Abstract: The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents a

Abstract: The present invention provides a type I insulin-like growth factor receptor (IGF-1R) inhibitor comprising, as an active ingredient, an indazole derivative represented by Formula (I): {wherein R1 represents —NR4R5 [wherein R4 represents a hydrogen atom or the like, R5 represents substituted or unsubstituted lower alkyl, —C(?O)R6 (wherein R6 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or the like], or the like, and R2 and R3 may be the same or different and each represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, or the like} or a pharmaceutically acceptable salt thereof, and the like.

Abstract: The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents a

Abstract: The present invention provides a type I insulin-like growth factor receptor (IGF-1R) inhibitor comprising, as an active ingredient, an indazole derivative represented by Formula (I): {wherein R1 represents —NR4R5 [wherein R4 represents a hydrogen atom or the like, R5 represents substituted or unsubstituted lower alkyl, —C(?O)R6 (wherein R6 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or the like], or the like, and R2 and R3 may be the same or different and each represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, or the like} or a pharmaceutically acceptable salt thereof, and the like.

Abstract: The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents a

Abstract: The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents

Abstract: A master cylinder of the invention supplies a brake fluid from a large diameter pressurizing chamber 56 to a small diameter hydraulic chamber 49 by opening a reverse flow checking opening and closing portion 61 by sliding movement of a stepped piston 16 forwardly, that is, fast fill and when the hydraulic pressure of the large diameter pressurizing chamber 56 rises, a control valve 86 escapes the hydraulic pressure of the large diameter pressurizing chamber 56 to a reservoir 12 to gradually lower in accordance with rise of the hydraulic pressure of the small diameter hydraulic chamber 49, thereby capable of reducing a strange feeling in a pedal feeling caused by sudden pressure release of the large diameter pressuring chamber 56.

Abstract: There is disclosed a pneumatic booster having a vacuum chamber connected to an intake pipe of an engine. An air outlet of an ejector is connected to the intake pipe through a vacuum control valve, and an air inlet of the ejector is connected to an air cleaner. A vacuum pick-up port of the ejector is connected to the vacuum chamber of a booster body. The vacuum control valve comprises a control chamber and a control piston, and the negative pressure in the booster is introduced into the control chamber and acts on the control piston. When the negative pressure in the booster is insufficient, the control piston acts to open the control valve and a negative pressure is supplied from the ejector to the vacuum chamber. When the negative pressure in the booster is sufficiently high, the control piston acts to close the control valve and stops the operation of the ejector, thus reducing an effect of the ejector with respect to an air/fuel ratio of the engine.

Abstract: A master cylinder including a cylinder having one end open to the outside. A secondary piston guide ring, a sleeve and a primary piston guide ring are adapted to be fitted in this order into the cylinder from the one open end. A piston is slidably fitted in an axial direction of the cylinder, into each of the secondary piston guide ring, the sleeve and the primary piston guide ring. A retainer is provided at the open end of the cylinder, and adapted to abut against the primary piston guide ring so as to prevent escape of the primary piston guide ring from the cylinder. An elastic member is provided between a rearward end portion of the sleeve and a forward end portion of the primary piston guide ring.

Abstract: A master cylinder of the invention supplies a brake fluid from a large diameter pressurizing chamber 56 to a small diameter hydraulic chamber 49 by opening a reverse flow checking opening and closing portion 61 by sliding movement of a stepped piston 16 forwardly, that is, fast fill and when the hydraulic pressure of the large diameter pressurizing chamber 56 rises, a control valve 86 escapes the hydraulic pressure of the large diameter pressurizing chamber 56 to a reservoir 12 to gradually lower in accordance with rise of the hydraulic pressure of the small diameter hydraulic chamber 49, thereby capable of reducing a strange feeling in a pedal feeling caused by sudden pressure release of the large diameter pressuring chamber 56.

Abstract: There is disclosed a pneumatic booster having a vacuum chamber connected to an intake pipe of an engine. An air outlet of an ejector is connected to the intake pipe through a vacuum control valve, and an air inlet of the ejector is connected to an air cleaner. A vacuum pick-up port of the ejector is connected to the vacuum chamber of a booster body. The vacuum control valve comprises a control chamber and a control piston, and the negative pressure in the booster is introduced into the control chamber and acts on the control piston. When the negative pressure in the booster is insufficient, the control piston acts to open the control valve and a negative pressure is supplied from the ejector to the vacuum chamber. When the negative pressure in the booster is sufficiently high, the control piston acts to close the control valve and stops the operation of the ejector, thus reducing an effect of the ejector with respect to an air/fuel ratio of the engine.

Abstract: A master cylinder of the present invention comprises a cylinder having one end open to the outside. A secondary piston guide ring, a sleeve and a primary piston guide ring are adapted to be fitted in this order into the cylinder from the one open end. A piston is slidable fitted in an axial direction of the cylinder, into each of the secondary piston guide ring, the sleeve and the primary piston guide ring. A retaining means is provided at the open end of the cylinder, and adapted to abut against the primary piston guide ring and prevent escape of the primary piston guide ring from the cylinder. An elastic member is provided between a rearward end portion of the sleeve and a forward end portion of the primary piston guide ring.

