Patents by Inventor Hing L. Sham

Hing L. Sham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
    Publication number: 20040259843
    Abstract: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
    Type: Application
    Filed: February 27, 2004
    Publication date: December 23, 2004
    Inventors: David J. Madar, Stevan W. Djuric, Melissa J. Michmerhuizen, Hana A. Kopecka, Xiaofeng Li, Kenton L. Longenecker, Zhonghua Pei, Daisy Pireh, Hing L. Sham, Kent D. Stewart, Bruce G. Szczepankiewicz, Paul E. Wiedeman, Hong Yong
  • Fused tri and tetra-cyclic pyrazole kinase inhibitors
    Publication number: 20040259904
    Abstract: Compounds having the formula (I) 1
    Type: Application
    Filed: March 3, 2004
    Publication date: December 23, 2004
    Inventors: Yunsong Tong, Akiyo K. Claiborne, Gaoquan Li, Nan-Horng Lin, Hing L. Sham, Thomas J. Sowin, Zhi-Fu Tao
  • Inhibitors of neuraminidases
    Patent number: 6831096
    Abstract: Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: December 14, 2004
    Assignee: Abbott Laboratories
    Inventors: Clarence J. Maring, Yu Gui Gu, Hui-Ju Chen, Yuanwei Chen, David A. Degoey, William J. Flosi, Vincent L. Giranda, David J. Grampovnik, Warren M. Kati, Dale J. Kempf, April Kennedy, Larry L. Klein, Allan C. Krueger, Zhen Lin, Darold L. Madigan, Keith F. McDaniel, Steven W. Muchmore, Hing L. Sham, Kent D. Stewart, Vincent S. Stoll, Minghua Sun, Noah P. Tu, Frank L. Wagenaar, Gary T. Wang, Sheldon Wang, Paul E. Wiedeman, Yibo Xu, Ming C. Yeung, Chen Zhao, Stephen Hanessian, Malken Bayrakdarian, Xuehong Luo
  • Protein kinase inhibitors
    Patent number: 6797825
    Abstract: Compounds having the formula or therapeutically acceptable salts thereof, are protein kinase inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: September 28, 2004
    Assignee: Abbott Laboratories
    Inventors: Nan-Horng Lin, Hing L. Sham, Ping Xia
  • Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
    Publication number: 20040121964
    Abstract: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
    Type: Application
    Filed: September 11, 2003
    Publication date: June 24, 2004
    Inventors: David J. Madar, Stevan W. Djuric, Melissa J. Feenstra, Hana A. Kopecka, Xiaofeng Li, Kenton L. Longenecker, ZhongHua Pei, Daisy Pireh, Hing L. Sham, Kent D. Stewart, Bruce G. Szczepankiewicz, Paul E. Wiedeman, Hong Yong
  • Inhibitors of neuraminidases
    Publication number: 20040097471
    Abstract: Disclosed are compounds of the formula: 1
    Type: Application
    Filed: September 24, 2002
    Publication date: May 20, 2004
    Inventors: Clarence J. Maring, Yu Gui Gu, Hui-Ju Chen, Yuanwei Chen, David A. Degoey, William J. Flosi, Vincent L. Giranda, David J. Grampovnik, Warren M. Kati, Dale J. Kempf, April Kennedy, Larry L. Klein, Allan C. Krueger, Zhen Lin, Darold L. Madigan, Keith F. McDaniel, Steven W. Muchmore, Hing L. Sham, Kent D. Stewart, Vincent S. Stoll, Minghua Sun, Noah P. Tu, Frank L. Wagenaar, Gary T. Wang, Sheldon Wang, Paul E. Wiedeman, Yibo Xu, Ming C. Yeung, Chen Zhao, Stephen Hanessian, Malken Bayrakdarian, Xuehong Luo
  • Urea kinase inhibitors
    Publication number: 20040034038
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: August 13, 2002
    Publication date: February 19, 2004
    Inventors: Goaquan Li, Qun Li, Tongmei Li, Nan-Horng Lin, Robert A. Mantei, Hing L. Sham, Gary T. Wang
  • Farnesyltransferase inhibitors
    Publication number: 20030216441
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: May 10, 2002
    Publication date: November 20, 2003
    Inventors: Stephen L. Gwaltney, Lissa T.J. Nelson, Stephen J. O'Connor, Hing L. Sham, Gerard M. Sullivan, Weibo Wang
  • Farnesyltransferase inhibitors
    Publication number: 20030199542
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: April 18, 2002
    Publication date: October 23, 2003
    Inventors: Keith W. Woods, Qun Li, Hing L. Sham
  • Farnesyltransferase inhibitors
    Publication number: 20030199544
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: April 18, 2003
    Publication date: October 23, 2003
    Inventors: Keith W. Woods, Qun Li, Hing L. Sham
  • Protein kinase inhibitors
    Publication number: 20030162785
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: December 12, 2002
    Publication date: August 28, 2003
    Inventors: Nan-Horng Lin, Hing L. Sham, Ping Xia
