Patents by Inventor Hirotsugu Kubo

Hirotsugu Kubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9708578
    Abstract: A measuring unit which is to be attached to a cell culture container configured to accommodate cells to be cultured and a culture solution, includes: a measurer which is configured to measure information related to the cells and the culture solution, in a non-contact manner; and a sensor which is configured to detect at least one of a position, a posture, an impact, an orientation, and vibration.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 18, 2017
    Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Mitsuhiro Oura, Hirotsugu Kubo, Katsuyoshi Suzuki, Katsuhide Tone, Teruo Okano, Tatsuya Shimizu
  • Patent number: 9658214
    Abstract: A method of analyzing cells, the method comprising: measuring a number of cells which are nuclear stained, in a to-be-determined tissue, and acquiring a histogram showing a fluorescence intensity based on a result of the measurement; analyzing the histogram, and acquiring data of predetermined parameters; comparing the data of the parameters with first thresholds predetermined for the parameters, to perform a first cancer determination for each of the parameters on the to-be-determined tissue; performing a scoring process for each of the parameters, on a result of the first cancer determination for each of the parameters, to calculate scores of the parameters; and combining the scores of the parameters with one another, thereby performing a second cancer determination on the to-be-determined tissue.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: May 23, 2017
    Assignee: NIHON KOHDEN CORPORATION
    Inventors: Takahiro Shioyama, Akane Suzuki, Hirotsugu Kubo, Sunao Takeda
  • Patent number: 9470572
    Abstract: A method of measuring a liquid level of a cell culture solution stored in a cell vessel, includes: irradiating the cell culture solution with at least two kinds of light beams including a first light beam having a first wavelength and a second light beam having a second wavelength; measuring a first absorbance of the cell culture solution with respect to the first light beam, and a second absorbance of the cell culture solution with respect to the second light beam; and determining a liquid level of the cell culture solution based on the first absorbance and the second absorbance.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: October 18, 2016
    Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Mitsuhiro Oura, Hirotsugu Kubo, Teruo Okano, Tatsuya Shimizu
  • Patent number: 9443127
    Abstract: A cell analyzing apparatus includes: a first histogram acquiring section which is configured to acquire a first histogram of fluorescence intensities by using a result of a measurement of a number of nuclear stained cells; a second histogram acquiring section which is configured to acquire a second histogram that is normalized based on a fluorescence intensity value indicating a maximum value of the first histogram; a determining section which is configured to determine whether cancer cells exist or not, based on one of the first histogram and the second histogram; and an outputting section which is configured to output a result of the determination performed by the determining section.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: September 13, 2016
    Assignee: Nihon Kohden Corporation
    Inventors: Sunao Takeda, Hirotsugu Kubo, Takahiro Shioyama, Akane Suzuki, Kenichi Nomura, Yo Kato, Nae Hinata
  • Patent number: 9304088
    Abstract: A method of measuring a pH of a solution includes: emitting light beams of two wavelengths from one side of a measuring region of a solution into which an indicator is mixed, while pulsating the solution in the measuring region; receiving at least one of transmitted light beams and reflected light beams of the emitted light beams on the other side of the measuring region, while pulsating the solution in the measuring region; obtaining absorbances of the two wavelengths based on the received at least one of the transmitted light beams and the reflected light beams; obtaining an absorbance ratio from the obtained absorbances; and calculating a pH value of the solution based on the obtained absorbance ratio and an absorbance ratio/pH value correspondence database which is previously stored.
    Type: Grant
    Filed: February 19, 2012
    Date of Patent: April 5, 2016
    Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Mitsuhiro Oura, Teruo Okano, Tatsuya Shimizu, Hirotsugu Kubo, Sunao Takeda, Shinji Yamamori
  • Patent number: 9291572
    Abstract: A pH measuring method includes: illuminating a medium solution, which includes: a first material; and a second material, with a plurality of light beams, which includes: a first light beam, a wavelength of which corresponds to a first absorption peak; a second light beam, a wavelength of which corresponds to a second absorption peak or a second convergence point; a third light beam, a wavelength of which corresponds to a third absorption peak or a third convergence point; and a fourth light beam, a wavelength of the fourth light beam at which an absorbance of at least one of the first and second materials is converged irrespective of a pH; receiving transmitted or reflected light beams of the first to fourth light beams; measuring absorbances at the wavelengths of the received light beams respectively; and calculating a pH of the medium solution based on the absorbances.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: March 22, 2016
    Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Mitsuhiro Oura, Hirotsugu Kubo, Sunao Takeda, Teruo Okano, Tatsuya Shimizu
  • Publication number: 20150078649
    Abstract: A cell analyzing apparatus includes: a first histogram acquiring section which is configured to acquire a first histogram of fluorescence intensities by using a result of a measurement of a number of nuclear stained cells; a second histogram acquiring section which is configured to acquire a second histogram that is normalized based on a fluorescence intensity value indicating a maximum value of the first histogram; a determining section which is configured to determine whether cancer cells exist or not, based on one of the first histogram and the second histogram; and an outputting section which is configured to output a result of the determination performed by the determining section.
