Patents by Inventor Hiroshi Nagase

Hiroshi Nagase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10442802
    Abstract: A morphinan derivative represented by the following general formula (I): (wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc., R2 represents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group, Y binds to a carbon atom as a ring-constituting atom of R2, R3, R4, and R5 represent hydrogen; hydroxy, etc., R6a and R6b represent hydrogen, etc., R7 and R8 represent hydrogen, etc., R9 and R10, which are the same or different, represent hydrogen, etc., X represents O or CH2, and Y represents C(?O)), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: October 15, 2019
    Assignee: NIPPON CHEMIPHAR CO., LTD.
    Inventors: Hiroshi Nagase, Hideaki Fujii, Akiyoshi Saitoh, Eriko Nakata, Masaaki Hirose, Isao Ooi, Kohei Hayashida
  • Publication number: 20190299722
    Abstract: A pneumatic tire 1 comprises a carcass 6 extending between bead cores of bead portions via a tread portion 2 and sidewall portions, and a belt layer 7 arranged on an outer side in a tire radial direction of the carcass 6 and inside of the tread portion 2. The pneumatic tire 1 further comprises a damping rubber body 30 arranged between the carcass 6 and the belt layer 7, and a noise damper 20 arranged on an inner cavity surface of the tread portion 2. A width W1 in a tire axial direction of the damping rubber body 30 is in a range of from 60% to 130% of a width W2 in the tire axial direction of the belt layer 7, and a water absorption rate of the noise damper 20 is in a range of from 10% to 25%.
    Type: Application
    Filed: November 27, 2017
    Publication date: October 3, 2019
    Applicant: Sumitomo Rubber Industries, Ltd.
    Inventors: Masako NAKATANI, Takahiro KAWACHI, Ayuko YAMADA, Takuya HORIGUCHI, Masataka HIRO, Takayuki NAGASE, Hiroshi ITO, Fumiya KATO, Subaru TOYA
  • Publication number: 20190290773
    Abstract: The present invention provides a novel alkylating agent specifically binding to the genetic mutation site of a driver oncogene. There are provided are a complex formed by binding an alkylating agent to a pyrrole imidazole polyamide specifically binding to the genetic mutation site of a driver oncogene, a driver oncogene mutation-specific alkylating agent comprising the aforementioned complex, and a pharmaceutical composition comprising the aforementioned complex.
    Type: Application
    Filed: April 8, 2019
    Publication date: September 26, 2019
    Applicant: Chiba Prefecture
    Inventors: Hiroki Nagase, Hiroshi Sugiyama, Toshikazu Bando
  • Patent number: 10396346
    Abstract: A method of manufacturing a negative electrode for a nonaqueous electrolyte secondary battery, the method includes mixing negative electrode active material particles and ferroelectric particles with each other to form first composite particles in which the ferroelectric particles are attached to the negative electrode active material particles; mixing the first composite particles and a binder with each other to form granulated particles; applying pressure to an aggregate of the granulated particles to form a sheet-shaped negative electrode mixture layer; and arranging the negative electrode mixture layer on a main surface of a negative electrode current collector foil.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: August 27, 2019
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Koji Kinoshita, Hiroshi Nagase, Tatsuya Hashimoto
  • Patent number: 10377763
    Abstract: The purpose of the present invention is to provide a compound useful as a prophylactic or therapeutic agent for various diseases and symptoms related to orexin receptors, and a medical usage of the same. The present invention provides a morphinan derivative represented by the general formula (I) below or a pharmaceutically acceptable acid addition salt thereof, the morphinan derivative having excellent selectivity for and antagonism against orexin receptors and excellent therapeutic and prophylactic effects on drug dependence, and an orexin receptor antagonist and a therapeutic or prophylactic agent for drug dependence each containing it as an active ingredient.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: August 13, 2019
    Assignee: UNIVERSITY OF TSUKUBA
    Inventors: Hiroshi Nagase, Naoshi Yamamoto, Yoko Irukayama, Tsuyoshi Saitoh, Masashi Yanagisawa, Yasuyuki Nagumo
  • Patent number: 10361424
    Abstract: A method of manufacturing a negative electrode for a nonaqueous electrolyte secondary battery, the method includes mixing negative electrode active material particles and ferroelectric particles with each other to form first composite particles in which the ferroelectric particles are attached to the negative electrode active material particles; mixing the first composite particles and a binder with each other to form granulated particles; applying pressure to an aggregate of the granulated particles to form a sheet-shaped negative electrode mixture layer; and arranging the negative electrode mixture layer on a main surface of a negative electrode current collector foil.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: July 23, 2019
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Koji Kinoshita, Hiroshi Nagase, Tatsuya Hashimoto
  • Patent number: 10350300
    Abstract: The present invention provides a novel alkylating agent specifically binding to the genetic mutation site of a driver oncogene. There are provided are a complex formed by binding an alkylating agent to a pyrrole imidazole polyamide specifically binding to the genetic mutation site of a driver oncogene, a driver oncogene mutation-specific alkylating agent comprising the aforementioned complex, and a pharmaceutical composition comprising the aforementioned complex.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: July 16, 2019
    Assignee: CHIBA PREFECTURE
    Inventors: Hiroki Nagase, Hiroshi Sugiyama, Toshikazu Bando
  • Patent number: 10351522
    Abstract: The present invention aims to provide a novel low-molecular-weight compound exhibiting an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: July 16, 2019
    Assignees: UNIVERSITY OF TSUKUBA, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hiroshi Nagase, Masashi Yanagisawa, Tsuyoshi Saitoh, Noriki Kutsumura, Yoko Irukayama
  • Publication number: 20190156935
    Abstract: A patient monitor is connectable to an imaging unit. The patient monitor includes a folder creating section and a file operating section. When a first event occurs, the folder creating section newly creates a first folder in a first hierarchy of a file system. When a second event occurs, the folder creating section newly creates a second folder in the first folder that is last created. The file operating section stores an image file relating to image information that is supplied from the imaging unit, in the second folder last created by the folder creating section.
