Abstract: The present invention aims to provide a novel compound capable of promoting cell proliferation in a cell culture (particularly three-dimensional cell culture). The hydrazide compound represented by the formula (I); wherein each symbol is as defined in DESCRIPTION, or a salt thereof, and a composition containing same can remarkably promote cell proliferation, sphere formation, cyst formation and/or organoid formation, and can also remarkably inhibit the activities of kinase such as LATS1, LATS2 and the like.

Abstract: The invention provides a method for producing a copolymer-containing varnish using a monomer having a specific unsaturated bond which does not cause the problem of gelation, a method for producing a composition, a method for producing a coating film, preferably compatible with biomaterials. The method for producing a copolymer-containing varnish comprises copolymerizing a monomer mixture containing compounds of formulas (1) and (2): wherein R1 represents a hydrogen atom or a methyl group, R2 represents an alkylene group having 1 to 6 carbon atoms, n represents an integer of 1 to 30, R11 represents a hydrogen atom or a methyl group, and A1 represents a monovalent organic group having a cationic property, in a solvent for polymerization, in the presence of a radical polymerization initiator, wherein % by mass of the compound of formula (1) in a phosphorus-containing compound contained in the monomer mixture is 70% by mass or more.

Abstract: A communication unit includes a detecting unit that detects a call instruction from a user as call instruction information; a searching unit that searches for a base station that is connectible, and collects base station information related to the base station; a memory unit that is used to store the base station information; a sending unit that sends connection request information, which indicates a connection request with respect to the base station, and call request information, which indicates a call request; a receiving unit that receives a response from the base station; and a communication control unit that controls connection with the base station.

Abstract: A vibration presentation device includes: an electrostatic or piezoelectric actuator; a first elastic body laminated on the actuator; a second elastic body laminated on the actuator on the opposite side to the first elastic body; an electrostatic or piezoelectric sensor disposed around the actuator; a cover that holds the first elastic body and the second elastic body such that the first elastic body and the second elastic body are compressed more than the actuator, the cover transmitting, when a pressing force in the laminate direction is applied to the cover from the outside, the pressing force to a sensor, and vibrating by vibration generated by the actuator; and a control device that drives the actuator when the sensor detects the pressing force.

Abstract: The invention provides a container for storing a biomaterial in which adhesion of a minute amount of a biomarker(s) contained in the biomaterial to the surface of the container for storage can be suppressed, and sample loss is reduced, while enabling analysis with accuracy and highly precision. In particular, the container for storing a biomaterial for reducing sample loss of a biomarker(s) contained in the biomaterial has a coating containing a copolymer which contains a recurring unit which contains a group represented by the following formula (a), a recurring unit which contains a group represented by the following formula (b), and optionally a recurring unit which contains a group represented by the following formula (c), on at least a part of the surface of the container: (wherein, Ua1, Ua2, Ub1, Ub2 and Ub3, An? and Rc are as defined herein).

Abstract: The invention provides a single-stranded oligonucleotide represented by the formula (I), wherein X and Y hybridize by a first nucleotide sequence portion and a second nucleotide sequence portion. X is composed of 7 to 100 nucleotides, contains at least one modified-nucleotide, and has a first nucleotide sequence capable of hybridizing with a second oligonucleotide. Y is composed of 4 to 100 nucleotides, enables hybridization with the above-mentioned first oligonucleotide, and has a second nucleotide sequence containing at least one ribonucleotide. At least one of the nucleotide sequences X, Xz and Y has an antisense sequence capable of hybridizing with a target RNA. At least one of L, Lx and Ly is a linking group that contains a non-nucleotide structure.

Abstract: The present invention aims to provide a novel kinase inhibitor and the like, and a therapeutic agent for a disease, a drug discovery screening method and the like utilizing such inhibitor and the like. The compound represented by the following formula (I) and a salt thereof can inhibit plural kinases including LATS (particularly LATS2) which is the major kinase in the Hippo signal transduction pathway. In addition, diseases or tissue damage associated with failure of cellular proliferation can be treated. Therefore, the present invention is beneficial, for example, in the research field of cell functions and diseases, in which the Hippo signal transduction pathway is involved, and the like. Furthermore, it is beneficial in the medical field for the treatment of such diseases and the like. wherein each symbol is as defined in the DESCRIPTION.

Abstract: Provided is an artificial nucleoside or artificial nucleotide capable of composing an artificial oligonucleotide having superior nuclease resistance. The artificial nucleoside or artificial nucleotide is a compound represented by formula (I) or a salt thereof (wherein, Bx represents a pyrimidine base or purine base, R1, R2, R3 and R4 represent hydrogen atoms, C1-6 alkyl groups or the like, Y represents NR5R6 (wherein, R5 and R6, independently of each other, represent a hydrogen atom, C1-6 alkyl group or the like, or R5 and R6, together with a nitrogen atom bound thereto, form a 3- to 11-membered nitrogen-containing non-aromatic heterocyclic group) or an optionally substituted C2-9 aromatic heterocyclic group, Z1 and Z2 represent hydrogen atoms, hydroxyl group-protecting groups, phosphorous-containing groups or the like, and n represents an integer of 1 to 3).

Abstract: The invention provides a cell culture vessel with a coating which inhibits adhesion of a peptide relating to cell proliferation on at least a part of the surface thereof. The coating desirably contains a copolymer containing a recurring unit which contains a group represented by formula (a) and a recurring unit which contains a group represented by formula (b). wherein Ua1, Ua2, Ua3, Ub1, Ub2, Ub3 and An? are as defined herein.

