Abstract: An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.

Abstract: The method includes forming a hole penetrating from one surface of a substrate to an electrode formed on the other surface of the substrate; forming an organic insulating film in the hole; removing at least a part of the organic insulating film formed in a bottom portion of the hole and not the organic insulating film formed on a side wall portion of the hole, to expose the electrode; cleaning an exposed surface of the electrode by using plasma of an inert gas; filling a conductive metal in the hole; removing at least a part of a surface of the organic insulating film by the reaction of oxygen plasma; and annealing the substrate in a dysoxidative atmosphere.

Abstract: A pre-treatment method for analyzing a specified portion in a specimen composed of a biological tissue includes the steps of preparing a specimen to be analyzed, determining a specified portion in the specimen; and applying an analysis inhibitor to a portion except the specified portion of the specimen using a droplet spray method.

Abstract: Provided is a method that achieves both of soft ionization and high ionization efficiency of a substance to be analyzed at each measurement site without impairing a two-dimensional distribution state of the substance to be analyzed in desorption ionization mass spectrometry of a substance to be measured. By applying, to a substance to be analyzed, an ionization assisting reagent including an organic acid including a functional group represented by —(CF2)COOH and having a boiling point of 150° C. or more, and a polyhydric alcohol having a melting point of 20° C. or less and a boiling point of 150° C. or more at normal pressure, the organic acid, which is a component of the ionization assisting reagent, effectively donates a proton to the substance to be analyzed, thereby improving ionization efficiency, and the polyhydric alcohol, which is a component of the ionization assisting reagent, inhibits fragmentation.

Abstract: A surface treating method for treating a surface of a substrate inside a process chamber includes the steps of generating an atmosphere containing no moisture in the process chamber, heating the substrate inside the atmosphere containing no moisture in the process chamber; and causing a reaction between the substrate and an adhesion accelerating agent by feeding the adhesion accelerating agent gas into the process chamber.

Abstract: A film deposition apparatus includes a film deposition chamber into which a substrate is carried, a heating mechanism that heats the substrate carried into the film deposition chamber, an adhesion accelerating agent feed mechanism that feeds an adhesion accelerating agent gas into the film deposition chamber, and a control part that controls the heating mechanism and the adhesion accelerating agent feed mechanism. When depositing a polyimide film on the substrate by feeding a first source gas formed of dianhydride and a second source gas formed of diamine into the film deposition chamber, the control part is configured to control the adhesion accelerating agent feed mechanism to treat a surface of the substrate with the adhesion accelerating agent gas by feeding the adhesion accelerating agent gas into the film deposition chamber until the substrate is heated to a predetermined temperature for depositing the polyimide film.

Abstract: An object of the present invention is to provide a method of comprehensively visualizing a constituent in tumor tissue or the like at a cellular level. The present invention provides a method of forming a two-dimensional distribution image of a target constituent based on information on the mass of constituents of the tissue section wherein, as the internal standard material, any one of actin, tubulin and GAPDH is used in the intracellular region, one of histone and nucleic acid is used in the nuclear region, and one of albumin and cytokine is used in the extracellular region.

Abstract: A power supply device includes a battery assembly, a box-shaped cover case, a cooling plate, and a waterproof sheet. The battery assembly includes rectangular battery cells arranged side by side. The cover case has an opening. Exterior surfaces of the battery assembly are covered with surfaces of the cover case other than the opening. The cooling plate is thermally coupled to one surface of the battery assembly through the opening. Coolant flows through the cooling plate whereby transferring heat from the battery assembly to the coolant. The waterproof sheet covers the one surface of the battery assembly. Gaps between the battery assembly and the cover case are filled with a sealing material so that a sealing layer is interposed between them. The waterproof sheet is fastened by the sealing layer.

Abstract: A more effective noise reduction method is provided. In the method, when mass spectrum information having a spatial distribution is processed, the whole data is taken as three-dimensional data (positional information is stored in an xy plane, and spectral information is stored along a z-axis direction), and three-dimensional wavelet noise reduction is performed by applying preferable basis functions to a spectral direction and a peak distribution direction (in-plane direction).

Abstract: The problem to be solved by the present invention is to provide a method for treating a polypeptide including a cysteine residue for enhancing the sensitivity of detection thereof in mass spectrometry using charged particles. A mass spectrometry method for a polypeptide including a cysteine residue is provided which includes treating the polypeptide including a cysteine residue with a cyanation agent, treating the cyanated polypeptide with a base, and then desorption ionizing the base-treated polypeptides using charged particles for mass spectrometry.

Abstract: The present invention is to provide an agent for treating Crohn's disease that is of unknown cause and for which no radical therapeutic drug is present. Provided is an agent for preventing or treating Crohn's disease, comprising an organic acid polymer represented by the following formula: [(O1/2)3Ge-A-CO2H]n, wherein n is 100-1,000, and A is a lower alkyl group. Preferably, A is a C1-C3 lower alkyl group and the degree of polymerization n is 200-900. The organic acid polymer according to the present invention is effective as an agent for treating Crohn's disease.

