Patents by Inventor Hiroshi Nagase
Hiroshi Nagase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5776945Abstract: The present invention relates to a 4a-aryldecahydroisoquinoline compound, which is represented by a compound 1, or a pharmacologically acceptable salt thereof. ##STR1## As the results of in vitro and in vivo pharmacological evaluations, it was found that the compounds of the present invention had excellent preventive effects on ischemic death of cerebral neurocytes, suppressive effects on development of cerebral infarction, and strong analgesic and antitussive effects; therefore the compounds of the present invention can be utilized in the medicinal field as a useful cerebral cytoprotective agent, which is aimed at preventing and treating cerebrovascular disorder, ischemic cerebral disorder, cerebral neurocyte disorder, and dementia, an analgesic, and an antitussive.Type: GrantFiled: May 8, 1997Date of Patent: July 7, 1998Assignee: Toray Industries, Inc.Inventors: Hiroshi Nagase, Yoshifumi Imamura, Hiroshi Ohno, Takashi Endo
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Patent number: 5739145Abstract: There are provided novel antitussive agents different from existing antitussive agents or those under development. Antitussive agents containing morphinan derivatives represented by compound 6: ##STR1## or pharmacologically acceptable acid-addition salts thereof and those derivatives or their salts as effective components.The antitussive agents according to the present invention have strong antitussive effects as highly selective .kappa.-opioid agonists, and may thus be applied as useful antitussive agents in the prophylaxis and treatment of coughing in a patient in need thereof.Type: GrantFiled: April 27, 1995Date of Patent: April 14, 1998Assignee: Toray Industries, Inc.Inventors: Hiroshi Nagase, Koji Kawai, Takashi Endoh, Shinya Ueno, Yuji Negishi
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Patent number: 5714483Abstract: An antitussive having high activity, which is free from side effects such as psychotomimetic, which may also be administered orally is disclosed. The antitussive according to the present invention comprises as an effective ingredient a .delta.-opioid antagonist or a pharamaceutically acceptable salt thereof.Type: GrantFiled: October 13, 1994Date of Patent: February 3, 1998Assignee: TORAY Industries, Inc.Inventors: Hiroshi Nagase, Junzo Kamei, Koji Kawai, Takashi Endo
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Patent number: 5539119Abstract: This invention is directed to a indole derivative represented by the general formula (1) ##STR1## wherein R.sub.1 stands for alkyl of 1 to 5 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms, cycloalkenylalkyl of 5 to 7 carbon atoms, aralkyl of 7 to 14 carbon atoms, trans-alkenyl of 4 or 5 carbon atoms, allyl, furanyl-2-ylalkyl of 1 to 5 carbon atoms, thienyl-2-ylalkyl of 1 to 5 carbon atoms, vinyloxycarbonyl, trichloroethoxycarbonyl, benzyloxycarbonyl, alkanoyl of 1 to 5 carbon atoms, aralkylcarbonyl of 7 to 14 carbon atoms, 2-furoyl, thiophene-2-carbonyl, cycloalkylcarbonyl of 4 to 7 carbon atoms, alkenylcarbonyl of 3 to 8 carbon atoms, or anisoyl, providing that said general formula (1) embraces a (+) form, a (-) form, and a (.+-.) form, or a pharmacologically acceptable salt thereof and to an immunorepressing agent having as an active component thereof the indole derivative or the pharmacologically acceptable salt thereof.Type: GrantFiled: March 24, 1993Date of Patent: July 23, 1996Assignee: Toray Industries, Inc.Inventors: Hiroshi Nagase, Akira Mizusuna, Yoshihiro Onoda, Koji Kawai, Shu Matsumoto, Takashi Endo
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Patent number: 5420310Abstract: The present invention provides a process for preparing 5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 derivative using 3a,8b-cis-dihydro-3H-5,7-dibromocyclopenta[b]benzofuran as a starting material, as well as compounds which are intermediates.Type: GrantFiled: November 20, 1992Date of Patent: May 30, 1995Assignee: Toray Industries, Inc.Inventors: Kiyotaka Ohno, Hiroshi Nagase, Yutaka Hosono, Hisanori Wakita, Koji Kawai, Hideo Yoshiwara