    Type: Application
    Filed: November 16, 2018
    Publication date: May 23, 2019
    Inventors: Mitsuhiro OURA, Sou KUMAGAI, Wataru MATUZAWA, Nobuyuki YASUMARU, Kazuya NAGASE, Hiroshi TORIGAI, Naoki FUKUSHIMA
  • Publication number: 20180369161
    Abstract: The present invention relates to a nalfurafine-containing percutaneous absorption patch having a support, a drug layer and a control layer which are laminated successively, wherein the drug layer contains at least one kind of a drug selected from the group consisting of nalfurafine and a salt thereof, and capable of maintaining a given level of drug skin permeation amount without permeation of an excess amount of the drug through the skin in a short time even when applied to the skin in which the horny cell layer and the like are damaged and the skin barrier is insufficient.
    Type: Application
    Filed: June 24, 2016
    Publication date: December 27, 2018
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Hiroshi NAGASE, Makiko TADA, Megumi YASHIMA, Takeshi SAIKI
  • Patent number: 10141602
    Abstract: A problem of the present invention is to provide a lithium solid battery in which generation of short-circuits caused by dendrite is inhibited. The present invention solves the problem by providing a lithium solid battery comprising a solid electrolyte layer having a sulfide glass containing an ion conductor which has a Li element, a P element and a S element, and having an average pore radius calculated by mercury press-in method being 0.0057 ?m or less.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: November 27, 2018
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Takamasa Ohtomo, Hisatsugu Yamasaki, Hiroshi Nagase
  • Publication number: 20180305369
    Abstract: The purpose of the present invention is to provide a compound useful as a prophylactic or therapeutic agent for various diseases and symptoms related to orexin receptors, and a medical usage of the same. The present invention provides a morphinan derivative represented by the general formula (I) below or a pharmaceutically acceptable acid addition salt thereof, the morphinan derivative having excellent selectivity for and antagonism against orexin receptors and excellent therapeutic and prophylactic effects on drug dependence, and an orexin receptor antagonist and a therapeutic or prophylactic agent for drug dependence each containing it as an active ingredient.
    Type: Application
    Filed: October 28, 2016
    Publication date: October 25, 2018
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Hiroshi NAGASE, Naoshi YAMAMOTO, Yoko IRUKAYAMA, Tsuyoshi SAITOH, Masashi YANAGISAWA, Yasuyuki NAGUMO
  • Publication number: 20180179151
    Abstract: The present invention aims to provide a novel low-molecular-weight compound exhibiting an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.
    Type: Application
    Filed: June 10, 2016
    Publication date: June 28, 2018
    Applicants: UNIVERSITY OF TSUKUBA, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hiroshi NAGASE, Masashi YANAGISAWA, Tsuyoshi SAITOH, Noriki KUTSUMURA, Yoko IRUKAYAMA
  • Patent number: 9963460
    Abstract: A morphinan derivative represented by the following formula (I), a tautomer or a stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a medicament, an analgesic and an antipruritic drug including the same as an active ingredient: wherein R is selected from hydrogen and C1-6 alkyl, and n represents an integer of 0 to 2.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: May 8, 2018
    Assignees: University of Tsukuba, Nippon Chemiphar Co., Ltd.
    Inventors: Hiroshi Nagase, Naoshi Yamamoto
  • Publication number: 20180057493
    Abstract: A morphinan derivative represented by the following general formula (I): (wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc., R2 represents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group, Y binds to a carbon atom as a ring-constituting atom of R2, R3, R4, and R5 represent hydrogen; hydroxy, etc., R6a and R6b represent hydrogen, etc., R7 and R8 represent hydrogen, etc., R9 and R10, which are the same or different, represent hydrogen, etc., X represents O or CH2, and Y represents C(?O)), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.
