Abstract: There is provided an improved process for producing novel compounds represented by the general formula: ##STR1## wherein the ring A represents a pyrrole ring which may be hydrogenated; X represents an amino, hydroxyl or mercapto group; R.sup.1, R.sup.2 and R.sup.3 each being the same as or different from the other, represents hydrogen or an alkyl, alkenyl or alkynyl group which may be substituted; R.sup.4 represents OR.sup.5 wherein R.sup.5 represents hydrogen or a hydrocarbon group which may be substituted or NHCH(COOR.sup.6)CH.sub.2 CH.sub.2 COOR.sup.7 wherein R.sup.6 and R.sup.7 each represents hydrogen or a hydrocarbon group which may be substituted; and n represents an integer of 1 to 4, or a salt thereof from compounds represented by the general formula: ##STR2## wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n are the same as defined above; Y.sup.1 and Y.sup.2 each represents oxygen or sulfur atom; R.sup.8 and R.sup.

Abstract: A novel compound of the formula: ##STR1## wherein a ring A stands for an optionally substituted 5-membered ring; B stands for an optionally substituted divalent cyclic or chain group; either one of Q.sup.1 and Q.sup.2 stands for N and the other stands for N or CH; X stands for an amino group, hydroxyl group or mercapto group; Y stands for H, halogen atom or a group bonded through C, N, O or S; Z stands for a straight-chain divalent group having 2 to 5 atoms constituted of optionally substituted carbon atoms or constituted of optionally substituted carbon atoms and one optionally substituted hetero-atom; COOR.sup.1 and COOR.sup.2 independently stand for an optionally esterified carboxyl group; n denotes an integer of 2 to 6; and R.sup.1 may be different in each of n repeating units, or their salts and it is useful as a therapeutic drug for tumor in mammals.

Abstract: New fused pyrimidines of the general formula (I): ##STR1## wherein the ring A is a pyridine ring which may be hydrogenated or a benzene ring which may be hydrogenated, X is an amino group or a hydroxyl group, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, fluorine or a lower alkyl group, and --COOR.sup.5 and --COOR.sup.6 are independently a carboxyl group which may be esterified, and salts thereof have excellent anti-tumor effects, and they can be produced by the following reaction scheme: ##STR2## in which A is, X, R.sup.1 to R.sup.4, --COOR.sup.5 have the above meanings.

Abstract: A compound of the formula ##STR1## wherein the ring A is a pyrrole or pyrroline ring, X is an amino group or a hydroxyl group, Y is a hydrogen atom, an amino group or a hydroxyl group, R is a hydrogen atom, a fluorine atom, an alkyl group, an alkenyl group or an alkynyl group, --COOR.sup.1 and --COOR.sup.2 are independently carboxyl groups which may be esterified and n is an integer of 2 to 4, and R may be different in each of the n repeating units, and salts thereof have excellent antitumor effects, and can be used as antitumor agents in mammals.

Abstract: Lipid derivatives represented by the formula: ##STR1## wherein R.sup.1 stands for an optionally substituted higher alkyl group, R.sup.2 stands for an optionally substituted lower alkyl group or an optionally substituted nitrogen-containing heterocyclic group, R.sup.3 stands for a tertiary amino group or a quaternary ammonium group, J stands for oxygen atom or S(O)t (where t deontes 0, 1 or 2), m and n respectively denotes 1 or 2, p denotes 0, 1 or 2, q and r respectively denote an integer of 2 to 5.and salts thereof have antitumor activities including differentiation-inducing activity and are useful as antitumor agents.

Abstract: A compound represented by the formula: ##STR1## wherein R represents a hydrogen atom or a lower alkyl group;R.sup.1 represents a higher alkyl group which may be substituted;R.sup.2 represents a hydrogen atom or a lower alkyl group, a lower alkanoyl group or a nitrogen-containing 5- to 7-membered heterocyclic group each of which may be substituted; X represents a divalent group represented by the formula:--(OCH.sub.2 CH.sub.2).sub.p --wherein p represents an integer of 1 to 5, a divalent group represented by the formula:--O(CH.sub.2).sub.q --wherein q represents an integer of 3 to 8, or a divalent group represented by the formula:--(OCH.sub.2 CH.sub.2).sub.p --J--(CH.sub.2).sub.q --wherein J represents an oxygen atom or a group represented by the formula: --S(O).sub.

Abstract: A compound of the formula ##STR1## wherein the ring .circle.A is a pyrrole or pyrroline ring, X is an amino group or a hydroxyl group, Y is a hydrogen atom, an amino group or a hydroxyl group, R is a hydrogen atom, a fluorine atom, an alkyl group, an alkenyl group or an alkynyl group, --COOR.sup.1 and --COOR.sup.2 are independently carboxyl groups which may be esterified and n is an integer of 2 to 4, and R may be different in each of the n repeating units, and salts thereof have excellent antitumor effects, and can be used as antitumor agents in mammals.

Abstract: New fused pyrimidines of the general formula (I): ##STR1## wherein the ring .circle. A is a pyridine ring which may be hydrogenated or a benzene ring which may be hydrogenated, X is an amino group or a hydroxyl group, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, fluorine or a lower alkyl group, and --COOR.sup.5 and --COOR.sup.6 are independently a carboxyl group which may be esterified, and salts thereof have excellent anti-tumor effects, and they can be produced by the following reaction scheme: ##STR2## in which .circle. A is, X, R.sup.1 to R.sup.4, --COOR.sup.5 have the above meanings.

