Abstract: This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.

Abstract: One embodiment provides a solenoid valve. The solenoid valve includes a fixed core, a movable core and a coil. A first valve seat member and a second valve seat member are fixed in the fixed core, and a valve body member is disposed therebetween. A spring member is interposed between the valve body member and the second valve seat member such that the valve body member is normally seated on the first valve seat member. The valve body member can move away from the first valve seat member to be seated on the second valve seat member, by being pushed by the movable core. And, a guide member holds the valve body member and the spring member to the second valve seat member so as not to move away from the second valve seat member.

Abstract: A front face side substrate provided between a supporting member and a receiving layer of a thermal transfer image-receiving sheet. The front face side substrate includes a front face side layer provided on one surface of a substrate layer and a rear face side layer provided on another surface of the substrate layer. The substrate layer includes (A) a propylene-based polymer, (B) calcium carbonate, and (C) titanium oxide, and the weight of (A) is 70% by weight to 94.5% by weight, the weight of (B) is 5% by weight to 28% by weight, and the weight of (C) is 0.5% by weight to 3% by weight, based on the assumption that the total weight of (A), (B) and (C) is 100% by weight. The front face side layer includes a modified propylene-based polymer, and the rear face side layer includes a propylene-based polymer.

Abstract: There is provided a gas turbine combustor capable of improving cooling performance of a combustion chamber thereof and reducing the amount of NOx emissions.

Abstract: An image processing device includes an association unit, a generation unit, an output unit, a reception unit, and a print unit. The association unit associates a first document image with a second image, the second image being an image of a reverse side of the first document image. The generation unit generates multiple images in accordance with a result of the association. The output unit outputs the multiple images generated by the generation unit. The reception unit receives a selection of an image output by the output unit, the selection being made by a user operation. The print unit prints the selected image.

Abstract: The present invention provides a connector includes a housing having a fitting opening for the object to be connected, signal contacts retained in the housing in parallel disposition, a pressure member capable of pressing the signal contacts, and power source contacts. The power source contacts are retained besides the signal contacts, have a thickness dimension larger than that of the signal contacts and are to be pressed by the pressure member together with the signal contacts. The power source contacts include a power source contact with a fixation function, having not only the power source connection function but also a function of temporally fixing the object to be connected at a correct insertion position with respect to the signal contacts as well as a function of clamping and fixing the object to be connected in a state of being pressed by the pressure member.

Abstract: This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.

Abstract: A gas turbine combustor includes: multiple gaseous fuel nozzles to inject gaseous fuel; a manifold to distribute gaseous fuel to the multiple gaseous fuel nozzles; a burner flange to secure a burner to an end cover; and a burner body to connect the manifold and the burner flange. Gaseous fuel passages are provided in the end cover, the burner flange, and the burner body. The gaseous fuel passage communicates with the manifold. A second manifold is provided in the burner flange. The gaseous fuel passage is provided in the burner body to make the second manifold communicate with the first mentioned manifold.

Abstract: A front face side substrate provided between a supporting member and a receiving layer of a thermal transfer image-receiving sheet. The front face side substrate includes a front face side layer provided on one surface of a substrate layer and a rear face side layer provided on another surface of the substrate layer. The substrate layer includes (A) a propylene-based polymer, (B) calcium carbonate, and (C) titanium oxide, and the weight of (A) is 70% by weight to 94.5% by weight, the weight of (B) is 5% by weight to 28% by weight, and the weight of (C) is 0.5% by weight to 3% by weight, based on the assumption that the total weight of (A), (B) and (C) is 100% by weight. The front face side layer includes a modified propylene-based polymer, and the rear face side layer includes a propylene-based polymer.

Abstract: Provided are: a targeting molecule targeting a target cell which is selected from the group consisting of a stellate cell, a myofibroblast, a cancer-associated fibroblast, a tumor cell and a cell expressing STRA6, said targeting molecule being selected from the group consisting of (1) a peptide containing an amino acid sequence in the cell-binding region of RBP, (2) a variant peptide of the aforesaid peptide (1), said variant peptide having a comparable targetability to peptide (1), and (3) a peptide mimetic having a comparable targetability to peptide (1) or peptide (2); a targeting agent, a carrier, a complex and a medicinal composition each comprising the targeting molecule; a method for treating, examining, diagnosing or monitoring a disease related to the aforesaid target cell; a method for labeling, detecting or imaging the target cell, etc.