Abstract: A master cylinder includes a cylinder, a piston slidably provided in the cylinder, an annular cup seal held on an inner circumferential surface of the cylinder, and a relief port formed in the piston. The piston and the cylinder define a pressure chamber for generating fluid pressure in front of the piston, and the cylinder and an outer circumferential surface of the piston define a fluid supply chamber which communicates with a reservoir. The cup seal is adapted to slide against the outer circumferential surface of the piston to separate the fluid supply chamber from the pressure chamber. The relief port provides communication between the pressure chamber and the fluid supply chamber. A control taper surface is formed on the outer circumferential surface of the piston rearwardly from the relief port. The control taper surface is tapered toward the front of the piston and is capable of abutting against an inner circumferential surface of the cup seal.

Abstract: A pneumatic booster includes a valve mechanism for introducing atmospheric air into a variable-pressure chamber in accordance with the movement of a plunger, propelling a power piston due to differential pressure generated between the variable-pressure chamber and a constant-pressure chamber and transmitting force by which the power piston is propelled through a valve body to an output shaft. The valve mechanism includes a poppet valve mechanism including a seal surface capable of abutting against an annular atmospheric valve seat formed in the plunger and a seal surface capable of abutting against an annular negative pressure valve seat formed on an inner surface of the valve body. The annular atmospheric valve seat of the plunger is located in a position forward in a direction of propelling of the power piston relative to the negative pressure valve seat and is substantially aligned with the negative pressure valve seat in an axial direction.

Abstract: A dual function brake fluid control apparatus is presented for performing antiskid operation as well as another control operation involving control of the fluid pressure when the apparatus is not performing an antiskid operation. The apparatus is provided with a pressure relief valve having a valve body and a piston. The relief valve is forced closed by a biasing spring acting on a valve body, and when in the open state relieves the discharge pressure of a pump to the intake side of the pump. The piston closes the relief valve when the fluid pressure from the master cylinder exceeds a specific value. This configuration allows setting the discharge fluid pressure of the pump to apply fluid pressure to the wheel cylinders for non-antiskid control operations higher than that for the antiskid control operation.

Abstract: A brake booster includes a housing, a partition adapted to divide the interior of the housing into two chambers, and two diaphragms adapted to divide the two chambers into constant and variable pressure chambers. A control valve includes a valve body carried by the diaphragms, and a plunger slidably received in the valve body. The control valve is operatively connected to the variable pressure chambers to develop a pressure differential across the diaphragms to cause the diaphragms to move in response to actuation of an input rod. A reaction disk is disposed between an output rod and the valve body to transmit the reaction of movement of the output rod to the input rod. An adjusting mechanism is disposed between the plunger and the reaction disk and compressible so as to develop a greater degree of pressure differential when a force applied by the input rod exceeds a predetermined level.

Abstract: A tandem pneumatic booster having a shell body, the inside of which is divided into two, front and rear, chambers by a center shell. Each chamber includes a negative pressure chamber and a working pressure chamber. A valve body is slidably fitted in the shell body and the center shell with seal members therebetween. The valve body is provided with an air passage for communication between the front and rear working pressure chambers. A valve mechanism is actuated in association with an input shaft to introduce atmospheric air into the front and rear working pressure chambers through the air passage so as to apply thrust to front and rear power pistons. The diaphragm of the front power piston has a bead on an inner periphery thereof. The valve body has a groove on an outer periphery thereof. A portion of the air passage which leads to the front working pressure chamber has a main passage portion extending axially in the valve body, and a bypass extending radially outward from the main passage portion.

Abstract: A brake fluid pressure adjustment device is presented for controlling the wheel lock of a vehicle by controlling the flow of the brake fluid from the main fluid path to the bypass path by means of a pumping mechanism which is in constant operation. The pumping mechanism includes a suction valve which only allows a unidirectional flow of brake fluid from the pump, and a reservoir to the pump; an electromagnetic device which forces open the bypass path between the pump and the reservoir by attracting the bypass path control valve element in one direction; and a discharge valve which allows only the flow of brake fluid from the pump to the main fluid path. Therefore, by controlling the actions of the electromagnetic means, it is possible to control the decrease, holding and increase actions of the pressure adjustment device, without stopping and starting the pump.

Abstract: A plunger moved with an input shaft is movably fitted in an axial bore of a valve body made of resin, and a valve mechanism selectively establishes and cuts off communication in a negative pressure passage and an atmosphere passage formed in the valve body according to the movement of the plunger. Also, a pair of radial holes formed to have a circular cross section are provided in the valve body by drilling work, and a plate type stop key formed in a fork shape having two claw branches is mounted by loosely inserting the branches in the radial holes. The stop key limits a movement range of the plunger. Also, a guide portion is formed on an outer circumference of the valve body to guide side surfaces of the stop key. The movement of the stop key is restricted by the guide portion and a step formed in the axial bore of the valve body. Therefore, a smooth operation of the pneumatic booster can be guaranteed.

Abstract: A master cylinder of the invention supplies a brake fluid from a large diameter pressurizing chamber 56 to a small diameter hydraulic chamber 49 by opening a reverse flow checking opening and closing portion 61 by sliding movement of a stepped piston 16 forwardly, that is, fast fill and when the hydraulic pressure of the large diameter pressurizing chamber 56 rises, a control valve 86 escapes the hydraulic pressure of the large diameter pressurizing chamber 56 to a reservoir 12 to gradually lower in accordance with rise of the hydraulic pressure of the small diameter hydraulic chamber 49, thereby capable of reducing a strange feeling in a pedal feeling caused by sudden pressure release of the large diameter pressurizing chamber 56.