Patents by Inventor Hiroshi Izui

Hiroshi Izui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200089475
    Abstract: A computer-implemented optimization problem arithmetic method includes receiving a combinatorial optimization problem, determining, based on scale or a requested accuracy of the combinatorial optimization problem, a partition mode and an execution mode, the partition mode defining a logically divided state of an arithmetic circuit, the execution mode defining a range of hardware resources to be utilized in arithmetic operation for each of partitions generated by logically dividing the arithmetic circuit, and causing the arithmetic circuit to execute arithmetic operation of the combinatorial optimization problem in accordance with the determined partition mode and the determined execution mode.
    Type: Application
    Filed: September 11, 2019
    Publication date: March 19, 2020
    Applicant: FUJITSU LIMITED
    Inventors: Hiroshi Kondou, Hiroyuki Izui, Tatsuhiro Makino, Noriaki Shimada
  • Publication number: 20200090051
    Abstract: An optimization problem operation method include accepting a combinatorial optimization problem to an operation unit that is capable of being divided into a plurality of partitions logically and solving the combinatorial optimization problem. The method include deciding a partition mode that prescribes a logical division state of the operation unit and an execution mode that prescribes a range of hardware resources used in an operation in the partition mode according to a scale or a requested precision of the combinatorial optimization problem. The method include causing execution of operations of the combinatorial optimization problem in parallel in the operation unit with the partition mode and the execution mode decided, based on the number of times obtained by dividing the number of times of execution of the combinatorial optimization problem by the number of divisions corresponding to the execution mode.
    Type: Application
    Filed: September 9, 2019
    Publication date: March 19, 2020
    Applicant: FUJITSU LIMITED
    Inventors: Noriaki Shimada, Hiroyuki Izui, Hiroshi Kondou, Tatsuhiro Makino
  • Patent number: 8969048
    Abstract: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: March 3, 2015
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yury Ivanovich Kozlov, Akito Chinen, Hiroshi Izui, Yoshihiko Hara, Hisashi Yasueda, Konstantin Vyacheslavovich Rybak, Ekaterina Aleksandrovna Slivinskaya, Joanna Yosifovna Katashkina
  • Publication number: 20140242643
    Abstract: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.
    Type: Application
    Filed: May 2, 2014
    Publication date: August 28, 2014
    Applicant: AJINOMOTO CO., INC.
    Inventors: Yury Ivanovich Kozlov, Akito Chinen, Hiroshi Izui, Yoshihiko Hara, Hisashi Yasueda, Konstantin Vyacheslavovich Rybak, Ekaterina Aleksandrovna Slivinskaya, Joanna Yosifovna Katashkina
  • Patent number: 8753849
    Abstract: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: June 17, 2014
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yury Ivanovich Kozlov, Akito Chinen, Hiroshi Izui, Yoshihiko Hara, Hisashi Yasueda, Konstantin Vyacheslavovich Rybak, Ekaterina Aleksandrovna Slivinskaya, Joanna Yosifovna Katashkina
  • Patent number: 8404474
    Abstract: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: March 26, 2013
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yury Ivanovich Kozlov, Akito Chinen, Hiroshi Izui, Yoshihiko Hara, Hisashi Yasueda, Konstantin Vyacheslavovich Rybak, Ekaterina Aleksandrovna Slivinskaya, Joanna Yosifovna Katashkina
  • Patent number: 8222007
    Abstract: The present invention describes an L-glutamic acid-producing bacterium which belongs to the genus Pantoea, Enterobacter, Klebsiella or Erwinia, wherein the bacterium has been modified by gene recombination to inactivate the rpoS gene. A method is also described for culturing the bacterium in a medium to cause accumulation of L-glutamic acid in the medium, and collecting L-glutamic acid from the medium.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: July 17, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yoshihiko Hara, Hiroshi Izui
  • Patent number: 8182739
