Patents by Inventor Hing L. Sham

Hing L. Sham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Retroviral protease inhibiting compounds
    Patent number: 5905068
    Abstract: A compound of the formula: ##STR1## is disclosed as a retroviral protease inhibitor compound. Also disclosed are methods and compositions for inhibiting an HIV infection.
    Type: Grant
    Filed: September 24, 1996
    Date of Patent: May 18, 1999
    Assignee: Abbott Laboratories
    Inventors: Xiaoqi Chen, Brian E. Green, Dale J. Kempf, Lin Li, Daniel W. Norbeck, Hing L. Sham
  • Retroviral protease inhibiting compounds
    Patent number: 5648497
    Abstract: A retroviral protease inhibiting compound of the formula A--X--B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhibitors.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: July 15, 1997
    Assignee: Abbott Laboraotries
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Lynn M. Codacovi, Hing L. Sham, Steven J. Wittenberger
  • Retroviral protease inhibiting compounds
    Patent number: 5631376
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: May 20, 1997
    Assignee: Abbott Laboratories
    Inventors: Daniel W. Norbeck, Hing L. Sham, Dale J. Kempf, Chen Zhao
  • Retroviral protease inhibiting compounds
    Patent number: 5625072
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: April 29, 1997
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Hing L. Sham, Chen Zhao
  • Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane
    Patent number: 5625092
    Abstract: Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl or benzyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: April 29, 1997
    Assignee: Abbott Laboratories
    Inventors: Timothy L. Stuk, Michael S. Allen, Anthony R. Haight, Francis A. J. Kerdesky, Denton C. Langridge, M. Robert Leanna, Linda M. Lijewski, Laura Melcher, Howard E. Morton, Daniel W. Norbeck, Daniel S. Reno, Timothy A. Robbins, David Scarpetti, Hing L. Sham, Thomas J. Sowin, Jien-Heh J. Tien, Chen Zhao
  • Retroviral protease inhibiting compounds
    Patent number: 5621109
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed wherein the terms R.sub.1, R.sub.2, R.sub.5, R.sub.6, Y, Y', m and n are herein defined.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: April 15, 1997
    Assignee: Abbott Laboratories
    Inventors: Daniel W. Norbeck, Hing L. Sham, Dale J. Kempf, Chen Zhao
  • Retroviral protease inhibiting compounds
    Patent number: 5616720
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: April 1, 1997
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Hing L. Sham, Chen Zhao, Daniel S. Reno
  • Retroviral protease inhibiting compounds
    Patent number: 5616714
    Abstract: A retroviral protease inhibiting compound of the formula A--X--B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhibitors.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: April 1, 1997
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Lynn M. Codacovi, Hing L. Sham, Steven J. Wittenberger
  • Retroviral protease inhibiting compounds
    Patent number: 5608072
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: March 4, 1997
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Hing L. Sham, Chen Zhao
  • Retroviral protease inhibiting compounds
    Patent number: 5597928
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: January 28, 1997
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Hing L. Sham, Chen Zhao
  • Retroviral protease inhibiting compounds
    Patent number: 5597927
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: January 28, 1997
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Hing L. Sham, Chen Zhao
  • Retroviral protease inhibiting compounds
    Patent number: 5591860
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: January 7, 1997
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Hing L. Sham, Chen Zhao
  • Retroviral protease inhibiting compounds
    Patent number: 5583232
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: December 10, 1996
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Hing L. Sham, Chen Zhao
  • Retroviral protease inhibiting compounds
    Patent number: 5583233
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
    Type: Grant
    Filed: March 30, 1995
    Date of Patent: December 10, 1996
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Hing L. Sham, Chen Zhao
  • Retroviral protease inhibiting compounds
    Patent number: 5580984
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
    Type: Grant
    Filed: March 28, 1995
    Date of Patent: December 3, 1996
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Hing L. Sham, Chen Zhao, Thomas J. Sowin, Daniel S. Reno, Anthony R. Haight
  • Retroviral protease inhibiting compounds
    Patent number: 5565418
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: October 15, 1996
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Hing L. Sham, Chen Zhao, Thomas J. Sowin, Daniel S. Reno, Michael S. Allen, Arthur J. Copper, Jien-Heh J. Tien
  • Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane
    Patent number: 5565604
    Abstract: Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl or benzyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: October 15, 1996
    Assignee: Abbott Laboratories
    Inventors: Timothy L. Stuk, Michael S. Allen, Anthony R. Haight, Linda M. Lijewski, Howard E. Morton, Daniel S. Reno, Hing L. Sham, Thomas J. Sowin
  • Process for the preparation of a substituted 2,5-Diamino-3-Hydroxyhexane
    Patent number: 5543549
    Abstract: Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R7a is loweralkyl or benzyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: August 6, 1996
    Assignee: Abbott Laboratories
    Inventors: Timothy L. Stuk, Michael S. Allen, Anthony R. Haight, Howard E. Morton, Daniel S. Reno, Hing L. Sham, Thomas J. Sowin, Jien-Heh J. Tien
  • Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane
    Patent number: 5543551
    Abstract: Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl or benzyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: August 6, 1996
    Assignee: Abbott Laboratories
    Inventors: Timothy L. Stuk, Michael S. Allen, Anthony R. Haight, Francis A. Kerdesky, Denton C. Langridge, M. Robert Leanna, Linda M. Lijewski, Laura Melcher, Howard E. Morton, Daniel W. Norbeck, Daniel S. Reno, Timothy A. Robbins, Hing L. Sham, Thomas J. Sowin, Jien-heh J. Tien, Chen Zhao, David Scarpetti
  • Process for the prepartation of a substituted 2,5-diamino-3-hydroxyhexane
    Patent number: 5543552
    Abstract: Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)- wherein R.sub.7a is loweralkyl or benzyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: August 6, 1996
    Assignee: Abbott Laboratories
    Inventors: Timothy L. Stuk, Michael S. Allen, Anthony R. Haight, M. Robert Leanna, Linda M. Lijewski, Laura Melcher, Howard E. Morton, Daniel S. Reno, Hing L. Sham, Thomas J. Sowin