Patents by Inventor Hiroshi Miyake

Hiroshi Miyake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060043999
    Abstract: A semiconductor circuit is disclosed, including a DLL circuit for supplying a desired signal-delay amount. The DLL circuit includes detecting means for detecting variations of a signal-delay amount, and delay-amount control means for generating a delay-amount control signal for controlling, depending on the variations of the signal-delay amount detected by the detecting means, the signal-delay amount of the DLL circuit. The semiconductor circuit further includes a part for monitoring circuit performance of the semiconductor circuit based on the delay-amount control signal.
    Type: Application
    Filed: December 23, 2004
    Publication date: March 2, 2006
    Inventors: Hiroshi Miyake, Noriyuki Tokuhiro
  • Patent number: 6924278
    Abstract: This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.
    Type: Grant
    Filed: November 24, 2003
    Date of Patent: August 2, 2005
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Miyake, Kazuhiko Take, Shinji Shigenaga, Hidenori Azami, Hiroshi Sasaki, Yoshiteru Eikyu, Kazuo Nakai, Junya Ishida, Takashi Manabe, Nobukiyo Konishi, Tadashi Terasaka
  • Publication number: 20050027121
    Abstract: This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.
    Type: Application
    Filed: November 24, 2003
    Publication date: February 3, 2005
    Applicant: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Miyake, Kazuhiko Take, Shinji Shigenaga, Hidenori Azami, Hiroshi Sasaki, Yoshiteru Eikyu, Kazuo Nakai, Junya Ishida, Takashi Manabe, Nobukiyo Konishi, Tadashi Terasaka
  • Publication number: 20040266774
    Abstract: The present invention is a compound and pharmaceutical composition comprising a compound of formula (I): 1
    Type: Application
    Filed: June 14, 2004
    Publication date: December 30, 2004
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Kiyotaka Ito, Glen W. Spears, Fumie Takahashi, Akira Yamada, Masaki Tomishima, Hiroshi Miyake
  • Patent number: 6770667
    Abstract: The present invention is a compound and pharmaceutical composition comprising a compound of formula (I): wherein R1 is a 4-(lower) alkyl-imidazol-1-yl or a 4,5-di(lower) alkyl-imidazol-1-yl group, R2 is a hydrogen atom or a lower alkyl group, and R3 is a fluorenyl group. The compound of formula (I) includes pharmaceutically acceptable salts: The compound of formula (I) and salts thereof have 5-HT antagonism activity.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: August 3, 2004
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kiyotaka Ito, Glen W. Spears, Fumie Takahashi, Akira Yamada, Masaki Tomishima, Hiroshi Miyake
  • Publication number: 20040077667
    Abstract: A quinazolinone derivatives having poly (adenosine 5′-diphaspho-ribose)polymerase (PARP) inhibotory activity represented by the formula (I), wherein R1 is optionally substituted cyclic amino groups or optionally substituted amino group, R2 is substituent, n means an integer from 0 to 4, and L is lower akkylene or lower alkenylene, or its prodrug, or their salts.
    Type: Application
    Filed: June 9, 2003
    Publication date: April 22, 2004
    Inventors: Nobuya Matsuoka, Akinori Iwashita, Shunji Yamazaki, Hiroshi Miyake, Mitsuru Ohkubo, Kazunori Kamijo, Isao Nakanishi, Kenji Murano, Kouji Hattori, Yoshiyuki Kido, Junya Ishida, Hirofumi Yamamoto
  • Publication number: 20040043380
    Abstract: The present invention provides a T cell line carrying a reporter gene that contains an LTR sequence of HIV and expressing CCR5. This T cell line is suitable for use in an efficient screening method for efficiently finding out a medicine such as an anti-HIV agent.
    Type: Application
    Filed: May 8, 2003
    Publication date: March 4, 2004
    Inventors: Hiroshi Miyake, Yuji Iizawa, Masanori Baba
  • Publication number: 20030114668
    Abstract: This invention relates to piperazine derivatives of formula (I), wherein Y is bond or lower alkylene, R1 is aryl which may have substituent(s), R2 is aryl or indolyl, each of which may have substituent(s), R3 is hydrogen or lower alkyl, and R4 is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human beings or animals.
    Type: Application
    Filed: January 7, 2000
    Publication date: June 19, 2003
    Inventors: HIROSHI MIYAKE, KAZUHIKO TAKE, SHINJI SHIGENAGA, HIDENORI AZAMI, HIROSHI SASAKI, YOSHITERU EIKYU, KAZUO NAKAI, JUNYA ISHIDA, TAKASHI MANABE, NOBUKIYO KONISHI, TADASHI TERASAKA
  • Publication number: 20030109023
    Abstract: The object of the present invention is to provide a T cell line capable of continuously producing human immunodeficiency virus (HIV) using CC chemokine receptor 5 (CCR5); and being in a state of continuously producing human immunodeficiency virus (HIV) or in a state wherein human immunodeficiency virus (HIV) is latently infecting, and a method for isolating and producing the T cell line.