Abstract: A hopper for continuously drawing out tires through a water tank including at least one line of declining roller conveyors disposed under an opening for charging the tires. A water tank is diposed under the roller conveyors which receives the tires and arranges the tires in a predetermined direction. A plurality of spaced-apart hooks draws the tires up out of the water tank. The pulled up tires are then transported through a slide plate and a belt-conveyor to a predetermined place.

Abstract: The present invention relates to a slide damper system used for a vertical type of furnace for continuously heat-treating charged solid matters. This slide damper system comprises at least two slide damper means disposed vertically apart from each other in the furnace. The slide damper means is provided with means for preventing clogging with foreign matter and/or means for heat-resisting as well as means for preventing two or more slide damper means from opening simultaneously.

Abstract: The present invention relates generally to a process and apparatus for recovering the oil component from a flow of dust-including dry-distilled gases produced in a furnace for thermal-decomposing solid polymer wastes, and more particularly to a process and apparatus for continuously recovering the oil component from a flow of dry-distilled gases comprising combustive gases, an oil component, moisture, and dust which are produced in a furnace for thermal-decomposing or dry-distilling polymer wastes such as waste rubber tires, waste plastics, etc.

Abstract: 7-Deazapurine derivatives of the formula: ##STR1## wherein R.sup.1 is phenyl which has, at the ortho position and/or para position as substituents, at least one group represented by the formula --O--R.sup.3, --S--R.sup.4 or ##STR2## (wherein R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are the same or different and each is hydrogen or an alkyl or phenyl group which may be substituted, whereby R.sup.5 and R.sup.6, together with the adjacent nitrogen atom, may form a cyclic amino group which may be substituted, and R.sup.3, R.sup.4, R.sup.5 and R.sup.6 each may represent a protective group), and may have a group or groups with a molecular weight of up to about 200 as a substituent at any position other than those having the said substituents introduced; R.sup.2 is an amino group which may be protected, or its salt, have a potent antitumor activity, and hence the compounds are useful as an antitumor agent.

Abstract: 7-Deazapurine derivatives of the formula (I): ##STR1## (R.sup.1 is an acyl group; each of R.sup.2 and R.sup.3 is an alkyl, alkenyl or aralkyl group of alternatively R.sup.2 and R.sup.3, taken together with the adjacent nitrogen atom, form a cyclic amino group, and each of said alkyl group, alkenyl group, aralkyl group and cyclic amino group has a methylene group in .alpha.-position) and salts thereof are of value as intermediates for the production of antitumor agents, biological reagents, etc.

Abstract: Novel 7-deazapurine derivatives of the formula: ##STR1## wherein X is halogen, Y is hydroxyl or di-C.sub.1-3 alkylamino, Z is a --NH-- or --NHC(.dbd.NH)-- group, l is an integer of 1 to 5, m is an integer of 0 to 2, and n is 1 when Z is a --NH-- group or n is 0 or 1 when Z is a --NHC(.dbd.NH)-- group, and salts thereof are selectively taken up by tumor cells.

Abstract: This invention relates to 4,5-deoxymaytansinoid compounds represented by the formula ##STR1## wherein X is a hydrogen atom or an alkyl or acyl group, Y is a hydrogen or chlorine atom, and R is a hydrogen atom or a carboxylic acid-derived acyl group, and methods of producing the same. The compounds are useful as antitumor, antiprotozoal and antifungal agents.

Abstract: Novel maytansinoids of the formula: ##STR1## wherein Y is H or Cl, and R is C.sub.2-15 alkyl, phenyl-C.sub.1-4 alkyl, pyridyl-C.sub.1-4 alkyl, imidazolyl-C.sub.1-4 alkyl, indolyl-C.sub.1-4 alkyl, furyl-C.sub.1-4 alkyl or thienyl-C.sub.1-4 alkyl, said R group being substituted by hydroxyl, halogen or C.sub.1-5 alkanoyloxy at its .alpha.- and/or .beta.-position, have antimitotic, antitumor and antimicrobial activities.

Abstract: Novel maytansinoids of the formula: ##STR1## wherein X is hydrogen or chlorine,R.sup.1 is C.sub.2-4 alkyl,R.sup.2 is C.sub.2-8 alkyl which may be substituted or methyl which is substituted,have antimicrobial, antimitotic and antitumor activities.

Abstract: Novel maytansinoids of the formula: ##STR1## wherein X is H or Cl, and R is a hydrocarbon residue or an azaheterocyclic group, said R group having at least one of water-solubilizing substituents, have antimitotic, antitumor and antimicrobial activities.

Abstract: Novel maytansinoids of the formula: ##STR1## wherein X is H or Cl, and Y is Cl, OH, SH, CN, NO.sub.2, --OR or --S(O).sub.n R wherein R is slkyl, aryl, aralkyl or azaheterocyclic group which may be substituted, and n is 0, 1 or 2, have antimitotic, antitumor and antimicrobial activities.

Abstract: An ozonizer which comprises a flat hollow metal grounded electrode and a discharge electrode plate spaced apart therefrom by a discharge space. The discharge electrode plate includes a flat hollow dielectric member, a high voltage electrode formed on the inner surface of the dielectric member, a spacer material provided within and held in a clamped state by the dielectric member, a lead conductor provided within and held in a clamped state by the spacer material and a connector connecting the lead conductor and high voltage electrode.