Patents by Inventor Hiroyuki Nakahira
Hiroyuki Nakahira has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8658639Abstract: The present invention provides a compound of formula (I): wherein R1a is optionally substituted C1-6 alkyl, etc.; R1m is hydrogen atom, etc.; G1, G2, G3 and G4 are (i), etc. ((i) G1 is —N(R1b)—, G2 is —CO—, G3 is —C(R1c)(R1d)—, and G4 is oxygen, etc.); R1b is optionally substituted C1-6 alkyl, etc.; R1c and R1d are each independently optionally substituted C1-6 alkyl, etc.; R2 is optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are each independently a group: -A-B (A is a single bond, etc., B is hydrogen atom, etc.), etc.; n is 1, etc.; R5 is C1-4 alkoxycarbonyl, etc., or a pharmaceutically acceptable salt thereof, which is useful as a renin inhibitor.Type: GrantFiled: June 24, 2010Date of Patent: February 25, 2014Assignee: Dainippon Sumitomo Pharma Co., LtdInventors: Satoshi Suetsugu, Nobuhisa Fukuda, Yoshio Nakai, Takashi Takada, Yohei Ikuma, Hiroyuki Nakahira
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Patent number: 8389511Abstract: The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein R1a is halogen, etc.; R1m is H, etc.; G1 is —N(R1b)—, etc.; G2 is —CO—, etc.; G3 is —C(R1c)(R1d)—, etc.; G4 is oxygen, etc.; R1b is optionally substituted C1-6 alkyl, etc.; R1c and R1d are independently the same or different, H, etc.; R3 is H, optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are independently the same or different, and a group: -A-B (said A is single bond, etc., and said B is H, etc.), etc.; and n is 1, etc.Type: GrantFiled: December 19, 2008Date of Patent: March 5, 2013Assignee: Dainippon Sumitomo Pharma Co., Ltd.Inventors: Hiroyuki Nakahira, Yohei Ikuma, Nobuhisa Fukuda, Kozo Yoshida, Hidenori Kimura, Satoshi Suetsugu, Akira Fusano, Kiyoto Sawamura, Junya Ikeda, Yoshio Nakai
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Patent number: 8229047Abstract: An analog complex filter combines an in-phase signal and a quadrature signal to output first and second analog signals. An analog-to-digital converter converts the first and second analog signals into first and second digital signals. A first digital complex filter attenuates a component corresponding to the quadrature signal of the first digital signal and outputs the resultant signal as a third digital signal, and attenuates a component corresponding to the in-phase signal of the second digital signal and outputs the resultant signal as a fourth digital signal. An IQ imbalance correction circuit corrects a quadrature error and an amplitude error between the third and fourth digital signals.Type: GrantFiled: March 23, 2011Date of Patent: July 24, 2012Assignee: Panasonic CorporationInventors: Kouichi Nagano, Hiroyuki Nakahira, Takashi Yamamoto
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Publication number: 20120122773Abstract: The present invention provides a compound of formula (I): wherein R1a is optionally substituted C1-6 alkyl, etc.; R1m is hydrogen atom, etc.; G1, G2, G3 and G4 are (i), etc. ((i) G1 is —N(R1b)—, G2 is —CO—, G3 is —C(R1c)(R1d)—, and G4 is oxygen, etc.); R1b is optionally substituted C1-6 alkyl, etc.; R1c and R1d are each independently optionally substituted C1-6 alkyl, etc.; R2 is optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are each independently a group: -A-B (A is a single bond, etc., B is hydrogen atom, etc.), etc.; n is 1, etc.; R5 is C1-4 alkoxycarbonyl, etc., or a pharmaceutically acceptable salt thereof, which is useful as a renin inhibitor.Type: ApplicationFiled: June 24, 2010Publication date: May 17, 2012Applicant: DAINIPPON SUMITOMO PHARMA CO., LTD.Inventors: Satoshi Suetsugu, Nobuhisa Fukuda, Yoshio Nakai, Takashi Takada, Yohei Ikuma, Hiroyuki Nakahira
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Publication number: 20110190278Abstract: The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein R1a is halogen, etc.; R1m is H, etc.; G1 is —N(R1b)—, etc.; G2 is —CO—, etc.; G3 is —C(R1c)(R1d)—, etc.; G4 is oxygen, etc.; R1b is optionally substituted C1-6 alkyl, etc.; R1c and R1d are independently the same or different, H, etc.; R3 is H, optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are independently the same or different, and a group: -A-B (said A is single bond, etc., and said B is H, etc.), etc.; and n is 1, etc.Type: ApplicationFiled: December 19, 2008Publication date: August 4, 2011Inventors: Hiroyuki Nakahira, Yohei Ikuma, Nobuhisa Fukuda, Kozo Yoshida, Hidenori Kimura, Satoshi Suetsugu, Akira Fusano, Kiyoto Sawamura, Junya Ikeda, Yoshio Nakai
