Patents by Inventor Hing Sham

Hing Sham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tricyclic compounds as histone methyltransferase inhibitors
    Patent number: 11584734
    Abstract: The present disclosure provides tricyclic compounds of formula (I) that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: February 21, 2023
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Ming Yu, Zhe Li, Qing Xu, Calvin Yee, Lina Setti, Hing Sham
  • Modulators of hemoglobin
    Patent number: 11014884
    Abstract: The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of hemoglobin, and methods for their use in treating disorders mediated by hemoglobin.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: May 25, 2021
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Brian W. Metcalf, Zhe Li, Qing Xu, Kobina N. Dufu, James Partridge, Hing Sham, Ming Yu
  • TRICYCLIC COMPOUNDS AS HISTONE METHYLTRANSFERASE INHIBITORS
    Publication number: 20200361896
    Abstract: The present disclosure provides tricyclic compounds of formula (I) that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Application
    Filed: August 13, 2018
    Publication date: November 19, 2020
    Inventors: Ming YU, Zhe LI, Qing XU, Calvin YEE, Lina SETTI, Hing SHAM
  • MODULATORS OF HEMOGLOBIN
    Publication number: 20200140384
    Abstract: The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of hemoglobin, and methods for their use in treating disorders mediated by hemoglobin.
    Type: Application
    Filed: September 30, 2019
    Publication date: May 7, 2020
    Inventors: Brian W. Metcalf, Zhe Li, Qing Xu, Kobina N. Dufu, James Partridge, Hing Sham, Ming Yu
  • Bridged bicyclic kallikrein inhibitors
    Patent number: 10144746
    Abstract: Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: December 4, 2018
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Zhe Li, Manuel Zancanella, Chul Yu, Lina Q. Setti, Hing Sham, Qing Xu, Calvin W. Yee, Ming Yu
  • BRIDGED BICYCLIC KALLIKREIN INHIBITORS
    Publication number: 20180194780
    Abstract: Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
    Type: Application
    Filed: November 8, 2017
    Publication date: July 12, 2018
    Inventors: Zhe Li, Manuel Zancanella, Chul Yu, Lina Q. Setti, Hing Sham, Qing Xu, Calvin W. Yee, Ming Yu
  • Bridged bicyclic kallikrein inhibitors
    Patent number: 9815853
    Abstract: Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: November 14, 2017
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Zhe Li, Manuel Zancanella, Chul Yu, Lina Setti, Hing Sham, Qing Xu, Calvin Yee, Ming Yu
  • Pyrazolopyridine pyrazolopyrimidine and related compounds
    Patent number: 9695166
    Abstract: In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: July 4, 2017
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Zhe Li, Qing Xu, Chul Yu, Calvin Yee, Stephen L. Gwaltney, II, Brian W. Metcalf, Steven Richards, Matthew A. Lardy, Lina Setti, Hing Sham
  • BRIDGED BICYCLIC KALLIKREIN INHIBITORS
    Publication number: 20160362427
    Abstract: Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
    Type: Application
    Filed: June 9, 2016
    Publication date: December 15, 2016
    Inventors: Zhe Li, Manuel Zancanella, Chul Yu, Lina Setti, Hing Sham, Qing Xu, Calvin Yee, Ming Yu
  • PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS
    Publication number: 20150315198
    Abstract: In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.
    Type: Application
    Filed: May 4, 2015
    Publication date: November 5, 2015
    Applicant: Global Blood Therapeutics, Inc.
    Inventors: Zhe Li, Qing Xu, Chul Yu, Calvin Yee, Stephen L. Gwaltney,, II, Brian W. Metcalf, Steven Richards, Matthew A. Lardy, Lina Setti, Hing Sham
  • Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome
    Patent number: 8748627
    Abstract: The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: June 10, 2014
    Assignee: AbbVie Inc.