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Patent number: 5403674Abstract: The invention provides a conductor comprising a reaction-sintered body of a conductive nitride produced from a powder of at least one metal selected from Ti, Zr, V, Nb, Ta, Cr, Ce, Co, Mn, Hf, W, Mo, Fe, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Yb, Lu, Th and Ni, and a process for producing such conductor by heating a molding containing a metal powder in a nitriding gaseous atmosphere containing no CO gas.Type: GrantFiled: September 9, 1993Date of Patent: April 4, 1995Assignee: Hitachi, Ltd.Inventors: Yoshiyuki Yasutomi, Tadahiko Miyoshi, Masahisa Sobue, Nobuyuki Yamashita, Hiroshi Nagase, Kiyohiko Tanno, Shoji Arimoto, Fumio Jooraku
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Patent number: 5332818Abstract: An immunosuppressive agent which has low toxicity and which exhibits excellent effectiveness even if it is orally administered is presented. The immunosuppressive agent of the present invention is characterized in that it contains .delta.-opioid antagonist having high selectivity to .delta.-opioid receptor. The present invention also provides a process of producing a naltrindole derivative characterized by reacting naltrexone or a salt thereof with a phenylhydrazine derivative in a solvent in the presence of methanesulfonic acid.Type: GrantFiled: March 22, 1993Date of Patent: July 26, 1994Assignee: Toray Industries, Inc.Inventors: Hiroshi Nagase, Koji Kawai, Shu Matsumoto, Takashi Endoh, Yoshiaki Katsura, Kohei Arakawa
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Patent number: 5271871Abstract: The invention provides a conductor comprising a reaction-sintered body of a conductive nitride produced from a powder of at least one metal selected from Ti, Zr, V, Nb, Ta, Cr, Ce, Co, Mn, Hf, W, Mo, Fe, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Yb, Lu, Th and Ni, and a process for producing such conductor by heating a molding containing a metal powder in a nitriding gaseous atmosphere containing no CO gas.Type: GrantFiled: September 3, 1991Date of Patent: December 21, 1993Assignee: Hitachi, Ltd.Inventors: Yoshiyuki Yasutomi, Tadahiko Miyoshi, Masahisa Sobue, Nobuyuki Yamashita, Hiroshi Nagase, Kiyohiko Tanno, Shoji Arimoto, Fumio Jooraku
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Patent number: 5244904Abstract: This invention is directed to a indole derivative represented by the general formula (1) ##STR1## wherein R.sub.1 stands for alkyl of 1 to 5 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms, cycloalkenylalkyl of 5 to 7 carbon atoms, aralkyl of 7 to 14 carbon atoms, trans-alkenyl of 4 to 5 carbon atoms, allyl, furanyl-2-ylalkyl of 1 to 5 carbon atoms, thienyl-2-ylalkyl of 1 to 5 carbon atoms, vinyloxycarbonyl, trichloroethoxycarbonyl, benzyloxycarbonyl, alkanoyl of 1 to 5 carbon atoms, aralkylcarbonyl of 7 to 14 carbon atoms, 2-furoyl, thiophene-2-carbonyl, cycloalkylcarbonyl of 4 to 7 carbon atoms, alkenylcarbonyl of 3 to 8 carbon atoms, or anisoyl, R.sub.2 for a hydrogen atoms, alkyl of 1 to 3 carbon atoms, benzyl, or alkanoyl of 1 to 5 carbon atoms, R.sub.3 for a hydrogen atoms, a fluorine atom, a chlorine atom, a bromine atom, nitro, or alkyl of 1 to 5 carbon atoms, R.sub.4 for a hydrogen atom, alkyl of 1 to 5 carbon atoms, benzyl, or phenyl, and R.sub.Type: GrantFiled: January 29, 1992Date of Patent: September 14, 1993Assignee: Toray Industries, Inc.Inventors: Hiroshi Nagase, Akira Mizusuna, Yoshihiro Onoda, Koji Kawai, Shu Matsumoto, Takashi Endo
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Patent number: 5202447Abstract: The present invention provides a process for preparing 5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 derivative [VII] using 3a,8b-cis-dihydro-3H-5,7-dibromocyclopenta[b]benzofuran (1) as a starting material, as well as compounds of the formulae (8) and (11) which are intermediates for the preparation of the compound of the formula (1).Type: GrantFiled: January 2, 1991Date of Patent: April 13, 1993Assignee: Toray Industries, Inc.Inventors: Kiyotaka Ohno, Hiroshi Nagase, Yutaka Hosono, Hisanori Wakita, Koji Kawai, Hideo Yoshiwara
