Abstract: A compound having the following formula wherein A is —O—; B is alkylene or alkenylene optionally containing —O—, —S—, —(NR7)—, —CO— or —N?; R1 and R2 are alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl, wherein the alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl is unsubstituted or substituted by halogen, cycloalkyl, aryl, adamantyl or amino; R3 is a substituted or unsubstituted pyridine ring; R5 and R6 are hydrogen or alkyl; R7 is hydrogen or alkyl; X is O or S; and each hydrogen of the said amino is unsubstituted or substituted by alkyl, alkoxycarbonyl, cycloalkyloxycarbonyl, arylalkoxycarbonyl or halogenoalkyloxycarbonyl. The compound is a TNF-? production inhibitor that is useful for treating autoimmune diseases such as rheumatoid arthritis.

Abstract: An ink container for containing ink to be supplied to an ink jet head to which the ink container is detachably mountable, includes an ink supply port for supplying the ink to the ink jet head; a air vent for fluid communication with ambience; a claw-like projection provided on a first side of the ink container; a latching lever provided on a second side opposite from the ink container, the latching lever being resiliently supported on the ink container and having a latching claw.

Abstract: A projection type display apparatus in accordance with the present invention is provided with a lamp unit including a light source, a cooling fan cooling the light source, and a cooling wind guide tube guiding a cooling wind generated by the cooling fan to the lamp unit, and the cooling wind guide tube is structured such as to have a movable type rectification plate which is movable by its own weight, and cools the light source without being affected by an installed direction of the projection type display apparatus.

Abstract: When pattern recognition of a fundus image is started in step S1, output from a fundus image sensing unit is compared with a regional pattern of stored fundus image specific regions in step S2, and it is decided whether to proceed to pattern recognition. If pattern recognition is possible, based on an AF evaluation value, the lens is driven, with which automatic focusing is completed.

Abstract: A fundus camera includes an illumination optical system including an illumination unit configured to illuminate a fundus of a subject's eye, a fundus observation photographing optical system including an image sensor and is configured to observe a fundus image, a focus index projection unit configured to project a focus index on a center region of a photographing portion of the fundus of the subject's eye, a display unit configured to display the fundus image captured by the image sensor, an enlargement unit configured to electrically enlarge the center region of the image captured by the image sensor on which the focus index is projected, an image synthesis unit configured to synthesize an output of the enlargement unit and an image output of a peripheral portion of the image captured by the image sensor, and an output unit configured to output an output of the image synthesis unit to the display unit.

Abstract: A massaging device having an applicator driven by a plurality of driving unit to move along two or more different axes to generate a combined massaging action to be applied to the user's body. A controller holds individual speed data each defining a speed at which each of the driving units reciprocates the applicator along each of the different axes, and to control the driving units to reciprocate the applicator in accordance with the associated speed data. The controller controls the speed of the applicator along one of the axes independently from the speed of the applicator moving along another of the axes. Accordingly, the applicator's movements along the different axes can be free from being interfered with each other even being subject to a load, thereby assuring to continue the combined massaging action.

Abstract: Genetic recombinant yeast expressing xylose reductase (XR), (wild-type or mutant) xylitol dehydrogenase (XDH), and xylulokinase (XK) and a method for highly efficiently producing ethanol from xylose using the yeast are provided. Pichia stipitis-derived XR and (wild-type or modified-type) XDH genes and Saccharomyces cerevisiae-derived XK gene were introduced via chromosomal integration. Thus, a genetic recombinant yeast having a high xylose fermentation rate, being capable of producing ethanol from xylose in high yields, and having high xylose fermentability in the presence of glucose, as well as a method using the recombinant yeast for highly efficiently producing ethanol from xylose or a saccharified solution from lignocellulose-based biomass are provided. Furthermore, a method for improving the xylose fermentability of the genetic recombinant yeast of the present invention via acclimatization treatment is also provided herein.

Abstract: A projection type image display apparatus for projecting optical fluxes from a light source onto a projection plane so as to display an image, provided with a reflection mirror arranged in such a manner that the reflection mirror interrupts an optical path of the projection light in the direct projection mode when the reflection mode is set and reflects the projection light to the backside of the projection type image display apparatus, and when the reflection mode is set, the projection type image display apparatus is tilted to the backside. The projection type image display apparatus is further provided with an adjustment leg arranged in a front portion of a bottom plane of the projection type image display apparatus and extended by a predetermined leg length, and thereby the projection type image display apparatus is tilted to the backside.

Abstract: The present invention relates to a process for producing ethanol by carrying out the following steps: performing enzymatic saccharification of pre-treated lignocellulosic biomass in a reaction system; performing ethanol fermentation of fermentable sugars obtained from the saccharified pre-treated lignocellulosic biomass in the same reaction zone as the enzymatic saccharification; distilling ethanol directly off from a reaction treatment liquid in the reaction zone, so as to recover the ethanol.

Abstract: An image forming apparatus includes: an intermediate transfer member onto which a image is primarily transferred from an image forming unit; a transfer unit to secondarily transfer the image from the intermediate transfer member to a media at a secondary-transfer position; a conveying unit configured to convey the media to the secondary-transfer position; and a conveying speed controller to control a speed of conveying the media. The conveying unit includes a first detector and a second detector downstream the first detector and upstream the secondary-transfer position. Based on a detection of the media by the first detector and a timing at which the image forming unit forms the image, the conveying speed controller changes the conveying speed until the second detector detects the media and changes, after the second detector detects the media, the conveying speed to a speed substantially the same as the intermediate transfer member speed.

