Patents by Inventor Hiroya Kirimura

Hiroya Kirimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10725048
    Abstract: Disclosed is a method for detecting a test substance, including a first contact step of bringing the test substance, a capturing body 1 that has binding properties to the test substance and is fixed to a substrate, and a capturing body 2 that has binding properties to the test substance and contains a label into contact with each other in a liquid to arrange at least a part of the capturing body 2 on the substrate; after the first contact step, a first dissociation step of dissociating a part of substances containing the capturing body 2 from the substrate and releasing it into the liquid; after the first dissociation step, a second contact step of bringing the test substance, the capturing body 1 that has binding properties to the test substance and is fixed to a substrate, and the capturing body 2 that has binding properties to the test substance and contains a label into contact with each other in the liquid to arrange at least a part of the capturing body 2 on the substrate; after the second contact step,
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: July 28, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Kenji Akama, Hiroya Kirimura
  • Publication number: 20190195901
    Abstract: A dispensing robot of an assay robot system includes a first contact surface oriented in a downward direction or an obliquely downward direction in a vertical direction and dispenses when the dispensing robot operates a pipette that allows a tip to be attached to a lower end of the pipette and the attached tip to be detached by pressing a tip ejector, the dispensing robot comprising: a robot arm having a hand to hold a pipette holding piece attached thereto; and a controller controls the robot arm such that the robot arm holds the pipette with the tip attached thereto by causing the hand to hold the pipette holding piece and that the robot arm is elevated and the tip ejector is pressed by bringing an upper end portion of the tip ejector of the held pipette into contact with the first contact surface from the downward direction.
    Type: Application
    Filed: December 21, 2018
    Publication date: June 27, 2019
    Applicants: KAWASAKI JUKOGYO KABUSHIKI KAISHA, SYSMEX CORPORATION, MEDICAROID CORPORATION
    Inventors: Yukio IWASAKI, Satoshi OUCHI, Eiji MITSUI, Junichi MATSUOKA, Hiroya KIRIMURA, Yukihiko KITANO
  • Patent number: 10267759
    Abstract: Disclosed is a method of detecting a test substance contained in a sample using a working electrode and a counter electrode. The method comprises (A) forming a complex on the working electrode, the complex comprising the test substance and a metal particle; (B) washing the working electrode; (C) adding a measurement solution to the working electrode and measuring a current, voltage or electric charge from the metal on the working electrode in the measurement solution by electrochemical measurement; and (D) detecting the test substance in the sample based on a measurement result obtained in the step (C). In the method, the step (B) comprises washing the working electrode using a measurement solution having the same composition as the composition of the measurement solution used in the step (C).
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: April 23, 2019
    Assignee: SYSMEX CORPORATION
    Inventors: Nobuyasu Hori, Yuichi Yasuda, Hiroya Kirimura, Yuzuru Takamura, Miyuki Chikae
  • Publication number: 20190025319
    Abstract: Disclosed is a method for detecting a test substance, including a first contact step of bringing the test substance, a capturing body 1 that has binding properties to the test substance and is fixed to a substrate, and a capturing body 2 that has binding properties to the test substance and contains a label into contact with each other in a liquid to arrange at least a part of the capturing body 2 on the substrate; after the first contact step, a first dissociation step of dissociating a part of substances containing the capturing body 2 from the substrate and releasing it into the liquid; after the first dissociation step, a second contact step of bringing the test substance, the capturing body 1 that has binding properties to the test substance and is fixed to a substrate, and the capturing body 2 that has binding properties to the test substance and contains a label into contact with each other in the liquid to arrange at least a part of the capturing body 2 on the substrate; after the second contact step,
    Type: Application
    Filed: July 13, 2018
    Publication date: January 24, 2019
    Applicant: SYSMEX CORPORATION
    Inventors: Kenji AKAMA, Hiroya KIRIMURA
  • Patent number: 10066261
    Abstract: The present invention relates to a method for amplifying a nucleic acid. More specifically, the present invention relates to a method for amplifying a nucleic acid in a light irradiation dependent manner under a substantially isothermal condition using a photo-responsive nucleic acid.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: September 4, 2018
    Assignees: SYSMEX CORPORATION, NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Seigo Suzuki, Hiroya Kirimura, Hiroyuki Asanuma
  • Patent number: 9885661
    Abstract: Disclosed is an analyte detection method for detecting an analyte contained in a biological sample, constituted by irradiating a light of a first peak wavelength on a complex containing an analyte and fluorescent substance which gives off light of a second peak wavelength of 450 nm or higher but not exceeding 900 nm when irradiated with light of the first wavelength of 190 nm or higher but not exceeding 350 nm, detecting the light of the second peak wavelength given off by the fluorescent substance when irradiated by light of the first peak wavelength, by a photodetector, wherein the photodetector has a quantum efficiency in the second peak wavelength that is two or more times the quantum efficiency in the first peak wavelength.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: February 6, 2018
    Assignee: SYSMEX CORPORATION
    Inventors: Ayato Tagawa, Hiroya Kirimura
  • Publication number: 20180011054
    Abstract: Provided is a method for detecting a test substance. In this method, metal is deposited or a complex containing a test substance and a metal particle is immobilized on a working electrode on an electrode substrate including the working electrode and a counter electrode. An oxidation potential is applied to the working electrode to generate metal ions, then a reduction potential is applied to a portion having an area smaller than an area of the portion to which an oxidation potential is applied in the working electrode to deposit metal on the surface of the portion to which the reduction potential is applied, and current, voltage or charge caused by the metal deposited is measured to detect metal ions or a test substance.
