Abstract: The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.

Abstract: The invention provides a cationic lipid, a lipid membrane structure containing same, and use thereof. The cationic lipid is represented by the formula (1) wherein R1a, R1b, R2a, R2b, R3a, R3b, Xa, Xb, Ya, Yb, Za, and Zb are as defined in the specification.

Abstract: A method for producing a multi-arm type polyethylene glycol derivative, which includes carrying out the following in order: Step (A): protecting an even number of hydroxyl groups, while leaving only the hydroxyl group at the 1-position of a polyhydric alcohol having an odd number of hydroxyl groups, other than the hydroxyl group at the 1-position by cyclic benzylidene acetalization, Step (B): linking two molecules of the compound obtained in step (A) to a compound for introducing a specific linker by etherification reaction, Step (C): deprotecting the cyclic benzylidene acetal structure at the terminal of the compound obtained in step (B), Step (D): polymerizing 3 to 600 mol of ethylene oxide to each hydroxyl group of the compound obtained in step (C) to obtain a multi-arm type polyethylene glycol derivative, and Step (E): functionalizing the hydroxyl group at the terminal of the multi-arm type polyethylene glycol derivative obtained in step (D).

Abstract: A branched monodispersed polyethylene glycol represented by the formula (1): wherein X1 is a functional group that forms a covalent bond upon a reaction with a functional group present in a biofunctional molecule; n is an integer of 4 to 50, which represents number of repeating units of ethylene oxide units; and L1 represents a single bond, —NH—, -L2-(CH2)m1— or -L2-(CH2)m1-L3-(CH2)2-, L2 represents an ether bond, an amide bond, an urethane bond or a single bond, L3 represents an ether bond, an amide bond or an urethane bond, and m1 and m2 represent each independently an integer of 1 to 5.

Abstract: An antenna device installed in a vehicle includes a stacked dipole antenna unit. The stacked dipole antenna unit has a plurality of dipole antennas that are arranged parallel to a plane perpendicular to a front-back direction of the vehicle.

Abstract: The piezoelectric vibration device disclosed herein includes: a piezoelectric vibrator including a plurality of terminals for external connection and a plurality of electrodes for mounting purpose; and an integrated circuit element mountable to the piezoelectric vibrator and including a plurality of mounting terminals connectable to the plurality of electrodes for mounting purpose. At least one of the electrodes for mounting purpose connected to the terminals for external connection has a wiring pattern extending more inward in a mounting region where the integrated circuit element is mounted than the mounting terminals of the integrated circuit element.

Abstract: A fluid-heating device for heating fluid includes: a heater having a heat generating part, the heat generating part being configured to generate heat upon application of current; an electric component configured to control the application of the current to the heater; a tank having an opening portion, the tank being configured to accommodate the heat generating part; a top-plate portion configured to close the opening portion of the tank, the top-plate portion being configured to form a fluid chamber through which the fluid flows; and a first communication port and a second communication port configured to allow the fluid to flow through the fluid chamber; wherein the electric component is provided on an outer side of the fluid chamber along the top-plate portion.

Abstract: A fluid-heating device for heating fluid includes a heater unit configured to have a heater and a heating portion, the heating portion being formed as to cover surrounding of the heater, wherein the heating portion has an inner heat exchange surface formed on an inner surface of a through hole penetrating through an inner side of the heater and an outer heat exchange surface formed on an outer-wall portion of an outer side of the heater, the inner heat exchange surface being configured to perform heat exchange with the fluid, and the outer heat exchange surface being configured to perform the heat exchange with the fluid.

Abstract: A purification method of a polyethylene glycol compound having one carboxyl group. In the method, an aqueous solution of the compound having a pH of 8 to 11 is prepared, the aqueous solution and a mixed organic solvent are mixed at a temperature of 15° C. or more and 50° C. or less and the mixture is separated into an organic layer and an aqueous layer. In the mixed organic solvent, a ratio of solvent I is from 25 to 60% by mass, and a ratio of solvent II is from 75 to 40% by mass. Solvent I is a hydrocarbon, solvent II is a halogenated hydrocarbon, a mixing ratio Y (organic solvent I/organic solvent II), a temperature T (° C.) at mixing and a weight average molecular weight M of the compound satisfy a relationship of 3.11×10?6M+0.084?Y?0.0135T??1.77×10?6M+0.404.

Abstract: In a crystal resonator plate (2), a support part (24) extends from only one corner part positioned in the +X direction and in the ?Z? direction of a vibrating part (22) to an external frame part (23) in the ?Z? direction. The vibrating part (22) and at least part of the support part (24) form an etching region (Eg) having a thickness thinner than a thickness of the external frame part (23). A stepped part is formed at a boundary of the etching region (Eg), and a first lead-out wiring (223) is formed over the support part (24) to the external frame part (23) so as to overlap with the stepped part. At least part of the stepped part that is superimposed on the first lead-out wiring (223) is formed so as not to be parallel to the X axis in plan view.

Abstract: A purification method of a polyethylene glycol compound having one carboxyl group. In the method, an aqueous solution of the compound having a pH of 8 to 11 is prepared, the aqueous solution and a mixed organic solvent are mixed at a temperature of 15° C. or more and 50° C. or less and the mixture is separated into an organic layer and an aqueous layer. In the mixed organic solvent, a ratio of solvent I is from 25 to 60% by mass, and a ratio of solvent II is from 75 to 40% by mass. Solvent I is a hydrocarbon, solvent II is a halogenated hydrocarbon, a mixing ratio Y (organic solvent I/organic solvent II), a temperature T (° C.) at mixing and a weight average molecular weight M of the compound satisfy a relationship of 3.11×10?6M+0.084?Y?0.0135T??1.77×10?6M+0.404.