Abstract: Provided is a method that achieves both of soft ionization and high ionization efficiency of a substance to be analyzed at each measurement site without impairing a two-dimensional distribution state of the substance to be analyzed in desorption ionization mass spectrometry of a substance to be measured. By applying, to a substance to be analyzed, an ionization assisting reagent including an organic acid including a functional group represented by —(CF2)COOH and having a boiling point of 150° C. or more, and a polyhydric alcohol having a melting point of 20° C. or less and a boiling point of 150° C. or more at normal pressure, the organic acid, which is a component of the ionization assisting reagent, effectively donates a proton to the substance to be analyzed, thereby improving ionization efficiency, and the polyhydric alcohol, which is a component of the ionization assisting reagent, inhibits fragmentation.

Abstract: A mass spectrometry method that makes it possible to perform high-sensitivity detection of a desorbed/ionized object substance to be measured in mass spectrometry in which the object substance to be measured is desorbed and ionized. The method includes placing at least an ionizing agent having two or more functional groups represented by Formula (1) below in a molecule: —(CF2)COOH??(1) wherein the ionizing agent has a boiling point of equal to or higher than 150° C. and an object molecule to be measured on a substrate and irradiating the ionizing agent and the object molecule to be measured with a primary beam selected from ions, neutral particles, electrons, and a laser beam.

Abstract: Apparatus for feeding molten resin includes a holding unit that moves on a track and at least a pair of holders capable of holding and releasing the molten resin accompanying the opening and closing of the holding unit. A base portion is utilized for supporting the holders so as to be opened and closed and for holding the molten resin together with the holders. The molten resin discharged from an extrusion-forming machine and cut by a cutter is held by the holding unit, and it fed from the holding unit to a female mold of a compression-0molding machine. At the time of cutting the molten resin, a cutter mark is formed by the cutter on a cut surface of the molten resin.

Abstract: A method for manufacturing a probe needle having beams and a contactor placed on tips of the beams comprises preparing a Si wafer 20, forming a seed layer 21 on the Si wafer 20, and forming grooves in a desired shape of the beams on the seed layer 21 by patterning a photoresist 23. Subsequently, the grooves are filled up with metal-plated layers 24a, 24b to form the desired shape of beams.

Abstract: The present invention relates to manufacture of container product with a constant level of quality, wherein the performance is constant, by resolving problems including transformation of perform performance caused by the temperature variation of the preform; or by the variation in the stretching blow molding due to a thermal difference between the surface and the inner part of the preform, resulting from the thickness thereof, in order to industrialize a new molding method recognized to be an excellent molding method from the point of view of economic efficiency and production efficiency, wherein compression molding and stretch blow molding are performed continuously. By a method or device for manufacturing continuously synthetic resin containers, preforms are molded by compression with a compression molding machine, then stretch blow molding is performed with a stretch blow molding machine.

Abstract: An object of the present invention is to provide a method of comprehensively visualizing a constituent in tumor tissue or the like at a cellular level. The present invention provides a method of forming a two-dimensional distribution image of a target constituent based on information on the mass of constituents of the tissue section wherein, as the internal standard material, any one of actin, tubulin and GAPDH is used in the intracellular region, one of histone and nucleic acid is used in the nuclear region, and one of albumin and cytokine is used in the extracellular region.

Abstract: The present invention intends to provide a high sensitivity method for identifying the type of a protein contained in each cell with a diameter of ten to several tens ?m and a sample treatment solution required for it. The above is achieved by three steps of (1) treating a slice of a diseased tissue with an aqueous solution containing gold particles and a digestive enzyme, and digesting restrictively a protein of interest, (2) measuring a 2-dimensional distribution of fragmented peptides by TOF-SIMS, and (3) visualizing a 2-dimensional distribution of the target protein in the slice of the diseased tissue using the results of the proteome analysis and by means of a numerical analysis.

Abstract: Target molecules in a sample can be detected at an improved sensitivity by means of a mass spectrometer. A sample with or without a matrix is placed on a substrate and irradiated with a converged and pulsed primary beam selected from an ion beam, a neutral particle beam or a laser beam. Secondary ions and neutral molecules are emitted along with protons from the irradiated point of the sample as an electric field is applied between the substrate and an extraction electrode disposed above the substrate. A proton-control electrode is arranged in axial symmetry with the trajectory of the primary beam. A voltage is applied thereto so that the generated electric field decelerates the flying protons to raise their adhering efficiency to the flying neutral molecules.

Abstract: There is provided a laminate comprising a hard coat layer having the outermost surface to which slipperiness has been imparted. The laminate comprises a transparent substrate and a hard coat layer provided on said transparent substrate. The hard coat layer is formed of a cured product of a composition comprising a fluorine-modified urethane acrylate and/or a polydimethylsiloxane having a polyether-modified acryl or polyether group.