Abstract: Disclosed are a microfluidic device and a sample analysis apparatus using the microfluidic device.

Abstract: A dialysis device implantable in a patient for dialysis includes a filtration unit. The filtration unit includes at least one dialysis chamber for containing and/or circulating dialysate; and at least one blood chamber for containing and/or circulating blood of the patient, disposed on at least one dialysis chamber and being in communication with the at least one dialysis chamber. Each of the at least one dialysis chamber and the at least one blood chamber comprise at least one inlet for circulating fluid into and/or out of the at least one dialysis chamber and the at least one blood chamber. The at least one dialysis chamber and the at least one blood chamber are configured such that the blood in the at least one blood chamber and the dialysate in the at least one dialysis chamber operably interact with each other for dialysis.

Abstract: Disclosed are a microfluidic device and a sample analysis apparatus using the microfluidic device.

Abstract: A dialysis device implantable in a patient for dialysis includes a filtration unit. The filtration unit includes at least one dialysis chamber for containing and/or circulating dialysate; and at least one blood chamber for containing and/or circulating blood of the patient, disposed on at least one dialysis chamber and being in communication with the at least one dialysis chamber. Each of the at least one dialysis chamber and the at least one blood chamber comprise at least one inlet for circulating fluid into and/or out of the at least one dialysis chamber and the at least one blood chamber. The at least one dialysis chamber and the at least one blood chamber are configured such that the blood in the at least one blood chamber and the dialysate in the at least one dialysis chamber operably interact with each other for dialysis.

Abstract: The present disclosure relates to pharmaceutical salts and polymorphic forms of pyrimidine derivatives that have inhibitory activities against mutant epidermal growth factor receptor (EGFR). The present disclosure further relates to the processes for the preparation of the pyrimidine derivatives and to the pharmaceutical salts and the polymorphic forms of the pyrimidine derivatives.

Abstract: A method may include generating an optimal operational window (OOW) that specifies operational parameter values for drilling operations using equipment at a rig site, based on data indicative of rig state and formation characteristics, and based on mutation-based optimization of the operational parameter values; and instructing a control system to perform the drilling operations according to the OOW using the equipment at the rig site.

Abstract: Methods and systems for compact presentation of automatically summarized information according to rule-based graphically represented information. One of the methods includes obtaining, via a user accessible user interface, a request for uploaded textual information to be analyzed. Ontology information is accessed based on an indicated type associated with the textual information, and ontology information for the type. The ontology information specifies nodes, with the nodes causing the server system to extract values for textual expressions defined by the nodes, and relational information between the nodes, with the relational information indicating links between textual expressions. The textual information is parsed based on the ontology information. The parsing causes traversal of the nodes and extraction of values from associated textual expressions based on the textual information. Values are obtained based on the parsing, with the values being utilized as summary information.

Abstract: Systems and methods automatically generate contours on an illustrated object for performing an animation. Contour lines are generated on the surface of the object according to criteria related to the shape of the surface of the object. Points of the contour lines that are occluded from a virtual camera are identified. The occluded points are removed to generate visible lines. The visible lines are extruded to define a three-dimensional volume defining contours of the object. The object itself, along with the three-dimensional volume, are illuminated and rendered. The parameters defining the opacity and color of the contour may differ from corresponding parameters of the rest of the object, so that the contours stand out and define portions of the object. The contours are useful in contexts such as defining areas of an object that is fuzzy or cloudy in appearance, as well as creating certain artistic effects.

Abstract: Systems and methods automatically generate contours on an illustrated object for performing an animation. Contour lines are generated on the surface of the object according to criteria related to the shape of the surface of the object. Points of the contour lines that are occluded from a virtual camera are identified. The occluded points are removed to generate visible lines. The visible lines are extruded to define a three-dimensional volume defining contours of the object. The object itself, along with the three-dimensional volume, are illuminated and rendered. The parameters defining the opacity and color of the contour may differ from corresponding parameters of the rest of the object, so that the contours stand out and define portions of the object. The contours are useful in contexts such as defining areas of an object that is fuzzy or cloudy in appearance, as well as creating certain artistic effects.

Abstract: An optical fiber connector with a connector housing that holds a ferrule includes a retractable shutter having a shutter plate and a shutter actuator. The shutter actuator is slidably connected to the connector housing for movement relative to the connector housing between a front position and a rear position. The shutter actuator is configured to engage the mating interface as the optical fiber connector is plugged into the mating interface whereby the shutter actuator moves relative to the connector housing from the front position to the back position. The shutter plate is connected to the shutter actuator such that the shutter actuator is configured to drive the shutter plate to move between an extended position and a retracted position. In the extended position, the shutter plate is located to shield the ferrule. In the retracted position, the shutter plate is located expose the ferrule.

