Abstract: The present invention discloses a fractionation device used for proteins and/or peptides, which has any of the following features: 1) At least one portion of a substrate surface with which proteins or the like are made in contact has an amount of adsorption of bovine serum albumin of 50 ng/cm2 or less with respect to the substrate surface, when a bovine serum albumin solution is made in contact therewith. 2) At least one portion of a substrate surface with which proteins or the like are made in contact has an amount of adsorption of human ?2-microglobulin of 3 ng/cm2 or less with respect to the substrate surface, when a protein aqueous solution consisting of human ?2-microglobulin and bovine serum albumin is made in contact with the substrate surface.

Abstract: The following is disclosed: (1) a membrane fractionator including a filtration section, a concentrating section, a recovery section and a liquid feed pump, wherein a flow channel connecting the filtration section, concentrating section and recovery section to each other constitutes a closed circuitry; (2) a method of biocomponent separation, characterized in that a sample derived from biocomponents is fed into an antibody adsorption membrane separation system having an antibody capable of adsorbing specified protein internally accommodated in the middle or a rear part of a membrane separation system that in the absence of antibodies adsorbing proteins, exhibits a permeation ratio between human alpha1-microglobulin and human albumin of 1.

Abstract: The present invention relates to a packaged beverage containing a vegetable juice and/or a fruit juice, which provides a good feeling upon drinking and is excellent in desorption of precipitates from the container and re-dispersibility of them. The present invention relates to a packaged beverage containing a vegetable juice and/or a fruit juice, which contains the following components (A) to (D): (A) from 0.5 to 5 wt. % of a reduced molecular weight alginate, (B) from 0.5 to 5 wt. % of a degraded guar gum, (C) from 2 to 30 vol. % of an insoluble solid, and (D) 85 wt. % or greater of water; and satisfying the following conditions: (1) (A)+(B)?7 wt. %, (2) ((A)+(B))/(C)?6 (wt. %/vol. %), (3) pH after heat sterilization: from 3 to 5, and (4) viscosity after heat sterilization: 300 mPa·s or less.

Abstract: The present invention relates to a substrate including a compound having blood anticoagulation activity and a hydrophilic polymer compound, wherein the amount of elution of the compound having blood anticoagulation activity is less than 0.6 ?g/ml, and a manufacturing method of a substrate, wherein after a compound having blood anticoagulation activity and a hydrophilic compound brought in contact with a substrate are irradiated with radiation, unreacted components are washed out.

Abstract: Provided is a packaged beverage which can be discharged from the beverage container uniformly because precipitates containing effective components derived from vegetables or fruits can be dispersed quickly by mild shaking, though the formation of precipitates during long-term storage is allowed from the viewpoint of incorporating the effective components in the beverage without damaging them; is excellent in desorption and re-dispersibility of the precipitates; and is easy to drink. A packaged beverage contains a vegetable juice and/or a fruit juice, which contains the following components (A) to (D): (A) from 0.5 to 12 wt. % of polydextrose, (B) from 0.5 to 12 wt. % of (b1) indigestible dextrose or (b2) a degraded guar gum, (C) from 2 to 30 vol. % of an insoluble solid, and (D) 50 wt. % or greater of water; and satisfying the following conditions: (1) ((A)+(b1))/(C)?8 (wt. %/vol. %) or ((A)+(b2))/(C)?3.4 (wt. %/vol.

Abstract: A semiconductor device, including a first semiconductor layer of the first conductivity type having a plurality of trenches formed therein. A second semiconductor layer of the second conductivity type composed of an epitaxial layer is buried in the trenches in the first semiconductor layer. The trench has surface orientations including a surface orientation of a sidewall at an upper stage made slower in epitaxial growth speed than a surface orientation of a sidewall at a lower stage.

Abstract: In order to prevent a protein or peptide from adsorbing on a resin molding, the resin molding is brought into contact with an aqueous solution of a nonionic surfactant, and then the resin molding is irradiated with radiation rays and also a concentration of the surfactant in the aqueous solution is made to be 0.05 times to 500 times a critical micelle concentration of the surfactant at 25° C.

Abstract: The present invention provides hollow fiber membranes and a hollow fiber membrane module having the same included therein, which even when highly filled, can reduce the size of the module and simultaneously maintain a crimped state enabling a good flow of a dialysate or buffer in the module by an easy process, characterized in that the hollow fiber membrane is provided with a crimp having a wavelength of 15 to 25 mm and a crimp angle determined by the wavelength and an amplitude of 0.09 to 0.32.

