Abstract: Disclosed is a fusion protein containing a brain-derived neurotrophic factor (BDNF). The fusion protein is a fusion protein of BDNF and a specific range of human anti-transferrin receptor antibody, which makes BDNF administered into the blood able to pass through the blood-brain barrier.

Abstract: Disclosed are a means to convert compounds having physiological or pharmacological activity and unable to pass through the blood-brain barrier into a form that allows them to pass through the blood-brain barrier, and compounds converted thereby. The means is an anti-human transferrin receptor antibody and the converted compounds are molecular conjugates between physiologically active protein or pharmacologically active low-molecular-weight compounds and an anti-human transferrin receptor antibody.

Abstract: Disclosed are a novel anti-human transferrin receptor antibody comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 4, 5, 6 and 7 that can pass through the blood-brain barrier, a fusion protein comprising a protein necessary to be brought into function in the central nervous system and the antibody, and method of their production. The fusion protein comprises amino acid sequences of an anti-human transferrin receptor antibody that recognizes an amino acid sequence selected from the group consisting of SEQ ID NOs:1, 2, and 3, and of other protein that is bound thereto on the C-terminal side.

Abstract: Disclosed is a method for production of recombinant human DNase I which is of such high purity as may be directly used as a medical drug. The method includes the steps of; culturing recombinant DNase I-producing mammalian cells, subjecting a culture supernatant to an anion-exchange column chromatography, subjecting to a column chromatography employing as solid phase a material having affinity for phosphate group, subjecting to a cation-exchange column chromatography, and subjecting to a dye affinity column chromatography.

Abstract: Disclosed are novel anti transferrin receptor antibody that can pass through the blood-brain barrier, a fusion protein comprising a protein necessary to be brought into function in the central nervous system and the antibody, and method of their production. The fusion protein comprises amino acid sequences of an anti-human transferrin receptor antibody that recognizes an amino acid sequence selected from the group consisting of SEQ ID NOs: 1, 2, and 3, and of other protein that is bound thereto on the C- terminal side.

Abstract: Disclosed is an efficient method for production of aminopeptidase. The method comprises either transforming host bacteria with an aminopeptidase gene and with a neutral protease gene, or transforming some part of host bacteria with an aminopeptidase gene while transforming the other part of the host bacteria with a neutral protease gene, culturing in a medium the hose bacteria transformed with the aminopeptidase gene and with the neutral protease gene, or culturing a mixture of the host bacteria transformed with the aminopeptidase gene and the host bacteria transformed with the neutral protease gene, to let both the aminopeptidase and the neutral protease be expressed, and collecting the aminopeptidase thus produced from the culture mixture.

Abstract: Disclosed is an electronic device in which a transparent member, a decorative plate, and a solar panel are arranged in this order in a metallic device case from an end side of an opening of the device case, wherein the decorative plate has light permeability and has a light refractive part made of a concavo-convex portion on a surface of the decorative plate on the side of the solar panel, and a semi-transmissive reflective plate having both light permeability and light reflectivity is provided between the decorative plate and the solar panel, and the semi-transmissive reflective plate has metal-free vapor deposited film.

Abstract: Disclosed is an efficient method for production of aminopeptidase. The method comprises either transforming host bacteria with an aminopeptidase gene and with a neutral protease gene, or transforming some part of host bacteria with an aminopeptidase gene while transforming the other part of the host bacteria with a neutral protease gene, culturing in a medium the hose bacteria transformed with the aminopeptidase gene and with the neutral protease gene, or culturing a mixture of the host bacteria transformed with the aminopeptidase gene and the host bacteria transformed with the neutral protease gene, to let both the aminopeptidase and the neutral protease be expressed, and collecting the aminopeptidase thus produced from the culture mixture.

Abstract: A display device of the invention relates to a display device capable of three-dimensionally representing display on a liquid crystal display element without a hologram. The display device includes a liquid crystal display element and a lens panel. The liquid crystal display element includes a plurality of transparent electrodes on opposed surfaces of a pair of transparent substrates between which a liquid crystal is provided. The lens panel is disposed on the bottom surface side of the liquid crystal display element, and has a plurality of lens portions. The respective lens portions are disposed in regions where the transparent electrodes correspond to each other, and formed in the same shape as that of the respective regions. When displaying information, e.g., a number and a character, on the liquid crystal display element, the information itself can be represented three-dimensionally through the lens portions. Thus, highly decorative display can be obtained.

Abstract: A method of removing polymer adhered to a sidewall of an etched metal layer formed on a substrate, includes (a) dissolving the polymer by providing chemicals onto a surface of the substrate, and (b) rinsing the chemicals out of the substrate by providing pure water onto a surface of the substrate, wherein at least a part of the step (a) is carried out in oxidation atmosphere.

