Patents by Inventor Hiroshi Nagase

Hiroshi Nagase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030057029
    Abstract: Disclosed herein is a building equipment managing method using a history database for recording the conditions of building equipment, a display device installed in public spaces of a building, and an input device installed in the public spaces of the building for inputting a request for the indication of necessary information, the method comprising the steps of: recording a change in a condition of the building equipment in the history database; and in response to receiving a request for indicating a content which is recorded in the history database from the input device, indicating on the display device the content which is recorded in the history database.
    Type: Application
    Filed: September 24, 2002
    Publication date: March 27, 2003
    Inventors: Atsuya Fujino, Toshihiko Hatakeyama, Seiji Kawanishi, Yoshio Matsuzaki, Takashi Matsudo, Osamu Dohi, Isamu Mutou, Hiroshi Nagase
  • Publication number: 20020137760
    Abstract: This invention provides an antipruritic comprising an ipoate &kgr; receptor agonist as an effective component, a new morphian quaternary ammonium salt derivative and a new morphian-N-oxide derivative which are useful in treating pruritus complicated with some diseases.
    Type: Application
    Filed: October 4, 2001
    Publication date: September 26, 2002
    Applicant: Toray Industries, Inc.
    Inventors: Hiroshi Nagase, Takashi Endoh, Toshiaki Tanaka, Kuniaki Kawamura
  • Patent number: 6440987
    Abstract: This invention provides an antipuritic comprising an opiate &kgr; receptor agonist as an effective component, a new morphian quaternary ammonium salt derivative and a new morphian-N-oxide derivative which are useful in treating puritus complicated with some diseases.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: August 27, 2002
    Assignee: Toray Industries, Inc.
    Inventors: Hiroshi Nagase, Takashi Endoh, Toshiaki Tanaka, Kuniaki Kawamura
  • Patent number: 6382361
    Abstract: An elevator system in which an elevator-car and a counter weight are suspended on a pulley system in a hoistway. The elevator system includes a receiving unit for receiving an electric power from a feeding unit provided in the hoistway, an inverter for converting the received electric power into ac power, a motor connected to an ac side of the inverter for driving the counter weight in up and down directions, a sensor for detecting a position of the receiving unit, and a control unit for controlling an inverter on the basis of the position detected by the position sensor. The counter weight carries the receiving means, the inverter, and the motor.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: May 7, 2002
    Assignee: Hitachi, Ltd.
    Inventors: Hideki Nihei, Hiroshi Nagase, Hiromi Inaba, Toshiyuki Tadokoro
  • Patent number: 6337330
    Abstract: An antitussive agent containing an octahydroisoquinoline derivative represented by the following compound or pharmacologically acceptable acid addition salt thereof: The compounds of the present invention have the significant antitussive action, and can thus be expected as medicines which can be used for all diseases accompanied with coughs, for example, various respiratory diseases such as cold, acute bronchitis, chronic bronchitis, bronchiectasis, pneumonia, pulmonary tuberculosis, silicosis and silicotuberculosis, lung cancer, upper respiratory inflammation (pharyngitis, laryngitis, nasal catarrhalis), asthmatic bronchitis, bronchial asthma, infantile asthma, (chronic) pulmonary emphysema, pneumoconiosis, pulmonary fibrosis, silicosis, pulmonary suppuration, pleurisy, tonsillitis, tussive urticaria, pertussis, etc. and coughs caused in bronchography or bronchoscopy, etc.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: January 8, 2002
    Assignee: Toray Industries, Inc.
    Inventors: Hiroshi Nagase, Koji Kawai, Akira Mizusuna, Junzo Kamei
  • Patent number: 6323348
    Abstract: The present invention provides a process for producing an optically active compound of cycloalkyl[b]benzofuran using a readily available optically active compound as a starting material by a reaction using a transition metal or the Mitsunobu reaction, or a combination thereof, followed by a cyclization reaction using a metal or an organometallic reagent. The process can exclude the needs of complicated optical resolution steps as well as enzyme reactions that requires a large amount of solvent and long reaction time besides repeatability is hardly obtained, providing a very useful production process that can apply for not only laboratory preparation but also for industrial scale productions.
    Type: Grant
    Filed: February 14, 2000
    Date of Patent: November 27, 2001
    Assignee: Toray Industries, Inc.
    Inventors: Hisao Nishiyama, Hisanori Wakita, Hiroshi Nagase
  • Patent number: 6323212
    Abstract: A morphinan derivative or its pharmacologically allowed acid addition salt represented with compound I, an analgesic and diuretic having its derivative or its salt as the active ingredient, and its production process are described. The compound of the present invention possesses strong analgesic activity and diuretic action as a highly selective &kgr;-opioid agonist, allowing it to be used as a useful analgesic and diuretic.
