Patents by Inventor Hirotsugu Kubo
Hirotsugu Kubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9708578Abstract: A measuring unit which is to be attached to a cell culture container configured to accommodate cells to be cultured and a culture solution, includes: a measurer which is configured to measure information related to the cells and the culture solution, in a non-contact manner; and a sensor which is configured to detect at least one of a position, a posture, an impact, an orientation, and vibration.Type: GrantFiled: March 15, 2013Date of Patent: July 18, 2017Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITYInventors: Mitsuhiro Oura, Hirotsugu Kubo, Katsuyoshi Suzuki, Katsuhide Tone, Teruo Okano, Tatsuya Shimizu
-
Patent number: 9658214Abstract: A method of analyzing cells, the method comprising: measuring a number of cells which are nuclear stained, in a to-be-determined tissue, and acquiring a histogram showing a fluorescence intensity based on a result of the measurement; analyzing the histogram, and acquiring data of predetermined parameters; comparing the data of the parameters with first thresholds predetermined for the parameters, to perform a first cancer determination for each of the parameters on the to-be-determined tissue; performing a scoring process for each of the parameters, on a result of the first cancer determination for each of the parameters, to calculate scores of the parameters; and combining the scores of the parameters with one another, thereby performing a second cancer determination on the to-be-determined tissue.Type: GrantFiled: July 19, 2013Date of Patent: May 23, 2017Assignee: NIHON KOHDEN CORPORATIONInventors: Takahiro Shioyama, Akane Suzuki, Hirotsugu Kubo, Sunao Takeda
-
Patent number: 9470572Abstract: A method of measuring a liquid level of a cell culture solution stored in a cell vessel, includes: irradiating the cell culture solution with at least two kinds of light beams including a first light beam having a first wavelength and a second light beam having a second wavelength; measuring a first absorbance of the cell culture solution with respect to the first light beam, and a second absorbance of the cell culture solution with respect to the second light beam; and determining a liquid level of the cell culture solution based on the first absorbance and the second absorbance.Type: GrantFiled: March 21, 2013Date of Patent: October 18, 2016Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITYInventors: Mitsuhiro Oura, Hirotsugu Kubo, Teruo Okano, Tatsuya Shimizu
-
Patent number: 9443127Abstract: A cell analyzing apparatus includes: a first histogram acquiring section which is configured to acquire a first histogram of fluorescence intensities by using a result of a measurement of a number of nuclear stained cells; a second histogram acquiring section which is configured to acquire a second histogram that is normalized based on a fluorescence intensity value indicating a maximum value of the first histogram; a determining section which is configured to determine whether cancer cells exist or not, based on one of the first histogram and the second histogram; and an outputting section which is configured to output a result of the determination performed by the determining section.Type: GrantFiled: September 17, 2014Date of Patent: September 13, 2016Assignee: Nihon Kohden CorporationInventors: Sunao Takeda, Hirotsugu Kubo, Takahiro Shioyama, Akane Suzuki, Kenichi Nomura, Yo Kato, Nae Hinata
-
Patent number: 9304088Abstract: A method of measuring a pH of a solution includes: emitting light beams of two wavelengths from one side of a measuring region of a solution into which an indicator is mixed, while pulsating the solution in the measuring region; receiving at least one of transmitted light beams and reflected light beams of the emitted light beams on the other side of the measuring region, while pulsating the solution in the measuring region; obtaining absorbances of the two wavelengths based on the received at least one of the transmitted light beams and the reflected light beams; obtaining an absorbance ratio from the obtained absorbances; and calculating a pH value of the solution based on the obtained absorbance ratio and an absorbance ratio/pH value correspondence database which is previously stored.Type: GrantFiled: February 19, 2012Date of Patent: April 5, 2016Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITYInventors: Mitsuhiro Oura, Teruo Okano, Tatsuya Shimizu, Hirotsugu Kubo, Sunao Takeda, Shinji Yamamori
-
