Abstract: Disclosed is a method for screening for a medicinal agent that can decrease a body weight, a medicinal agent that can reduce a visceral fat, a medicinal agent that can reduce a triglyceride in the liver, and a medicinal agent that can ameliorate obesity and fatty liver. The method involves a step of measuring the inhibitory activity of a candidate substance on a sphingomyelin synthase, wherein the candidate substance is determined to have at least one function selected from the group consisting of an anti-obesity agent, a visceral fat-reducing agent, a fatty liver-treating agent and an adiponectin expression enhancer when the candidate substance has an inhibitory activity on the sphingomyelin synthase.

Abstract: A mirror includes a substrate, a reflection layer, and a protection layer. The substrate includes a surface having an attachment area and a reflection area. The reflection layer is formed on the reflection area. The protection layer is formed on the reflection area on which the reflection layer is formed and the attachment area. Material of the protection layer is homogeneous across the reflection area and the attachment area.

Abstract: A flaw detection image analyzer (10) takes in an inspection procedure command stored in a flaw detection condition database (40), takes in a flaw detection image signal corresponding to a flaw detection image indicated by the taken inspection procedure command from a database (50) for flaw detection image signal, and displays the flaw detection image based on the flaw detection image signal on a display (30), with a display range and a contrast indicated by the inspection procedure command in an arrangement pattern of image indicated by the inspection procedure command. Consequently, optimum images can be displayed sequentially with optimum arrangement pattern, optimum display range and contrast according to a flaw to be inspected when a flaw is detected by observing an ultrasonic flaw detection image.

Abstract: An image-capturing device including: an imaging optical system which is configured to capture an optical image of a subject; an imaging optical system retaining member which retains the imaging optical system; an imaging element which is configured to convert the optical image into an electrical signal; a substrate which is arranged on a back side of the imaging optical system retaining member and retains the imaging element; and a plurality of substrate joint pieces each of which extends from the imaging optical system retaining member toward the substrate, wherein tip parts of the plurality of substrate joint pieces on a substrate side and the substrate are joined by an indirect bond structure using at least one joint intermediate member which is adhered to at least one of the tip parts of the plurality of substrate joint pieces and the substrate with an adhesive, and a fixation structure.

Abstract: A base tube for an electrophotographic photoconductive member, is provided with a cylindrical body on which a photoconductive layer is formed; and a first slanting portion formed on a peripheral surface of an end portion of the cylindrical body, and slanting inward toward an end face of the end portion with respect to an axis of the cylindrical body. An axial length of the first slanting portion of the cylindrical body is within a range of 0.3 to 5 mm.

Abstract: A disclosed image pickup apparatus includes a first member holding a lens, and a second member holding an image pickup element converting an image formed via the lens into an electric signal, the second member having an approximately rectangular shape and two approximately arc-shaped location cutout portions at respective diagonal corners of the approximately rectangular shape. In the image pickup apparatus, the first and the second members are bonded via an indirect bonding structure portion where the first and second members are bonded via a fixing member with an ultraviolet curable adhesive and a filler bonding structure portion where the first and second members are bonded by supplying a thermosetting adhesive therebetween.

Abstract: Pharmaceutical compositions containing as an active ingredient compounds of the general formula (I), prodrugs of the same, pharmaceutically acceptable salts of both, or solvates of them and exhibiting thrombopoietin receptor agonism: X1—Y1-Z1-W1??(I) wherein X1 is optionally substituted aryl, optionally substituted heteroaryl or the like; Y1 is —NRACO—(CH2)0-2— or the like (wherein RA is a hydrogen or the like); Z1 is optionally substituted phenylene or the like; and W1 is a group represented by the below formula: wherein R1, R2, R3, and R4 are each independently a hydrogen atom, optionally substituted lower alkyl or the like, a broken line (---) represents the presence or absence of bond.

Abstract: The present invention is intended to provide a method of rapidly, simply and accurately measuring a recombinant protein. As means for resolution, the protein quantity is measured by causing the expression of a fusion protein with the target protein and epitope tags containing two types of epitopes, bringing them into contact with detection antibodies which specifically recognize each epitope, and detecting a phenomenon caused by both detection antibodies coming close to each other.

Abstract: Pharmaceutical compositions containing as an active ingredient compounds of the general formula (I), prodrugs of the same, pharmaceutically acceptable salts of both, or solvates of them and exhibiting thrombopoietin receptor agonism: X1—Y1-Z1-W1??(I) wherein X1 is optionally substituted aryl, optionally substituted heteroaryl or the like; Y1 is —NRACO—(CH2)0-2— or the like (wherein RA is a hydrogen or the like); Z1 is optionally substituted phenylene or the like; and W1 is a group represeted by the below formula: wherein R1, R2, R3, and R4 are each independently a hydrogen atom, optionally substituted lower alkyl or the like, a broken line ( - - - ) represents the presence or absence of bond.