    Type: Application
    Filed: September 17, 2014
    Publication date: March 19, 2015
    Applicant: Nihon Kohden Corporation
    Inventors: Sunao TAKEDA, Hirotsugu KUBO, Takahiro SHIOYAMA, Akane SUZUKI, Kenichi NOMURA, Yo KATO, Nae HINATA
  • Publication number: 20140030728
    Abstract: A method of analyzing cells, the method comprising: measuring a number of cells which are nuclear stained, in a to-be-determined tissue, and acquiring a histogram showing a fluorescence intensity based on a result of the measurement; analyzing the histogram, and acquiring data of predetermined parameters; comparing the data of the parameters with first thresholds predetermined for the parameters, to perform a first cancer determination for each of the parameters on the to-be-determined tissue; performing a scoring process for each of the parameters, on a result of the first cancer determination for each of the parameters, to calculate scores of the parameters; and combining the scores of the parameters with one another, thereby performing a second cancer determination on the to-be-determined tissue.
    Type: Application
    Filed: July 19, 2013
    Publication date: January 30, 2014
    Applicant: NIHON KOHDEN CORPORATION
    Inventors: Takahiro Shioyama, Akane Suzuki, Hirotsugu Kubo, Sunao Takeda
  • Publication number: 20130330248
    Abstract: A cell isolation apparatus in which tissue and fluid that are accommodated in a container are pipetted by a pipette, and cells are isolated from the tissue, the cell isolation apparatus includes: a nozzle to which the pipette is attached; a pump which is connected to the nozzle; a controller which is configured to control an operation of the pump to cause air to be ejected from the nozzle or to be sucked into the nozzle, thereby causing the pipette to perform pipetting; and a condition inputting unit in which a user inputs a condition of control of the controller.
    Type: Application
    Filed: May 29, 2013
    Publication date: December 12, 2013
    Applicant: NIHON KOHDEN CORPORATION
    Inventors: Takahiro SHIOYAMA, Akane SUZUKI, Hirotsugu KUBO
  • Publication number: 20130260445
    Abstract: A measuring unit which is to be attached to a cell culture container configured to accommodate cells to be cultured and a culture solution, includes: a measurer which is configured to measure information related to the cells and the culture solution, in a non-contact manner; and a sensor which is configured to detect at least one of a position, a posture, an impact, an orientation, and vibration.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 3, 2013
    Applicants: TOKYO WOMEN'S MEDICAL UNIVERSITY, NIHON KOHDEN CORPORATION
    Inventors: Mitsuhiro Oura, Hirotsugu Kubo, Katsuyoshi Suzuki, Katsuhide Tone, Teruo Okano, Tatsuya Shimizu
  • Publication number: 20130255374
    Abstract: A method of measuring a liquid level of a cell culture solution stored in a cell vessel, includes: irradiating the cell culture solution with at least two kinds of light beams including a first light beam having a first wavelength and a second light beam having a second wavelength; measuring a first absorbance of the cell culture solution with respect to the first light beam, and a second absorbance of the cell culture solution with respect to the second light beam; and determining a liquid level of the cell culture solution based on the first absorbance and the second absorbance.
