Abstract: The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.

Abstract: An object of the invention is to increase productivity of a coil. A coil forming device according to the present invention includes: a first bending unit 200A that performs a compression bending process with respect to a linear conductor; and a second bending unit 200B that performs a draw bending process with respect to the linear conductor, wherein the first bending unit 200A and the second bending unit 200B are integrated in one device, and wherein the first bending unit 200A and the second bending unit 200B are switched to access one linear conductor so as to perform the compression bending process and the draw bending process onto the one linear conductor.

Abstract: A non-transitory computer readable recording medium storing a machine learning program for causing a computer to execute a process includes extracting a feature related to a surface structure of a substance based on an atomic arrangement of the substance, and training a machine learning model that predicts information regarding a chemical reaction that occurs in a substance that corresponds to an input explanatory variable using training data that includes, as an explanatory variable, atomic arrangement information regarding the atomic arrangement of the substance and the extracted feature and includes, as an objective variable, information regarding the chemical reaction that occurs in the substance.

Abstract: Provided is a sulfide solid electrolyte that has a novel crystal structure and exhibits an ionic conductivity, the sulfide solid electrolyte containing a lithium atom, a phosphorus atom, a sulfur atom, and at least one kind of halogen atom selected from a chlorine atom and a bromine atom, and having a specific diffraction peak in powdery X-ray diffractometry using CuK? line, and a method for producing a sulfide solid electrolyte, the method including mixing a solvent 1 having a heteroatom and a raw material 1 containing specific atoms to prepare a mixture, preparing a solution that contains a raw material 2 containing a halogen atom and a solvent 2 having a heteroatom, mixing the mixture and the solution to prepare a fluid, and heating the fluid.

Abstract: A non-transitory computer-readable recording medium storing a water inundation depth determination program for causing a computer to execute processing including: detecting a first type of a target and a first submersion position of the target included in a first captured image; and outputting a first submersion depth corresponding to the first type and the first submersion position by referring to depth information in which a depth is associated with a pair of a type and a submersion position.

Abstract: One of the purposes of the present invention is to provide: a compound which can be used as a binder having ion conductivity; and a battery which contains the compound. One aspect of the present invention is a compound comprising P and S as constituent elements, a group comprising one or more elements selected from the group consisting of O, N and halogen, the group bonding to the P, and a disulfide bond.

Abstract: A method for producing a lithium compound, by which a high purity lithium compound can be produced from low-grade lithium carbonate containing impurities, such as salt water. The method includes: mixing lithium carbonate, an acid containing an organic acid, and water in a reaction tank 1 to produce an aqueous organic acid lithium solution containing an organic acid lithium; mixing the organic acid lithium and a metal hydroxide in a reaction tank 2 to produce an aqueous lithium hydroxide solution; and returning an organic acid, which is regenerated by using an electrochemical device from an organic acid metal by-produced by producing the aqueous lithium hydroxide solution to the reaction tank 1 and using the regenerated organic acid as the organic acid. An apparatus for producing a lithium compound, including the reaction tank 1, the reaction tank 2, the electrochemical device, and a return pipe, which each have a specific function.

Abstract: A resin composition containing a compound including phosphorus and sulfur as constituent elements and having a disulfide bond, and a thermoplastic resin.

Abstract: A non-transitory computer-readable recording medium storing a display control program for causing a computer to execute processing, the processing including: determining priorities of a plurality of facilities positioned within a specific area according to a value related to congestion determined on the basis of the upper limit number of people in each of the plurality of facilities and the number of visitors calculated on the basis of an image captured in each of the plurality of facilities; selecting a specific number of facilities from the plurality of facilities on the basis of the determined priorities; and displaying, for each of the specific number of selected facilities, a position on a map and alert information according to the value related to the congestion.