Patent number: 9291572Abstract: A pH measuring method includes: illuminating a medium solution, which includes: a first material; and a second material, with a plurality of light beams, which includes: a first light beam, a wavelength of which corresponds to a first absorption peak; a second light beam, a wavelength of which corresponds to a second absorption peak or a second convergence point; a third light beam, a wavelength of which corresponds to a third absorption peak or a third convergence point; and a fourth light beam, a wavelength of the fourth light beam at which an absorbance of at least one of the first and second materials is converged irrespective of a pH; receiving transmitted or reflected light beams of the first to fourth light beams; measuring absorbances at the wavelengths of the received light beams respectively; and calculating a pH of the medium solution based on the absorbances.Type: GrantFiled: April 6, 2012Date of Patent: March 22, 2016Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITYInventors: Mitsuhiro Oura, Hirotsugu Kubo, Sunao Takeda, Teruo Okano, Tatsuya Shimizu
-
Publication number: 20150078649Abstract: A cell analyzing apparatus includes: a first histogram acquiring section which is configured to acquire a first histogram of fluorescence intensities by using a result of a measurement of a number of nuclear stained cells; a second histogram acquiring section which is configured to acquire a second histogram that is normalized based on a fluorescence intensity value indicating a maximum value of the first histogram; a determining section which is configured to determine whether cancer cells exist or not, based on one of the first histogram and the second histogram; and an outputting section which is configured to output a result of the determination performed by the determining section.Type: ApplicationFiled: September 17, 2014Publication date: March 19, 2015Applicant: Nihon Kohden CorporationInventors: Sunao TAKEDA, Hirotsugu KUBO, Takahiro SHIOYAMA, Akane SUZUKI, Kenichi NOMURA, Yo KATO, Nae HINATA
-
Publication number: 20140030728Abstract: A method of analyzing cells, the method comprising: measuring a number of cells which are nuclear stained, in a to-be-determined tissue, and acquiring a histogram showing a fluorescence intensity based on a result of the measurement; analyzing the histogram, and acquiring data of predetermined parameters; comparing the data of the parameters with first thresholds predetermined for the parameters, to perform a first cancer determination for each of the parameters on the to-be-determined tissue; performing a scoring process for each of the parameters, on a result of the first cancer determination for each of the parameters, to calculate scores of the parameters; and combining the scores of the parameters with one another, thereby performing a second cancer determination on the to-be-determined tissue.Type: ApplicationFiled: July 19, 2013Publication date: January 30, 2014Applicant: NIHON KOHDEN CORPORATIONInventors: Takahiro Shioyama, Akane Suzuki, Hirotsugu Kubo, Sunao Takeda
-
Publication number: 20130330248Abstract: A cell isolation apparatus in which tissue and fluid that are accommodated in a container are pipetted by a pipette, and cells are isolated from the tissue, the cell isolation apparatus includes: a nozzle to which the pipette is attached; a pump which is connected to the nozzle; a controller which is configured to control an operation of the pump to cause air to be ejected from the nozzle or to be sucked into the nozzle, thereby causing the pipette to perform pipetting; and a condition inputting unit in which a user inputs a condition of control of the controller.Type: ApplicationFiled: May 29, 2013Publication date: December 12, 2013Applicant: NIHON KOHDEN CORPORATIONInventors: Takahiro SHIOYAMA, Akane SUZUKI, Hirotsugu KUBO
-
Publication number: 20130260445Abstract: A measuring unit which is to be attached to a cell culture container configured to accommodate cells to be cultured and a culture solution, includes: a measurer which is configured to measure information related to the cells and the culture solution, in a non-contact manner; and a sensor which is configured to detect at least one of a position, a posture, an impact, an orientation, and vibration.Type: ApplicationFiled: March 15, 2013Publication date: October 3, 2013Applicants: TOKYO WOMEN'S MEDICAL UNIVERSITY, NIHON KOHDEN CORPORATIONInventors: Mitsuhiro Oura, Hirotsugu Kubo, Katsuyoshi Suzuki, Katsuhide Tone, Teruo Okano, Tatsuya Shimizu
-
Publication number: 20130255374Abstract: A method of measuring a liquid level of a cell culture solution stored in a cell vessel, includes: irradiating the cell culture solution with at least two kinds of light beams including a first light beam having a first wavelength and a second light beam having a second wavelength; measuring a first absorbance of the cell culture solution with respect to the first light beam, and a second absorbance of the cell culture solution with respect to the second light beam; and determining a liquid level of the cell culture solution based on the first absorbance and the second absorbance.Type: ApplicationFiled: March 21, 2013Publication date: October 3, 2013Applicants: TOKYO WOMEN'S MEDICAL UNIVERSITY, NIHON KOHDEN CORPORATIONInventors: Mitsuhiro Oura, Hirotsugu Kubo, Teruo Okano, Tatsuya Shimizu