    Abstract: A concentric-circular-gradient functional material for biogenic use is produced using first, second, third and forth cylindrical partitions, and a cylindrical dice which are concentrically stood on a supporting stand. Ti powder (A) fills the first cylindrical partition. A first mixed powder including Ti powder (A) and biogenic material powder (B) fills between the first and second cylindrical partitions. A second mixed powder including a smaller amount of Ti powder (A) than the first mixed powder fills between the second and third cylindrical partitions. A third mixed powder including a smaller amount of Ti powder (A) than the second mixed powder fills between the third and fourth cylindrical partitions. The biogenic material powder (B) fills between the fourth cylindrical partition and the dice. The first to fourth partitions are pulled out. The dice is capped using a punch. The powders are sintered using a discharge plasma sintering machine.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: May 22, 2012
    Assignee: Nihon University
    Inventors: Michiharu Okano, Hiroshi Izui
  • Patent number: 8129151
    Abstract: L-Glutamic acid is produced by culturing in a liquid culture medium a microorganism belonging to the genus Pantoea or Serratia and having an ability to produce L-glutamic acid, which increases in an activity of enzyme catalyzing a reaction for L-glutamic acid biosynthesis or which decreases in or is deficient in an activity of an enzyme catalyzing a reaction branching from a pathway for L-glutamic acid biosynthesis and producing a compound other than L-glutamic acid, and collecting produced L-glutamic acid from the culture medium.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: March 6, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Mika Moriya, Hiroshi Izui, Eiji Ono, Kazuhiko Matsui, Hisao Ito, Yoshihiko Hara
  • Patent number: 8080396
    Abstract: A microorganism is cultured in a medium, and is able to produce one or two or more kinds of L-amino acids including L-glutamic acid, L-glutamine, L-proline, L-ornithine, L-citrulline and L-arginine, and is modified to increase ?-ketoglutarate synthase activity. The L-amino acids are collected from the medium or the cells.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: December 20, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Seizaburo Shiraga, Noriko Murayama, Hiroshi Izui, Hisao Ito, Hisashi Yasueda, Yoshihiro Usuda, Kazuhiko Matsui
  • Patent number: 8058035
    Abstract: A microorganism which has an L-amino acid producing ability and has been modified so that succinate dehydrogenase activity and ?-ketoglutarate dehydrogenase activity are decreased is cultured in a medium to produce and accumulate an L-amino acid in the medium or cells of the microorganism, and the L-amino acid is collected from the medium or cells to produce the L-amino acid.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: November 15, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yoshihiko Hara, Hiroshi Izui, Jun Nakamura, Ranko Nishi
  • Publication number: 20100267094
    Abstract: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.
    Type: Application
    Filed: June 28, 2010
    Publication date: October 21, 2010
    Inventors: Yury Ivanovich Kozlov, Akito Chinen, Hiroshi Izui, Yoshihiko Hara, Hisashi Yasueda, Konstantin Vyacheslavovich Rybak, Ekaterina Aleksandrovna Slivinskaya, Joanna Yosifovna Katashkina
  • Patent number: 7785845
    Abstract: L-Glutamic acid is produced by culturing a microorganism in which an expression of L-glutamic acid-export gene, a yhfK gene, is enhanced or overexpressed, in a medium to produce and cause accumulation of L-glutamic acid in the medium, and collecting L-glutamic acid from the medium.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: August 31, 2010
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yoshihiko Hara, Hiroshi Izui, Hisao Ito
  • Patent number: 7785858
    Abstract: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.
    Type: Grant
    Filed: August 10, 2005
    Date of Patent: August 31, 2010
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yury Ivanovich Kozlov, Akito Chinen, Hiroshi Izui, Yoshihiko Hara, Hisashi Yasueda, Konstantin Vyacheslavovich Rybak, Ekaterina Aleksandrovna Slivinskaya, Joanna Yosifovna Katashkina
  • Publication number: 20100168868
    Abstract: A layered gradient material which comprises a plurality of layers composed of a mixture of hydroxyapatite and calcium tertiary phosphate and is obtained by producing a layered body by stacking a plurality of layers in which the compounding ratio of hydroxyapatite to calcium tertiary phosphate is stepwise or continuously changed and then sintering the layered body by the spark plasma sintering method is excellent in mechanical strength such as compressive strength, flexural strength and Young's modulus, and further, is excellent in biological reactivity such that in the case where it is used as a bone substitute material, bone destruction and new bone reconstruction actively occur. Accordingly, it is extremely useful as a biological material such as a bone substitute material, artificial tooth root and dental cement.