    Type: Application
    Filed: March 21, 2013
    Publication date: October 3, 2013
    Applicants: TOKYO WOMEN'S MEDICAL UNIVERSITY, NIHON KOHDEN CORPORATION
    Inventors: Mitsuhiro Oura, Hirotsugu Kubo, Teruo Okano, Tatsuya Shimizu
  • Publication number: 20120252110
    Abstract: A cell culture apparatus includes: an isolator in which a sterile space accommodating a cell incubator filled with a culture solution containing cells to be cultured is disposed; a sampling unit configured to sample the culture solution in the cell incubator; a delivery flow path through which an inside of the sterile space and an outside of the sterile space communicate with each other, the delivery flow path configured to limit a flow in the delivery flow path to a direction that is directed from the inside of the sterile space toward the outside of the sterile space; and a culture solution delivering section configured to deliver the sampled culture solution to the outside of the sterile space via the delivery flow path.
    Type: Application
    Filed: March 28, 2012
    Publication date: October 4, 2012
    Applicants: Tokyo Women's Medical University, Nihon Kohden Corporation
    Inventors: Mitsuhiro OURA, Teruo OKANO, Tatsuya SHIMIZU, Hirotsugu KUBO, Sunao TAKEDA
  • Publication number: 20120253692
    Abstract: A pH measuring method includes: illuminating a medium solution, which includes: a first material; and a second material, with a plurality of light beams, which includes: a first light beam, a wavelength of which corresponds to a first absorption peak; a second light beam, a wavelength of which corresponds to a second absorption peak or a second convergence point; a third light beam, a wavelength of which corresponds to a third absorption peak or a third convergence point; and a fourth light beam, a wavelength of the fourth light beam at which an absorbance of at least one of the first and second materials is converged irrespective of a pH; receiving transmitted or reflected light beams of the first to fourth light beams; measuring absorbances at the wavelengths of the received light beams respectively; and calculating a pH of the medium solution based on the absorbances.
    Type: Application
    Filed: April 6, 2012
    Publication date: October 4, 2012
    Inventors: Mitsuhiro OURA, Hirotsugu Kubo, Sunao Takeda, Teruo Okano, Tatsuya Shimizu
  • Publication number: 20120214250
    Abstract: A method of measuring a pH of a solution includes: emitting light beams of two wavelengths from one side of a measuring region of a solution into which an indicator is mixed, while pulsating the solution in the measuring region; receiving at least one of transmitted light beams and reflected light beams of the emitted light beams on the other side of the measuring region, while pulsating the solution in the measuring region; obtaining absorbances of the two wavelengths based on the received at least one of the transmitted light beams and the reflected light beams; obtaining an absorbance ratio from the obtained absorbances ; and calculating a pH value of the solution based on the obtained absorbance ratio and an absorbance ratio/pH value correspondence database which is previously stored.
    Type: Application
    Filed: February 19, 2012
    Publication date: August 23, 2012
    Applicants: Tokyo Women's Medical University, Nihon Kohden Corporation
    Inventors: Mitsuhiro Oura, Teruo Okano, Tatsuya Shimizu, Hirotsugu Kubo, Sunao Takeda, Shinji Yamamori
  • Publication number: 20120214225
    Abstract: A cell incubator includes: a culture cell accommodating section which accommodates cells to be cultured and a culture solution; and an RFID tag which is attached to the culture cell accommodating section and which is configured to transmit predetermined information to a communicating apparatus in response to reception of a signal that is wirelessly transmitted from the communicating apparatus.
    Type: Application
    Filed: February 19, 2012
    Publication date: August 23, 2012
    Applicants: Tokyo Women's Medical Uuniversity, Nihon Kohden Corporation
    Inventors: Mitsuhiro OURA, Teruo Okano, Tatsuya Shimizu, Hirotsugu Kubo, Katsuyoshi Suzuki, Sunao Takeda
  • Patent number: 7126587
    Abstract: In case where a key having a detection region (inner frame) in which user's instructions can be accepted is displayed according to a certain operation status of an apparatus, and in case where there is an invalid region in which the user's instruction is not detectable is adjacent to a key display region (outer frame) of the key, the detection region of the key is caused to be larger than the key display region by utilizing the invalid region. Moreover, the detection region is expanded/shrunk according to key arrangement and a number of keys to be displayed. With this, the detection region of the key is expanded/shrunk according to according to the key arrangement on the screen in a display-cum-operation device in which a display device and a coordinate input device are integrated.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: October 24, 2006
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Masaaki Kawakami, Hirotsugu Kubo, Masaki Shiozaki
  • Publication number: 20050225540
    Abstract: In case where a key having a detection region (inner frame) in which user's instructions can be accepted is displayed according to a certain operation status of an apparatus, and in case where there is an invalid region in which the user's instruction is not detectable is adjacent to a key display region (outer frame) of the key, the detection region of the key is caused to be larger than the key display region by utilizing the invalid region. Moreover, the detection region is expanded/shrunk according to key arrangement and a number of keys to be displayed. With this, the detection region of the key is expanded/shrunk according to according to the key arrangement on the screen in a display-cum-operation device in which a display device and a coordinate input device are integrated.
