Abstract: A high-resolution fluorescence image in which an afterimage is suppressed is obtained, even when a fluorescence detection interval is shortened. Provided is a scanning observation apparatus including a scanning unit that spatially scans pulsed excitation light emitted from a light source at prescribed time intervals on a specimen; a fluorescence detecting unit that detects fluorescence generated by exciting a fluorescent substance inside the specimen with the excitation light scanned by the scanning unit, in synchronization with the emission of the excitation light; and a fluorescence correcting unit that subtracts, from a fluorescence intensity detected by the fluorescence detecting unit, an afterimage fluorescence component calculated on the basis of time-sequential fluorescence detected by the fluorescence detecting unit prior thereto, at each scanning position, to correct the fluorescence intensity at the scanning position.

Abstract: There is provided an inside observation apparatus of an endoscope and the like which can perform an inside observation for irradiating an illumination light to a minute area of a surface of an object (for example, a living tissue) having a light scattering property and detecting a back-scattered light of the illumination light, can increase a detected light amount by a simply and low cost configuration by making an area of a detection region larger than an illumination region, and can reduce a time necessary to detect an body (for example, a blood vessel) to be observed and detect a region deeper than a conventional region.

Abstract: There is provided an inside observation apparatus of an endoscope and the like which can perform an inside observation for irradiating an illumination light to a minute area of a surface of an object (for example, a living tissue) having a light scattering property and detecting a back-scattered light of the illumination light, can increase a detected light amount by a simply and low cost configuration by making an area of a detection region larger than an illumination region, and can reduce a time necessary to detect an body (for example, a blood vessel) to be observed and detect a region deeper than a conventional region.

Abstract: High-precision observation is made possible while allowing contact between a distal end of an objective lens and an optical element without damaging the distal end of the objective lens and the optical element even when attaching to and detaching from the distal end of the objective lens. Provided is an objective lens adapter including a fixed member that is fixed to a lens tube of an objective lens, a distal-end member including an optical element that is made to be placed in contact with the distal-end surface of the objective lens, and an elastic member that is disposed between the distal-end member and the fixed member and that urges the optical element in a direction that causes the optical element to contact the distal-end surface of the objective lens.

Abstract: There is provided a lighting system having a high spatial resolution appropriate to a high-frequency component by evanescent waves in a negative refraction lens. The lighting system includes a light emitter thin film (106) which includes a light emitting material which emits light when an energy is applied, a cathode (101) for applying an electron beam (102) which is the energy, to the light emitter thin film (106), and a negative refraction lens (110) which is formed of a material exhibiting negative refraction, and has an optical system for projecting light emitted from the light emitter thin film (106), on an object.

Abstract: Light emitter excitation light (108) of a wavelength ?1 emitted by a light source (101) is collected on a light emitter (107) by a collective lens (102). The light emitter (107) is held on a substrate (104), and emits fluorescent light of a wavelength ?2 when the light emitter excitation light (108) of the wavelength ?1 is irradiated. A diameter of the light emitter (107) being formed to be smaller than the wavelength ?2, this fluorescent light includes evanescent waves, and advances through the substrate (104) as an object illuminating light (109) having the light emitter (107) as a point light source.

Abstract: There is provided an inside observation apparatus of an endoscope and the like which can perform an inside observation for irradiating an illumination light to a minute area of a surface of an object (for example, a living tissue) having a light scattering property and detecting a back-scattered light of the illumination light, can increase a detected light amount by a simply and low cost configuration by making an area of a detection region larger than an illumination region, and can reduce a time necessary to detect an body (for example, a blood vessel) to be observed and detect a region deeper than a conventional region.

Abstract: Optical spectrum of a light irradiated on the object, a spontaneous light emitted from within the object or a surface thereof, a scattered light, a transmitted light, a reflected light or a refracted light from within the object or a surface thereof generated by irradiating light on the object is resolved by amplifying said lights in a bandwidth narrower than the bandwidth of the optical spectrum of said lights. Thus, a method for detecting optical spectrum is provided in which signal intensity is amplified while deterioration of spectral data is suppressed.

Abstract: There is provided a lighting system having a high spatial resolution appropriate to a high-frequency component by evanescent waves in a negative refraction lens. The lighting system includes a light emitter thin film (106) which includes a light emitting material which emits light when an energy is applied, a cathode (101) for applying an electron beam (102) which is the energy, to the light emitter thin film (106), and a negative refraction lens (110) which is formed of a material exhibiting negative refraction, and has an optical system for projecting light emitted from the light emitter thin film (106), on an object.

Abstract: A microscope examination apparatus including a light source; an illumination optical system configured to guide light from the light source to a specimen; an objective lens configured to collimate return light from the specimen, the objective lens being provided in such a manner as to be displaceable at least in a direction intersecting an optical axis of the objective lens; an image-forming lens configured to image the return light from the specimen, which is collimated by the objective lens; an optical detector configured to detect the return light imaged by the image-forming lens; a microscope main body including the image-forming lens and the optical detector; and an objective-lens driving mechanism configured to drive the objective lens in a direction correcting image blur due to a displacement of the specimen.

