Patents by Inventor Hing Sham

Hing Sham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME
    Publication number: 20070219251
    Abstract: The present invention relates to compounds of formula (I) which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
    Type: Application
    Filed: February 15, 2007
    Publication date: September 20, 2007
    Inventors: Yu Gui Gu, Xiangdong Xu, Moshe Weitzberg, Hing Sham
  • NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME
    Publication number: 20070219258
    Abstract: The present invention relates to compounds of formula (I) which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
    Type: Application
    Filed: February 15, 2007
    Publication date: September 20, 2007
    Inventors: Robert Keyes, Yu Gu, Hing Sham
  • Thienopyridones as AMPK activators for the treatment of diabetes and obesity
    Publication number: 20060287356
    Abstract: The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
    Type: Application
    Filed: August 24, 2006
    Publication date: December 21, 2006
    Inventors: Rajesh Iyengar, Andrew Judd, Gang Zhao, Philip Kym, Hing Sham, Yugui Gu, Gang Liu, Mei Liu, Hongyu Zhao, Richard Clark, Ernst Frevert, Barbara Cool, Tianyuan Zhang, Robert Keyes, Todd Hansen, Zhili Xin
  • Farnesyltransferase Inhibitors
    Publication number: 20060264476
    Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
    Type: Application
    Filed: July 25, 2006
    Publication date: November 23, 2006
    Inventors: Akiyo Claiborne, Stephen Gwaltney, Lisa Hasvold, Qun Li, Tongmei Li, Nan-Horng Lin, Robert Mantei, Todd Rockway, Hing Sham, Gerard Sullivan, Yunsong Tong, Gary Wang, Le Wang, Xilu Wang, Wei-Bo Wang
  • Novel acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome
    Publication number: 20060178400
    Abstract: The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
    Type: Application
    Filed: November 7, 2005
    Publication date: August 10, 2006
    Inventors: Bruce Beutel, Heidi Camp, Richard Clark, Yu-Gui Gu, Todd Hansen, Robert Keyes, Qun Li, Gang Liu, Hing Sham, Xiaojun Wang, Moshe Weitzberg, Zhili Xin, Xiangdong Xu, Tianyuan Zhang
  • Inhibitors of c-Jun N-terminal kinases
    Publication number: 20060173050
    Abstract: The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.
    Type: Application
    Filed: January 23, 2006
    Publication date: August 3, 2006
    Inventors: Gang Liu, Hing Sham, Bruce Szczepankiewicz, Zhili Xin, Hongyu Zhao, Michael Serby, Bo Liu, Mei Liu
  • Isoxazole carboxamide derivatives as ghrelin receptor modulators
    Publication number: 20060089398
    Abstract: The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
    Type: Application
    Filed: March 10, 2004
    Publication date: April 27, 2006
    Inventors: Gang Liu, Hongyu Zhao, Michael Serby, Bo Liu, Zhili Xin, Lissa Nelson, Bruce Szczepankiewicz, Hing Sham
  • Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
    Publication number: 20050277638
    Abstract: The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.
    Type: Application
    Filed: December 22, 2004
    Publication date: December 15, 2005
    Inventors: Andrew Souers, Christine Collins, Ju Gao, Andrew Judd, Philip Kym, Mathew Mulhern, Hing Sham, Dariusz Wodka
  • Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
    Publication number: 20050215784
    Abstract: The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
    Type: Application
    Filed: January 13, 2005
    Publication date: September 29, 2005
    Inventors: David Madar, Stevan Djuric, Melissa Michmerhuizen, Hana Kopecka, Xiaofeng Li, Kenton Longenecker, Zhonghua Pei, Daisy Pireh, Hing Sham, Kent Stewart, Bruce Szczepankiewicz, Paul Wiedeman, Hong Yong
  • Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
    Publication number: 20050215603
    Abstract: The present invention relates to compounds of formula (I), which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
    Type: Application
    Filed: March 8, 2004
    Publication date: September 29, 2005
    Inventors: Irini Akritopoulou-Zanze, Daria Darczak, Jurgen Dinges, Stevan Djuric, Ethan Hoff, Hana Kopecka, Jyoti Patel, Zhonghua Pei, Qi Shuai, Kathy Sarris, Hing Sham, Paul Wiedeman
  • Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
    Publication number: 20050209249
    Abstract: The present invention relates to compounds of formula (I), which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
    Type: Application
    Filed: March 8, 2005
    Publication date: September 22, 2005
    Inventors: Irini Akritopoulou-Zanze, Daria Darczak, Jurgen Dinges, Stevan Djuric, Ethan Hoff, Hana Kopecka, Jyoti Patel, Zhonghua Pei, Qi Shuai, Kathy Sarris, Hing Sham, Paul Wiedeman
  • Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
    Publication number: 20050209274
    Abstract: The present invention is directed to compounds of formula (I), which antagonize of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.