Abstract: A robotic document feeder system may comprise a robotic arm coupled to a Bernoulli cup assembly powered by a vacuum source; a base disposed over an imaging surface of a document scanner, wherein the base comprises a designated scan area through which a document may be imaged by the document scanner; an input bin for storing at least one document to be imaged by the document scanner; and an output bin for storing the at least one document after it has been imaged by the document scanner. The system may further comprise an alignment mechanism in proximity to the designated scan area and configured to align the document substantially over the imaging surface of the document scanner; at least one automated door configured to close the designated scan area after the document has been placed in the designated scan area; and a camera positioned above the designated scan area for imaging a second side of the document.

Abstract: The present disclosure relates to pharmaceutical salts and polymorphic forms of forms of pyrimidine derivatives that have inhibitory activities against mutant epidermal growth factor receptor (EGFR). The present disclosure further relates to the processes for the preparation of the pyrimidine derivatives and to the pharmaceutical salts and the polymorphic forms of the pyrimidine derivatives.

Abstract: A dialysis device implantable in a patient for dialysis includes a filtration unit. The filtration unit includes at least one dialysis chamber for containing and/or circulating dialysate; and at least one blood chamber for containing and/or circulating blood of the patient, disposed on at least one dialysis chamber and being in communication with the at least one dialysis chamber. Each of the at least one dialysis chamber and the at least one blood chamber comprise at least one inlet for circulating fluid into and/or out of the at least one dialysis chamber and the at least one blood chamber. The at least one dialysis chamber and the at least one blood chamber are configured such that the blood in the at least one blood chamber and the dialysate in the at least one dialysis chamber operably interact with each other for dialysis.

Abstract: A dialysis device implantable in a patient for dialysis includes a filtration unit. The filtration unit includes at least one dialysis chamber for containing and/or circulating dialysate; and at least one blood chamber for containing and/or circulating blood of the patient, disposed on at least one dialysis chamber and being in communication with the at least one dialysis chamber. Each of the at least one dialysis chamber and the at least one blood chamber comprise at least one inlet for circulating fluid into and/or out of the at least one dialysis chamber and the at least one blood chamber. The at least one dialysis chamber and the at least one blood chamber are configured such that the blood in the at least one blood chamber and the dialysate in the at least one dialysis chamber operably interact with each other for dialysis.

Abstract: A spring push with a main body, a crimp portion and two extensions also provides a trigger extending from the main body. The extensions provide engagement with the connector housing and also surfaces to engage the spring. The spring push may be a single component or be comprised of two separate pieces. An adapter is also disclosed with a cut-out portion on a bottom side.

Abstract: A dialysis device implantable in a patient for dialysis includes a filtration unit. The filtration unit includes at least one dialysis chamber for containing and/or circulating dialysate; and at least one blood chamber for containing and/or circulating blood of the patient, disposed on at least one dialysis chamber and being in communication with the at least one dialysis chamber. Each of the at least one dialysis chamber and the at least one blood chamber comprise at least one inlet for circulating fluid into and/or out of the at least one dialysis chamber and the at least one blood chamber. The at least one dialysis chamber and the at least one blood chamber are configured such that the blood in the at least one blood chamber and the dialysate in the at least one dialysis chamber operably interact with each other for dialysis.

Abstract: Methods and systems for compact presentation of automatically summarized information according to rule-based graphically represented information. One of the methods includes obtaining, via a user accessible user interface, a request for uploaded textual information to be analyzed. Ontology information is accessed based on an indicated type associated with the textual information, and ontology information for the type. The ontology information specifies nodes, with the nodes causing the server system to extract values for textual expressions defined by the nodes, and relational information between the nodes, with the relational information indicating links between textual expressions. The textual information is parsed based on the ontology information. The parsing causes traversal of the nodes and extraction of values from associated textual expressions based on the textual information. Values are obtained based on the parsing, with the values being utilized as summary information.

Abstract: Computer-implemented systems and methods for processing a document package are disclosed. A method for processing a document may include analyzing one or more documents to determine potential signer information, determining on such information, a respective set of signers, and sending electronic notifications to the signers. The notifications may include selectable links configured to provide access to the electronic documents associated with the signers. Upon selection of a link, an interactive user interface may be provided including access to the electronic documents. Signature data from a signer may be received via the interactive user interface. Based on the signature data, the system may determine whether completion criteria associated with the one or more documents is satisfied; in response to the completion criteria being satisfied, further electronic notifications to at least the signers may be sent out.

Abstract: Systems and methods for treating disc herniation include surgical and endoscopic access and removal of disc tissue. The tissue removal devices that may be used include flexible elongate members, such as a cable, that may be inserted into a vertebral disc and rotated to pulverize the disc material and facilitate its removal.

Abstract: A robotic document feeder system may comprise a robotic arm coupled to a Bernoulli cup assembly powered by a vacuum source; a base disposed over an imaging surface of a document scanner, wherein the base comprises a designated scan area through which a document may be imaged by the document scanner; an input bin for storing at least one document to be imaged by the document scanner; and an output bin for storing the at least one document after it has been imaged by the document scanner. The system may further comprise an alignment mechanism in proximity to the designated scan area and configured to align the document substantially over the imaging surface of the document scanner; at least one automated door configured to close the designated scan area after the document has been placed in the designated scan area; and a camera positioned above the designated scan area for imaging a second side of the document.