Abstract: An object is to provide a semiconductor device having a structure with which parasitic capacitance between wirings can be sufficiently reduced. An oxide insulating layer serving as a channel protective layer is formed over part of an oxide semiconductor layer overlapping with a gate electrode layer. In the same step as formation of the oxide insulating layer, an oxide insulating layer covering a peripheral portion of the oxide semiconductor layer is formed. The oxide insulating layer which covers the peripheral portion of the oxide semiconductor layer is provided to increase the distance between the gate electrode layer and a wiring layer formed above or in the periphery of the gate electrode layer, whereby parasitic capacitance is reduced.

Abstract: A rolling mill includes three or more rolling rolls aligned along a circumferential direction and arranged so each rotary shaft is skewed with respect to a pass line of a material to be rolled, wherein the material to be rolled made of a pipe or bar material passes between the rolling rolls while being rotated to undergo diameter reducing rolling. At least one rolling roll selected from the three or more rolling rolls is smaller in roll diameter than at least one other rolling roll. When at least one rolling roll having a relatively maximum roll diameter defined as a maximum diameter rolling roll and at least one rolling roll smaller in roll diameter than the maximum is defined as a small diameter rolling roll, the small diameter rolling roll has a roll diameter equal to or less than 90% of the roll diameter of the maximum diameter rolling roll.

Abstract: An image forming apparatus includes a stacking portion including a lifting portion, a feeding member feeding a sheet stacked on the lifting portion to a conveyance passage, a position detector detecting movement of the sheet stacked on to a feedable position to the conveyance passage, a driver including a motor and performing the lifting operation of the lifting portion, a rotation detector detecting rotation of the motor, and a controller. The controller determines a factor that the position detector does not detect the movement of the sheet stacked on the lifting portion to the feedable position within a predetermined time based on a detection result of the rotation detector while controlling the driver to lift up the lifting portion.

Abstract: The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.

Abstract: An object is to provide a high reliable semiconductor device including a thin film transistor having stable electric characteristics. In a method for manufacturing a semiconductor device including a thin film transistor in which an oxide semiconductor film is used for a semiconductor layer including a channel formation region, heat treatment (which is for dehydration or dehydrogenation) is performed so as to improve the purity of the oxide semiconductor film and reduce impurities such as moisture. Besides impurities such as moisture existing in the oxide semiconductor film, heat treatment causes reduction of impurities such as moisture existing in the gate insulating layer and those in interfaces between the oxide semiconductor film and films which are provided over and below the oxide semiconductor film and are in contact with the oxide semiconductor film.

Abstract: An object of the present invention is to provide an anti-CLDN4/anti-CD137 bispecific antibody usable in treatment of cancer. An anti-CLDN4/anti-CD137 bispecific antibody produced using an anti-CLDN4 antibody binding to CLDN4 and an anti-CD137 antibody binding to CD137 had agonistic activity for CD137, promoted production of interferon ? by a T cell, and exhibited cytotoxic activity against a cancer cell expressing CLDN4 on a cell surface thereof. Besides, it was shown that the anti-CLDN4/anti-CD137 bispecific antibody can be safely administered to monkeys. Therefore, the anti-CLDN4/anti-CD137 bispecific antibody is usable in treatment of human cancer.

Abstract: The present disclosure provides a cathode material which has improved charge/discharge efficiency; and a battery using the same. The cathode material includes a cathode active material and a first solid electrolyte material; and the first solid electrolyte material contains Li, M and X; however, does not include sulfur. M represents at least one element that is selected from the group consisting of metalloid elements and metal elements other than Li. X represents at least one selected from the group consisting of Cl and Br, and I. The cathode active material includes lithium iron phosphate.

Abstract: A positive electrode active material includes: a rich phase; a poor phase; and a two-phase coexistence phase in which the rich phase and the poor phase coexist. A method of managing a battery includes, in a many particle model in which the positive electrode active material is represented by a plurality of particles each distinguished by a particle number indicating a reaction sequence of the positive electrode active material, assuming that the charge carriers are equal in content among one or more particles belonging to each of the rich phase, the poor phase, and the two-phase coexistence phase: calculating an overvoltage of each of the particles for each of the phases; calculating a reaction current density based on the overvoltage for each of the phases; and estimating an SOC of the storage battery based on the reaction current density in each of the phases.