Abstract: The invention provides an antisense oligonucleotide reduced in toxicity. The antisense oligonucleotide has a central region, a 5?-side region and a 3?-side region, wherein the central region has a nucleotide (2?-3? bridged nucleotide) in which the 2?-position and the 3?-position of a sugar moiety are bridged and/or a non-bridged nucleotide (3?-position-modified non-bridged nucleotide) having a substituent at the 3?-position.

Abstract: The invention provides a single-stranded oligonucleotide represented by the formula [Xz-Lx]m-X-Y-[Ly-Yz]n, wherein X is represented by Xa-Xb, Xa is coupled with Y, and Xb and Y hybridize. Xa is composed of 1 to 40 nucleotides and contains at least one modified-nucleotide. Xb is composed of 4 to 40 nucleotides and contains at least one modified-nucleotide. Y is composed of 4 to 40 nucleotides and contains at least one ribonucleotide. Xz and Yz are composed of 5 to 40 nucleotides and contain at least one modified-nucleotide. Nucleotide sequences X, Xz and Yz have an antisense sequence capable of hybridizing with a target RNA. Lx and Ly are composed of 0 to 20 nucleotides.

Abstract: In a server device, an acquirer acquires history information of a target vehicle. A first derivation unit derives the degree of deterioration of parts of the target vehicle based on the history information acquired by the acquirer. The second derivation unit derives a warranty fee or a warranty condition for a warranty on the parts of the target vehicle according to the degree of deterioration derived by the first derivation unit.

Abstract: A server apparatus including circuitry configured to: acquire identification information of an assessment target vehicle from a terminal apparatus configured to provide information to an external server of an assessor; acquire history information of the assessment target vehicle based on the identification information; acquire pieces of history information of a plurality of vehicles; derive statistical information on the pieces of history information for each of vehicle models; and provide first provision information based on the history information of the assessment target vehicle to the terminal apparatus and provide second provision information based on the statistical information regarding a vehicle model of the assessment target vehicle to the terminal apparatus or the external server.

Abstract: A server apparatus includes circuitry configured to acquire identification information of a vehicle exhibited in an auction from an auction company, acquire history information of the exhibited vehicle based on the acquired identification information, derive provision information including a driving tendency of a past driver of the exhibited vehicle based on the acquired history information, and provide the derived provision information to the auction company.

Abstract: In a first server device, a first acquirer acquires identification information of a target vehicle. A second acquirer acquires vehicle information of the target vehicle including date and time information and maintenance information of the target vehicle including date and time information based on the identification information that has been acquired. A second derivation unit derives information to be provided, based on the vehicle information and the maintenance information that have been acquired. A provider provides the information to be provided that has been derived.

Abstract: A server apparatus includes circuitry configured to: acquire identification information of an assessment target vehicle from an external server of an assessor; acquire history information of the assessment target vehicle based on the identification information; acquire pieces of history information of a plurality of vehicles; derive statistical information on the pieces of history information for each of vehicle models; and provide first provision information based on the history information of the assessment target vehicle and second provision information based on the statistical information regarding a vehicle model of the assessment target vehicle, to the external server.

Abstract: A vibration presentation device includes: an electrostatic or piezoelectric actuator; a first elastic body laminated on the actuator; a second elastic body laminated on the actuator on the opposite side to the first elastic body; an electrostatic or piezoelectric sensor disposed around the actuator; a cover that holds the first elastic body and the second elastic body such that the first elastic body and the second elastic body are compressed more than the actuator, the cover transmitting, when a pressing force in the laminate direction is applied to the cover from the outside, the pressing force to a sensor, and vibrating by vibration generated by the actuator; and a control device that drives the actuator when the sensor detects the pressing force.

Abstract: An object of the present invention is to provide a cryopreservation vessel which has a coating that is capable of inhibiting the adhesion of cells or proteins and is resistant not only to aqueous solvents but also to organic solvents (for example, cryoprotectants, in particular, dimethyl sulfoxide).

Abstract: A semiconductor device includes an element drive unit configured to control a control terminal of a voltage-control type semiconductor element using the control signal as input, the element drive unit including a control circuit that is driven using the control signal as a power supply. The element drive unit includes: a first voltage divider circuit that is connected between an input terminal to which the control signal is input and a low potential side terminal connected to a low potential side terminal of the voltage-control type semiconductor element and is configured such that a first divided voltage is not greater than a set voltage; a semiconductor switching element configured to control the first voltage divider circuit; and a second voltage divider circuit for making the semiconductor switching element conductive. The first divided voltage is supplied to the control terminal of the voltage-control type semiconductor element and the control circuit.

Abstract: Provided is a single-stranded oligonucleotide that is capable of controlling a target gene with high efficiency and can be easily produced. The single-stranded oligonucleotide is represented by the formula X-L-Y wherein X and Y hybridize by a first nucleotide sequence portion and a second nucleotide sequence portion. X is composed of 7 to 100 nucleotides, contains at least one modified nucleotide, and has a first nucleotide sequence that is capable of hybridizing with a second oligonucleotide and contains at least four contiguous nucleotides recognized by RNase H. Y is composed of 4 to 100 nucleotides, and has a second nucleotide sequence that is capable of hybridizing with a second oligonucleotide and contains at least one ribonucleotide. At least one of nucleotide sequence X and nucleotide sequence Y has an antisense sequence capable of hybridizing with a target RNA. L is a group derived from a third oligonucleotide that is degraded under physiological conditions.