    Type: Application
    Filed: February 25, 2005
    Publication date: September 22, 2005
    Inventors: John Lynch, Christine Collins, Jennifer Freeman, Ju Gao, Rajesh Iyengar, Andrew Judd, Philip Kym, Mathew Mulhern, Hing Sham, Andrew Souers, Gang Zhao, Dariusz Wodka
  • Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
    Publication number: 20050187279
    Abstract: The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.
    Type: Application
    Filed: December 22, 2004
    Publication date: August 25, 2005
    Inventors: Andrew Souers, Christine Collins, Ju Gao, Andrew Judd, Philip Kym, Mathew Mulhern, Hing Sham, Dariusz Wodka
  • Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
    Publication number: 20050187387
    Abstract: The present invention is directed to compounds of formula (I), which antagonize of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.
    Type: Application
    Filed: February 25, 2004
    Publication date: August 25, 2005
    Inventors: John Lynch, Christine Collins, Jennifer Freeman, Ju Gao, Rajesh Iyengar, Andrew Judd, Philip Kym, Mathew Mulhern, Hing Sham, Andrew Souers, Gang Zhao
  • Cell proliferation inhibitors
    Publication number: 20050187246
    Abstract: Compounds having formula (I) inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
    Type: Application
    Filed: April 19, 2005
    Publication date: August 25, 2005
    Inventors: Qun Li, Hing Sham, Keith Woods, Beth Steiner, Stephen Gwaltney, Kenneth Barr, Hovis Imade, Saul Rosenberg
  • Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists
    Publication number: 20050171131
    Abstract: The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity, and disorders associated with obesity such as noninsulin dependent diabetes mellitus.
    Type: Application
    Filed: September 23, 2004
    Publication date: August 4, 2005
    Inventors: Christi Kosogof, Bo Liu, Gang Liu, Mei Liu, Lissa Nelson, Michael Serby, Hing Sham, Bruce Szczepankiewicz, Zhili Xin, Hongyu Zhao
  • Cell proliferation inhibitors
    Patent number: 6924304
    Abstract: Compounds having formula (I) inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: August 2, 2005
    Assignee: Abbott Laboratories
    Inventors: Qun Li, Hing Sham, Keith W. Woods, Beth A. Steiner, Stephen L. Gwaltney, II, Kenneth J. Barr, Hovis M. Imade, Saul Rosenberg
  • Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
    Publication number: 20050137187
    Abstract: The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.
    Type: Application
    Filed: December 23, 2003
    Publication date: June 23, 2005
    Inventors: Andrew Souers, Christine Collins, Ju Gao, Andrew Judd, Philip Kym, Mathew Mulhern, Hing Sham, Dariusz Wodka
  • Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
    Publication number: 20050137243
    Abstract: The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.
    Type: Application
    Filed: December 23, 2003
    Publication date: June 23, 2005
    Inventors: Andrew Souers, Christine Collins, Ju Gao, Andrew Judd, Philip Kym, Mathew Mulhern, Hing Sham, Anil Vasudevan, Dariusz Wodka
  • Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
    Publication number: 20050131019
    Abstract: The present invention relates to compounds of formula (I), which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, ?-cell failure, obesity, satiety disorders, atherosclerosis, and various immunomodulatory diseases.
    Type: Application
    Filed: September 7, 2004
    Publication date: June 16, 2005
    Inventors: Zhonghua Pei, Xiaofeng Li, Kenton Longenecker, Hing Sham, Paul Wiedeman