-
Publication number: 20120252110Abstract: A cell culture apparatus includes: an isolator in which a sterile space accommodating a cell incubator filled with a culture solution containing cells to be cultured is disposed; a sampling unit configured to sample the culture solution in the cell incubator; a delivery flow path through which an inside of the sterile space and an outside of the sterile space communicate with each other, the delivery flow path configured to limit a flow in the delivery flow path to a direction that is directed from the inside of the sterile space toward the outside of the sterile space; and a culture solution delivering section configured to deliver the sampled culture solution to the outside of the sterile space via the delivery flow path.Type: ApplicationFiled: March 28, 2012Publication date: October 4, 2012Applicants: Tokyo Women's Medical University, Nihon Kohden CorporationInventors: Mitsuhiro OURA, Teruo OKANO, Tatsuya SHIMIZU, Hirotsugu KUBO, Sunao TAKEDA
-
Publication number: 20120253692Abstract: A pH measuring method includes: illuminating a medium solution, which includes: a first material; and a second material, with a plurality of light beams, which includes: a first light beam, a wavelength of which corresponds to a first absorption peak; a second light beam, a wavelength of which corresponds to a second absorption peak or a second convergence point; a third light beam, a wavelength of which corresponds to a third absorption peak or a third convergence point; and a fourth light beam, a wavelength of the fourth light beam at which an absorbance of at least one of the first and second materials is converged irrespective of a pH; receiving transmitted or reflected light beams of the first to fourth light beams; measuring absorbances at the wavelengths of the received light beams respectively; and calculating a pH of the medium solution based on the absorbances.Type: ApplicationFiled: April 6, 2012Publication date: October 4, 2012Inventors: Mitsuhiro OURA, Hirotsugu Kubo, Sunao Takeda, Teruo Okano, Tatsuya Shimizu
-
Publication number: 20120214250Abstract: A method of measuring a pH of a solution includes: emitting light beams of two wavelengths from one side of a measuring region of a solution into which an indicator is mixed, while pulsating the solution in the measuring region; receiving at least one of transmitted light beams and reflected light beams of the emitted light beams on the other side of the measuring region, while pulsating the solution in the measuring region; obtaining absorbances of the two wavelengths based on the received at least one of the transmitted light beams and the reflected light beams; obtaining an absorbance ratio from the obtained absorbances ; and calculating a pH value of the solution based on the obtained absorbance ratio and an absorbance ratio/pH value correspondence database which is previously stored.Type: ApplicationFiled: February 19, 2012Publication date: August 23, 2012Applicants: Tokyo Women's Medical University, Nihon Kohden CorporationInventors: Mitsuhiro Oura, Teruo Okano, Tatsuya Shimizu, Hirotsugu Kubo, Sunao Takeda, Shinji Yamamori
-
Publication number: 20120214225Abstract: A cell incubator includes: a culture cell accommodating section which accommodates cells to be cultured and a culture solution; and an RFID tag which is attached to the culture cell accommodating section and which is configured to transmit predetermined information to a communicating apparatus in response to reception of a signal that is wirelessly transmitted from the communicating apparatus.Type: ApplicationFiled: February 19, 2012Publication date: August 23, 2012Applicants: Tokyo Women's Medical Uuniversity, Nihon Kohden CorporationInventors: Mitsuhiro OURA, Teruo Okano, Tatsuya Shimizu, Hirotsugu Kubo, Katsuyoshi Suzuki, Sunao Takeda
-
Patent number: 7126587Abstract: In case where a key having a detection region (inner frame) in which user's instructions can be accepted is displayed according to a certain operation status of an apparatus, and in case where there is an invalid region in which the user's instruction is not detectable is adjacent to a key display region (outer frame) of the key, the detection region of the key is caused to be larger than the key display region by utilizing the invalid region. Moreover, the detection region is expanded/shrunk according to key arrangement and a number of keys to be displayed. With this, the detection region of the key is expanded/shrunk according to according to the key arrangement on the screen in a display-cum-operation device in which a display device and a coordinate input device are integrated.Type: GrantFiled: March 24, 2005Date of Patent: October 24, 2006Assignee: Sharp Kabushiki KaishaInventors: Masaaki Kawakami, Hirotsugu Kubo, Masaki Shiozaki