Abstract: A camera module is configured to capture an optical image of a target area and includes a lens member, an imager, a light transmitting member, and a seat. The lens member is configured to receive light from the target area. The imager has a curved portion convex in a direction away from the lens member and is configured to capture the optical image formed on the curved portion. The light transmitting member optically couples the lens member and the imager. The seat has a supporting portion that supports an outer rim of the imager and a fluid space defined inside the supporting portion. A heat dissipation fluid undergoes convection in the fluid space. The curved portion is interposed between the light transmitting member and the seat having the supporting portion and the fluid space.

Abstract: An electromagnetic actuator includes: a mover, reciprocating along a predetermined axis line; a first stator and a second stator, accommodating the mover to be capable of reciprocating in a direction of the axis line and arranged spaced apart in the direction of the axis line; and a bobbin, arranged around the first stator and the second stator and around which a coil for excitation is wound. The bobbin includes: a through hole, through which the first stator and the second stator pass; and a positioning part, partially formed in the through hole, allowing the first stator and the second stator to be fitted thereinto, and positioning the first stator and the second stator on the axis line.

Abstract: An electromagnetic actuator includes: a mover, reciprocating along an axis line; a first stator and a second stator, accommodating the mover to be capable of reciprocating and arranged spaced apart in the direction of the axis line; a bobbin, arranged around the first stator and the second stator and around which a coil for excitation is wound; a tube member, surrounding the bobbin, connected to the first stator, forming a magnetic path and having a predetermined plate thickness; and a flat plate member, connected to the second stator and the tube member and forming a magnetic path. The tube member includes an annular end face having a width equal to the plate thickness on one end in the direction of the axis line, and is fixed to the flat plate member by metallurgical joining or press fitting with the annular end face closely joined to the flat plate member.

Abstract: An object of the present invention is to provide an anti-CLDN4/anti-CD137 bispecific antibody usable in treatment of cancer. An anti-CLDN4/anti-CD137 bispecific antibody produced using an anti-CLDN4 antibody binding to CLDN4 and an anti-CD137 antibody binding to CD137 had agonistic activity for CD137, promoted production of interferon ? by a T cell, and exhibited cytotoxic activity against a cancer cell expressing CLDN4 on a cell surface thereof. Besides, it was shown that the anti-CLDN4/anti-CD137 bispecific antibody can be safely administered to monkeys. Therefore, the anti-CLDN4/anti-CD137 bispecific antibody is usable in treatment of human cancer.

Abstract: A build apparatus builds a first structural layer by irradiating a first beam position, builds a first build object and irradiating the first build object, a second irradiation beam position builds a second build object. The build apparatus further builds a second structural layer by irradiating the first structural layer, a third irradiation beam position builds a third build object and by irradiating the third build object, a fourth irradiation beam position builds a fourth build object. At least one of a distance between first and second position and a distance between third and fourth position is shorter than a distance between second and third position. Thus, the build apparatus builds a structural object including the first and second structural objects and is inclined with respect to an optical axis direction.

Abstract: An objective of the present invention is to provide an anti-TSPAN8/anti-CD3 bispecific antibody and an anti-TSPAN8 antibody usable in treatment or prevention in human. A human monoclonal antibody producing mouse was immunized with a peritoneal disseminated cancer cell isolated from a patient, to obtain an antibody 16B11 and an antibody 16B12 that selectively bind to a peritoneal disseminated cancer cell. These antibodies were anti-TSPAN8 antibodies that bind to the region from amino acid positions 126 to 155 of TSPAN8 and exhibited strong binding activity to TSPAN8 expressed in the peritoneal disseminated cancer cell. Further, an anti-TSPAN8(16B11)-anti-CD3 bispecific antibody produced based on the sequence of 16B11 exhibited a cytotoxic activity against the TSPAN8-expressing cancer cell in vitro, exerted an anti-tumor action on TSPAN8-expressing cancer cell-bearing mice in vivo, and extended the lifetime of peritoneal dissemination model mice.