    Type: Grant
    Filed: February 10, 1997
    Date of Patent: November 27, 2001
    Assignee: Toray Industries, Inc.
    Inventors: Hiroshi Nagase, Koji Kawai, Kuniaki Kawamura, Jun Hayakawa, Takashi Endoh
  • Publication number: 20010044449
    Abstract: A remedy for drug dependence in which the active ingredient is an opioid &kgr; receptor agonist in which the typical compound is represented by the following formula.
    Type: Application
    Filed: July 12, 1999
    Publication date: November 22, 2001
    Inventors: HIROSHI NAGASE, TAKASHI ENDOH, TSUTOMU SUZUKI, KUNIAKI KAWAMURA, KOJI OSHIMA, HIDEAKI INADA
  • Patent number: 6316461
    Abstract: This invention provides an antipruritc comprising an opiate &kgr; receptor agonist as an effective component, a new morphinan quaternary ammonium salt derivative and a new morphinan-N-oxide derivative which are useful in treating pruritus complicated with some diseases.
    Type: Grant
    Filed: July 13, 2000
    Date of Patent: November 13, 2001
    Assignee: Toray Industries, Inc.
    Inventors: Hiroshi Nagase, Jun Utsumi, Takashi Endoh, Toshiaki Tanaka, Junzo Kamei, Kuniaki Kawamura
  • Patent number: 6291470
    Abstract: A novel compound which is a &dgr;-opioid antagonist having high selectivity and activity, that exhibits immunosuppressive action, antiallergic action, anti-inflammatory action and brain cell-protecting action is disclosed. The compound according to the present invention is an indole derivative represented by the formula (I): and pharmaceutically acceptable acid addition salts thereof. The present invention also provides an immunosuppressive agent, antiallergic agent, anti-inflammatory agent and brain cell-protecting agent comprising the derivative or the salt as an effective ingredient.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: September 18, 2001
    Assignee: Toray Industries, Inc.
    Inventors: Hiroshi Nagase, Akira Mizusuna, Koji Kawai, Izumi Nakatani
  • Patent number: 6277859
    Abstract: A morphinan derivative or its pharmacologically allowed acid addition salt represented with compound I, an analgesic and diuretic having its derivative or its salt as the active ingredient, and its production process are described. The compound of the present invention possesses strong analgesic activity and diuretic action as a highly selective &kgr;-opioid agonist, allowing it to be used as a useful analgesic and diuretic.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: August 21, 2001
    Assignee: Toray Industries, Inc.
    Inventors: Hiroshi Nagase, Koji Kawai, Kuniaki Kawamura, Jun Hayakawa, Takashi Endoh
  • Publication number: 20010004033
    Abstract: An elevator in which an elevator-car and a counter weight are hung like a draw well. The elevator includes a receiving unit for receiving an electric power from a feeding unit provided in a hoistway, an inverter for converting the received electric power into ac power, a motor connected to an ac side of the inverter, for driving the counter weight in up and down directions, a sensor for detecting a position of a receiving unit, and a control unit for controlling an inverter on the basis of the position detected by the position sensor. The counter weight has the receiving means, the inverter, and the motor.
    Type: Application
    Filed: December 11, 2000
    Publication date: June 21, 2001
    Inventors: Hideki Nihei, Hiroshi Nagase, Hiromi Inaba, Toshiyuki Tadokoro
  • Patent number: 6207825
    Abstract: A compound represented by the following formula (12) useful as an intermediate for production of drug or agricultural chemical: (wherein R21 to R25 are each independently a hydrogen atom, a hydroxyl group, a halogen atom, an alkyl group of 1 to 4 carbon atoms, an alkoxy group of 1 to 4 carbon atoms, a perfluoroalkyl group of 1 to 4 carbon atoms, a cyano group, a nitro group, an amino group, a carboxyl group, a thiol group, an alkylthio group of 1 to 4 carbon atoms or a carbamoyl group) can be produced by reacting a compound represented by the formula (13): (wherein R21 to R25 have the same definitions as given above) with 1,1-cyclopropanedicarboxylic acid. The compound of the formula (12) is useful as a raw material for production of a pyrrolidinone compound useful as an active ingredient of drug.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: March 27, 2001
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Hajime Iizuka, Hiroshi Nagase, Naruyoshi Mita
  • Patent number: 6187782
    Abstract: Novel morphinan derivatives and pharmaceutically acceptable acid addition salts thereof as compounds having abilities to bind to opioid &egr;-receptor, which have agonist or antagonist activities, are disclosed. The morphinan derivatives according to the present invention are represented by the formula (I).
    Type: Grant
    Filed: November 25, 1998
    Date of Patent: February 13, 2001
    Assignee: Toray Industries, Inc.
