Abstract: A blood pressure measurement device includes an outer case; a base; a pump provided on the base such that the pump is shifted from a center of the outer case and located on one side as viewed in a circumferential direction of a living body; a drive unit provided on the base and located on one side of the pump as viewed in a direction orthogonal to the circumferential direction; an on-off valve provided on another side of the pump as viewed in the direction orthogonal to the circumferential direction; a pressure sensor provided on said another side of the pump as viewed in the direction orthogonal to the circumferential direction; and packing provided between the on-off valve and the pressure sensor and the base.

Abstract: A blood pressure measurement device includes an outer case; a base; a pump provided on a surface of the base such that the pump is shifted from a center of the outer case and located on one side as viewed in a circumferential direction of a living body; a first pressure sensor and a second pressure sensor that are provided such that the first pressure sensor and the second pressure sensor are arranged side by side in the circumferential direction and located on one side as viewed in a direction orthogonal to the circumferential direction; and a first on-off valve and a second on-off valve that are provided such that the first on-off valve and the second on-off valve are arranged side by side in the circumferential direction with reference to the first pressure sensor and the second pressure sensor.

Abstract: A polymer powder includes a polyamide, wherein a melting point determined in differential scanning calorimetry is 190° C. or higher, a difference between the melting point and a melting onset temperature, which is defined in differential scanning calorimetry as a lowest temperature among temperatures at each of which a first temperature differential value of Heat Flow (W/g) observed between a peak top temperature of an endothermic peak, observed when 10 mg of powder is heated at a rate of 20° C./min from 30° C. in a nitrogen atmosphere, and a temperature point of ?50° C. from the peak top, becomes ?0.2 (W/g.° C.), is less than 30° C., and a D50 particle size is 1 ?m or more and 100 ?m or less.

Abstract: The present invention provides a method of producing a microorganism having an ability of assimilating a first factor including: a step of subjecting a microorganism to random mutagenesis; and a step of culturing the microorganism in the presence of a highly concentrated first factor and then selecting the grown microorganism.

Abstract: A method of optimizing a synthesis reaction condition for a compound which is synthesized through one or a plurality of reaction steps, the method including: controlling the expression amount of at least one enzyme among one or a plurality of enzymes in the reaction steps by using a wild type and/or a mutant of a promoter; and measuring the synthesis amount of a target compound.

Abstract: In the step for a passenger conveyor, a sleeve includes a sleeve main body, which has a tubular shape and is slidable with respect to a main shaft portion along an axis line of the step shaft, a claw to be hooked to a level-difference portion formed at a boundary between the main shaft portion and a projecting shaft portion, and a connecting portion configured to connect the sleeve main body and the claw. The connecting portion includes an arm portion which is elastically deformable in a direction in which the claw is unhooked from the level-difference portion. A mounting portion, having a recessed portion formed therein, is fixed to the step main body. The recessed portion is fitted over an outer peripheral surface of the sleeve main body. An open portion of the recessed portion is smaller than an outer diameter of the sleeve main body.

Abstract: An object of the present invention is to provide, as a method for immobilizing a protein molecule, protein immobilization method and means in which orientation of a molecule to be immobilized can be controlled, the molecule can be stably immobilized without a complicated process and a chemical group used for immobilization does not affect the activity and the function of the protein. Specifically, the present invention relates to a method for immobilizing a molecule including the steps of forming a labeled molecule by attaching a label peptide sequence comprising a hydroxyl group-containing amino acid to a molecule; and bringing a molecule having a phenylboronic acid group into contact with the labeled molecule, to capture the labeled molecule by the molecule having a phenylboronic acid group.

Abstract: An object of the present invention is to provide a method capable of easily and directly performing DNA sequencing by directly detecting pyrophosphoric acid released by an enzymatic reaction, particularly with a DNA polymerase or a DNA ligase. The present invention provides a method and a device for detecting pyrophosphoric acid by measuring an electrical change occurring when a boronic acid group immobilized on an electrically conductive support reversibly binds to pyrophosphoric acid.

Abstract: An object of the present invention is to provide, as a method for immobilizing a protein molecule, protein immobilization method and means in which orientation of a molecule to be immobilized can be controlled, the molecule can be stably immobilized without a complicated process and a chemical group used for immobilization does not affect the activity and the function of the protein. Specifically, the present invention relates to a method for immobilizing a molecule including the steps of forming a labeled molecule by attaching a label peptide sequence comprising a hydroxyl group-containing amino acid to a molecule; and bringing a molecule having a phenylboronic acid group into contact with the labeled molecule, to capture the labeled molecule by the molecule having a phenylboronic acid group.

