Abstract: The present invention pertains to an imidazolylamide derivative represented by formula (1) that exhibits an exceptional suppressive effect on cancer cell sphere formation ability and that is useful as an antitumor agent that can be administered orally, or a pharmacologically acceptable salt thereof.

Abstract: The present invention provides a compound having TrkA inhibitory activity, or a pharmaceutically acceptable salt thereof. The present invention relates to a compound represented by Formula (I): wherein ?X is ?O or the like, R5 and R5A are hydrogen atoms or the like, -A- is —NR1— or the like, B is substituted or unsubstituted aromatic carbocyclyl or the like, R1 is substituted or unsubstituted alkyl or the like, R2 is a hydrogen atom or the like, —W— is —CH2— or the like, —WA— is —CH2— or the like, R13 is substituted or unsubstituted aromatic carbocyclyl or the like, R14 is substituted or unsubstituted aromatic heterocyclyl or the like, R15 is substituted or unsubstituted alkyl or the like, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same.

Abstract: The present invention addresses the problem of providing a super-liquid-repellent coating film that has improved abrasion resistance. Provided as a means for solving the problem is a coating film that has a fluorine atom content of 1 to 60 wt %, the coating film having a surface that has an average surface roughness Ra of 0.5 to 20, a surface area ratio of 1.7 to 5, a contact angle with water of 150° or more, a contact angle with n-hexadecane of 80° or more, and a surface that has a contact angle with water of 150° or more after being rubbed 100 times with a PET film under a load of 100 g.

Abstract: An object, of the present invention is to provide a new liquid-repellent coating film. This object can be achieved by a coating film that has a fluorine content of less than 1 wt %, a water contact angle (droplet: 2 ?L) of 115° or more, and a water contact angle of 300° or more after surface friction with a PET film (under a load of 100 gf/cm2; 1500 reciprocations); and that satisfies at least one of the following regarding surface roughness indices: (a) an average surface roughness Ra of 1.6 ?m or more; and (b) a Wenzel roughness factor of 1.2 or more.

Abstract: A sheet conveyance apparatus includes a conveyance roller, a first rotary member forming a first nip portion conveying a sheet in a first conveyance direction, a rotation axis of the first rotary member being inclined with respect to a rotation axis of the conveyance roller such that a center of one end of the first rotary member is positioned at a different position in the first conveyance direction with respect to a center of the other end, and a second rotary member forming a second nip portion conveying a sheet in a second conveyance direction, a rotation axis of the second rotary member being inclined with respect to the rotation axis of the conveyance roller such that a center of one end of the second rotary member is positioned at a different position in the second conveyance direction with respect to a center of the other end.

Abstract: A sheet conveying device includes a blocking member having a blocking surface with which a leading end of a sheet that is being conveyed comes into contact for obliquity correction. The blocking member is rotated by being pushed by the sheet against an urging force of a positioning unit that positions the blocking member to be in the standby position. The blocking member is rotatable to be in a sheet-passage-allowing orientation in which the sheet is allowed to pass. When a trailing end of the sheet that is being conveyed has passed the blocking member, the blocking member that is in the sheet-passage-allowing orientation rotates in a same direction as a sheet conveyance direction and is positioned to be in a standby position.

Abstract: A temperature-responsive substrate having on its surface a layer containing at least one polymer, the at least one polymer being responsive to temperature and containing a fluorine-containing monomer-derived unit. Also disclosed is a polymer and composition for use in producing the substrate, as well as methods for producing, using and evaluating the substrate.

Abstract: A tool for fixing a protective textile sleeve about an elongate member contained therein and method of use thereof is provided. The tool includes a clamp assembly having opposed clamp members attached to one another for pivotal movement relative to one another between an open state and a closed state. The clamp members have clamping surfaces, wherein at least one of the clamping surfaces has at least one outlet. A fluid source is arranged in fluid communication with the at least one outlet, and a heat source is configured to heat fluid from the fluid source to create steam. The steam is dispensed outwardly from the at least one outlet to cause an adhesive on the sleeve to become activated to bond with an adjacent abutting surface.

Abstract: A sheet conveyance apparatus conveying a sheet includes a conveyance roller and first and second rotary members. A first virtual line and a second virtual line cross each other when viewed in the rotation axis direction of the conveyance roller, with the first virtual line passing through the rotation center of a first longitudinal end of the first rotary member and a rotation center of a second longitudinal end of the first rotary member when viewed in the rotation axis direction of the conveyance roller. A second virtual line passes through the rotation center of a third longitudinal end of the second rotary member and the rotation center of a fourth longitudinal end of the second rotary member when viewed in the rotation axis direction of the conveyance roller.

Abstract: A sheet conveying device includes a blocking member having a blocking surface with which a leading end of a sheet that is being conveyed comes into contact for obliquity correction. The blocking member is rotated by being pushed by the sheet against an urging force of a positioning unit that positions the blocking member to be in the standby position. The blocking member is rotatable to be in a sheet-passage-allowing orientation in which the sheet is allowed to pass. When a trailing end of the sheet that is being conveyed has passed the blocking member, the blocking member that is in the sheet-passage-allowing orientation rotates in a same direction as a sheet conveyance direction and is positioned to be in a standby position.

Abstract: The present invention provides a compound having a TrkA inhibitory activity or a pharmaceutically acceptable salt thereof. The present invention relates to a compound represented by Formula (I): wherein -L- is —C(?X)—, or the like, —Z— is —NR5—, or the like, —ZA— is —NR5A—, or the like, B is substituted or unsubstituted aromatic carbocyclyl, or the like, Y is a single bond, or the like, the ring C is a substituted or unsubstituted aromatic heterocycle, or the like, R2 is a hydrogen atom, or the like, and the group represented by is a group represented by Formula: or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.