Abstract: An objective of the present invention is to provide an anti-TSPAN8/anti-CD3 bispecific antibody and an anti-TSPAN8 antibody usable in treatment or prevention in human. A human monoclonal antibody producing mouse was immunized with a peritoneal disseminated cancer cell isolated from a patient, to obtain an antibody 16B11 and an antibody 16B12 that selectively bind to a peritoneal disseminated cancer cell. These antibodies were anti-TSPAN8 antibodies that bind to the region from amino acid positions 126 to 155 of TSPAN8 and exhibited strong binding activity to TSPAN8 expressed in the peritoneal disseminated cancer cell. Further, an anti-TSPAN8(16B11)-anti-CD3 bispecific antibody produced based on the sequence of 16B11 exhibited a cytotoxic activity against the TSPAN8-expressing cancer cell in vitro, exerted an anti-tumor action on TSPAN8-expressing cancer cell-bearing mice in vivo, and extended the lifetime of peritoneal dissemination model mice.

Abstract: An objective of the present invention is to provide an anti-TSPAN8/anti-CD3 bispecific antibody and an anti-TSPAN8 antibody usable in treatment or prevention in human. A human monoclonal antibody producing mouse was immunized with a peritoneal disseminated cancer cell isolated from a patient, to obtain an antibody 16B11 and an antibody 16B12 that selectively bind to a peritoneal disseminated cancer cell. These antibodies were anti-TSPAN8 antibodies that bind to the region from amino acid positions 126 to 155 of TSPAN8 and exhibited strong binding activity to TSPAN8 expressed in the peritoneal disseminated cancer cell. Further, an anti-TSPAN8(16B11)-anti-CD3 bispecific antibody produced based on the sequence of 16B11 exhibited a cytotoxic activity against the TSPAN8-expressing cancer cell in vitro, exerted an anti-tumor action on TSPAN8-expressing cancer cell-bearing mice in vivo, and extended the lifetime of peritoneal dissemination model mice.

Abstract: A solid-state imaging element includes a pixel and an image processing unit. The pixel has a common transistor, a charge accumulation unit, and a power supply. The common transistor has a first terminal and a second terminal. The common transistor maintains a voltage of the first terminal at a predetermined voltage with a voltage applied from the power supply and outputs a voltage corresponding to a change in a voltage of the charge accumulation unit from the second terminal, based on a condition that an element voltage is a ground voltage. The common transistor outputs a voltage corresponding to a change in a voltage of the charge accumulation unit from the first terminal, based on the element voltage is higher than the ground voltage. The image processing unit generates a luminance image according to a change in the voltage output from the second terminal of the common transistor.

Abstract: An image forming apparatus includes a stacking portion including a lifting portion, a feeding member feeding a sheet stacked on the lifting portion to a conveyance passage, a position detector detecting movement of the sheet stacked on to a feedable position to the conveyance passage, a driver including a motor and performing the lifting operation of the lifting portion, a rotation detector detecting rotation of the motor, and a controller. The controller determines a factor that the position detector does not detect the movement of the sheet stacked on the lifting portion to the feedable position within a predetermined time based on a detection result of the rotation detector while controlling the driver to lift up the lifting portion.

Abstract: A solid-state imaging element includes a pixel and an image processing unit. The pixel has a common transistor, a charge accumulation unit, and a power supply. The common transistor has a first terminal and a second terminal. The common transistor maintains a voltage of the first terminal at a predetermined voltage with a voltage applied from the power supply and outputs a voltage corresponding to a change in a voltage of the charge accumulation unit from the second terminal, based on a condition that an element voltage is a ground voltage. The common transistor outputs a voltage corresponding to a change in a voltage of the charge accumulation unit from the first terminal, based on the element voltage is higher than the ground voltage. The image processing unit generates a luminance image according to a change in the voltage output from the second terminal of the common transistor.

Abstract: The present invention provides a method for treating SWI/SNF complex-deficient cancers comprising a glutathione (GSH) metabolic pathway inhibitor, a pharmaceutical composition comprising a glutathione (GSH) metabolic pathway inhibitor for therapy in SWI/SNF complex-deficient cancers, and a glutathione (GSH) metabolic pathway inhibitor for use in treating SWI/SNF complex-deficient cancers. The present invention also provides a method for detecting and/or selecting a susceptible patient to a glutathione (GSH) metabolic pathway inhibitor.