Abstract: The present invention is characterized in that a base material comprises ester groups in the main chain and/or in the side chain(s), and comprises a polymer having hydrophobic groups. Particularly, the hydrophobic groups can be introduced by irradiating the base material with a radiation during the base material contacts an aqueous solution of a monohydric alcohol or an aqueous solution of an alcohol having not less than 2 hydroxyl groups, which is a monomer or a polymer, and which has one or more carbon atoms between the carbon atoms to each of which the hydroxyl group is bound in the monomer or in each monomer constituting the polymer.

Abstract: The present invention discloses a fractionation device used for proteins and/or peptides, which has any of the following features: 1) At least one portion of a substrate surface with which proteins or the like are made in contact has an amount of adsorption of bovine serum albumin of 50 ng/cm2 or less with respect to the substrate surface, when a bovine serum albumin solution is made in contact therewith. 2) At least one portion of a substrate surface with which proteins or the like are made in contact has an amount of adsorption of human ?2-microglobulin of 3 ng/cm2 or less with respect to the substrate surface, when a protein aqueous solution consisting of human ?2-microglobulin and bovine serum albumin is made in contact with the substrate surface.

Abstract: The present invention relates to a hydrophilic substance production method characterized in that polyvinylpyrrolidone-containing material wetted with an aqueous solution of a cationic polymer is treated with radiation. The invention makes it possible to produce material for blood treatment that prevents adsorption of blood platelets.

Abstract: The present invention relates to a hydrophilic substance production method characterized in that polyvinylpyrrolidone-containing material wetted with an aqueous solution of a cationic polymer is treated with radiation. The invention makes it possible to produce material for blood treatment that prevents adsorption of blood platelets.

Abstract: The following is disclosed: (1) a membrane fractionator including a filtration section, a concentrating section, a recovery section and a liquid feed pump, wherein a flow channel connecting the filtration section, concentrating section and recovery section to each other constitutes a closed circuitry; (2) a method of biocomponent separation, characterized in that a sample derived from biocomponents is fed into an antibody adsorption membrane separation system having an antibody capable of adsorbing specified protein internally accommodated in the middle or a rear part of a membrane separation system that in the absence of antibodies adsorbing proteins, exhibits a permeation ratio between human alpha1-microglobulin and human albumin of 1.

Abstract: A semiconductor device is provided with a substrate with a cavity inside, the substrate including a device formation area located above the cavity, a plurality of trenches formed in the substrate to communicate with the cavity and surround the device formation area, and an oxide film formed around each of the trenches to continuously surround the device formation area.

Abstract: The present invention provides a semiconductor device, which comprises a first semiconductor layer of the first conductivity type having a plurality of trenches formed therein. A second semiconductor layer of the second conductivity type composed of an epitaxial layer is buried in the trenches in the first semiconductor layer. The trench has surface orientations including a surface orientation of a sidewall at an upper stage made slower in epitaxial growth speed than a surface orientation of a sidewall at a lower stage.

Abstract: The invention provides a method of preparing a biological components-containing solution suitable for clinical proteome analysis by mass spectrometry, electrophoresis, liquid chromatography or the like and an apparatus for the method.

Abstract: A semiconductor device is provided with a substrate with a cavity inside, the substrate including a device formation area located above the cavity, a plurality of trenches formed in the substrate to communicate with the cavity and surround the device formation area, and an oxide film formed around each of the trenches to continuously surround the device formation area.

Abstract: The present invention provides a modified substrate including a hydrophilic polymer wherein the soluble hydrophilic polymer ratio is 15 weight percent or less and the number of adhered human blood platelets is 10/4.3×103 ?m2 or less. In addition, the present invention provides a method for producing a modified substrate including a step of irradiating the substrate with radiation while the substrate is brought into contact with an aqueous solution containing a hydrophilic polymer and an antioxidant. The present invention provides a modified substrate having high hematologic compatibility wherein the hydrophilic polymer is immobilized on the surface of the substrate, and a method for producing the same.

Abstract: The present invention relates to a hydrophilic substance production method characterized in that polyvinylpyrrolidone-containing material wetted with an aqueous solution of a cationic polymer is treated with radiation. The invention makes it possible to produce material for blood treatment that prevents adsorption of blood platelets.

Abstract: A blood processing apparatus which retains little residual blood is provided by a hollow fiber flux fixed to a housing by a partition, with the end portion opened. A blood port provided with a blood intake is attached to the opened end plane. The angle of the blood intake interior wall of the blood port has an inclination &thgr; of 1.5° or less as to the center axis of the blood port. The distance h of the interior face of the blood port and the flux-holding partition it faces is 0.08 D≦h≦0.13 D where Q represents the intersection between a hypothetical line which passes through the end portion P of the inner plane of the blood port and is orthogonal with the partition and a hypothetical extension line from the ceiling plane of the blood port, h represents the distance between the partition and the intersection Q, and D represents the diameter at the end portion of the inner plane of the blood port. The blood processing apparatus is used for blood purifying, dialysis, ultrafiltration, and the like.