Patents by Inventor Hiroyuki Kawai

Hiroyuki Kawai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230044329
    Abstract: The present invention relates to a separator for electrochemical elements, the separator comprising synthetic fibers and beaten cellulose fibers, wherein the beaten cellulose fibers have a Canadian standard freeness measured in accordance with JIS P 8121 of 50 ml or more and 500 ml or less, and in a fiber diameter distribution histogram of the beaten cellulose fibers, (1) the fibers have a maximum frequency peak in a range of 50 ?m or less, and (2) a ratio of the fibers having a fiber diameter of 20 ?m or less is 55% or more.
    Type: Application
    Filed: November 16, 2020
    Publication date: February 9, 2023
    Applicant: KURARAY CO., LTD.
    Inventors: Toshimichi KUSUNOKI, Tomohiro HAYAKAWA, Hiroyuki KAWAI, Jun ARAMAKI
  • Publication number: 20220411459
    Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
    Type: Application
    Filed: October 29, 2020
    Publication date: December 29, 2022
    Inventors: Xiaohui DU, John EKSTEROWICZ, Valeria R. FANTIN, Daqing SUN, Qiuping YE, Jared MOORE, Tatiana ZAVOROTINSKAYA, Brian R. BLANK, Yosup REW, Kejia WU, Liusheng ZHU, Johnny PHAM, Hiroyuki KAWAI, Chien-Hung YEH
  • Patent number: 11530236
    Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: December 20, 2022
    Assignee: ORIC PHARMACEUTICALS, INC.
    Inventors: Xiaohui Du, John Eksterowicz, Valeria R. Fantin, Daqing Sun, Qiuping Ye, Jared Moore, Tatiana Zavorotinskaya, Brian R. Blank, Yosup Rew, Kejia Wu, Liusheng Zhu, Johnny Pham, Hiroyuki Kawai, Chien-Hung Yeh
  • Publication number: 20220396569
    Abstract: Provided herein are GLP-1 receptor modulator compounds, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment, and/or diagnosis.
    Type: Application
    Filed: May 3, 2022
    Publication date: December 15, 2022
    Inventors: Xiaohui DU, Ray FUCINI, Xu RAN, Chien-Hung YEH, Xiang ZHOU, Subas Man SAKYA, Xiaofang WANG, Hiroyuki KAWAI, Craig LEE, Sumanta GARAI
  • Patent number: 11502307
    Abstract: A manufacturing method of a gas diffusion layer with a microporous layer includes coating a gas diffusion layer containing titanium with a precursor containing an electroconductive material, a water-repellent resin, and a polyethylene oxide, and heating the gas diffusion layer coated with the precursor to form a microporous layer containing the electroconductive material and the water-repellent resin on a surface of the gas diffusion layer. The heating atmosphere is a non-oxidation atmosphere where an oxygen concentration is no more than 0.3% by volume.
    Type: Grant
    Filed: September 16, 2020
    Date of Patent: November 15, 2022
    Assignees: Toyota Jidosha Kabushiki Kaisha, Toho Titanium Co., Ltd.
    Inventors: Hiroyuki Kawai, Yosuke Inoue
  • Publication number: 20220331343
    Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
    Type: Application
    Filed: July 15, 2020
    Publication date: October 20, 2022
    Inventors: Xiaohui DU, John EKSTEROWICZ, Valeria R. FANTIN, Daqing SUN, Qiuping YE, Jared MOORE, Tatiana ZAVOROTINSKAYA, Brian R. BLANK, Hiroyuki KAWAI, Chien-Hung YEH, Yosup REW, Kejia WU, Johnny PHAM
  • Publication number: 20220306822
    Abstract: To provide surface-modified fibers and reinforcing fibers that are capable of enhancing the adhesiveness to rubber, without the use of resorcinol and formaldehyde, and a molded article using the same. Surface-modified fibers include fibers, and a surface-modifying layer covering at least a part of a surface of the fibers, and have a solid surface zeta potential on a surface of the surface-modifying layer of ?20.0 to 30.0 mV.
    Type: Application
    Filed: November 10, 2020
    Publication date: September 29, 2022
    Applicant: KURARAY CO., LTD.
