Abstract: The present invention discloses fused heterobicyclic 2-aryl- and 2-heteroarylthiazolyl compounds and their pharmaceutically acceptable salts and esters thereof, which are useful for inhibiting the growth of cancerous cells, inhibiting human breast carcinoma tumor growth in particular and to treat diseases or disorders associated with securin.

Abstract: The present invention discloses fused bicyclic 2-aryl- or 2-heteroarylthiazolyl compounds and their pharmaceutically acceptable salts and esters thereof, which are useful for inhibiting the growth of cancerous cells, inhibiting human breast carcinoma tumor growth in particular and to treat diseases or disorders associated with securin, including elevated securin levels.

Abstract: The invention relates to [a]-fused indole compounds of the Formula II, or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein. The invention also relates to compositions comprising the compounds of Formula II, and methods for making and using the compounds.

Abstract: An instrument assesses the transmurality of an ablation lesion from a first surface of a targeted biological tissue to an opposed second surface thereof. The instrument includes at least a first electrode operably attached to an ablation instrument adapted to engage a tissue first surface, and at least a second electrode adapted to engage a tissue second surface, the at least second electrode positioned generally opposed to the at least first electrode. Alternatively, the at least second electrode may be adapted to be placed within a chamber of an organ. These electrodes facilitate measuring at least one of conduction time, conduction velocity, phase angle, and impedance through at least a portion of the targeted tissue to determine the transmurality of the ablation lesion.

Abstract: A flexible microwave antenna assembly for a surgical ablation instrument capable of conforming to a tissue surface for ablation thereof. The ablation instrument includes a transmission line having a proximal portion suitable for connection to an electromagnetic energy source. The antenna assembly includes a flexible antenna coupled to the transmission line for radially generating an electric field sufficiently strong to cause tissue ablation. A flexible shield device is coupled to the antenna to substantially shield a surrounding area of the antenna from the electric field radially generated therefrom while permitting a majority of the field to be directed generally in a predetermined direction. A flexible insulator is disposed between the shield device and the antenna which defines a window portion enabling the transmission of the directed electric field in the predetermined direction.

Abstract: In order to generate a financial-aid application, a system provides an electronic template that is compatible with a format of the financial-aid application, and the system retrieves stored financial information for a first individual. This financial information includes one or more income tax returns that are stored in a format that is compatible with financial planning software. Furthermore, the system merges the financial information with the electronic template to complete at least a portion of the financial-aid application.

Abstract: The present disclosure is a method for bridging requests for access to resources between requesters in a distributed network and an authenticator servicing the distributed network. The bridging mechanism has security features including a naming service for machine authentication and machine process rules to authorize what process machines can perform. The security proxy bridge intercepts an access request, and checks the IP address for machine authentication as well as the machine process rules and if both verifications are successful, the bridge then forwards the request for access to the authenticator. The security proxy framework utilizes a data structure that provides a method for storing selected security information stored as data records supporting an authentication and authorization system for users to access resources on multiple components of a distributed network supporting multiple business units of an enterprise.

Abstract: A flexible microwave antenna assembly for a surgical ablation instrument capable of conforming to a tissue surface for ablation thereof. The ablation instrument includes a transmission line having a proximal portion suitable for connection to an electromagnetic energy source. The antenna assembly includes a flexible antenna coupled to the transmission line for radially generating an electric field sufficiently strong to cause tissue ablation. A flexible shield device is coupled to the antenna to substantially shield a surrounding area of the antenna from the electric field radially generated therefrom while permitting a majority of the field to be directed generally in a predetermined direction. A flexible insulator is disposed between the shield device and the antenna which defines a window portion enabling the transmission of the directed electric field in the predetermined direction.

Abstract: An adhesion promotion process and composition for enhancing adhesion between a copper conducting layer and a dielectric material during manufacture of a printed circuit board. The composition contains a corrosion inhibitor, an inorganic acid, and an alcohol which is effective to increase copper-loading in the composition.

Abstract: An adhesion promotion process and composition for enhancing adhesion between a copper conducting layer and a dielectric material during manufacture of a printed circuit board. The composition contains a corrosion inhibitor, an inorganic acid, and an alcohol which is effective to increase copper-loading in the composition.

Abstract: A system and method for bridging requests for access to resources between requestors in a distributed network and an authenticator servicing the distributed network is provided. The bridging mechanism has security features including a naming service for machine authentication and machine process rules to authorize what process machines can perform. The security proxy bridge intercepts an access request, and checks the IP address for machine authentication as well as the machine process rules and if both verifications are successful, the bridge then forwards the request for access to the authenticator. The security proxy framework utilizes a data structure that provides a method for storing selected security information stored as data records supporting an authentication and authorization system for users to access resources on multiple components of a distributed network supporting multiple business units of an enterprise.