-
Publication number: 20050225540Abstract: In case where a key having a detection region (inner frame) in which user's instructions can be accepted is displayed according to a certain operation status of an apparatus, and in case where there is an invalid region in which the user's instruction is not detectable is adjacent to a key display region (outer frame) of the key, the detection region of the key is caused to be larger than the key display region by utilizing the invalid region. Moreover, the detection region is expanded/shrunk according to key arrangement and a number of keys to be displayed. With this, the detection region of the key is expanded/shrunk according to according to the key arrangement on the screen in a display-cum-operation device in which a display device and a coordinate input device are integrated.Type: ApplicationFiled: March 24, 2005Publication date: October 13, 2005Inventors: Masaaki Kawakami, Hirotsugu Kubo, Masaki Shiozaki
-
Patent number: 6693948Abstract: The present invention provides an arc-melting apparatus which attains extremely high efficiency by preheating scraps using exhaust gas from the melting chamber. The arc-melting apparatus needs for no device to carry and supply an iron source to a melting chamber, which makes it possible to preheat the next charge. The arc-melting apparatus has a melting furnace which melts scraps, a preheating shaft connected directly to an upper part of one side of the melting furnace, an arc electrode for melting scraps in the melting furnace, a bucket for supplying scraps to the preheat shaft so as to continuously maintain scraps in the melting furnace and in the preheating shaft, a tapping portion having a tapping hole, being projected outward from the melting furnace and a tilting device for tilting the melting furnace on a side of the tapping portion. The tapping portion is arranged at an orthogonal direction to the direction of the supplied cold iron source.Type: GrantFiled: May 1, 2003Date of Patent: February 17, 2004Assignee: JP Steel Plantech Co.Inventors: Hideaki Mizukami, Ryuji Yamaguchi, Takashi Nakayama, Teruo Tatefuku, Norio Ao, Toshimichi Maki, Yasuhiro Sato, Hirotsugu Kubo
-
Publication number: 20030193986Abstract: The present invention provides an arc-melting apparatus which attains extremely high efficiency by preheating scraps using exhaust gas from the melting chamber. The arc-melting apparatus needs for no device to carry and supply an iron source to a melting chamber, which makes it possible to preheat the next charge. The arc-melting apparatus has a melting furnace which melts scraps, a preheating shaft connected directly to an upper part of one side of the melting furnace, an arc electrode for melting scraps in the melting furnace, a bucket for supplying scraps to the preheat shaft so as to continuously maintain scraps in the melting furnace and in the preheating shaft, a tapping portion having a tapping hole, being projected outward from the melting furnace and a tilting device for tilting the melting furnace on a side of the tapping portion. The tapping portion is arranged at an orthogonal direction to the direction of the supplied cold iron source.Type: ApplicationFiled: May 1, 2003Publication date: October 16, 2003Applicant: JP STEEL PLANTECH CO.Inventors: Hideaki Mizukami, Ryuji Yamaguchi, Takashi Nakayama, Teruo Tatefuku, Norio Ao, Toshimichi Maki, Yasuhiro Sato, Hirotsugu Kubo
-
Publication number: 20020009118Abstract: The present invention provides an arc-melting apparatus, which attains extremely high efficiency by preheating scraps using exhaust gas from the melting chamber. The arc-melting apparatus needs for no device to carry and supply an iron source to a melting chamber, which makes it possible to preheat the next charge. The arc-melting apparatus has a melting furnace which melts scraps, a preheating shaft connected directly to an upper part of one side of the melting furnace, an arc electrode for melting scraps in the melting furnace, a bucket for supplying scraps to the preheat shaft so as to continuously maintain scraps in the melting furnace and in the preheating shaft, a tapping portion having a tapping hole, being projected outward from the melting furnace and a tilting device for tilting the melting furnace on a side of the tapping portion. The tapping portion is arranged at an orthogonal direction to the direction of the supplied cold iron source.Type: ApplicationFiled: February 1, 2001Publication date: January 24, 2002Applicant: NKK CORPORATION, 1-2, Marunouchi 1-chome, Chiyoda-ku, Tokyo, JapanInventors: Hideaki Mizukami, Ryuji Yamaguchi, Takashi Nakayama, Teruo Tatefuku, Norio Ao, Toshimichi Maki, Yasuhiro Sato, Hirotsugu Kubo