    Type: Application
    Filed: July 18, 2017
    Publication date: January 11, 2018
    Applicant: SYSMEX CORPORATION
    Inventors: Nobuyasu HORI, Hiroya KIRIMURA, Yuzuru TAKAMURA, Miyuki CHIKAE
  • Publication number: 20160122809
    Abstract: The present invention relates to a method for amplifying a nucleic acid. More specifically, the present invention relates to a method for amplifying a nucleic acid in a light irradiation dependent manner under a substantially isothermal condition using a photo-responsive nucleic acid.
    Type: Application
    Filed: October 20, 2015
    Publication date: May 5, 2016
    Applicants: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY, SYSMEX CORPORATION
    Inventors: Seigo SUZUKI, Hiroya KIRIMURA, Hiroyuki ASANUMA
  • Publication number: 20160116428
    Abstract: Disclosed is a method of detecting a test substance contained in a sample using a working electrode and a counter electrode. The method comprises (A) forming a complex on the working electrode, the complex comprising the test substance and a metal particle; (B) washing the working electrode; (C) adding a measurement solution to the working electrode and measuring a current, voltage or electric charge from the metal on the working electrode in the measurement solution by electrochemical measurement; and (D) detecting the test substance in the sample based on a measurement result obtained in the step (C). In the method, the step (B) comprises washing the working electrode using a measurement solution having the same composition as the composition of the measurement solution used in the step (C).
    Type: Application
    Filed: October 27, 2015
    Publication date: April 28, 2016
    Applicant: SYSMEX CORPORATION
    Inventors: Nobuyasu HORI, Yuichi YASUDA, Hiroya KIRIMURA, Yuzuru TAKAMURA, Miyuki CHIKAE
  • Patent number: 9157884
    Abstract: In order to provide a method of electrochemically detecting a target substance, a method of electrochemically detecting an analyte, and a detection set which have a theoretical advantage in the measurement sensitivity obtained by a conventional electrochemical detection method using a working electrode with a trapping substance immobilized, can reuse the working electrode, and can detect an analyte regardless of the size thereof, there is provided a method including: attracting the target substance containing a labeling substance in a liquid sample to a working electrode in which a trapping substance for trapping the target substance containing a labeling substance is not present; and electrochemically detecting the target substance containing a labeling substance.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: October 13, 2015
    Assignee: SYSMEX CORPORATION
    Inventors: Masayoshi Seike, Nobuyasu Hori, Seigo Suzuki, Shigeki Iwanaga, Hiroya Kirimura
  • Patent number: 9157885
    Abstract: The present invention provides a method for electrochemically detecting a target substance and a method for electrochemically detecting an analyte using a probe holding substrate with a probe for trapping a target substance or an analyte held on the substrate body as well as a test chip and a detection set using the above detection methods.
    Type: Grant
    Filed: September 24, 2011
    Date of Patent: October 13, 2015
    Assignee: SYSMEX CORPORATION
    Inventors: Shigeki Iwanaga, Hiroya Kirimura
  • Patent number: 9057688
    Abstract: A detection device for detecting a test substance which is capable of detecting a test substance and a sample substance with high sensitivity, an electrode substrate, a working electrode, an inspection tip, a method of detecting a test substance, and a method of detecting a sample substance are provided in which a reflective part (reflective layer) is disposed on the working electrode so as to reflect excitation light emitted from a light source and passing through the working electrode toward the working electrode.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: June 16, 2015
    Assignee: SYSMEX CORPORATION
    Inventors: Nobuyasu Hori, Hiroya Kirimura
  • Publication number: 20150104880
    Abstract: Disclosed is an analyte detection method for detecting an analyte contained in a biological sample, constituted by irradiating a light of a first peak wavelength on a complex containing an analyte and fluorescent substance which gives off light of a second peak wavelength of 450 nm or higher but not exceeding 900 nm when irradiated with light of the first wavelength of 190 nm or higher but not exceeding 350 nm, detecting the light of the second peak wavelength given off by the fluorescent substance when irradiated by light of the first peak wavelength, by a photodetector, wherein the photodetector has a quantum efficiency in the second peak wavelength that is two or more times the quantum efficiency in the first peak wavelength.
    Type: Application
    Filed: October 7, 2014
    Publication date: April 16, 2015
    Inventors: Ayato TAGAWA, Hiroya KIRIMURA
  • Publication number: 20150093836
    Abstract: The present invention relates to a method for controlling dissociation of a double stranded nucleic acid. The present invention also relates to a method for controlling strand exchange reaction of a double stranded nucleic acid. The present invention further relates to a method for amplifying a nucleic acid.
