Abstract: A monitoring method includes a calculation step and an output step. The calculation step includes calculating an alarm generation time, in which at least one of a vital alarm notifying an abnormality of physiological information and a technical alarm is generated, or a ratio of the alarm generation time. The output step includes outputting the calculated alarm generation time or the calculated ratio.

Abstract: A method of direct transdifferentiation of somatic cells into other somatic cells may be convenient and still have good reproducibility, excellent production efficiency, and short performed time. Methods for direct transdifferentiation of somatic cells into other somatic cells may include: (a) introducing a GLIS family gene, a mutated GLIS family gene or a gene product thereof into somatic cells; and (b) culturing the gene-introduced somatic cells in a culture medium containing a component that induces differentiation of the somatic cells or precursor cells of the somatic cells into other somatic cells.

Abstract: Herein disclosed is a monitor, including: a measurement section that acquires measured values of a plurality of parameters showing a health state of a living body; a classification setting section that classifies a relationship among the measured values of the plurality of parameters into a plurality of types of detection states; a status setting section that respectively assigns any of a plurality of types of alarm statuses to the plurality of types of detection states; a state specifying section that specifies one of the plurality of types of detection states on the basis of the measured values acquired by the measurement section; and an annunciation section that outputs an alarm corresponding to the alarm status assigned to the specified detection state.

Abstract: An alarm information processing apparatus includes: an acquirer that acquires alarm information generated in a predetermined period of time and identification information; at least one processor configured to: select first alarm information together with first identification information and second alarm information together with second identification information; and analyze statistics about the first alarm information and the second alarm information; and an output configured to output the statistics about alarms analyzed by the processor in a comparable form.

Abstract: To provide a base sequence for protein expression that can increase the yield of protein such as diastatic enzyme by further activating a promoter of a particular gene. A base sequence 1 for protein expression includes: a gene 3 encoding protein 2; a promoter 4 of the gene 3, the promoter being linked upstream of the gene 3; and a cis element 5 whose activity is improved by an artificial transcription factor 6, the cis element being linked further upstream of the promoter 4. The cis element 5 is represented by SEQ ID NO: 1.

Abstract: To provide a base sequence for protein expression that can increase the yield of protein such as diastatic enzyme by further activating a promoter of a particular gene. A base sequence 1 for protein expression includes: a gene 3 encoding protein 2; a promoter 4 of the gene 3, the promoter being linked upstream of the gene 3; and a cis element 5 whose activity is improved by an artificial transcription factor 6, the cis element being linked further upstream of the promoter 4. The cis element 5 is represented by SEQ ID NO: 1.

Abstract: An alarm information processing apparatus includes: an acquirer that acquires alarm information generated in a predetermined period of time and identification information; at least one processor configured to: select first alarm information together with first identification information and second alarm information together with second identification information; and analyze statistics about the first alarm information and the second alarm information; and an output configured to output the statistics about alarms analyzed by the processor in a comparable form.

Abstract: This invention provides a novel means that allows efficient secretion and production of a target protein in a host cell. This invention concerns a novel polypeptide having an activity of improving the secretion productivity of a target protein, a gene comprising a nucleotide sequence encoding such polypeptide, a vector comprising such gene, a transformant obtained by transforming a host cell with such vector, and a method for producing a protein comprising a step of culturing such transformant and recovering a target protein from the culture product.

Abstract: A biological signal measuring system includes: first and second optical sensors attached to first and second body portions of a subject; a first average oxygen saturation acquiring section acquiring a first average value corresponding to an average value of the first oxygen saturation corresponding to an arterial oxygen saturation in the first body portion in a predetermined time period starting at a first time; a second average oxygen saturation acquiring section acquiring a second average value corresponding to an average value of the second oxygen saturation corresponding to an arterial oxygen saturation in the second body portion in the predetermined time period starting at a second time that is different from the first time; and a difference value acquiring section acquiring a difference value, to be displayed, between the first average value and the second average value.

Abstract: A physiological parameter measuring apparatus is configured to perform a screening for a likelihood of the critical congenital heart disease, based on the oxygen saturations at two locations on a body of a patient and the difference between the oxygen saturations, and to display the likelihood as a result of the screening. The physiological parameter measuring apparatus manages, with respect to each patient, a scheduled time for starting the screening, the result of the screening, and information relating to the patient. The physiological parameter measuring apparatus can display a first screen containing information relating to the scheduled time, a second screen for receiving the instruction to perform the screening, and a third screen containing the result of the screening. A physiological parameter measuring system includes sensors to be attached to the body at the two locations, and the physiological parameter measuring apparatus.