    Type: Application
    Filed: March 24, 2005
    Publication date: October 13, 2005
    Inventors: Masaaki Kawakami, Hirotsugu Kubo, Masaki Shiozaki
  • Patent number: 6693948
    Abstract: The present invention provides an arc-melting apparatus which attains extremely high efficiency by preheating scraps using exhaust gas from the melting chamber. The arc-melting apparatus needs for no device to carry and supply an iron source to a melting chamber, which makes it possible to preheat the next charge. The arc-melting apparatus has a melting furnace which melts scraps, a preheating shaft connected directly to an upper part of one side of the melting furnace, an arc electrode for melting scraps in the melting furnace, a bucket for supplying scraps to the preheat shaft so as to continuously maintain scraps in the melting furnace and in the preheating shaft, a tapping portion having a tapping hole, being projected outward from the melting furnace and a tilting device for tilting the melting furnace on a side of the tapping portion. The tapping portion is arranged at an orthogonal direction to the direction of the supplied cold iron source.
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: February 17, 2004
    Assignee: JP Steel Plantech Co.
    Inventors: Hideaki Mizukami, Ryuji Yamaguchi, Takashi Nakayama, Teruo Tatefuku, Norio Ao, Toshimichi Maki, Yasuhiro Sato, Hirotsugu Kubo
  • Publication number: 20030193986
    Abstract: The present invention provides an arc-melting apparatus which attains extremely high efficiency by preheating scraps using exhaust gas from the melting chamber. The arc-melting apparatus needs for no device to carry and supply an iron source to a melting chamber, which makes it possible to preheat the next charge. The arc-melting apparatus has a melting furnace which melts scraps, a preheating shaft connected directly to an upper part of one side of the melting furnace, an arc electrode for melting scraps in the melting furnace, a bucket for supplying scraps to the preheat shaft so as to continuously maintain scraps in the melting furnace and in the preheating shaft, a tapping portion having a tapping hole, being projected outward from the melting furnace and a tilting device for tilting the melting furnace on a side of the tapping portion. The tapping portion is arranged at an orthogonal direction to the direction of the supplied cold iron source.
    Type: Application
    Filed: May 1, 2003
    Publication date: October 16, 2003
    Applicant: JP STEEL PLANTECH CO.
    Inventors: Hideaki Mizukami, Ryuji Yamaguchi, Takashi Nakayama, Teruo Tatefuku, Norio Ao, Toshimichi Maki, Yasuhiro Sato, Hirotsugu Kubo
  • Publication number: 20020009118
    Abstract: The present invention provides an arc-melting apparatus, which attains extremely high efficiency by preheating scraps using exhaust gas from the melting chamber. The arc-melting apparatus needs for no device to carry and supply an iron source to a melting chamber, which makes it possible to preheat the next charge. The arc-melting apparatus has a melting furnace which melts scraps, a preheating shaft connected directly to an upper part of one side of the melting furnace, an arc electrode for melting scraps in the melting furnace, a bucket for supplying scraps to the preheat shaft so as to continuously maintain scraps in the melting furnace and in the preheating shaft, a tapping portion having a tapping hole, being projected outward from the melting furnace and a tilting device for tilting the melting furnace on a side of the tapping portion. The tapping portion is arranged at an orthogonal direction to the direction of the supplied cold iron source.
    Type: Application
    Filed: February 1, 2001
    Publication date: January 24, 2002
    Applicant: NKK CORPORATION, 1-2, Marunouchi 1-chome, Chiyoda-ku, Tokyo, Japan
    Inventors: Hideaki Mizukami, Ryuji Yamaguchi, Takashi Nakayama, Teruo Tatefuku, Norio Ao, Toshimichi Maki, Yasuhiro Sato, Hirotsugu Kubo