Abstract: An instrument assesses the transmurality of an ablation lesion from a first surface of a targeted biological tissue to an opposed second surface thereof. The instrument includes at least a first electrode operably attached to an ablation instrument adapted to engage a tissue first surface, and at least a second electrode adapted to engage a tissue second surface, the at least second electrode positioned generally opposed to the at least first electrode. Alternatively, the at least second electrode may be adapted to be placed within a chamber of an organ. These electrodes facilitate measuring at least one of conduction time, conduction velocity, phase angle, and impedance through at least a portion of the targeted tissue to determine the transmurality of the ablation lesion.

Abstract: An instrument is provided to assess the transmurality of an ablation lesion from a first surface of a targeted biological tissue to an opposed second surface thereof. The instrument includes at least a first electrode operably attached to an ablation instrument adapted to engage a tissue first surface, and at least a second electrode adapted to engage a tissue second surface, the at least second electrode positioned generally opposed to the at least first electrode. Alternatively, the at least second electrode may be adapted to be placed within a chamber of an organ. These electrodes each measure at least one of conduction time, conduction velocity, phase angle, and impedance through at least a portion of the targeted tissue to determine the transmurality of the ablation lesion.

Abstract: A catheter system with an enhanced steering system, allowing for positioning the distal portion of the catheter proximate to a desired biological target tissue site, is provided. The system includes an elongated tubular member having a steerable distal end configured to deflect, or otherwise direct, and properly position at least a portion of the distal end comprising an ablation device during a surgical procedure allowing for the placement of the deflected portion adjacent or proximate to the target tissue surface. The steering system may alternatively be incorporated into a separate guiding catheter as part of the catheter system.

Abstract: A flexible microwave antenna assembly for a surgical ablation instrument capable of conforming to a tissue surface for ablation thereof. The ablation instrument includes a transmission line having a proximal portion suitable for connection to an electromagnetic energy source. The antenna assembly includes a flexible antenna coupled to the transmission line for radially generating an electric field sufficiently strong to cause tissue ablation. A flexible shield device is coupled to the antenna to substantially shield a surrounding area of the antenna from the electric field radially generated therefrom while permitting a majority of the field to be directed generally in a predetermined direction. A flexible insulator is disposed between the shield device and the antenna which defines a window portion enabling the transmission of the directed electric field in the predetermined direction.

Abstract: A flexible microwave antenna assembly for a surgical ablation instrument is capable of conforming to a tissue surface for ablation thereof. The ablation instrument includes a transmission line having a proximal portion suitable for connection to an electromagnetic energy source, and includes a flexible antenna coupled to the transmission line for radially generating an electric field sufficiently strong to cause tissue ablation. A flexible shield device is coupled to the antenna to substantially shield a surrounding area of the antenna from the electric field radially generated therefrom while permitting a majority of the field to be directed generally in a predetermined direction. A flexible insulator is disposed between the shield device and the antenna to define a window portion enabling the transmission of the directed electric field in the predetermined direction.

Abstract: A flexible microwave antenna assembly for a surgical ablation instrument capable of conforming to a tissue surface for ablation thereof. The ablation instrument includes a transmission line having a proximal portion suitable for connection to an electromagnetic energy source. The antenna assembly includes a flexible antenna coupled to the transmission line for radially generating an electric field sufficiently strong to cause tissue ablation. A flexible shield device is coupled to the antenna to substantially shield a surrounding area of the antenna from the electric field radially generated therefrom while permitting a majority of the field to be directed generally in a predetermined direction. A flexible insulator is disposed between the shield device and the antenna which defines a window portion enabling the transmission of the directed electric field in the predetermined direction.

Abstract: Methods and systems for matching the communication protocol of a calling device with one of a plurality of communication protocols supported by an answering device are provided. Initially, a predetermined amount of data is received and buffered in a memory component. Following, an analysis is performed to match the received data with one of the communication protocols supported by the answering device. Communication protocols that can be detected and matched include, for example, the V.110, V.120 and ISDN protocols. During the buffering and analyzing steps, a predetermined data pattern such as mark idle can be transmitted to the calling device. Thereafter, the answering device is configured to answer the call according to the protocol matched in the analyzing step. A timer can be utilized to limit the period for matching to a predetermined length, after which time the answering device can be configured to answer the call in analog mode.

Abstract: Techniques for cooling electronics assemblies are provided. A divider, such as an electronic card, is utilized to define flow channels through the chassis of the electronics assembly. The divider is parallel to the electronic cards and air movers, such as fans, can be utilized in a push-pull configuration to cause air to flow and counter-flow through the flow channels to cool the electronic cards.

Abstract: A downloadable postage rate calculating device including a platform for receiving a parcel and providing a weight for the parcel, and a processor configured to receive current rates information downloaded from a computer or other similar device. The processor calculates a postage amount for the parcel based on at least a portion of the current rates information and the weight of the parcel. The processor can also compare the postage amount for a first carrier and shipping method, with that of a second carrier and shipping method, or between two shipping methods offered by the same carrier.