Abstract: A marine propulsion device includes a first gear, a second gear, a third gear, a circulator, a case, and an attachment body. The second gear is meshed with the first gear. The third gear is meshed with the first gear, and the third gear is coaxial with the second gear and opposed to the second gear. The circulator is between the second gear and the third gear. The case includes an internal space in which the first gear, the second gear, the third gear, and the circulator are located. The case includes an attachment hole to which the circulator is attached. The attachment body is inserted into the attachment hole so as to attach the circulator to the case.

Abstract: Two-speed transmission apparatus for electric vehicle comprises a planetary gear mechanism 16, friction brake 28 and friction clutch 26 in coaxial arrangement between input axis 10 and output axis 12, first speed is obtained by fastening the friction brake 28 and one-on-one second speed is obtained by fastening friction clutch 26. The electric actuator 30 to switch first speed and second speed comprises electric motor 32, a torque-thrust converting mechanism 36 and pusher 34. The torque-thrust converting mechanism 36 comprises inside cylindrical screw 40 being rotated by control motor 32 and outside cylindrical nut 42 which is screwed with cylindrical screw 40 and is connected to pusher 34 so as to integrally axis-move. The control motor 32 may include an electromagnetic brake to fasten the friction brake 28 and the friction clutch 26. Thrust of the axial direction may be transmitted by the swing of an arm 316.

Abstract: A display device includes: a first substrate, a second substrate, a light-blocking portion, a pixel, and a wiring line. The second substrate has a main face opposite a main face of the first substrate. The light-blocking portion is disposed on the main face of the first substrate, including an opening, and blocking light. The pixel is disposed on the main faces of the first substrate and the second substrate and delimited by at least a part of the opening. The wiring line is disposed on the main face of the second substrate and at least partially overlapping the opening. The wiring line has a projection protruding toward a first substrate side. The projection has a surface including a curved surface and comprises a plurality of projections disposed at intervals in locations overlapping at least the opening.

Abstract: A fuel cell system for a load device may include a fuel cell, a battery, and a controller configured to control the fuel cell and the battery. The controller may be configured to: cumulatively calculate first accumulated electric energy generated by the fuel cell; cumulatively calculate a power generation efficiency average at the time of storage of the first accumulated electric energy; calculate required power generation efficiency to generate electric power that meets a power demand of the load device; under a first condition where the power generation efficiency average is lower than the required power generation efficiency, cause the fuel cell to generate electric power that meets the power demand; and under a second condition where the power generation efficiency average is higher, cause the fuel cell to generate electric power at a specific operating point and cause the battery to discharge deficient electric power.

Abstract: An object of the present invention is to provide an effective vaccine that can prevent and treat infection with CMV. A fusion protein of the present invention is a fusion protein of envelope glycoprotein B (gB protein) and a pentamer of the cytomegalovirus (CMV). A vaccine for prevent or treat infection with cytomegalovirus (CMV) of the present invention is a subunit vaccine containing a fusion protein of envelope glycoprotein B (gB protein) and a pentamer of CMV as an antigen.

Abstract: A steering apparatus includes a turning shaft movable in the vehicle widthwise direction, a pinion shaft meshed with the turning shaft, a first housing that retains therein the turning shaft and the pinion shaft, a ball screw that transmits drive force generated by a drive source to the turning shaft, and a second housing that retains therein the ball screw. A retaining portion capable of storing water is provided at an inner circumferential surface of the second housing. A lower end surface of the retaining portion is located below at least a lower end surface of the ball screw. A first end portion of the retaining portion in the axial direction of the turning shaft is located between a belt member that links the ball screw with the drive source and a rack end stopper at the drive-source side.

Abstract: A steering apparatus includes a turning shaft movable in a vehicle widthwise direction, a pinion shaft meshed with the turning shaft and a first housing that retains therein the turning shaft and the pinion shaft. An inner circumferential surface of the first housing facing with the turning shaft is provided with an inclined portion that continuously changes an internal diameter. When a portion where a tooth of the turning shaft and a tooth of the pinion shaft are meshed with each other is defined as a meshed portion, the inclined portion is formed below at least the meshed portion.

Abstract: An anti-HSV monoclonal antibody or an antigen-binding fragment thereof is an anti-HSV gB monoclonal antibody or an antigen-binding fragment thereof that specifically binds to herpes simplex virus (HSV) envelope glycoprotein B (gB), comprising: a heavy chain variable region comprising a heavy chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 3, a heavy chain CDR2 consisting of the amino acid sequence set forth in SEQ ID NO: 4, and a heavy chain CDR3 consisting of the amino acid sequence set forth in SEQ ID NO: 5; and a light chain variable region comprising a light chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 6, a light chain CDR2 consisting of the amino acid sequence set forth in SEQ ID NO: 7, and a light chain CDR3 consisting of the amino acid sequence set forth in SEQ ID NO: 8.

Abstract: A fuel cell system includes a fuel cell including a fuel electrode being supplied with fuel gas and an oxidant electrode being supplied with oxidant gas and generating electric power by causing the fuel gas and the oxidant gas to react with each other, a voltmeter measuring an output voltage of the fuel cell, an ammeter measuring an output current of the fuel cell, a restricting valve provided upstream and downstream of an oxidant electrode side of the fuel cell and being opened in a power generation state and being closed in a stopped state or under the oxygen consuming control, and a load control unit controlling a current value of an output current to be output by the fuel cell and, under the oxygen consuming control, controlling the output voltage of the fuel cell such that the output current reduces as the output voltage of the fuel cell increases.

