibitor thereto; a method for producing each of the surface-modified tool and apparatus; a biomedical structure and a production method therefor; and a microchannel device and a production method therefor. The invention provides a cell adhesion inhibitor comprising, as an active ingredient, a polymer comprising a repeating unit having a sulfinyl group in a side chain thereof.

Abstract: Provided are an ejection member and an aerosol product using the same capable of obtaining a desired shape of an ejection material by suppressing adhesion of the ejection ejection materials to each other. An ejection member 20 to be connected to an aerosol container 10 filled with a foaming content is provided with an expansion chamber E for promoting foaming of the foaming content from the aerosol container 10 and a plurality of nozzles 22c for ejecting the foaming content in the expansion chamber E to the outside. The expansion chamber E is provided with an introduction port 21e for introducing the foaming content from the aerosol container 10 and a delivery port 22b for delivering the foaming content to the nozzle 22c side. The nozzles 22c each have a slit-shaped ejection port 22d. The communication path that communicates the ejection port 22d and the delivery port 22b has a slit-shaped slit portion 22e.

Abstract: Provided is a cell adhesion inhibitor which exhibits low cytotoxicity and an excellent cell adhesion prevention effect; a tool and an apparatus each having a surface modified through application of the cell adhesion inhibitor thereto; a method for producing each of the surface-modified tool and apparatus; a biomedical structure and a production method therefor; and a microchannel device and a production method therefor. The invention provides a cell adhesion inhibitor comprising, as an active ingredient, a polymer comprising a repeating unit having a sulfinyl group in a side chain thereof.

Abstract: Provided is a multilayer-structured discharge container having a simple structure, capable of facilitating the loading of a substance to be contained and a pressurizing agent, and capable of facilitating the ejection of the pressurizing agent after use. A discharge container in which a valve mechanism is provided with a stem having two independent in-stem paths, one in-stem path communicates with an in-holder discharge path, the other in-stem path communicates with an in-holder gas path, a contained substance is discharged by closing the other in-stem path, and the pressurizing agent is ejected by opening the other in-stem path. The discharge container is capable of causing a pressurization chamber and the atmosphere to communicate by removing a push-button from a valve assembly and pressing down a stem of a valve mechanism (switching operation).

Abstract: A valve assembly in which contents respectively packed in multiple storage parts which cannot be reacted with each other in the middle of passage, an aerosol container equipped with the valve assembly, and an aerosol products are provided. An aerosol container comprises an outer container, two inner bags inserted into the outer container, and valve assembly which closes inner bags and outer container. The valve assembly comprises aerosol valves which are separated independently from each other and a holding member for holding the aerosol valves and for fixing the aerosol valves to the outer container.

Abstract: A discharge container includes a container body made of metal having an opening, and a valve assembly fixed to the opening of the container body. The container body has a cylindrical barrel portion, a cylindrical neck portion having a diameter smaller than the barrel portion, and a bead portion formed on top of the neck portion. The opening has a cylindrical portion and the bead portion formed above the cylindrical portion. The valve assembly is equipped with a plug portion inserted into the opening, a flange portion which is provided above on the bead portion, a valve structure which opens and closes a pathway of a content and is fixed to the plug portion, an O-ring provided on an outer surface of the plug portion, and a cover cap fixing the valve assembly to the container body.

Abstract: Disclosed are crystals of 2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-methyl-1H-imidazole-5-carboxylic acid useful as therapeutic or prophylactic agents for gout, hyperuricemia, and the like, and a method for producing the crystals.

Abstract: Provided is a multilayer-structured discharge container having a simple structure, capable of facilitating the loading of a substance to be contained and a pressurizing agent, and capable of facilitating the ejection of the pressurizing agent after use. A discharge container in which a valve mechanism is provided with a stem having two independent in-stem paths, one in-stem path communicates with an in-holder discharge path, the other in-stem path communicates with an in-holder gas path, a contained substance is discharged by closing the other in-stem path, and the pressurizing agent is ejected by opening the other in-stem path. The discharge container is capable of causing a pressurization chamber and the atmosphere to communicate by removing a push-button from a valve assembly and pressing down a stem of a valve mechanism (switching operation).