    Type: Application
    Filed: November 29, 2007
    Publication date: July 1, 2010
    Inventors: Michiharu Okano, Hiroshi Izui, Yasumasa Fukase, Yasuaki Tokuhashi
  • Publication number: 20100124777
    Abstract: L-Glutamic acid is produced by culturing a coryneform bacterium having L-glutamic acid producing ability, in which trehalose synthesis ability is decreased or deleted by, for example, disrupting a gene coding for trehalose-6-phosphate synthase, a gene coding for maltooligosyltrehalose synthase, or both of these genes to produce and accumulate L-glutamic acid in the medium, and collecting the L-glutamic acid from the medium.
    Type: Application
    Filed: April 19, 2007
    Publication date: May 20, 2010
    Applicant: Ajinomoto Co., Inc.
    Inventors: Hiromi Ohtaki, Jun Nakamura, Hiroshi Izui, Tsuyoshi Nakamatsu
  • Publication number: 20100062497
    Abstract: A microorganism is cultured in a medium, and is able to produce one or two or more kinds of L-amino acids including L-glutamic acid, L-glutamine, L-proline, L-ornithine, L-citrulline and L-arginine, and is modified to increase ?-ketoglutarate synthase activity. The L-amino acids are collected from the medium or the cells.
    Type: Application
    Filed: September 8, 2009
    Publication date: March 11, 2010
    Inventors: Seizaburo Shiraga, Noriko Murayama, Hiroshi Izui, Hisao Ito, Hisashi Yasueda, Yoshihiro Usuda, Kazuhiko Matsui
  • Publication number: 20090286290
    Abstract: A microorganism which has an L-amino acid producing ability and has been modified so that succinate dehydrogenase activity and ?-ketoglutarate dehydrogenase activity are decreased is cultured in a medium to produce and accumulate an L-amino acid in the medium or cells of the microorganism, and the L-amino acid is collected from the medium or cells to produce the L-amino acid.
    Type: Application
    Filed: June 4, 2009
    Publication date: November 19, 2009
    Inventors: YOSHIHIKO HARA, HIROSHI IZUI, JUN NAKAMURA, RANKO NISHI
  • Publication number: 20090263874
    Abstract: L-Glutamic acid is produced by culturing in a liquid culture medium a microorganism belonging to the genus Enterobacter or Serratia and having an ability to produce L-glutamic acid, which increases in an activity of enzyme catalyzing a reaction for L-glutamic acid biosynthesis or which decreases in or is deficient in an activity of an enzyme catalyzing a reaction branching from a pathway for L-glutamic acid biosynthesis and producing a compound other than L-glutamic acid, and collecting produced L-glutamic acid from the culture medium.
    Type: Application
    Filed: January 17, 2007
    Publication date: October 22, 2009
    Applicant: AJINOMOTO CO. INC
    Inventors: Mika Moriya, Hiroshi Izui, Eiji Ono, Kazuhiko Matsui, Hisao Ito, Yoshihiko Hara
  • Patent number: RE42350
    Abstract: A microorganism is provided which can metabolize a carbon source at a specific pH in a liquid medium containing L-glutamic acid at a saturation concentration and the carbon source, and which has ability to accumulate L-glutamic acid in an amount exceeding the amount corresponding to the saturation concentration in the liquid medium at the pH. Also provided is a method for producing L-glutamic acid by fermentation, which comprises culturing the microorganism in a liquid medium of which pH is adjusted to a pH at which L-glutamic acid is precipitated, to produce and accumulate L-glutamic acid and precipitate L-glutamic acid in the medium.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: May 10, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hiroshi Izui, Mika Moriya, Seiko Hirano, Yoshihiko Hara, Hisao Ito, Kazuhiko Matsui