Abstract: Light emitter excitation light (108) of a wavelength ?1 emitted by a light source (101) is collected on a light emitter (107) by a collective lens (102). The light emitter (107) is held on a substrate (104), and emits fluorescent light of a wavelength ?2 when the light emitter excitation light (108) of the wavelength ?1 is irradiated. A diameter of the light emitter (107) being formed to be smaller than the wavelength ?2, this fluorescent light includes evanescent waves, and advances through the substrate (104) as an object illuminating light (109) having the light emitter (107) as a point light source.

Abstract: The present invention enables switching between wide-field observation and high-magnification observation during in vivo examination of a small laboratory animal or the like using a narrow-diameter objective lens, without changing the objective lens. There is provided a microscope optical system including an objective lens for collecting light from an examination target; an image-forming lens for imaging the light collected by the objective lens onto a detection device; and an auxiliary optical system, having positive power, which is provided so as to be capable of being inserted in and removed from a light path between the objective lens and the image-forming lens.

Abstract: High-precision observation is made possible while allowing contact between a distal end of an objective lens and an optical element without damaging the distal end of the objective lens and the optical element even when attaching to and detaching from the distal end of the objective lens. Provided is an objective lens adapter including a fixed member that is fixed to a lens tube of an objective lens, a distal-end member including an optical element that is made to be placed in contact with the distal-end surface of the objective lens, and an elastic member that is disposed between the distal-end member and the fixed member and that urges the optical element in a direction that causes the optical element to contact the distal-end surface of the objective lens.

Abstract: The invention provides a microscope examination apparatus including a light source; an illumination optical system configured to guide light from the light source to a specimen; an objective lens configured to collimate return light from the specimen, the objective lens being provided in such a manner as to be displaceable at least in a direction intersecting an optical axis of the objective lens; an image-forming lens configured to image the return light from the specimen, which is collimated by the objective lens; an optical detector configured to detect the return light imaged by the image-forming lens; a microscope main body including the image-forming lens and the optical detector; and an objective-lens driving mechanism configured to drive the objective lens in a direction correcting image blur due to a displacement of the specimen.

Abstract: The present invention makes an objective lens easier to handle during disinfection or sterilization and protects the objective lens during, for example, transport, storage, or handling. The present invention provides an objective-lens protector including a substantially ring-shaped mounting portion surrounding a circumference of an objective lens, the mounting portion detachably mounted on the objective lens such that a threaded mount formed on the objective lens for mounting the objective lens to a microscope main body is exposed; a protecting member fixed to the mounting portion, extending substantially along the entire length of the objective lens mounted on the mounting portion, and arranged at a distance outwardly in a radial direction of the objective lens so as to surround the objective lens; and a locking mechanism provided on the mounting portion to prevent the objective lens from moving relative to the mounting portion in a circumferential direction.

Abstract: An easily viewable examination image in which blurring occurring in an image is reduced without operating an examination optical system in real time matching the motion of a specimen is obtained. There is provided an examination method comprising, prior to examining an examination site of a specimen, acquiring an image of the specimen surface of an examination region including the examination site, over a predetermined time range; extracting a plurality of feature points by processing the acquired image of the specimen surface; calculating a motion trajectory for each of the extracted feature points over the time range; and disposing an optical axis of an examination optical system at a position where the motion trajectory of a feature point disposed in the examination site is minimized.

Abstract: The invention provides a microscope examination apparatus including a light source; an illumination optical system configured to guide light from the light source to a specimen; an objective lens configured to collimate return light from the specimen, the objective lens being provided in such a manner as to be displaceable at least in a direction intersecting an optical axis of the objective lens; an image-forming lens configured to image the return light from the specimen, which is collimated by the objective lens; an optical detector configured to detect the return light imaged by the image-forming lens; a microscope main body including the image-forming lens and the optical detector; and an objective-lens driving mechanism configured to drive the objective lens in a direction correcting image blur due to a displacement of the specimen.

Abstract: The present invention enables switching between wide-field observation and high-magnification observation during in vivo examination of a small laboratory animal or the like using a narrow-diameter objective lens, without changing the objective lens. There is provided a microscope optical system including an objective lens for collecting light from an examination target; an image-forming lens for imaging the light collected by the objective lens onto a detection device; and an auxiliary optical system, having positive power, which is provided so as to be capable of being inserted in and removed from a light path between the objective lens and the image-forming lens.

Abstract: A microscope system includes a light source and an objective unit. The objective unit includes an objective optical system, including a small-diameter distal optical system arranged at an end brought near to or into contact with a specimen, for focusing light from the light source onto the specimen; a threaded mount at a coupling position; and an outer cylinder enclosing the small-diameter distal optical system. The microscope system further includes an imaging optical system for forming an image of light from the specimen through the objective optical system and a microscope main body for housing the imaging optical system. The objective unit is detachable from and attachable to the microscope main body with the threaded mount. Conditional expression Df/Da?0.3 is satisfied, where Df represents the outer diameter of the outer cylinder and Da represents the outer diameter of the threaded mount.

Abstract: The invention provides a microscope examination apparatus including a light source; an illumination optical system configured to guide light from the light source to a specimen; an objective lens configured to collimate return light from the specimen, the objective lens being provided in such a manner as to be displaceable at least in a direction intersecting an optical axis of the objective lens; an image-forming lens configured to image the return light from the specimen, which is collimated by the objective lens; an optical detector configured to detect the return light imaged by the image-forming lens; a microscope main body including the image-forming lens and the optical detector; and an objective-lens driving mechanism configured to drive the objective lens in a direction correcting image blur due to a displacement of the specimen.