Abstract: A fuel cell system includes: a fuel cell that is supplied with a reaction gas to generate electricity; a plurality of auxiliary components used for power generation of the fuel cell; and a control device that causes the fuel cell to generate electricity when a predetermined scavenging start condition is satisfied and controls the auxiliary components using electric power generated by the fuel cell to perform a scavenging process of removing water in a flow path of the reaction gas using the reaction gas, during a stop period in which electric power is not supplied to a load from the fuel cell system.

Abstract: A modified protein of a herpes simplex virus (HSV) envelope glycoprotein B (gB), in which at least one non-neutralizing antibody-inducing epitope (non-neutralizing epitope) present in domain IV and domain I of wild-type HSV gB is inactivated (de-epitoped).

Abstract: The modified HSV gD protein of the present invention is a modified protein of a herpes simplex virus (HSV) envelope glycoprotein D (gD), wherein the modified HSV gD protein is derived from a wild-type HSV gD by modification of at least one of B cell epitopes having low or no neutralizing antibody-inducing activity compared to a B cell epitope present in a receptor-binding domain (RBD) (decotopes) in the ectodomain of the wild-type HSV gD, so that the modified epitope does not function as an epitope.

Abstract: A novel vaccine antigen for prevention of Respiratory Syncytial Virus (RSV) infection is created which surpasses conventional vaccines comprising as an antigen RSV F protein alone in view of efficacy and/or safety. A vaccine is prepared which comprises as an antigen a RSV F/G chimeric protein wherein a portion of RSV F protein as a basic structure is replaced with a whole or a portion of Conserved Central Domain sequence of RSV G protein or wherein a whole or a portion of Conserved Central Domain sequence of RSV G is added to the basic structure. As a result of assessment of both efficacy and safety, a vaccine comprising as an antigen the F/G chimeric protein of the present invention confirmed to be more excellent than a vaccine comprising as an antigen RSV F protein alone in view of efficacy and/or safety.

Abstract: An object of the present invention is to provide an effective vaccine capable of preventing and treating congenital infection with CMV. The vaccine for preventing or treating congenital infection with cytomegalovirus (CMV) according to the present invention comprises a CMV envelope glycoprotein B (gB protein) antigen and a pentamer antigen.

Abstract: This sound effect generation method includes: generating a sound effect with respect to a sound by using an all-pole filter having a coefficient generated on the basis of an actual measurement value of impulse response; and outputting the sound effect.

Abstract: A fuel cell system includes: a fuel cell that is supplied with a reaction gas to generate electricity; a plurality of auxiliary components used for power generation of the fuel cell; and a control device that causes the fuel cell to generate electricity when a predetermined scavenging start condition is satisfied and controls the auxiliary components using electric power generated by the fuel cell to perform a scavenging process of removing water in a flow path of the reaction gas using the reaction gas, during a stop period in which electric power is not supplied to a load from the fuel cell system.

Abstract: The present invention is directed to provide a modified CMV gB protein that can induce a group of antibodies including a high ratio of neutralizing antibodies that exhibit a high neutralizing activity against a CMV gB protein, in comparison with a wild type CMV gB, upon induction of immunity and that can be used in the prevention and/or treatment of CMV infection and a CMV vaccine comprising the modified CMV gB protein. The modified CMV gB protein according to the present invention is a modified CMV gB protein having an improved ability to induce body region-recognizing antibodies and comprising modification in a head region.

Abstract: The modified HSV gD protein of the present invention is a modified protein of a herpes simplex virus (HSV) envelope glycoprotein D (gD), wherein the modified HSV gD protein is derived from a wild-type HSV gD by modification of at least one of B cell epitopes having low or no neutralizing antibody-inducing activity compared to a B cell epitope present in a receptor-binding domain (RBD) (decotopes) in the ectodomain of the wild-type HSV gD, so that the modified epitope does not function as an epitope.

Abstract: A modified protein of a herpes simplex virus (HSV) envelope glycoprotein B (gB), in which at least one non-neutralizing antibody-inducing epitope (non-neutralizing epitope) present in domain IV and domain I of wild-type HSV gB is inactivated (de-epitoped).

Abstract: An anti-HSV monoclonal antibody or an antigen-binding fragment thereof is an anti-HSV gB monoclonal antibody or an antigen-binding fragment thereof that specifically binds to herpes simplex virus (HSV) envelope glycoprotein B (gB), comprising: a heavy chain variable region comprising a heavy chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 3, a heavy chain CDR2 consisting of the amino acid sequence set forth in SEQ ID NO: 4, and a heavy chain CDR3 consisting of the amino acid sequence set forth in SEQ ID NO: 5; and a light chain variable region comprising a light chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 6, a light chain CDR2 consisting of the amino acid sequence set forth in SEQ ID NO: 7, and a light chain CDR3 consisting of the amino acid sequence set forth in SEQ ID NO: 8.