  • Protein kinase inhibitors
    Publication number: 20030119839
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: December 13, 2001
    Publication date: June 26, 2003
    Inventors: Nan-Horng Lin, Hing L. Sham, Ping Xia
  • Farnesyltransferase inhibitors
    Publication number: 20030087940
    Abstract: Substituted imidazoles and thiazoles having the formula 1
    Type: Application
    Filed: November 30, 2001
    Publication date: May 8, 2003
    Inventors: Akiyo K. Claiborne, Stephen L. Gwaltney, Lisa A. Hasvold, Qun Li, Tongmei Li, Nan-Horng Lin, Robert A. Mantei, Todd W. Rockway, Hing L. Sham, Gerard M. Sullivan, Yunsong Tong, Gary Wang, Le Wang, Xilu Wang, Wei-Bo Wang
  • Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
    Patent number: 6518305
    Abstract: Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
    Type: Grant
    Filed: October 19, 1999
    Date of Patent: February 11, 2003
    Assignee: Abbott Laboratories
    Inventors: Clarence J. Maring, Yuanwei Chen, David A. Degoey, Vincent L. Giranda, David J. Grampovnik, Yu Gui Gu, Warren M. Kati, Dale J. Kempf, April Kennedy, Allan C. Krueger, Zhen Lin, Darold L. Madigan, Steven W. Muchmore, Hing L. Sham, Kent D. Stewart, Vincent S. Stoll, Minghua Sun, Gary T. Wang, Sheldon Wang, Ming C. Yeung, Chen Zhao
  • Compositions and methods for enhancing the bioavailability of pharmaceutical agents
    Publication number: 20020198160
    Abstract: This invention relates to enhancing the bioavailability of pharmaceutically active agents. In particular, this invention relates to the use of lopinavir, its pharmaceutically acceptable equivalents, and derivatives thereof as P-glycoprotein inhibitors.
    Type: Application
    Filed: April 29, 2002
    Publication date: December 26, 2002
    Inventors: Elizabeth A. Everitt, Edward K. Han, Sajeev P. Cherian, Dale J. Kempf, Hing L. Sham, Shi-Chung Ng
  • Inhibitors of neuraminidases
    Patent number: 6455571
    Abstract: Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
    Type: Grant
    Filed: October 19, 1999
    Date of Patent: September 24, 2002
    Assignee: Abbott Laboratories
    Inventors: Clarence J. Maring, Yu Gui Gu, Hui-Ju Chen, Yuanwei Chen, David A. Degoey, William J. Flosi, Vincent L. Giranda, David J. Grampovnik, Warren M. Kati, Dale J. Kempf, April Kennedy, Larry L. Klein, Allan C. Krueger, Zhen Lin, Darold L. Madigan, Keith F. McDaniel, Steven W. Muchmore, Hing L. Sham, Kent D. Stewart, Vincent S. Stoll, Minghua Sun, Noah P. Tu, Frank L. Wagenaar, Gary T. Wang, Sheldon Wang, Paul E. Wiedeman, Yibo Xu, Ming C. Yeung, Chen Zhao, Stephen Hanessian, Malken Bayrakdarian, Xuehong Luo
  • Farnesyltransferase inhibitors
    Publication number: 20020115640
    Abstract: Substituted imidazoles and thiazoles having the formula 1
    Type: Application
    Filed: July 25, 2001
    Publication date: August 22, 2002
    Inventors: Akiyo K. Claiborne, Stephen L. Gwaltney,, Lisa A. Hasvold, Qun Li, Tongmei Li, Nan-Horng Lin, Robert A. Mantei, Todd W. Rockway, Hing L. Sham, Gerard M. Sullivan, Yunsong Tong, Gary Wang, Le Wang, Xilu Wang, Wei-Bo Wang
  • Substituted phenyl farnesyltransferase inhibitors
    Publication number: 20020019527
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: April 25, 2001
    Publication date: February 14, 2002
    Inventors: Wei-Bo Wang, Michael L. Curtin, Stephen A. Fakhoury, Stephen L. Gwaltney, Lisa A. Hasvold, Charles W. Hutchins, Qun Li, Nan-Horng Lin, Lissa Taka Jennings Nelson, Steve O'Connor, Hing L. Sham, Gerard M. Sullivan, Gary T. Wang, Xilu Wang
  • Oxazoline antiproliferative agents
    Patent number: 6228868
    Abstract: Compounds having Formula I are useful for treating cancer. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of treating cancer in a mammal.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: May 8, 2001
    Assignee: Abbott Laboratories
    Inventors: Stephen L. Gwaltney, II, Hwan-Soo Jae, Douglas M. Kalvin, Gang Liu, Hing L. Sham, Qun Li, Akiyo K. Claiborne, Le Wang, Kenneth J. Barr, Keith W. Woods
  • Imidazole antiproliferative agents
    Patent number: 6201001
    Abstract: Compounds of formula I inhibit celluar proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
    Type: Grant
    Filed: August 2, 1999
    Date of Patent: March 13, 2001
    Assignee: Abbott Laboratories
    Inventors: Le Wang, Qun Li, Hing L. Sham, Keith W. Woods