Abstract: A method of producing a polyoxyethylene derivative (1): where L1 is a divalent linker, X is a functional group capable of reacting with a physiologically active substance, a is 1 or 2, and n is from 11 to 3,650. The method includes Step (A): protecting 4 or 6 hydroxyl groups in a polyhydric alcohol having 5 or 7 hydroxyl groups by cyclic benzylidene acetalization to obtain a compound having a hydroxyl group at a 1-position and a protective group of a cyclic benzylidene acetal structure; Step (B): polymerizing from 11 to 3,650 moles of ethylene oxide to the compound obtained in the step (A) to obtain a polyoxyethylene derivative; Step (C): converting the hydroxyl group at a terminal of the polyoxyethylene derivative to a functional group capable of reacting with a physiologically active substance; and Step (D): deprotecting the protective group of the polyoxyethylene derivative.

Abstract: To provide a degradable polyethylene glycol derivative in which polyethylene glycol chains are linked by a disulfide linker capable of accurately controlling the degradation rate under different reductive environments in the living body, and whose division rate into a polyethylene glycol chain of low molecular weight in the living body is able to be accurately controlled. A degradable polyethylene glycol derivative represented by formula (1). R1, R2, R3 and R4 represent each independently a hydrogen atom or a hydrocarbon group having from 1 to 6 carbon atoms, and at least one of R1, R2, R3 and R4 is the hydrocarbon group; P1 is a straight-chain or branched polyethylene glycol chain having a number of ethylene glycol units of 3 or more; P2 is a straight-chain polyethylene glycol chain having a number of ethylene glycol units of 3 or more; w is an integer of 1 to 8; u is an integer of 1 to 10; X1 is a chemically reactive functional group; and Z1, Z2 and Z3 are each independently a selected divalent spacer.

Abstract: Provided herein are narrowly distributed multi-armed polyethylene glycol compounds, and hydrogels containing the same. Also provided are methods for treating, adhering, or sealing a biological tissue with hydrogels, and kits for making a hydrogel. Drug releasing compositions also are provided that include a narrowly distributed multi-armed polyethylene glycol compound.

Abstract: A vehicle air-conditioner safety device includes a controller which, in a case in which an abnormality has occurred in a heating device that heats coolant with a heater, determines whether or not the abnormality is a restorable abnormality or a non-restorable abnormality. When the abnormality is determined to be the restorable abnormality, it is determined whether or not the restorable abnormality has been removed. Heating by the heater is prohibited when the restorable abnormality or the non-restorable abnormality has occurred. Heating by the heater is restored when the restorable abnormality has been removed after heating by the heater is prohibited due to occurrence of the restorable abnormality.

Abstract: A branched hetero polyethylene glycol according to the present invention is represented by the formula [1]: wherein X and Y represent each an atomic group containing at least a functional group which reacts with a functional group present in a bio-functional molecule to form a covalent bond and the functional group contained in the atomic group X and the functional group contained in the atomic group Y are different from each other; s is an integer of 2 to 8, which represents the number of polyethylene glycol chains; n is the number of average added moles for the polyethylene glycol chain and 20?n?2000; and E is a branching linker moiety having s-valent bonding valency for the polyethylene glycol chains and having monovalent bonding valency for the functional group Y.

Abstract: Hermeticity of an annular sealing bonding material to seal a vibrating part is improved. In the crystal resonator 10, a resonator-plate-side first bonding pattern 251 annularly formed on a crystal resonator plate 2 is bonded to a sealing-member-side first bonding pattern 321 annularly formed on a first sealing member 3, and a resonator-plate-side second bonding pattern 252 annularly formed on the crystal resonator plate 2 is bonded to a sealing-member-side second bonding pattern 421 annularly formed on a second sealing member 4. Thus, annular bonding materials 11a and 11b, which hermetically seal a vibrating part 22 causing piezoelectric resonance, are formed. Inner peripheral edge parts 111a and 111b and outer peripheral edge parts 112a and 112b of the bonding materials 11a and 11b are formed denser than intermediate parts 113a and 113b between the inner and outer peripheral edge parts 111a and 112a, and between the inner and outer peripheral edge parts 111b and 112b.

Abstract: A branched hetero polyethylene glycol according to the present invention is represented by the formula [1]: wherein X and Y represent each an atomic group containing at least a functional group which reacts with a functional group present in a bio-functional molecule to form a covalent bond and the functional group contained in the atomic group X and the functional group contained in the atomic group Y are different from each other; s is an integer of 2 to 8, which represents the number of polyethylene glycol chains; n is the number of average added moles for the polyethylene glycol chain and 20?n?2000; and E is a branching linker moiety having s-valent bonding valency for the polyethylene glycol chains and having monovalent bonding valency for the functional group Y.

Abstract: A correlation processing method includes generating a correlation code in which a code value of a chip boundary period is set to a value of a replica code, and a code value of a chip center period other than the chip boundary period is set to a predetermined value, and performing a correlation calculation with respect to the correlation code and a received code signal obtained by demodulating a received signal from a positioning satellite.

Abstract: Provided herein are narrowly distributed multi-armed polyethylene glycol compounds, and hydrogels containing the same. Also provided are methods for treating, adhering, or sealing a biological tissue with hydrogels, and kits for making a hydrogel. Drug releasing compositions also are provided that include a narrowly distributed multi-armed polyethylene glycol compound.