    Type: Application
    Filed: September 26, 2014
    Publication date: April 2, 2015
    Applicants: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY, SYSMEX CORPORATION
    Inventors: Seigo SUZUKI, Hiroya KIRIMURA, Hiroyuki ASANUMA
  • Patent number: 8920626
    Abstract: A sample substance S is captured by a capture substance 10 which is immobilized on a working electrode body 161 to provide a method of electrochemically detecting a sample substance capable of detecting the sample substance with high sensitivity. A complex which includes, on a soluble carrier 21, a sample substance S and a labeled binder 20 that has a modified labeled substance 23 containing a labeled substance 20 bound to modified labeled substance 23 containing a labeled substance 24 and a binder 22 that binds to the sample substance S, formed on the working electrode 161. The soluble carrier 21 is dissolved, and the modified labeled substance 23 is attracted to the working electrode 161.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: December 30, 2014
    Assignee: Sysmex Corporation
    Inventors: Seigo Suzuki, Masayoshi Seike, Shigeki Iwanaga, Nobuyasu Hori, Hiroya Kirimura
  • Publication number: 20140291166
    Abstract: A method for electrochemically detecting an analyte contained in a sample using a working electrode and a counter electrode, comprising: allowing an electrolyte solution which contains a solution prepared by dissolving an imidazolium iodide compound in a protic solvent to be into contact with the working electrode and the counter electrode; and electrochemically detecting the analyte contained in the sample in the presence of the electrolyte solution is disclosed. A kit to be used for the method for electrochemically detecting an analyte is also disclosed.
    Type: Application
    Filed: March 27, 2014
    Publication date: October 2, 2014
    Applicant: SYSMEX CORPORATION
    Inventors: Fumiya FUTAMATSU, Hiroya KIRIMURA, Shigeki IWANAGA, Seigo SUZUKI, Nobuyasu HORI, Yuichi YASUDA
  • Publication number: 20120267258
    Abstract: In order to provide a method for electrochemically detecting an analyte which can detect an analyte with high detection sensitivity, when detecting an analyte S trapped on a working electrode, a label binding substance 90 in which a labeling substance 93 and a first binding substance 92 which traps the analyte S are at least retained on a support 91 composed of polypeptide is brought into contact with the analyte. Alternatively, a complex containing the analyte S and a label binding substance 290 in which a labeling substance 293 is retained on a binding substance 291 which binds to the analyte S via a modulator 292 is formed. Then, the labeling substance present on the working electrode is electrochemically detected.
    Type: Application
    Filed: April 20, 2012
    Publication date: October 25, 2012
    Applicants: NARA INSTITUTE OF SCIENCE AND TECHNOLOGY, SYSMEX CORPORATION
    Inventors: Yukiharu URAOKA, Bin Zheng, Seigo SUZUKI, Hiroya KIRIMURA, Masayoshi SEIKE, Shigeki IWANAGA, Nobuyasu HORI
  • Publication number: 20120161268
    Abstract: To provide an electrode and working electrode substrate capable of detecting a sample substance, and a manufacturing method capable of producing the electrode by simply operations, the present invention provides, in a photocurrent detection electrode, an adhesive layer containing linker molecules interposed between an electrode body constituted by a semiconductor for receiving electrons released from a test substance by photoexcitation, and a metal layer constituted by a metal.
    Type: Application
    Filed: December 28, 2011
    Publication date: June 28, 2012
    Applicant: SYSMEX CORPORATION
    Inventors: Shigeki IWANAGA, Seigo SUZUKI, Masayoshi SEIKE, Nobuyasu HORI, Hiroya KIRIMURA
  • Publication number: 20120132543
    Abstract: A sample substance S is captured by a capture substance 10 which is immobilized on a working electrode body 161 to provide a method of electrochemically detecting a sample substance capable of detecting the sample substance with high sensitivity. A complex which includes, on a soluble carrier 21, a sample substance S and a labeled binder 20 that has a modified labeled substance 23 containing a labeled substance 20 bound to modified labeled substance 23 containing a labeled substance 24 and a binder 22 that binds to the sample substance S, formed on the working electrode 161. The soluble carrier 21 is dissolved, and the modified labeled substance 23 is attracted to the working electrode 161.
    Type: Application
    Filed: November 29, 2011
    Publication date: May 31, 2012
    Applicant: SYSMEX CORPORATION
    Inventors: Seigo SUZUKI, Masayoshi SEIKE, Shigeki IWANAGA, Nobuyasu HORI, Hiroya KIRIMURA
  • Publication number: 20120103836
    Abstract: A detection device for detecting a test substance which is capable of detecting a test substance and a sample substance with high sensitivity, an electrode substrate, a working electrode, an inspection tip, a method of detecting a test substance, and a method of detecting a sample substance are provided in which a reflective part (reflective layer) is disposed on the working electrode so as to reflect excitation light emitted from a light source and passing through the working electrode toward the working electrode.
    Type: Application
    Filed: October 20, 2011
    Publication date: May 3, 2012
    Applicant: SYSMEX CORPORATION
    Inventors: Nobuyasu HORI, Hiroya KIRIMURA