Abstract: A display device of the invention relates to a display device capable of three-dimensionally representing display on a liquid crystal display element without a hologram. The display device includes a liquid crystal display element and a lens panel. The liquid crystal display element includes a plurality of transparent electrodes on opposed surfaces of a pair of transparent substrates between which a liquid crystal is provided. The lens panel is disposed on the bottom surface side of the liquid crystal display element, and has a plurality of lens portions. The respective lens portions are disposed in regions where the transparent electrodes correspond to each other, and formed in the same shape as that of the respective regions. When displaying information, e.g., a number and a character, on the liquid crystal display element, the information itself can be represented three-dimensionally through the lens portions. Thus, highly decorative display can be obtained.

Abstract: A method of removing polymer adhered to a sidewall of an etched metal layer formed on a substrate, includes (a) dissolving the polymer by providing chemicals onto a surface of the substrate, and (b) rinsing the chemicals out of the substrate by providing pure water onto a surface of the substrate, wherein at least a part of the step (a) is carried out in oxidation atmosphere.

Abstract: An analog hand mechanism having hands in a watch case, and a plate-like luminescent device in the watch case, to illuminate the analog hand mechanism. A metallic layer or a metallic ink layer, for giving a feeling of metallic gloss by receiving illumination of light emitted from the surface of the luminescent device, is disposed on at least a side of the upper surface and the lower surface of the luminescent device.

Abstract: A translucent or transparent panel member which has a protrusion on the upper surface thereof is disposed on the upper surface of a plate-like luminescent member, to form a luminescent device. The luminescent device is manufactured by forming a protrusion on the upper surface of the panel member, providing a masking layer on the peripheral side surface and the upper surface, of the protrusion, forming a printed layer on the upper surface of the panel member, forming a printed layer on the upper surface of the protrusion after removing the masking layer from the protrusions, and arranging the panel member on the upper surface of the plate-like luminescent member. Such a plate-like luminescent device is arranged in the timepiece case to illuminate the analog hand mechanism. Such a plate-like luminescent device is also arranged in an electronic apparatus case to illuminate a liquid crystal display device of the electronic apparatus.

Abstract: The present invention relates to a display device which is used for various types of electronic apparatuses, e.g., an electronic watch, an electronic pocket notebook, and the like, and an electronic device. In the device or apparatus, a solar battery member having a lot of light passing openings for passing light is provided between a liquid crystal display member and a plate-like light emitting member disposed at a position lower than that of the liquid crystal display member.

Abstract: The watch and method of manufacture thereof includes an analog hand mechanism having hands in a watch case, and a plate-like luminescent device in the watch case, to illuminate the analog hand mechanism. A metallic layer or a metallic ink layer, for giving a feeling of metallic gloss by receiving illumination of light emitted from the surface of the luminescent device, is disposed on at least a side of the upper surface and the lower surface of the luminescent device.

Abstract: The present invention relates to a display device which is used for various types of electronic apparatuses, e.g., an electronic watch, an electronic pocket notebook, and the like, and an electronic device. In the device or apparatus, a solar battery member having a lot of light passing openings for passing light is provided between a liquid crystal display member and a plate-like light emitting member disposed at a position lower than that of the liquid crystal display member.

Abstract: An analog hand mechanism having hands in a watch case, and a plate-like luminescent device in the watch case, to illuminate the analog hand mechanism. A metallic layer or a metallic ink layer, for giving a feeling of metallic gloss by receiving illumination of light emitted from the surface of the luminescent device, is disposed on at least a side of the upper surface and the lower surface of the luminescent device.

Abstract: A thin antenna 20 having a satisfactory length, its making method, and an electronic device such as a wristwatch having such antenna. The antenna 20 is formed on a lower surface of a transparent plate 5 by printing an ornamental layer 22 on a lower surface of the transparent plate 5, forming a conductive ink layer 23 on the ornamental layer 22, and further forming plated metal layers 24, 25 on the conductive ink layer 23. Since the antenna 20 is thin as a whole, it may be provided within a small electronic device such as a wristwatch.

Abstract: This invention provides a structure of an apparatus case with a rotation member which can selectively restrict the rotation of a rotation bezel, rotatably mounted on a case body, in one or both of the forward and reverse directions. First and second rotation bezels are rotatably mounted on the case body, and a plate spring for restricting the rotation of the first rotation bezel is provided below the second rotation bezel. The plate spring is partly bent to rise it, thereby forming a hook. A rugged portion is formed on the lower surface of the first rotation bezel and an opening into which the hook is inserted is formed in the second rotation bezel. When the hook does not engage with the rugged portion, the first rotation bezel is freely rotatable. When the hook is inserted into the opening and is engaged with the rugged portion by rotating the second rotation bezel, the first rotation bezel is rotatable only in one of the forward and reverse directions.