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Publication number: 20110170643Abstract: An analog complex filter combines an in-phase signal and a quadrature signal to output first and second analog signals. An analog-to-digital converter converts the first and second analog signals into first and second digital signals. A first digital complex filter attenuates a component corresponding to the quadrature signal of the first digital signal and outputs the resultant signal as a third digital signal, and attenuates a component corresponding to the in-phase signal of the second digital signal and outputs the resultant signal as a fourth digital signal. An IQ imbalance correction circuit corrects a quadrature error and an amplitude error between the third and fourth digital signals.Type: ApplicationFiled: March 23, 2011Publication date: July 14, 2011Applicant: PANASONIC CORPORATIONInventors: Kouichi NAGANO, Hiroyuki Nakahira, Takashi Yamamoto
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Publication number: 20110043693Abstract: A synchronization control circuit is provided with a first sampling means for sampling the envelope signal of the modulation signal at a first sampling timing, a second sampling means for sampling the envelope signal at a second sampling timing, a third sampling means for sampling the envelope signal at a third sampling timing, a phase error calculation means for calculating a phase error value indicating the amount of synchronization deviation between the modulation signal and the reference clock signal using the outputs of the first, second, and third sampling means, a delay control means for generating a delay control signal on the basis of the phase error value, and a delay generation means for generating the first, second, and third sampling timing by delaying the reference clock signal based on the delay control signal. Thereby, a synchronization control circuit that can reduce the circuit size required for obtaining the synchronization with relative to the Early/Late system can be provided.Type: ApplicationFiled: September 20, 2010Publication date: February 24, 2011Inventors: Hiroyuki Nakahira, Takashi Yamamoto, Kouji Okamoto, Akira Yamamoto
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Publication number: 20110009433Abstract: Disclosed is a compound composed of an easily-handleable crystal form and having storage stability that is practical enough to be used as an active ingredient of a pharmaceutical product. Specifically disclosed is 6-[(3R)-3-aminopiperidin-1-yl]-5-(2-chloro-5-fluorobenzyl)-1,3-dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione monohydro chloride hemihydrate.Type: ApplicationFiled: March 3, 2009Publication date: January 13, 2011Applicant: DAINIPPON SUMITOMO PHARMA CO., LTD.Inventors: Yasumitsu Sakurai, Yukihiro Nishio, Hiroyuki Nakahira
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Publication number: 20100056497Abstract: The present invention relates to a compound of the formula (I) being useful as a renin inhibitor, or a pharmaceutically acceptable salt thereof. wherein R1a is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R1b is an optionally substituted C1-6 alkoxy, etc.; R1c is a hydrogen atom, an optionally substituted C1-6 alkoxy, etc.; R2 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are independently the same or different, and each is a group of the formula: -A-B (in which A is a single bond, —(CH2)sO—, —(CH2)sN(R4)CO—, etc., B is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.), etc.; R4 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; s is 0, etc.; and n is 1, etc.Type: ApplicationFiled: January 30, 2008Publication date: March 4, 2010Applicant: DAINIPPON SUMITOMO PHARMA CO., LTDInventors: Hiroyuki Nakahira, Yohei Ikuma, Nobuhisa Fukuda, Tomonori Kobayashi, Shinya Tosaki
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Patent number: 7601728Abstract: Compounds represented by the general formula (I), prodrugs thereof, or pharmaceutically acceptable salts of both are provided as compounds which have high DPP-IV inhibiting activity and are improved in safety, toxicity and so on: (I) wherein the solid line and dotted line between A1 and A2 represents a double bond (A1?A2) or the like; A1 is C(R4) or the like; A2 is nitrogen atom or the like; R1 is hydrogen atom, optionally substituted alkly group, or the like; R2 is hydrogen atom, optionally substituted alkyl group, or the like; R3 is hydrogen atom, halogen atom, or the like; R4 is hydrogen atom, hydroxyl, halogen atom, or the like; and Y is a group represented by the general formula (A) or the like; (A) [wherein m1 is 0, 1, 2 or 3; and the group (A) may be freed from R6 or substituted with one or two R6's which are each independently halogen atom or the like.Type: GrantFiled: May 28, 2008Date of Patent: October 13, 2009Assignee: Dainippon Sumitomo Pharma Co., Ltd.Inventors: Hiroyuki Nakahira, Hidenori Kimura, Hitoshi Hochigai
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Publication number: 20090228538Abstract: Conventional multi-input multiplication and addition circuit having fixed multipliers has problems in that when the number of inputs increases, the number of partial product generator circuits would increase, and also the number of stages of the addition blocks would increase. In order to solve the above-described problems, it is constructed such that there are provided a multi-input encoder (11) which comprises a plurality of encoder parts (11a) each of which accomplishes a function corresponding to generation of a partial product in multiplication, and which also has a plurality of outputs which correspond to the multi-bit output of the respective encoder parts, and a multi-input adder circuit (12) which adds the plural outputs from the multi-input encoder (11).Type: ApplicationFiled: October 24, 2006Publication date: September 10, 2009Inventors: Kouichi Nagano, Hiroyuki Nakahira