    Type: Application
    Filed: March 17, 2016
    Publication date: March 1, 2018
    Applicants: UNIVERSITY OF TSUKUBA, SCHOOL JURIDICAL PERSON KITASATO INSTITUTE, NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY, NIPPON CHEMIPHAR CO., LTD.
    Inventors: Hiroshi NAGASE, Hideaki FUJII, Akiyoshi SAITOH, Eriko NAKATA, Masaaki HIROSE, Isao OOI, Kohei HAYASHIDA
  • Patent number: 9853509
    Abstract: Torque is improved in a composite torque rotating electric machine that uses permanent magnets having a low residual magnetic flux density such as ferrite magnets, and includes: a stator comprising armature windings arranged at a fixed interval at multiple positions on the inner periphery; a rotor which has a permanent magnet in a cylindrical core comprising laminated magnetic steel sheets and is arranged inside of the stator; and magnetic flux blocking units provided across the circumferential direction on the outer periphery of the rotor that block the closed loop magnetic flux generated around the stator windings. The magnetic flux blocking units can be multiple permanent magnets, with a non-magnetic body such as an air gap disposed between them. The distance between the permanent magnets and the non-magnetic part can be smaller than the interval at which the armature windings are arranged.
    Type: Grant
    Filed: May 28, 2012
    Date of Patent: December 26, 2017
    Assignee: AIDA ENGINEERING, LTD.
    Inventors: Yukinari Fujisawa, Masataka Yahara, Hiroshi Nagase, Fumio Tajima, Yoshihiro Yamaguchi
  • Patent number: 9815787
    Abstract: The present invention aims to provide a novel low-molecular-weight compound having an orexin agonist activity, which is expected to be useful as a superior agent for the treatment or prophylaxis of narcolepsy. The present invention provides a compound showing superior orexin agonist activity which is represented by the formula (I) wherein each symbol is as defined in the DESCRIPTION, and a pharmaceutically acceptable acid addition salt thereof, as well as an orexin agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: November 14, 2017
    Assignee: University of Tsukuba
    Inventors: Hiroshi Nagase, Takashi Nagahara
  • Patent number: 9806571
    Abstract: A composite torque rotating electric machine includes a stator having armature windings arranged at multiple positions in a circumferential direction, a rotor having a cylindrical core, first permanent magnets arranged on axes (d) and in the circumferential direction on the outer periphery of the rotor, second permanent magnets arranged on axes (d) on the inner periphery side of the rotor across from the permanent magnets on the outer circumference side, third permanent magnets on axes (q) and extending in the longitudinally and radially of the rotor, and air gaps on the outer periphery side of the third permanent magnets and intermediate in the circumferential direction of the first permanent magnets. The radial distance between the first and second magnets is greater than the circumferential distance between the first permanent magnets and the air gaps. A rectifier having multiple slits is disposed between the first permanent magnets and the air gaps.
    Type: Grant
    Filed: May 28, 2012
    Date of Patent: October 31, 2017
    Assignee: AIDA ENGINEERING, LTD.
    Inventors: Yukinari Fujisawa, Masataka Yahara, Hiroshi Nagase, Fumio Tajima, Yoshihiro Yamaguchi
  • Patent number: 9624223
    Abstract: The present invention relates to a morphinan derivative represented by the following general formula (I), wherein R1 represents hydrogen, C1-6 alkyl, C6-10 aryl, etc., R2 and R3, which are the same or different, represent hydrogen, hydroxy, etc., R4 and R5 represent hydrogen, C1-6 alkyl, etc., R6 represents hydrogen, hydroxy, C1-6 alkyl, etc., X represents O or CH2, Y represents C?O, C(?O)O, etc., and m and n, which are the same or different, represent an integer of 0 to 2 (m and n are not 0 at the same time), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof, as well as an analgesic, antianxiety drug, etc. containing the same as an active ingredient.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: April 18, 2017
    Assignees: THE KITASATO INSTITUTE, NIPPON CHEMIPHAR CO., LTD.
    Inventors: Hiroshi Nagase, Hideaki Fujii, Eriko Nakata, Yoshikazu Watanabe, Daisuke Saito, Toshihiro Takahashi
  • Patent number: 9543622
    Abstract: The main object of the present invention is to provide a lithium solid state secondary battery system capable of restoring the decrease of output characteristics of a lithium solid state secondary battery without deteriorating an anode. The present invention attains the above-mentioned object by providing a lithium solid state secondary battery system including a lithium solid state secondary battery and an overdischarge treating unit, wherein an anode active material layer of the above-mentioned lithium solid state secondary battery contains an anode active material and a sulfide solid electrolyte material containing Li, A (A is at least one kind of P, S, Ge, Al and B) and S and having an ortho-composition, and the above-mentioned anode current collector includes a metal.
    Type: Grant
    Filed: July 26, 2011
    Date of Patent: January 10, 2017
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Hiroshi Nagase, Shigenori Hama