Patents by Inventor Hiroshi Izui

Hiroshi Izui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6596517
    Abstract: A method for producing L-glutamic acid by fermentation, which comprises culturing a microorganism having L-glutamic acid-producing ability at a first pH that is suitable for growth of the microorganism, and then culturing the microorganism at a second pH that is suitable for L-glutamic acid production by the microorganism and is lower than the first pH.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: July 22, 2003
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hiroshi Izui, Yoshihiko Hara, Masakazu Sato, Naoki Akiyoshi
  • Publication number: 20030119153
    Abstract: L-Glutamic acid is produced by culturing in a liquid culture medium a microorganism belonging to the genus Enterobacter or Serratia and having an ability to produce L-glutamic acid, which increases in an activity of enzyme catalyzing a reaction for L-glutamic acid biosynthesis, or which decreases in or is deficient in an activity of an enzyme catalyzing a reaction branching from a pathway for L-glutamic acid biosynthesis and producing a compound other than L-glutamic acid, and collecting produced L-glutamic acid from the culture medium.
    Type: Application
    Filed: December 10, 2002
    Publication date: June 26, 2003
    Applicant: AJINOMOTO CO. INC.
    Inventors: Mika Moriya, Hiroshi Izui, Eiji Ono, Kazuhiko Matsui, Hisao Ito, Yoshihiko Hara
  • Publication number: 20030003550
    Abstract: L-Glutamine is produced by culturing a coryneform bacterium which has L-glutamine producing ability and has been modified so that its intracellular glutamine synthetase activity should be enhanced, preferably which has been further modified so that its intracellular glutamate dehydrogenase activity should be enhanced, in a medium to produce and accumulate L-glutamine in the medium and collecting the L-glutamine.
    Type: Application
    Filed: February 5, 2002
    Publication date: January 2, 2003
    Applicant: AJINOMOTO CO. INC
    Inventors: Jun Nakamura, Hiroshi Izui, Kayo Moriguchi, Hiroki Kawashima, Tsuyoshi Nakamatsu, Osamu Kurahashi
  • Publication number: 20020182688
    Abstract: A method for producing L-glutamic acid by fermentation, which comprises culturing a microorganism having L-glutamic acid-producing ability at a first pH that is suitable for growth of the microorganism, and then culturing the microorganism at a second pH that is suitable for L-glutamic acid production by the microorganism and is lower than the first pH.
    Type: Application
    Filed: February 20, 2002
    Publication date: December 5, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Hiroshi Izui, Yoshihiko Hara, Masakazu Sato, Naoki Akiyoshi
  • Publication number: 20020137150
    Abstract: L-Glutamic acid is produced by culturing a coryneform bacterium having L-glutamic acid producing ability, in which trehalose synthesis ability is decreased or deleted by, for example, disrupting a gene coding for trehalose-6-phosphate synthase, a gene coding for maltooligosyltrehalose synthase, or both of these genes to produce and accumulate L-glutamic acid in the medium, and collecting the L-glutamic acid from the medium.
    Type: Application
    Filed: July 2, 2001
    Publication date: September 26, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Hiromi Ohtaki, Jun Nakamura, Hiroshi Izui, Tsuyoshi Nakamatsu
  • Publication number: 20020004231
    Abstract: A method for producing L-glutamic acid which comprises culturing a microorganism belonging to the genus Klebsiella, Erwinia or Pantoea and having an ability to produce L-glutamic acid in a culture medium, and collecting produced L-glutamic acid from the culture medium. The microbial strain used is preferably a strain which decreases in or is deficient in an activity of an enzyme catalyzing a reaction branching from a pathway for L-glutamic acid biosynthesis and producing a compound other than L-glutamic acid, or a strain which increase in an activity of an enzyme catalyzing a reaction for L-glutamic acid biosynthesis.
    Type: Application
    Filed: December 18, 2000
    Publication date: January 10, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Mika Moriya, Hiroshi Izui, Eiji Ono, Kazuhiko Matsui, Hisao Ito, Yoshihiko Hara
  • Patent number: 6331419
    Abstract: L-Glutamic acid is produced by culturing in a liquid culture medium a microorganism belonging to the genus Enterobacter or Serratia. Further, the microorganism having an ability to produce L-glutamic acid, which increases in an activity of enzyme catalyzing a reaction for L-glutamic acid biosynthesis, or which decreases in or is deficient in an activity of an enzyme catalyzing a reaction branching from a pathway for L-glutamic acid biosynthesis and producing a compound other than L-glutamic acid, and collecting produced L-glutamic acid from the culture medium.
    Type: Grant
    Filed: March 18, 1999
    Date of Patent: December 18, 2001
    Assignee: Ajinomoto Co., Inc.
    Inventors: Mika Moriya, Hiroshi Izui, Eiji Ono, Kazuhiko Matsui, Hisao Ito, Yoshihiko Hara
  • Publication number: 20010019836
    Abstract: L-Glutamic acid is produced by culturing in a liquid culture medium a microorganism belonging to the genus Enterobacter or Serratia and having an ability to produce L-glutamic acid, which increases in an activity of enzyme catalyzing a reaction for L-glutamic acid biosynthesis, or which decreases in or is deficient in an activity of an enzyme catalyzing a reaction branching from a pathway for L-glutamic acid biosynthesis and producing a compound other than L-glutamic acid, and collecting produced L-glutamic acid from the culture medium.
    Type: Application
    Filed: February 16, 2001
    Publication date: September 6, 2001
    Applicant: AJINOMOTO CO., INC
    Inventors: Mika Moriya, Hiroshi Izui, Eiji Ono, Kazuhiko Matsui, Hisao Ito, Yoshihiko Hara
  • Patent number: 6197559
    Abstract: A method for producing L-glutamic acid which comprises culturing a microorganism belonging to the genus Klebsiella, Erwinia or Pantoea and having an ability to produce L-glutamic acid in a culture medium, and collecting produced L-glutamic acid from the culture medium. The microbial strain used is preferably a strain which decreases in or is deficient in an activity of an enzyme catalyzing a reaction branching from a pathway for L-glutamic acid biosynthesis and producing a compound other than L-glutamic acid, or a strain which increase in an activity of an enzyme catalyzing a reaction for L-glutamic acid biosynthesis.
    Type: Grant
    Filed: March 18, 1999
    Date of Patent: March 6, 2001
    Assignee: Ajinomoto Co., Inc.
    Inventors: Mika Moriya, Hiroshi Izui, Eiji Ono, Kazuhiko Matsui, Hisao Ito, Yoshihiko Hara
  • Patent number: 5908768
    Abstract: A fermentative process for producing L-glutamic acid efficiently and at low cost is disclosed. Also disclosed are microorganisms having improved ability to produce L-glutamic acid. These microorganisms belong to the genus Escherichia, have resistance to an aspartic acid antimetabolite, and are deficient in .alpha.-ketoglutaric acid dehydrogenase activity. The process comprises cultivating one of these microorganisms in a liquid medium, accumulating L-glutamic acid in the culture medium, and collecting L-glutamic acid. In particular, E. coli AF13199 (FERM BP-5807).
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: June 1, 1999
    Assignee: Ajinomoto Co., Inc.
    Inventors: Eiji Ono, Nobuharu Tsujimoto, Hiroshi Izui, Kazuhiko Matsui