Abstract: A mirror includes a substrate, a reflection layer, and a protection layer. The substrate includes a surface having an attachment area and a reflection area. The reflection layer is formed on the reflection area. The protection layer is formed on the reflection area on which the reflection layer is formed and the attachment area. Material of the protection layer is homogeneous across the reflection area and the attachment area.

Abstract: The invention provides a more highly accurate assay for measuring the transcriptional activity of a test substance. Disclosed is a reporter gene assay, comprising the steps of contacting a cell having a vector wherein a reporter gene containing a gene encoding an epitope tag is ligated downstream to a recognition sequence of a transcription factor and a nucleotide sequence necessary for transcriptional initiation, with a test substance and detection antibodies; detecting a phenomenon caused by the two kinds of detection antibodies coming close to each other; and correlating the detected phenomenon with the effect of the test substance on transcriptional regulatory mechanism.

Abstract: A method and an apparatus for fixing a part and a part support for mounting the part by use of adhesive via an intermediate member are disclosed. The adhesive is implemented by photocuring adhesive while the intermediate member is formed of a material transparent for light. The intermediate member is free from coloring and deformation when illuminated by light for curing the adhesive. The adhesive is prevented from dropping or turning round to other portions during assembly.

Abstract: An optical scanning device configured to irradiate an object with light generating from a light source via at least one mirror with a first end portion and second end portion which are attached to a housing and to scan the object with the irradiating light is provided, wherein the first end portion of the at least one mirror is movably supported by the housing and the second end portion of the at least one mirror is bonded to the housing.

Abstract: There is disclosed a test apparatus including a driver that outputs a test signal, a first switch that is provided between the driver and a terminal of the first device under test, a second switch that is provided between the driver and a terminal of the second device under test, a first termination resistor that terminates the output signal from the driver in the terminal of the first device under test, a second termination resistor that terminates the output signal from the driver in the terminal of the second device under test, and a substitute resistor that is decoupled from the driver when the driver is connected to the terminals of the first and second device under test, and is connected to the driver when the driver and the terminal of the second device under test are disconnected.

Abstract: Abase tube for an electrophotographic photoconductive member, is provided with a cylindrical body on which a photoconductive layer is formed; and a first slanting portion formed on a peripheral surface of an end portion of the cylindrical body, and slanting inward toward an end face of the end portion with respect to an axis of the cylindrical body. An axial length of the first slanting portion of the cylindrical body is within a range of 0.3 to 5 mm.

Abstract: Pharmaceutical compositions containing as an active ingredient compounds of the general formula (I), prodrugs of the same, pharmaceutically acceptable salts of both, or solvates of them and exhibiting thrombopoietin receptor agonism: X1—Y1-Z1 ??(I) wherein X1 is optionally substituted aryl, optionally substituted heteroaryl or the like; Y1 is —NRACO—(CH2)0-2— or the like (wherein RA is hydrogen atom or the like); and Z1 is a cyclic group fused the same or different two ring selected from optionally substituted carbocyclic group and optionally substituted heterocyclic group.

Abstract: There is provided a test apparatus that tests a plurality of device under tests.

Abstract: Pharmaceutical compositions containing as an active ingredient compounds of the general formula (I), prodrugs of the same, pharmaceutically acceptable salts of both, or solvates of them and exhibiting thrombopoietin receptor agonism: wherein X1 is optionally substituted heteroaryl or the like; Y1 is —NRACO— (CH2)0-2— or the like (wherein RA is a hydrogen or the like); Z1 is optionally substituted arylene or the like; and A1 is a ring represented by general formula (II) or (III):

Abstract: Providing a fixing structure for parts of optical element by which fixing of parts of optical element with high accuracy can be achieved after positional adjustment in axes with an arrangement the positional adjustment in axes of parts of optical element is easily achieved before the fixing of the parts of optical element. The fixing structure comprises lens 3 having an edge surface which is a side surface surrounding a light beam passing surface; an intermediate holding member 5 having a first attaching surface 5a which is facing to the side surface and having a second attaching surface 5b which has a different angle from said first attaching surface 5a; and a housing 2 having an attaching surface 2c which is facing to the second attaching surface 5b; the housing 2 and the lens 3 which has been adjusted the positional relation to the housing 2 are adhered and fixed through the intermediate holding member 5.

Abstract: A method and an apparatus for fixing a part and a part support for mounting the part by use of adhesive via an intermediate member are disclosed. The adhesive is implemented by photocuring adhesive while the intermediate member is formed of a material transparent for light. The intermediate member is free from coloring and deformation when illuminated by light for curing the adhesive. The adhesive is prevented from dropping or turning round to other portions during assembly.