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Publication number: 20090192129Abstract: Compounds represented by the general formula (I), prodrugs thereof, or pharmaceutically acceptable salts of both are provided as compounds which have high DPP-IV inhibiting activity and are improved in safety, toxicity and so on: (I) wherein the solid line and dotted line between A1 and A2 represents a double bond (A1=A2) or the like; A1 is C(R4) or the like; A2 is nitrogen atom or the like; R1 is hydrogen atom, optionally substituted alkly group, or the like; R2 is hydrogen atom, optionally substituted alkyl group, or the like; R3 is hydrogen atom, halogen atom, or the like; R4 is hydrogen atom, hydroxyl, halogen atom, or the like; and Y is a group represented by the general formula (A) or the like; (A) [wherein m1 is 0, 1, 2 or 3; and the group (A) may be freed from R6 or substituted with one or two R6's which are each independently halogen atom or the like.Type: ApplicationFiled: June 23, 2008Publication date: July 30, 2009Applicant: Dainippon Sumitomo Pharma Co., Ltd.Inventors: Hiroyuki Nakahira, Hidenori Kimura, Hitoshi Hochigai
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Publication number: 20090149483Abstract: Compounds represented by the general formula (I), prodrugs thereof, or pharmaceutically acceptable salts of both are provided as compounds which have high DPP-IV inhibiting activity and are improved in safety, toxicity and so on: (I) wherein the solid line and dotted line between A1 and A2 represents a double bond (A1=A2) or the like; A1 is C(R4) or the like; A2 is nitrogen atom or the like; R1 is hydrogen atom, optionally substituted alkly group, or the like; R2 is hydrogen atom, optionally substituted alkyl group, or the like; R3 is hydrogen atom, halogen atom, or the like; R4 is hydrogen atom, hydroxyl, halogen atom, or the like; and Y is a group represented by the general formula (A) or the like; (A) [wherein m1 is 0, 1, 2 or 3; and the group (A) may be freed from R6 or substituted with one or two R6's which are each independently halogen atom or the like.Type: ApplicationFiled: May 28, 2008Publication date: June 11, 2009Applicant: Dainippon Sumitomo Pharma Co., Ltd.Inventors: Hiroyuki Nakahira, Hidenori Kimura, Hitoshi Hochigai
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Patent number: 7523154Abstract: A write compensation circuit of a recording device includes a first delay portion driven by a first driving voltage, for receiving a clock signal, delaying the clock signal by a first delay time, and outputting the delayed clock signal, and a voltage supplying portion for supplying the first driving voltage to the first delay portion in such a manner that the first delay time is substantially equal to a clock period of the clock signal.Type: GrantFiled: August 8, 2005Date of Patent: April 21, 2009Assignee: Panasonic CorporationInventors: Hirokuni Fujiyama, Shiro Dosho, Hiroyuki Nakahira, Akira Yamamoto, Hiroki Mouri
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Publication number: 20080318922Abstract: Compounds represented by the general formula (I), prodrugs thereof, or pharmaceutically acceptable salts of both are provided as compounds which have high DPP-IV inhibiting activity and are improved in safety, toxicity and so on: (I) wherein the solid line and dotted line between A1 and A2 represents a double bond (A1=A2) or the like; A1 is C(R4) or the like; A2 is nitrogen atom or the like; R1 is hydrogen atom, optionally substituted alkyl group, or the like; R2 is hydrogen atom, optionally substituted alkyl group, or the like; R3 is hydrogen atom, halogen atom, or the like; R4 is hydrogen atom, hydroxyl, halogen atom, or the like; and Y is a group represented by the general formula (A) or the like; (A) [wherein m1 is 0, 1, 2 or 3; and the group (A) may be freed from R6 or substituted with one or two R6's which are each independently halogen atom or the like.Type: ApplicationFiled: December 21, 2005Publication date: December 25, 2008Applicant: Dainippon Sumitomo Pharma Co., Ltd.Inventors: Hiroyuki Nakahira, Hidenori Kimura, Hitoshi Hochigai
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Publication number: 20080123508Abstract: Conventional signal write correction circuits involve a problem that when n-phase clock is selected, the waveform may be distorted in high speed operation if the last-phase clock is selected. Two delay selection circuits (16a, 16b) select the odd-numbered edges and the even-numbered edges of a multipulse signal used for write correction. To select the edges, each of the delay selection circuits (16a, 16b) uses two enable signals. The exclusive OR of the outputs of the two delay selection circuits (16a, 16b) is taken to generate the timing of the multipulse signal.Type: ApplicationFiled: September 27, 2005Publication date: May 29, 2008Applicant: Matsushita Electric Industrial Co., Ltd.Inventors: Kouichi Nagano, Hiroyuki Nakahira