    Inventors: Eiichi ISHIDA, Daisuke KODA, Toru ASADA, Shinichi TAKEMOTO, Shuhei YORIMITSU, Hiroyuki KAWAI
  • Patent number: 11450922
    Abstract: To provide a separator which has a combination of a preferable air permeability enabling high prevention of internal short circuit and a high retention rate of such an air permeability in an electrolytic solution, and has more improved uniformity of the air permeability. A separator comprising a porous sheet and cellulose nanofibers, wherein the porous sheet comprises a binder component having the SP value of 11 to 16 (cal/cm3)1/2, and the porous sheet has the cellulose nanofibers at the inside and on the surface thereof, and wherein the cellulose nanofibers are combined with the porous sheet by fusion of the binder component.
    Type: Grant
    Filed: December 25, 2018
    Date of Patent: September 20, 2022
    Assignee: KURARAY CO., LTD.
    Inventors: Tomoki Sakai, Hiroyuki Kawai, Tomohiro Hayakawa, Toshimichi Kusunoki
  • Publication number: 20220220147
    Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
    Type: Application
    Filed: March 17, 2022
    Publication date: July 14, 2022
    Inventors: Xiaohui DU, John EKSTEROWICZ, Valeria R. FANTIN, Daqing SUN, Qiuping YE, Jared MOORE, Tatiana ZAVOROTINSKAYA, Brian R. BLANK, Yosup REW, Kejia WU, Liusheng ZHU, Johnny PHAM, Hiroyuki KAWAI
  • Patent number: 11325938
    Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: May 10, 2022
    Assignee: ORIC PHARMACEUTICALS, INC.
    Inventors: Xiaohui Du, John Eksterowicz, Valeria R. Fantin, Daqing Sun, Qiuping Ye, Jared Moore, Tatiana Zavorotinskaya, Brian R. Blank, Yosup Rew, Kejia Wu, Liusheng Zhu, Johnny Pham, Hiroyuki Kawai
  • Publication number: 20220079924
    Abstract: Described herein are glucocorticoid receptor modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
    Type: Application
    Filed: October 9, 2019
    Publication date: March 17, 2022
    Inventors: Xiaohui DU, John EKSTEROWICZ, Valeria R. FANTIN, Yosup REW, Daqing SUN, Qiuping YE, Haiying ZHOU, Hiroyuki KAWAI, Jared MOORE, Johnny PHAM, Kejia WU, Liusheng ZHU
  • Publication number: 20220069417
    Abstract: An alkaline battery separator containing an alkali resistant fiber and a binder, wherein the alkaline battery separator has two surfaces which are a surface A that is smoother comparing with the other surface and has an arithmetic mean surface roughness Ra (A), and a surface B that is rougher and has an arithmetic mean surface roughness Ra (B), the amount of the binder is 5 to 20% by mass based on the total mass of the separator, a value obtained by dividing the arithmetic mean surface roughness Ra (A) by the arithmetic mean surface roughness Ra (B) [Ra (A)/Ra (B)] is 0.700 or more and 0.980 or less, and the arithmetic mean surface roughness Ra (B) of the surface B is 3.0 ?m or more and 10 ?m or less.
    Type: Application
    Filed: December 13, 2019
    Publication date: March 3, 2022
    Applicant: KURARAY CO., LTD.
    Inventors: Tomohiro HAYAKAWA, Haruna MITSUMORI, Toshimichi KUSUNOKI, Hiroyuki KAWAI
  • Publication number: 20220049062
    Abstract: Provided are reinforcing fibers using an adhesive component not containing resorcinol and formaldehyde, which are excellent in adhesiveness to rubber and which can be efficiently produced while preventing contamination of production facilities, and a method for producing them, as well as a molded article using them. The reinforcing fibers have an adhesive component that contains a conjugated diene rubber and an oil, in at least a part of the surfaces thereof, wherein the vapor pressure at 20° C. of the oil is 10 Pa or less.
    Type: Application
    Filed: February 21, 2020
    Publication date: February 17, 2022
    Applicant: KURARAY CO., LTD.
    Inventors: Toru ASADA, Daisuke KODA, Shuhei YORIMITSU, Shinichi TAKEMOTO, Hiroyuki KAWAI
  • Patent number: 11130778
    Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: September 28, 2021
    Assignee: ORIC PHARMACEUTICALS, INC.