Abstract: To provide a base sequence for protein expression that can increase the yield of protein such as diastatic enzyme by further activating a promoter of a particular gene. A base sequence 1 for protein expression includes: a gene 3 encoding protein 2; a promoter 4 of the gene 3, the promoter being linked upstream of the gene 3; and a cis element 5 whose activity is improved by an artificial transcription factor 6, the cis element being linked further upstream of the promoter 4. The cis element 5 is represented by SEQ ID NO: 1.

Abstract: An optical sensor includes: a light emitter; a light receiver; a rod-shaped grasping member in which one of the light emitter and the light receiver is disposed, and which is to be grasped by a hand of a subject; and a clamping member which is adapted to clamp a part of the hand of the subject with the grasping member, another one of the light emitter and the light receiver being disposed in the clamping member.

Abstract: This invention provides a novel means that allows efficient secretion and production of a target protein in a host cell. This invention concerns a novel polypeptide having an activity of improving the secretion productivity of a target protein, a gene comprising a nucleotide sequence encoding such polypeptide, a vector comprising such gene, a transformant obtained by transforming a host cell with such vector, and a method for producing a protein comprising a step of culturing such transformant and recovering a target protein from the culture product.

Abstract: To provide a base sequence for protein expression that can increase the yield of protein such as diastatic enzyme by further activating a promoter of a particular gene. A base sequence 1 for protein expression includes: a gene 3 encoding protein 2; a promoter 4 of the gene 3, the promoter being linked upstream of the gene 3; and a cis element 5 whose activity is improved by an artificial transcription factor 6, the cis element being linked further upstream of the promoter 4. The cis element 5 is represented by SEQ ID NO: 1.

Abstract: To provide a base sequence for protein expression that can increase the yield of protein such as diastatic enzyme by further activating a promoter of a particular gene. A base sequence 1 for protein expression includes: a gene 3 encoding protein 2; a promoter 4 of the gene 3, the promoter being linked upstream of the gene 3; and a cis element 5 whose activity is improved by an artificial transcription factor 6, the cis element being linked further upstream of the promoter 4. The cis element 5 is represented by SEQ ID NO: 1.

Abstract: To provide a base sequence for protein expression that can increase the yield of protein such as diastatic enzyme by further activating a promoter of a particular gene. A base sequence 1 for protein expression includes: a gene 3 encoding protein 2; a promoter 4 of the gene 3, the promoter being linked upstream of the gene 3; and a cis element 5 whose activity is improved by an artificial transcription factor 6, the cis element being linked further upstream of the promoter 4. The cis element 5 is represented by SEQ ID NO: 1.

Abstract: A physiological parameter measuring apparatus is configured to perform a screening for a likelihood of the critical congenital heart disease, based on the oxygen saturations at two locations on a body of a patient and the difference between the oxygen saturations, and to display the likelihood as a result of the screening. The physiological parameter measuring apparatus manages, with respect to each patient, a scheduled time for starting the screening, the result of the screening, and information relating to the patient. The physiological parameter measuring apparatus can display a first screen containing information relating to the scheduled time, a second screen for receiving the instruction to perform the screening, and a third screen containing the result of the screening. A physiological parameter measuring system includes sensors to be attached to the body at the two locations, and the physiological parameter measuring apparatus.

Abstract: A physiological information measuring apparatus includes: a display controller that, based on information indicating a respiration interval of a patient, is configured to produce a respiration interval graph in which a first axis indicates time information, and a second axis indicates a length of the respiration interval, and that is configured to control a displaying section to display the respiration interval graph, the display controller that is configured to reset a value of the second axis of the respiration interval graph, at each time when the respiration interval starts.

Abstract: A biological information monitor includes: a first measuring unit which measures a pulse wave propagation time of a patient; a second measuring unit which measures a blood pressure of the patient; a calculating unit which calculates an estimated blood pressure value of the patient based on the pulse wave propagation time of the patient; a setting unit which sets a threshold; and a determining unit which compares the estimated blood pressure value with the threshold. The second measuring unit is activated to measure the blood pressure of the patient at least one of at time intervals and at a time when an operator operates the second measuring unit, and the second measuring unit is activated to measure the blood pressure of the patient by the determining unit based on the comparison result.

Abstract: This invention provides a novel means that allows efficient secretion and production of a target protein in a host cell. This invention concerns a novel polypeptide having an activity of improving the secretion productivity of a target protein, a gene comprising a nucleotide sequence encoding such polypeptide, a vector comprising such gene, a transformant obtained by transforming a host cell with such vector, and a method for producing a protein comprising a step of culturing such transformant and recovering a target protein from the culture product.