    Inventors: Hiroshi Nagase, Hideaki Fujii, Takashi Endoh, Koji Kawai
  • Patent number: 6177438
    Abstract: A morphinan derivative or its pharmaceutically acceptable acid addition salt represented with, for example, and an analgesic, diuretic, antitussive and brain cell protector having its derivative or its salt as the active ingredient are described. The compound of the present invention possesses strong analgesic activity, diuretic action and antitussive action as a highly selective &kgr;-opioid agonist, allowing it to be used as a useful analgesic, diuretic and antitussive. On the other hand, the compound of the present invention also possesses remarkable cerebro-neuroprotective activity, thus allowing it be used as a useful cerebro-neuroprotective agents.
    Type: Grant
    Filed: November 21, 1996
    Date of Patent: January 23, 2001
    Assignee: Toray Industries, Inc.
    Inventors: Hiroshi Nagase, Jun Hayakawa, Kuniaki Kawamura, Koji Kawai, Takashi Endoh
  • Patent number: 6174891
    Abstract: This invention provides an antipruritic comprising an opiate &kgr; receptor agonist as an effective component, a new morphinan quaternary ammonium salt derivative and a new morphinan-N-oxide derivative which are useful in treating pruritus complicated with some diseases.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: January 16, 2001
    Assignee: Toray Industries, Inc.
    Inventors: Hiroshi Nagase, Jun Utsumi, Takashi Endoh, Toshiaki Tanaka, Junzo Kamei, Kuniaki Kawamura
  • Patent number: 6172078
    Abstract: The present invention provides a quinolinomorphinan derivative or a pharmacologically acceptable acid addition salt thereof, and an agent for curing or preventing cerebral disorders composed of the derivative and salt thereof, which is represented by the following formula (I): (wherein R1 represents cyclopropylmethyl or the like; R2 and R3 independently represent hydroxy, methoxy, or the like; R4 represents hydrogen, methyl, amino or the like; and (R5)m represents hydrogen, substituted benzo, or the like. The compounds of the present invention prevent damages of the cerebral nerve cells and are useful as medicine for curing or preventing various cerebral diseases such as cerebral stroke, traumatic cerebral diseases, cerebral edema, and cerebral neurodegenerative diseases.
    Type: Grant
    Filed: January 13, 1999
    Date of Patent: January 9, 2001
    Assignee: Toray Industries, Inc.
    Inventors: Hiroshi Nagase, Yoshifumi Imamura, Hiroshi Ohno, Masanobu Kaneeda, Susumu Matsuda, Yasushi Miyauchi
  • Patent number: 6156762
    Abstract: The present invention provides an indolomorphinan derivative or a pharmacologically acceptable acid addition salt thereof, and an agent for curing and preventing cerebral disorders composed of the derivative and salt thereof, which is represented by the following formula (I): ##STR1## [wherein R.sup.1 represents cyclopropylmethyl or the like; R.sup.2 and R.sup.3 each represent hydroxy methoxy, or the like; R.sup.4 represents hydrogen, methyl, benzyl, 3-isothiocyanatopropyl, or the like; and (R.sup.5).sub.m represents hydrogen, substituted benzo, or the like]. The compounds of the present invention have the excellent effect of preventing damage of the cerebral nerve cells.
    Type: Grant
    Filed: September 24, 1998
    Date of Patent: December 5, 2000
    Assignee: Toray Industries, Inc.
    Inventors: Hiroshi Nagase, Yoshifumi Imamura, Junichi Hirokawa, Susumu Matsuda, Yasushi Miyauchi
  • Patent number: 6147084
    Abstract: The present invention relates to a novel brain cell protective agent having for its active ingredient a morphinan derivative represented with Compound 1 ##STR1## or pharmacologically acceptable acid addition salt thereof. The compounds used in the present invention were found to have excellent defensive effects against brain nerve cell necrosis in both in vitro and in vivo pharmacological evaluations, and can be used as useful preventive and therapeutic agents of ischemic brain disorders, brain nerve cell disorders and dementia.
    Type: Grant
    Filed: March 4, 1999
    Date of Patent: November 14, 2000
    Assignee: Toray Industries, Inc.
    Inventors: Hiroshi Nagase, Yoshifumi Imamura, Takashi Endo, Susumu Matsuda, Yasushi Miyauchi
  • Patent number: 6103914
    Abstract: Optically active materials of tricyclic compounds, for example, cyclopenta [b] benzofuran derivatives represented by the following formula: ##STR1## wherein R.sub.1, R.sub.2, Y and Z independently represent hydrogen, halogen, an alkyl group, or an aryl group; and n represents 0 to 4, are directly produced by adding an optically active alcohol, amine and/or metal salt thereof.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: August 15, 2000
    Assignee: Toray Industries, Inc.
    Inventors: Hisao Nishiyama, Hiroshi Nagase, Hisanori Wakita