Abstract: An ink container for containing ink to be supplied to an ink jet head to which the ink container is detachably mountable, includes an ink supply port for supplying the ink to the ink jet head; a air vent for fluid communication with ambience; a claw-like projection provided on a first side of the ink container; a latching lever provided on a second side opposite from the ink container, the latching lever being resiliently supported on the ink container and having a latching claw.

Abstract: A chair type stretching apparatus in this invention comprises a seat, a backrest, a flexible sheet, a tension means, and a controller. The flexible sheet is disposed on a top of the seat to extend an entire width of the seat. The tension means is provided on the seat and is configured to apply tensional force to the flexible sheet so as to move a center of the flexible sheet toward an upper direction of the seat. The controller is configured to control the tension means in order to move the center of the flexible sheet to a vertical direction. The tension means is provided on at least one width end of the seat in order to apply the tensional force along a width direction of the seat to the flexible sheet, whereby the tension means moves the center of the flexible sheet to the vertical direction.

Abstract: A CPU provides a fluorescent light detecting head with an irradiation instruction, in response to which the fluorescent light detecting head irradiates an ultraviolet ray for detection on an ultraviolet curing resin material to be examined. The CPU then acquires from the fluorescent light detecting head an intensity of a fluorescent light emitted from a photo polymerization initiator included in the ultraviolet curing resin material when receiving the ultraviolet ray for detection. The CPU retrieves a predetermined number of past data of the intensity of the fluorescent light from a storage unit and performs a (moving) average calculation processing to calculate the intensity of the fluorescent light at the current time. The CPU performs an estimation processing of a state of the ultraviolet curing resin material based on the calculated intensity of the fluorescent light.

Abstract: The chair type stretching apparatus in this invention comprises a seat, a backrest, a flexible sheet, a tension means, and a controller. The backrest has a width. The flexible sheet is disposed in front of the backrest to be movable between a normal position and a projected position. The flexible sheet in the normal position lies in a close relation with a front surface of the backrest. The flexible sheet in the projected position is spaced away from the front surface of the backrest. The tension means is provided on the backrest in order to apply tensional force to the flexible sheet so as to move a center of the flexible sheet toward a front direction of the backrest. The tension means is provided on at least one width end of the backrest in order to apply tensional force along a width direction of the backrest to the flexible sheet.

Abstract: An objective of the present invention is to provide safe viral vectors for gene therapy that can be introduced by a simple technique and sufficiently express genes of interest in vivo. The present inventors demonstrated that anti-tumor effect can be produced when a heparin-binding cytokine such as granulocyte macrophage colony stimulating factor (GM-CSF) and a chemokine such as TARC or RANTES are expressed in vivo using a viral vector based on a negative-strand RNA virus. The present inventors also demonstrated that the protective effect of the vector is superior to that of conventional adenovirus vectors. Thus, the present invention relates to negative-strand RNA viral vectors comprising a cytokine gene and a chemokine gene. The viral vectors are suitable for treatment of cancers, in particular, metastatic cancers. The present invention also provides compositions comprising such viral vectors, and gene therapy methods using them.

Abstract: An image forming apparatus includes at least one image forming section, which includes an image bearing body, a charging unit that charges an area on a surface of the image-bearing body, and a developing unit that supplies a developer material to the charged area to form a developer image on the image bearing body. The developer image is transferred from the image-bearing body onto a transporting unit. A detector detects a density of the developer image on the transporting unit. The controller performs a charging voltage correcting operation in which the controller provides a test charging voltage to the charging unit for forming the developer image, and then a normal charging voltage for normal printing is determined based on the density. The controller also performs a developer-supplying voltage correcting operation in which a developer-supplying voltage supplied to a developer supplying unit is determined based on the density.

Abstract: A radiator core support structure includes a radiator core support, a first heat exchanger and a second heat exchanger. The radiator core support has a lower radiator core support member. The first heat exchanger is arranged to face a front surface of the lower radiator core support member to cover a front surface thereof. The second heat exchanger is aligned with the first heat exchanger at a rear side thereof. The lower radiator core support member is formed with an airflow space that is formed inside of the lower radiator core support member to extend in a lateral direction of a vehicle. The airflow space is fluidically connected with an intake opening portion that is formed on the front surface of the lower radiator core support member at a position where the first heat exchanger faces the lower radiator core support member to cover, and also with an exhaust opening portion that is formed at on a partial portion of the lower radiator core support member.

Abstract: A fundus camera includes an illumination optical system including an illumination unit configured to illuminate a fundus of a subject's eye, a fundus observation photographing optical system including an image sensor and is configured to observe a fundus image, a focus index projection unit configured to project a focus index on a center region of a photographing portion of the fundus of the subject's eye, a display unit configured to display the fundus image captured by the image sensor, an enlargement unit configured to electrically enlarge the center region of the image captured by the image sensor on which the focus index is projected, an image synthesis unit configured to synthesize an output of the enlargement unit and an image output of a peripheral portion of the image captured by the image sensor, and an output unit configured to output an output of the image synthesis unit to the display unit.

Abstract: The present invention provides a novel cellulase-producing fungus, i.e. Acremonium cellulolyticus CF-2612 strain or a mutant thereof, which has an ability to produce cellulase so highly, a method for producing cellulase and/or hemicellulase by culturing said fungus, and a method for degrading or saccharifying biomass using the cellulase and/or hemicellulase.