    Inventors: Yu Gui Gu, Moshe Weitzberg, Xiangdong Xu, Richard F. Clark, Tianyuan Zhang, Qun Li, Todd M. Hansen, Hing Sham, Bruce A. Beutel, Heidi S. Camp, Xiaojun Wang
  • Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome
    Patent number: 7928243
    Abstract: The present invention relates to compounds of formula (I): Pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic diseases or conditions are also provided.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: April 19, 2011
    Assignee: Abbott Laboratories
    Inventors: Yu Gui Gu, Richard F. Clark, Qun Li, Moshe Weitzberg, Hing Sham
  • Heterocyclic kinase inhibitors
    Patent number: 7456169
    Abstract: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: November 25, 2008
    Assignee: Abbott Laboratories Inc.
    Inventors: Lisa A. Hasvold, Laura Hexamer, Gaoquan Li, Nan-Horng Lin, Hing Sham, Thomas J. Sowin, Gerard M. Sullivan, Le Wang, Ping Xia
  • NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME
    Publication number: 20080161368
    Abstract: The present invention relates to compounds of formula (I): Pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic diseases or conditions are also provided.
    Type: Application
    Filed: December 5, 2007
    Publication date: July 3, 2008
    Inventors: Yu Gui Gu, Richard F. Clark, Qun Li, Moshe Weitzberg, Hing Sham
  • RETROVIRAL PROTEASE INHIBITING COMPOUNDS
    Publication number: 20080139811
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Application
    Filed: February 27, 2007
    Publication date: June 12, 2008
    Inventors: Hing Sham, Daniel Norbeck, Xiaoqi Chen, David Betebenner, Dale Kempf, Thomas Herrin, Gondi Kumar, Stephen Condon, Arthur Cooper, Daniel Dickman, Steven Hannick, Lawrence Kolaczkowski, Patricia Oliver, Daniel Plata, Peter Stengel, Eric Stoner, Jieh-Heh Tien, Jih-Hua Liu, Ketan Patel
  • PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV)
    Publication number: 20080119464
    Abstract: The present invention relates to compounds of formula (I), which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
    Type: Application
    Filed: January 30, 2008
    Publication date: May 22, 2008
    Inventors: Irini Akritopoulou-Zanze, Daria Darczak, Jurgen Dinges, Stevan Djuric, Ethan Hoff, Hana Kopecka, Jyoti Patel, Zhonghua Pei, Qi Shuai, Kathy Sarris, Hing Sham, Paul Wiedeman
  • PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV)
    Publication number: 20070265302
    Abstract: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
    Type: Application
    Filed: July 25, 2007
    Publication date: November 15, 2007
    Inventors: David Madar, Stevan Djuric, Melissa Michmerhuizen, Hana Kopecka, Xiaofeng Li, Kenton Longenecker, Zhonghua Pei, Daisy Pireh, Hing Sham, Kent Stewart, Bruce Szezepankiewicz, Paul Wiedeman, Hong Yong
  • Heterocyclic Kinase Inhibitors
    Publication number: 20070254867
    Abstract: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Application
    Filed: August 23, 2006
    Publication date: November 1, 2007
    Inventors: Lisa Hasvold, Laura Hexamer, Gaoquan Li, Nan-Horng Lin, Hing Sham, Thomas Sowin, Gerard Sullivan, Le Wang, Ping Xia
  • Pharmaceutical Compositions as Inhibitors of Dipeptidyl Peptidase-IV (DPP-IV)
    Publication number: 20070238753
    Abstract: The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
    Type: Application
    Filed: June 1, 2007
    Publication date: October 11, 2007
    Inventors: David Madar, Stevan Djuric, Melissa Michmerhuizen, Hana Kopecka, Xiaofeng Li, Kenton Longenecker, Zhonghua Pei, Daisy Pireh, Hing Sham, Kent Stewart, Bruce Szczepankiewicz, Paul Wiedeman, Hong Yong
  • NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME
    Publication number: 20070225332
    Abstract: The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
    Type: Application
    Filed: February 15, 2007
    Publication date: September 27, 2007
    Inventors: Yu Gui Gu, Moshe Weitzberg, Xiangdong Xu, Richard Clark, Tianyuan Zhang, Qun Li, Todd Hansen, Hing Sham, Bruce Beutel, Heidi Camp, Xiaojun Wang