Abstract: An information processing apparatus includes a reception unit and a display controller. The reception unit receives an operation for selecting a destination from a transmission destination list containing a registered mail address of the destination to which an image is to be transmitted. The display controller displays an object image in a predetermined display region. The object image indicates a parameter of an image reading unit that reads the image. When the destination is selected by the operation, the display controller makes the display region display the mail address registered in the transmission destination list in place of the object image. When a preset time period elapses, the display controller sets the display back to the object image.

Abstract: A fuel nozzle for gas turbine combustor of the present invention includes a diffusion combustion burner including a diffusion fuel nozzle, a premixing combustion burner including a premixing fuel nozzle, an end flange to which the diffusion combustion burner and the premixing combustion burner are mechanically joined, and a diffusion combustion burner support which fixes the diffusion combustion burner to the end flange and is mounted around the premixing fuel nozzle in a manner to cover a root portion of the premixing fuel nozzle, the root portion being a junction between the premixing fuel nozzle and the end flange. An outside diameter of the premixing fuel nozzle longitudinally varies in a manner to progressively increase toward the junction. A maximum diameter of the root portion of the premixing fuel nozzle is greater than an inside diameter of a hole formed in the diffusion combustion burner support.

Abstract: Provided herein are compositions, methods and kits for modulating expression of target genes, particularly of tissue inhibitor of metalloproteinase 1 and of tissue inhibitor of metalloproteinase 2 (TIMP1 and TIMP2, respectively). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding TIMP1 and TIMP2, for example, the gene encoding human TIMP1 and TIMP2. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with TIMP1 and TIMP2 including fibrotic diseases and disorders including liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.

Abstract: This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.

Abstract: This invention provides compounds, compositions and methods for modulating the expression of human GST-? using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.

Abstract: This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. A nucleic acid molecule can have a) a polynucleotide sense strand and a polynucleotide antisense strand; b) each strand of the molecule being from 15 to 30 nucleotides in length; c) a contiguous region of from 15 to 30 nucleotides of the antisense strand being complementary to a sequence of an mRNA encoding p21; and d) at least a portion of the sense strand can be complementary to at least a portion of the antisense strand, and the molecule has a duplex region of from 15 to 30 nucleotides in length.

Abstract: This invention provides compounds, compositions and methods for modulating the expression of human GST-? using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. A nucleic acid molecule can have a) a polynucleotide sense strand and a polynucleotide antisense strand; b) each strand of the molecule being from 15 to 30 nucleotides in length; c) a contiguous region of from 15 to 30 nucleotides of the antisense strand being complementary to a sequence of an mRNA encoding GST-?; and d) at least a portion of the sense strand can be complementary to at least a portion of the antisense strand, and the molecule has a duplex region of from 15 to 30 nucleotides in length.

Abstract: A highly-reliable combustor is provided that allows flash back of flame into a premixer to be suppressed. The combustor has a mixing chamber forming member 110 that forms a mixing chamber thereinside. The mixing chamber includes a first mixing chamber 200 broadening toward a downstream side. The member 110 includes air introduction holes 202, 203, 204 formed in a plurality of rows in an axial direction, with the air introduction holes being arranged plurally in a circumferential direction of the mixing chamber. The member 110 includes a fuel ejection hole 206 provided in a wall surface which forms the air introduction hole. The air introduction holes 202, 203, 204 are circumferentially eccentrically installed. The air introduction holes 202 located in the most upstream row are more inclined toward the downstream side than the air introduction holes 203, 204 located in the rows other than the most upstream row.

Abstract: A driving apparatus (101) is provided with: a first base part (110); a second base part (120); an elastic part (210) configured to couple the first base part with the second base part; and a driven part (400) supported by the second base part in a drivable aspect. According to such a driving apparatus, for example, if a driving force is applied to the first base part, the driving force is transmitted to the second base part via the elastic part. Thus, the driven part supported by the second base part can be preferably driven.

Abstract: Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.