    Type: Application
    Filed: November 4, 2002
    Publication date: June 12, 2003
    Inventors: Hiroshi Miyake, Yuji Iizawa, Masanori Baba
  • Patent number: 6250414
    Abstract: To provide a working vehicle with a simple body structure, an HST case containing a hydraulic stepless transmission is disposed between an engine adjacent one end in a fore and aft direction of a vehicle body, and a propelling transmission case disposed adjacent the other end in the fore and aft direction. The HST case, with the engine and propelling transmission case, forms the vehicle body. With this construction, a driving deck is located at a relatively low level so that the driver may board and alight from the deck with ease. Despite the low level of the deck, the bottom of the vehicle body is at a relatively high level to be free from contact with projections on unleveled terrain. Frame strength may be increased where the HST case is connected between a main clutch housing connected to the rear of the engine and the propelling transmission case.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: June 26, 2001
    Assignee: Kubota Corporation
    Inventors: Kenichi Sato, Yasunobu Nakatani, Hiroshi Miyake, Keishiro Nishi, Akiyoshi Ono, Motonobu Nishii, Yoichi Sugihara, Shota Nagasawa, Kiyoshi Hanamoto
  • Patent number: 5939413
    Abstract: This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or Tachykinin-mediated diseases in human beings or animals.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: August 17, 1999
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masaaki Matsuo, Daijiro Hagiwara, Takashi Manabe, Nobukiyo Konishi, Shinji Shigenaga, Kenji Murano, Hiroshi Matsuda, Hiroshi Miyake
  • Patent number: 5883098
    Abstract: A piperazine compound of the formula: ##STR1## wherein: X is carbonyl or sulfonyl;Y is a direct bond or lower alkylene; andR.sub.1, R.sub.2, R.sub.3, R.sub.4 are as defined herein. The compounds are advantageously used as Tachykinin antagonists in the treatment of respiratory diseases, ophthalmic diseases and inflammatory diseases, for example.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: March 16, 1999
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masaaki Matsuo, Daijiro Hagiwara, Takashi Manabe, Nobukiyo Konishi, Shinji Shigenaga, Kenji Murano, Hiroshi Matsuda, Hiroshi Miyake
  • Patent number: 5849679
    Abstract: A non-ionic surfactant represented by the general formula (1) or (2) shown below, an emulsified composition and a dispersion containing same are disclosed. Also disclosed is a method of preparing glycoside compound having nonionic surface active properties. The nonionic surfactant has good safety to human bodies and is excellent in producing foam with good feeling in touch.General formula ?1!:?Z(OH).sub.q-1 !--O?C.sub.3 H.sub.5 (OH)O!--R.sup.1 ?1!wherein ?Z(OH).sub.q-1 ! stands for a saccharide residue excluding the hydroxyl group connected to the carbon atom in anomeric position among q hydroxyl groups connected to the saccharide compound of the formula ?Z(OH).sub.q !, --O?C.sub.3 H.sub.5 (OH)O!-- for a glycerol residue excluding 2 hydrogen atoms from glycerol HO?C.sub.3 H.sub.5 (OH)O!--H, and R.sup.1 for an aliphatic group having 1-12 carbon atoms,General formula ?2!:?Z(OH).sub.q-1 !--O?C.sub.3 H.sub.5 (OH)O!.sub.x --R.sup.2 ?2!wherein ?Z(OH)!.sub.
    Type: Grant
    Filed: June 13, 1996
    Date of Patent: December 15, 1998
    Assignee: Lion Corporation
    Inventors: Haruhiko Toda, Hiroshi Miyake, Kazuhiko Matsuda, Masahiro Sato
  • Patent number: 5670505
    Abstract: A piperazine compound of the formula: ##STR1## wherein: X is carbonyl or sulfonyl;Y is a direct bond or lower alkylene; andR.sub.1, R.sub.2, R.sub.3, R.sub.4 are as defined herein. The compounds are advantageously used as Tachykinin antagonists in the treatment of respiratory diseases, ophthalmic diseases and inflammatory diseases, for example.