    Inventors: Xiaohui Du, John Eksterowicz, Valeria R. Fantin, Daqing Sun, Qiuping Ye, Jared Moore, Tatiana Zavorotinskaya, Brian R. Blank, Yosup Rew, Kejia Wu, Liusheng Zhu, Johnny Pham, Hiroyuki Kawai, Chien-Hung Yeh
  • Publication number: 20210222036
    Abstract: Reinforcing fibers containing hydrophilic fibers and an adhesive component, wherein at least a part of the surfaces of the hydrophilic fibers have the adhesive component, the adhesive component contains a modified conjugated diene rubber having a hydrogen-bonding functional group in a part of the conjugated diene rubber, and the number of the hydrogen-bonding functional groups in the modified conjugated diene rubber is 2 to 150 per molecule on average; a method for producing the reinforcing fibers; and a molded article using the reinforcing fibers.
    Type: Application
    Filed: May 28, 2019
    Publication date: July 22, 2021
    Applicant: KURARAY CO., LTD.
    Inventors: Toru ASADA, Daisuke KODA, Shinichi TAKEMOTO, Hiroyuki KAWAI, Shuhei YORIMITSU
  • Publication number: 20210214387
    Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
    Type: Application
    Filed: March 17, 2021
    Publication date: July 15, 2021
    Inventors: Xiaohui DU, John EKSTEROWICZ, Valeria R. FANTIN, Daqing SUN, Qiuping YE, Jared MOORE, Tatiana ZAVOROTINSKAYA, Brian R. BLANK, Yosup REW, Kejia WU, Liusheng ZHU, Johnny PHAM, Hiroyuki KAWAI, Chien-Hung YEH
  • Patent number: 11053610
    Abstract: A polyvinyl alcohol fiber that can easily be fibrillated at a low manufacture cost is provided. The readily fibrillative polyvinyl alcohol fiber contains a polyalkylene oxide in addition to a polyvinyl alcohol. A mass ratio of the polyalkylene oxide ranges from 3 to 40% relative to the total mass of the polyvinyl alcohol and the polyalkylene oxide. A method for manufacturing the polyvinyl alcohol fiber is also provided.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: July 6, 2021
    Assignee: KURARAY CO., LTD.
    Inventors: Masami Kawakami, Toshiaki Kobayashi, Hiroyuki Kawai, Shinichi Takemoto, Tomohiro Hayakawa
  • Publication number: 20210184224
    Abstract: A manufacturing method of a gas diffusion layer with a microporous layer includes coating a gas diffusion layer containing titanium with a precursor containing an electroconductive material, a water-repellent resin, and a polyethylene oxide, and heating the gas diffusion layer coated with the precursor to form a microporous layer containing the electroconductive material and the water-repellent resin on a surface of the gas diffusion layer. The heating atmosphere is a non-oxidation atmosphere where an oxygen concentration is no more than 0.3% by volume.
    Type: Application
    Filed: September 16, 2020
    Publication date: June 17, 2021
    Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, TOHO TITANIUM CO., LTD.
    Inventors: Hiroyuki Kawai, Yosuke INOUE
  • Patent number: 11028120
    Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: June 8, 2021
    Assignee: ORIC PHARMACEUTICALS, INC.
    Inventors: Xiaohui Du, John Eksterowicz, Valeria R. Fantin, Daqing Sun, Qiuping Ye, Jared Moore, Tatiana Zavorotinskaya, Brian R. Blank, Yosup Rew, Kejia Wu, Liusheng Zhu, Johnny Pham, Hiroyuki Kawai, Chien-Hung Yeh
  • Publication number: 20210130390
    Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
    Type: Application
    Filed: December 8, 2020
    Publication date: May 6, 2021
    Inventors: Xiaohui DU, John EKSTEROWICZ, Valeria R. FANTIN, Daqing SUN, Qiuping YE, Jared MOORE, Tatiana ZAVOROTINSKAYA, Brian R. BLANK, Yosup REW, Kejia WU, Liusheng ZHU, Johnny PHAM, Hiroyuki KAWAI, Chien-Hung YEH