Abstract: An object of the present invention is to provide sulfide solid electrolyte glass ceramics that have a high ionic conductivity and an enhanced water resistance, and is also to provide a method of producing the sulfide solid electrolyte glass ceramics. Sulfide solid electrolyte glass ceramics that have peaks at 20.2° and 23.6° in an X-ray diffractometry (XRD) using the CuK? line, a crystallite diameter of 30 nm or more, and a P2S64? phosphorus proportion obtained by a solid 31P-NMR spectroscopy of 4.5% by mol or less, and a method of producing the sulfide solid electrolyte glass ceramics are provided.

Abstract: To provide an electrode composite material that is excellent in conductivity through the excellent contact state of a solid electrolyte and an electrode active material, and is capable of exhibiting a high battery capability, containing the sulfide solid electrolyte and the electrode active material, having an electron conductivity parameter X represented by the prescribed expression satisfying 0.30?X?2.10.

Abstract: A gas detection element for detection of a measurement target gas is provided. The gas detection element includes a gas detection layer including a chemochromic pigment; and a spacer. The spacer is permeable to the measurement target gas, is disposed on a first surface of the gas detection layer, and has an area smaller than an area of the gas detection layer.

Abstract: A compound comprising phosphorus atoms and sulfur atoms as constituent elements and having a peak in Raman spectroscopy, the peak being attributable to a disulfide bond bonding between two phosphorus atoms.

Abstract: A non-transitory computer-readable recording medium storing a display control program for causing a computer to execute processing, the processing including: determining priorities of a plurality of facilities positioned within a specific area according to a value related to congestion determined on the basis of the upper limit number of people in each of the plurality of facilities and the number of visitors calculated on the basis of an image captured in each of the plurality of facilities; selecting a specific number of facilities from the plurality of facilities on the basis of the determined priorities; and displaying, for each of the specific number of selected facilities, a position on a map and alert information according to the value related to the congestion.

Abstract: A gas sensing element includes a gas detection layer including a pigment, the gas detection layer including a first surface; and a backing material disposed on the first surface of the gas detection layer. When reducing gas causes the gas sensing element to change in color, a color change ?L* of the gas sensing element is greater than or equal to 5.

Abstract: A gas detection element for detection of a measurement target gas is provided. The gas detection element includes a gas detection layer including a chemochromic pigment; and a spacer. The spacer is permeable to the measurement target gas, is disposed on a first surface of the gas detection layer, and has an area smaller than an area of the gas detection layer.

Abstract: A gas detection system includes (1) an output device configured to output data acquired by monitoring a gas sensing element including a gas detection layer including a pigment; and (2) an information processing apparatus configured to process the data output by the output device, wherein the information processing apparatus includes a determining unit configured to determine whether the gas sensing element has detected gas, based on the data, and a display control unit configured to display, on an indication element, information indicating a position of the gas sensing element that has detected the gas or information indicating a status of gas leakage determined based on the data, when the determining unit determines that the gas sensing element has detected the gas.

Abstract: A gas sensing element includes a gas detection layer including a pigment, the gas detection layer including a first surface; and a backing material disposed on the first surface of the gas detection layer. When reducing gas causes the gas sensing element to change in color, a color change ?L* of the gas sensing element is greater than or equal to 5.

Abstract: The disclosed pharmaceutical preparation comprises a compound represented by the chemical formula (A) or a pharmaceutically acceptable salt thereof, which is dispersed in a matrix consisting of a water-soluble high molecular weight substance; and Crospovidone: The pharmaceutical preparation is excellent in the solubility and the storage stability even if the amount of the compound or the salt included in each individual dosage unit is increased.

Abstract: A solid electrolyte glass at least including: at least one alkali metal element; a phosphorus (P) element; a sulfur (S) element; and one or more halogen elements selected from I, Cl, Br and F; wherein the solid electrolyte glass has two exothermic peaks that are separated from each other in a temperature range of 150° C. to 350° C. as determined by differential scanning calorimetry (in a dry nitrogen atmosphere at a temperature-elevating speed of 10° C./min from 20 to 600° C.).