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Patent number: 5085806Abstract: The invention provides a conductor comprising a reaction-sintered body of a conductive nitride produced from a powder of at least one metal selected from Ti, Zr, V, Nb, Ta, Cr, Ce, Co, Mn, Hf, W, Mo, Fe, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Yb, Lu, Th and Ni, and a process for producing such conductor by heating a molding containing a metal powder in a nitriding gaseous atmosphere containing no CO gas.Type: GrantFiled: March 6, 1989Date of Patent: February 4, 1992Assignee: Hitachi, Ltd.Inventors: Yoshiyuki Yasutomi, Tadahiko Miyoshi, Masahisa Sobue, Nobuyuki Yamashita, Hiroshi Nagase, Kiyohiko Tanno, Shoji Arimoto, Fumio Jooraku
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Patent number: 5019773Abstract: Sine wave signals generated from a position detector are used as analog values to detect a fine position of a rotating or moving body, a rise or fall edge of the sine wave signal is used to detect a coarse position of the rotating or moving body, and the position or speed of the rotating or moving body is detected based on a signal indicative of the detected coarse position when the rotating or moving body is at high speed and based on a signal indicative of the detected fine position when the rotating or moving body is at low speed to thereby provide optimal control from high speed to low speed. Especially at extremely low driving, speed detection with superhigh resolution is effected using the analog value to decrease an uneven rotation of the rotating body.Type: GrantFiled: August 22, 1989Date of Patent: May 28, 1991Assignee: Hitachi, Ltd.Inventors: Yasuyuki Sugiura, Rika Oue, Kunio Miyashita, Hiroshi Nagase, Nobuyoshi Mutoh, Sumio Kobayashi, Hiroshi Sugai
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Patent number: 4983875Abstract: An actuator suitable for use in a joint device for driving a robot arm or in a subject follow-up device in a video camera, etc., is designed to have a mobility of a freedom of two degrees or more and is adapted to drive a movable part directly using first piezoelectric motor elements each of which consists of piezoelectric elements having a non-ring-like configuration and an elastic body and second piezoelectric motor elements each of which consists of at most one ring-like piezoelectric element and an elastic member. The actuator exhibits a simplified structure, is small and lightweight, provides a powerful driving power and has a wide range of mobility.Type: GrantFiled: June 19, 1989Date of Patent: January 8, 1991Assignee: Hitachi, Ltd.Inventors: Ryoso Masaki, Masahiro Kayama, Hiroshi Hayashida, Hideki Nihei, Yasunori Katayama, Hiroshi Nagase, Toshihiko Matsuda, Kenzo Kamiyama
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Patent number: 4965504Abstract: A control apparatus for controlling a PWM inverter, the PWM inverter receiving AC power and generating an AC output having a controlled frequency to be supplied to an AC motor, comprises a circuit for generating, on the basis of a given running command, a PWM signal controlling the inverter with a given sampling period, and a circuit for controlling the PWM signal generating circuit, whereby the AC motor generates an electromagnetic tone preselected so as to correspond to desired information when the AC motor is driven by output of the inverter controlled by the PWM signal. The above described desired information may be information representing the running state of the motor or selected music.Type: GrantFiled: September 13, 1989Date of Patent: October 23, 1990Assignee: Hitachi, Ltd.Inventors: Shigeta Ueda, Kazuo Honda, Takashi Ikimi, Toshihiko Matsuda, Hiroshi Nagase, Nobuyoshi Mutoh
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Patent number: 4883735Abstract: A negatively chargeable toner for use in dry electrophotography, said toner comprising (A) a resinous binder composed of at least one resin selected from copolymers of styrene and/or alpha-methylstyrene with alkyl (meth)acrylates, (B) 2 to 10 parts by weight, per 100 parts by weight of the resinous binder, of a copolymer containing a sulfonic acid group, said copolymer having a weight average molecular weight of from 2,000 to 15,000 and composed of 80 to 98% by weight of recurring units represented by the formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group, and 20 to 2% by weight of recurring units represented by the formula ##STR2## and (C) a coloring agent.Type: GrantFiled: January 25, 1988Date of Patent: November 28, 1989Assignee: Fujikura Kasei Co., Ltd.Inventors: Masao Watanabe, Hiroshi Nagase