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Publication number: 20080101176Abstract: There has been an issue that the operation of a semiconductor circuit performing edge timing control cannot follow up in the multipulse generation process where high multiplication of speed progresses every year. A light strategy drive comprises a control register (22) storing timing edge information for generating the edge of a recording waveform signal, a PLL (23) generating a clock for generating the edge of a recording waveform signal, and a timing control circuit (24) for receiving timing edge information corresponding to the recording waveform signal from the control register (22) to output timing edge information having a predetermined amount of delay in parallel and compounding the edges based on the timing edge information outputted in parallel. Timing edge can be controlled with high precision even at the time of high speed operation, and a high precision multipulse can be generated.Type: ApplicationFiled: October 20, 2005Publication date: May 1, 2008Applicant: Matsushita Electric Industrial Co., Ltd.Inventors: Hiroki Mouri, Hiroyuki Nakahira, Kouichi Nagano
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Patent number: 7321620Abstract: The present invention provides an equalizer capable of accurately compensating for non-linearity of an input signal due to the asymmetry phenomenon, etc., during the disk production process. Two tap coefficients are provided in a coefficient unit. A comparator compares the value of a middle tap signal, which is a reference signal, and a threshold, so as to produce a selection signal based on the comparison result. The coefficient unit selects one of the two tap coefficients as the selected tap coefficient based on the selection signal, and a tap signal is multiplied with the selected tap coefficient. Thus, it is possible to adaptively switch the tap coefficients of the equalizer as a whole based on the value of the middle tap signal, which is the reference signal. Therefore, it is possible to accurately compensate for the non-linearity of the input signal.Type: GrantFiled: March 10, 2003Date of Patent: January 22, 2008Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Hiroyuki Nakahira, Koichi Nagano, Koji Okamoto, Akira Yamamoto
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Publication number: 20070296396Abstract: It is an object of the present invention to provide a phase difference measurement circuit that can accurately measure any phase difference without requiring a pulse signal having a pulse width that is sufficiently narrower than a pulse width to be measured, i.e., a very-high-speed pulse signal, which is required when measuring a phase difference of two signals with accuracy. The phase difference measurement circuit is provided with a waveform control circuit (103) which outputs one (102) of two input signals for each predetermined period, a comparison pulse generation circuit (104) which converts a phase difference between the input signal (101) and the input signal (102) that is outputted for each predetermined period into a phase difference pulse (1042) at each predetermined timing, a periodic signal generation circuit (105) which generates a periodic signal (1051) by accumulating the phase difference pulse (1042), and a measurement circuit (106) which measures the period of the periodic signal (1051).Type: ApplicationFiled: September 21, 2005Publication date: December 27, 2007Applicant: Matsushita Electric Industrial Co., Ltd.Inventor: Hiroyuki Nakahira
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Publication number: 20070105890Abstract: Disclosed is a compound represented by the formula (1) below which has a high DPP-IV inhibitory activity and is improved in safety, toxicity and the like. Also disclosed is a prodrug of such a compound and pharmaceutically acceptable salts of them. (In the formula, R1 represents a hydrogen atom, an optionally substituted alkyl group or the like; R2 and R3 independently represent a hydrogen atom, an optionally substituted alkyl group or the like; R4 and R5 independently represent a hydrogen atom, an optionally substituted alkyl group or the like: R6 represents a hydrogen atom, an optionally substituted aryl group or the like; and —Y—NH2, represents a group represented by the following formula (A): (wherein m is 0, 1 or 2; and R7 may not exist or one or two R7 may exist and independently represent an optionally substituted alkyl group or the like) or the like.Type: ApplicationFiled: November 24, 2004Publication date: May 10, 2007Inventors: Hiroyuki Nakahira, Hidenori Kimura, Tomonori Kobayashi, Hitoshi Hochigai