Abstract: A heat exchanger includes: a surface with a water-repellent coating. The surface has a surface structure that includes protrusions. Condensed water droplets, each having a droplet diameter that allows a subcooled state to be maintained even under a predetermined freezing condition, combine with one other on the surface and generate an energy. The surface structure uses the energy to remove the combined condensed water droplets from the surface.

Abstract: The present invention provides a compound having TrkA inhibitory activity, or a pharmaceutically acceptable salt thereof. The present invention relates to a compound represented by Formula (I): wherein ?X is ?O or the like, R5 and R5A are hydrogen atoms or the like, -A- is —NR1— or the like, B is substituted or unsubstituted aromatic carbocyclyl or the like, R1 is substituted or unsubstituted alkyl or the like, R2 is a hydrogen atom or the like, —W— is —CH2— or the like, —WA— is —CH2— or the like, R13 is substituted or unsubstituted aromatic carbocyclyl or the like, R14 is substituted or unsubstituted aromatic heterocyclyl or the like, R15 is substituted or unsubstituted alkyl or the like, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same.

Abstract: The present invention provides a compound having TrkA inhibitory activity, or a pharmaceutically acceptable salt thereof. The present invention relates to a compound represented by Formula (I): wherein ?X is ?O or the like, R5 and R5A are hydrogen atoms or the like, -A- is —NR1— or the like, B is substituted or unsubstituted aromatic carbocyclyl or the like, R1 is substituted or unsubstituted alkyl or the like, R2 is a hydrogen atom or the like, —W— is —CH2— or the like, —WA— is —CH2— or the like, R13 is substituted or unsubstituted aromatic carbocyclyl or the like, R14 is substituted or unsubstituted aromatic heterocyclyl or the like, R15 is substituted or unsubstituted alkyl or the like, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same.

Abstract: The present invention provides a mutated histidine decarboxylase suitable for a practical use. Specifically, the present invention provides a mutated histidine decarboxylase having at least one amino acid residue mutated as compared to a wild-type histidine decarboxylase, and having higher histidine decarboxylase activity and/or stability than the wild-type histidine decarboxylase, and also a use thereof. The mutated histidine decarboxylase has Motifs (1) to (6), and an amino acid residue in at least one motif thereof can be mutated. The mutated histidine decarboxylase can also have a mutation of at least one amino acid residue in an amino acid sequence designated by SEQ ID NO: 3 and in a homologous sequence thereto.

Abstract: A tool and method for fixing a textile sleeve about an elongate member is provided. The tool includes at least one clamp assembly having opposed heating clamp members movable between open and closed states and opposed cooling clamp members movable between open and closed states. Each of the heating and cooling clamp members have respective heating and cooling clamp surfaces configured for clamping abutment with the textile sleeve. The heating clamp surfaces are operably connected to a source of power to be selectively heated and the cooling clamp surfaces are operably connected to a source of coolant to be selectively cooled. A carrier is configured to support the textile sleeve for movement from a loading position to a location between the heating clamp members; from the heating clamp members to a position between the cooling clamp members, and from the position between the cooling clamp members to an unloading position.

Abstract: A self-wrapping sleeve and method of construction thereof is provided. The sleeve includes an elongate multilayered tubular wall having opposite edges extending along a longitudinal axis of the sleeve between opposite ends of the sleeve. The opposite edges are biased into a self-wrapping configuration about the longitudinal axis to define an internal cavity bounded by the tubular wall. The tubular wall includes a non-woven layer of intertwined fibers and a textile layer of interlaced filaments, wherein the non-woven layer is fixed to the textile layer via needled fibers of the non-woven layer being entangled with filaments of the textile layer.

Abstract: A tool for fixing a protective textile sleeve about an elongate member contained therein and method of use thereof is provided. The tool includes a clamp assembly having opposed clamp members attached to one another for pivotal movement relative to one another between an open state and a closed state. The clamp members have clamping surfaces, wherein at least one of the clamping surfaces has at least one outlet. A fluid source is arranged in fluid communication with the at least one outlet, and a heat source is configured to heat fluid from the fluid source to create steam. The steam is dispensed outwardly from the at least one outlet to cause an adhesive on the sleeve to become activated to bond with an adjacent abutting surface.

Abstract: The drive device drives a drive member and is provided with a power-side gear and a drive-side gear. The power-side gear is driven by a force output from a power source so as to drive the drive member in a range between a first stop position and a second stop position. In addition, the drive-side gear meshes with the power-side gear and transmits the force obtained from the power-side gear to the drive member. Also, the drive-side gear and the power-side gear are configured so as to disengage from each other when the drive member has reached the first stop position and/or the second stop position.

Abstract: There is provided an epoxy composition which has difficulty in precipitating a crystal during storage, is homogeneous and can be stored for a long period; and a cured product of the composition having excellent transparency, heat resistance, and light resistance can be obtained on curing. An ?-type tris-(2,3-epoxypropyl)-isocyanurate crystal including ?-type tris-(2,3-epoxypropyl)-isocyanurate in the crystal in a ratio of 2% by mass to 15% by mass. A method for producing the ?-type tris-(2,3-epoxypropyl)-isocyanurate crystal including step (i) separating ?-type tris-(2,3-epoxypropyl)-isocyanurate contained in a tris-(2,3-epoxypropyl)-isocyanurate solution from the solution as a solid to obtain a crystal with an increased content ratio of ?-type tris-(2,3-epoxypropyl)-isocyanurate.