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Patent number: 4843100Abstract: This invention relates to a benzoylurea derivative of the formula: ##STR1## wherein X.sup.1 and X.sup.2 are hydrogen, halogen, alkyl or alkoxy; and one of Y.sup.1, Y.sup.2, Y.sup.3, Y.sup.4 and Y.sup.5 is halogenoalkylsulfinyl or halogenoalkylsulfonyl, and the others are hydrogen, halogen or alkyl, exhibiting excellent insecticidal and ovicidal activities (particularly, molt inhibitory activity), their production and use.Type: GrantFiled: June 19, 1987Date of Patent: June 27, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroshi Nagase, Yasuo Sato
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Patent number: 4840863Abstract: A positively chargeable toner for use in dry electrophotography, said toner comprising (A) a resinous binder composed of at least one resin selected from copolymers of styrene and/or alpha-methylstyrene with alkyl (meth)acrylates, polyester resins and epoxy resins, (B) 1 to 100 parts by weight, per 100 parts by weight of the resinous binder, of a copolymer containing a quaternary ammonium salt group, said copolymer having a weight average molecular weight of from 2,000 to 10,000 and composed of 65 to 97% by weight of recurring units represented by the formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group, and 35 to 3% by weight of recurring units represented by the formula ##STR2## wherein R.sub.2 represents a hydrogen atom or a methyl group, R.sub.3 represents an alkylene group, and each of R.sub.4, R.sub.5 and R.sub.6 represents an alkyl group, and (C) a coloring agent.Type: GrantFiled: April 15, 1987Date of Patent: June 20, 1989Assignee: Fujikura Kasei Co., Ltd.Inventors: Akira Otsu, Hiroshi Nagase
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Patent number: 4822804Abstract: Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives such as5,6,7-trinor-4,8-inter-m-phenylene-2-nor-16,16-dimethyl PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(S)-methyl PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(R)-methyl PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2-nor-16,16-dimethyl-.omega.-homo PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(S)-methyl-.omega.-homo PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(R)-methyl-.omega.-homo PGI.sub.2,5,6, 7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16,16-dimethyl-16-p ropoxy PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2,18,19,20-tetranor-16,16-dimethyl-17-et ho xy PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2,18,19,20-tetranor-16,16-dimethyl-17-pr op oxy PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16-phenoxy PGI.sub.2 and methyl esters thereof.5,6,7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16,16-dimethyl-16 -phenoxy PGI.sub.Type: GrantFiled: September 29, 1987Date of Patent: April 18, 1989Assignee: Toray Industries, Inc.Inventors: Kiyotaka Ohno, Hiroshi Nagase, Mamoru Ishikawa, Kazuhisa Matsumoto, Shintaro Nishio
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Patent number: 4775692Abstract: Disclosed herein are novel prostaglandin I.sub.2 (PGI.sub.2) derivatives exhibiting excellent in vivo duration and activities, said derivatives being represented by the general formula: ##STR1## wherein R.sub.1, X, R.sub.2 and R.sub.3 are as defined herein.Type: GrantFiled: January 23, 1987Date of Patent: October 4, 1988Assignee: Toray Industries, Inc.Inventors: Kiyotaka Ohno, Atsushi Ohtake, Hiroshi Nagase, Shintaro Nishio, Toshiya Takahashi, Hisanori Wakita
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Patent number: 4702989Abstract: A pressure-fixable toner is produced by: dispersing or dissolving a mixture containing (a) a colorant and/or magnetic particles, (b) a pressure fixable binding material, and (c) a capsule wall-forming resin, in an organic solvent; dispersing the resulting dispersion or solution in a dispersion-stabilizing solution; heating the dispersion to evaporate off the solvent; dispersing the resulting encapsulated toner in a lower alcohol to remove the solvent remaining within the encapsulated toner; and thereafter drying the toner. The toner can be used to develop images in electrophotographic systems.Type: GrantFiled: April 7, 1986Date of Patent: October 27, 1987Assignee: Fujikura Kasei Co., Ltd.Inventors: Norihide Sugiyama, Katsuro Funato, Hiroshi Nagase, Seiichi Yamamoto, Shigeo Miyamori