    Type: Grant
    Filed: November 28, 1994
    Date of Patent: September 23, 1997
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masaaki Matsuo, Daijiro Hagiwara, Takashi Manabe, Nobukiyo Konishi, Shinji Shigenaga, Kenji Murano, Hiroshi Matsuda, Hiroshi Miyake
  • Patent number: 5654400
    Abstract: A method of making a peptide compound of the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl,R.sup.2 is lower alkyl or halogen,R.sup.3 is hydrogen, lower alkyl or halogen,R.sup.4 is lower alkyl,R.sup.5 is ar(lower)alkyl,R.sup.6 is amino or optionally protected hydroxy, andX is O, S or N--R.sup.7, in which R.sup.7 is N,N-di(lower)alkylamino(lower)alkyl,which is useful as tachykinin antagonist.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: August 5, 1997
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masaaki Matsuo, Daijiro Hagiwara, Hiroshi Miyake
  • Patent number: 5648963
    Abstract: An ATM exchange which is comprised of a multistage cascade connection of ATM switches of self-routing module structures which are provided with a plurality of outgoing lines and incoming lines, wherein it provides at the output side and the input side of the ATM switches output side conversion interfaces and input side conversion interfaces both for connection of adjoining ATM switches and uses optical cables to connect the output side interfaces and input side interfaces facing thereto. By this, it is possible to maintain the correct exchange operation even if the length of the transfer lines (outgoing lines and incoming lines) laid between ATM switches becomes greater along with extension of the ATM switches in the exchange.
    Type: Grant
    Filed: October 7, 1992
    Date of Patent: July 15, 1997
    Assignee: Fujitsu Limited
    Inventors: Hiroshi Miyake, Yasuhiro Aso, Shuji Yoshimura
  • Patent number: 5638056
    Abstract: A first carrier signal generator (15) generates a carrier signal (S1) at a first frequency to modulate a preset identification code (S). A second carrier signal generator (16) generates a carrier signal (S2) at a second frequency, distinct from the first frequency. A modulator (14) affixes the identification code (S) to the carrier signal (S2), and outputs the carrier signal (S2) to a light-emitting circuit (17). When a "smart" or "learning" remote controller, of the type that demodulates frequency, receives the identification code (S), the carrier signal (Sw) of the second frequency is demodulated at the first frequency, compressed and stored in memory. The carrier signal (S2) set at the second frequency can cause the memory capacity of the remote controller to overflow, thereby preventing the identification code (S) from being stored in the learning remote controller.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: June 10, 1997
    Assignee: Kabushiki Kaisha Toyoda Jidoshokki Seisakusho
    Inventors: Yutaka Nakashima, Hiroshi Miyake, Atsuhisa Ando, Yukihiro Yamamoto, Tomonori Suzuki, Masachika Kamiya
  • Patent number: 5633232
    Abstract: Disclosed herein are compounds of the following formula: ##STR1## wherein R.sup.1 is a group of the formula ##STR2## "X" is CH.sub.2 or N, "Z" is O, S, or N--R.sup.6, "A" is an amino acid residue, and Y, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 are substituent variables as defined herein.The compounds are antagonists of tachykinin, and as such are useful for alleviation of pain and for treatment of disorders including asthma, bronchitis, rhinitis, conjunctivitis, dermatitis, arthritis, and urticaria.
    Type: Grant
    Filed: June 10, 1994
    Date of Patent: May 27, 1997
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masaaki Matsuo, Daijiro Hagiwara, Hiroshi Miyake
  • Patent number: 5513180
    Abstract: A television signal and ATM cell switching system for switching ATM cells of data other than television signals and for supplying one channel among a plurality of channels of television signals transmitted from a source to a subscriber to carry out one-way communication of the television signals from the source to the subscribers and two-way communication of the data other than the television signals between the network and the subscribers comprising, a television signal transmitting unit for transmitting television signals in the form of ATM cells, an ATM switching unit for switching ATM cell data other than the television signals, a television signal cell inserting circuit for receiving a plurality of channels of the television signals from the television signal transmitting unit, and for receiving ATM cell data other than the television signals after being switched by the ATM switching unit, the television signal inserting circuit comprising, a demultiplexing circuit for demultiplexing the output of the AT
    Type: Grant
    Filed: March 15, 1994
    Date of Patent: April 30, 1996
    Assignee: Fujitsu Limited
    Inventors: Hiroshi Miyake, Yasuhiro Aso
  • Patent number: 5468731
    Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is aryl, or a group of the formula: ##STR2## wherein X is CH or N, and Z is O or N--R.sup.5,in which R.sup.5 is hydrogen or lower alkyl,R.sup.2 is hydroxy or lower alkoxy,R.sup.3 is hydrogen or lower alkyl which may have suitable substituent(s),R.sup.4 is ar(lower)alkyl which may have suitable substituent(s),A is carbonyl or sulfonyl, andY is a bond or lower alkenylene,and pharmaceutically acceptable salt thereof. The disclosed compounds are useful for treating respiratory diseases such as bronchaedema.
    Type: Grant
    Filed: June 28, 1994
    Date of Patent: November 21, 1995
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masaaki Matsuo, Daijiro Hagiwara, Hiroshi Miyake