Abstract: To provide a multi-wire saw that, at the start of cutting of an ingot, prevents a wire from being displaced in grooves of guide rollers due to the wire being lifted. A wire is wound around a plurality of wire guide rollers to be positioned in a feeding direction of an ingot, and in this state, a wire-lifting restraining member that is a body of rotation and restrains the wire from being lifted by being brought into contact with the wire is disposed near the wire guide rollers.

Abstract: Thermostable DNA ligases with enhanced DNA binding activity and reaction activity are obtained. These modified thermostable DNA ligases having enhanced DNA binding activity compared to the wild type can be obtained by substituting a negatively charged amino acid (for example, the amino acid corresponding to the aspartic acid at position 540 of SEQ ID NO: 1) present at the N-terminal side of the C-terminal helix moiety of thermostable DNA ligases from thermophilic bacteria, hyperthermophilic bacteria, thermophilic archaea, or hyperthermophilic archaea, with a non-negatively charged amino acid (for example, alanine, serine, arginine, or lysine).

Abstract: The invention is a slurry for slicing a silicon ingot, containing a basic material, such as an alkali metal hydroxide, abrasive powder and water, in which the slurry contains the basic material in an amount of from 2 to 6% by mass and glycerin in an amount of from 25 to 55% by mass, based on a total mass of components of the slurry excluding the abrasive powder.

Abstract: Disclosed is a modified hyperthermophilic DNA ligase having improved DNA binding ability and reactivity. The modified hyperthermophilic DNA ligase has an amino acid sequence corresponding to the amino acid sequence of a heat-resistant DNA ligase derived from a thermophilic bacterium, a hyperthermophilic bacterium, a thermophilic archaebacterium, or a hyperthermophilic archaebacterium, except with at least two of the charged amino acids in the C-terminal helix region each being substituted by alanine, threonine, or serine residues.

Abstract: It is intended to obtain DNA ligase improved in binding ability and reactivity with DNA, particularly thermostable DNA ligase improved in binding ability and reactivity with DNA. The present invention provides a DNA ligase mutant improved in binding ability and reactivity with DNA, which is obtained by partially or completely deleting a C-terminal helix portion of DNA ligase. Particularly, the mutant is derived from a thermostable bacterium.

Abstract: Thermostable DNA ligases with enhanced DNA binding activity and reaction activity are obtained. These modified thermostable DNA ligases having enhanced DNA binding activity compared to the wild type can be obtained by substituting a negatively charged amino acid (for example, the amino acid corresponding to the aspartic acid at position 540 of SEQ ID NO: 1) present at the N-terminal side of the C-terminal helix moiety of thermostable DNA ligases from thermophilic bacteria, hyperthermophilic bacteria, thermophilic archaea, or hyperthermophilic archaea, with a non-negatively charged amino acid (for example, alanine, serine, arginine, or lysine).

Abstract: Chirality distribution in the molecular structure of protein or the like and magnetic domain structure are analyzed with high resolution less than 10 nm. A transmission electron microscope equipped with a spin-polarized electron source is used for holography observation. The phase of transmission spin-polarized electrons changes due to the existence of chirality structure or magnetization in a sample, which is observed as an interference pattern phase shift in holography measurement.

Abstract: To provide a multi-wire saw that, at the start of cutting of an ingot, prevents a wire from being displaced in grooves of guide rollers due to the wire being lifted. A wire is wound around a plurality of wire guide rollers to be positioned in a feeding direction of an ingot, and in this state, a wire-lifting restraining member that is a body of rotation and restrains the wire from being lifted by being brought into contact with the wire is disposed near the wire guide rollers.

Abstract: It is intended to provide an assay for the presence, absence or amount of a nucleic-acid fragment having a certain nucleotide sequence, for example, a polyA length, a difference in the number of repetition of a direct repeat sequence (e.g., microsatellite), single nucleotide substitution (or single nucleotide polymorphism), and nucleotide sequence insertion or deletion, and to provide a genetic testing using the same. The present invention relates to a nucleotide analysis method, comprising: hybridizing at least two probes to a nucleic-acid fragment; ligating the at least two probes using ligase; exchanging, to ATP, pyrophosphoric acid produced through the ligation reaction; and detecting chemiluminescence reaction dependent on the ATP.

Abstract: The invention is a slurry for slicing a silicon ingot, containing a basic material, such as an alkali metal hydroxide, abrasive powder and water, in which the slurry contains the basic material in an amount of from 2 to 6% by mass and glycerin in an amount of from 25 to 55% by mass, based on a total mass of components of the slurry excluding the abrasive powder.

Abstract: An object of the present invention is to provide a method for amplification of long nucleic acid, wherein the method allows nucleic acid fragments containing the same nucleotide sequence information to efficiently amplify at the same base length. The present invention relates to a method for amplification of long nucleic acid sequence, wherein the method uses primers being modified at the 5? end with a phosphate group and performs a cooperative reaction using DNA polymerase and DNA ligase.