Patents by Inventor Hisahiko Iwamoto

Hisahiko Iwamoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200399399
    Abstract: An object of the present invention is to provide a monoclonal antibody capable of sufficiently inhibiting a non-specific reaction caused by a non-specific factor, a non-specific reaction inhibitor containing the monoclonal antibody, and the like. The present invention relates to a monoclonal antibody against dog IgM produced by a hybridoma with accession No. NITE BP-02556.
    Type: Application
    Filed: February 21, 2019
    Publication date: December 24, 2020
    Applicant: TANAKA KIKINZOKU KOGYO K.K.
    Inventors: Keita SUZUKI, Hisahiko IWAMOTO
  • Publication number: 20200399672
    Abstract: The present invention relates to an immunochromatographic analysis device for detecting chikungunya virus, including a sample loading part, a labeling substance retaining part, a chromatographic medium part having a detection part, and an absorption part, wherein the labeling substance retaining part contains a first antibody against the chikungunya virus, including a specific heavy chain variable region and a specific light chain variable region or an antigen-binding fragment thereof, and the detection part contains a second antibody against the chikungunya virus, including a specific heavy chain variable region and the light chain variable region or an antigen-binding fragment thereof, and a third antibody against the chikungunya virus, including a specific heavy chain variable region and the light chain variable region or an antigen-binding fragment thereof.
    Type: Application
    Filed: February 8, 2019
    Publication date: December 24, 2020
    Inventors: Tatsuo SHIODA, Emi NAKAYAMA, Keita SUZUKI, Hisahiko IWAMOTO
  • Publication number: 20200378965
    Abstract: An object of the present invention is to provide a monoclonal antibody capable of sufficiently inhibiting a non-specific reaction caused by a non-specific factor, a non-specific reaction inhibitor containing the monoclonal antibody, and the like. The present invention relates to a monoclonal antibody against dog IgM produced by a hybridoma with accession No. NITE BP-02557.
    Type: Application
    Filed: February 21, 2019
    Publication date: December 3, 2020
    Applicant: TANAKA KIKINZOKU KOGYO K.K.
    Inventors: Keita SUZUKI, Hisahiko IWAMOTO
  • Patent number: 10852300
    Abstract: The present invention is intended to provide an immunochromatographic analyzer that enables a quick and easy, high-sensitivity detection of Mycoplasma pneumoniae, and thus more reliable and faster diagnosis of mycoplasma pneumonia. The immunochromatographic analyzer according to the present invention is for detecting Mycoplasma pneumoniae, and includes a sample adding section, a label-substance retaining section, a chromatographic medium section having a detection section, and an absorbing section. The label-substance retaining section and the detection section contain an antibody that strongly recognizes domain III of P30 protein of Mycoplasma pneumoniae consisting of the amino acid sequence of SEQ ID NO: 2.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: December 1, 2020
    Assignee: TANAKA KIKINZOKU KOGYO K.K.
    Inventors: Keita Suzuki, Hisahiko Iwamoto
  • Publication number: 20200225198
    Abstract: The invention relates to an immunochromatographic device which contains a nitrous acid compound and an organic acid or an organic acid derivative and which is for detecting a detection target in an analyte wherein a sample droplet-receiving member, a labeling substance-holding member, a chromatography medium member and an absorption member are arranged in a manner that a sample develops in this order and wherein a part containing the nitrous acid compound and a part containing the organic acid or the like are at upstream positions from the labeling substance-containing part, and the part containing the nitrous acid compound and the part containing the organic acid or the like are not substantially in contact with each other in the thickness direction.
    Type: Application
    Filed: March 3, 2017
    Publication date: July 16, 2020
    Inventors: Keita SUZUKI, Yuya KATO, Hisahiko IWAMOTO
  • Patent number: 10613086
    Abstract: Disclosed herein is an immunoassay method for detecting the detection target antigen in an analyte through extraction with an extraction agent. The method is characterized in that the detection is performed in the presence of a cyclic oligosaccharide. The method is also characterized in the use of an immunochromatography kit for detecting gram-positive bacteria in an analyte, and that is configured from an analyte dilution solution, a sample dropping part, an antigen extracting part, a labeling substance retaining part, an immunochromatography medium having a detection part, and an absorption part, and in which an organic acid is retained in the antigen extracting part. The immunochromatography kit contains a cyclic oligosaccharide and a nitrite compound by containing at least one of a cyclic oligosaccharide, a nitrite compound, and a mixture thereof in the analyte dilution solution and/or the sample dropping part.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: April 7, 2020
    Assignee: TANAKA KIKINZOKU KOGYO K.K.
    Inventors: Yuya Kato, Hisahiko Iwamoto
  • Patent number: 10591469
    Abstract: The present invention is intended to provide an immunoassay method that enables an immunoassay with high sensitivity at a high development rate without causing aggregation of insoluble carriers or non-specific reaction while improving test efficiency and reducing labor. The present invention relates to an immunoassay method that uses a test device, and the method includes: extracting an antigen of a detection target in an analyte with an extraction agent; and detecting the detection target with a detection reagent capable of binding the antigen. The extraction agent is a nitrous acid generated on the test device by a contact reaction between a nitrite salt and a heterocyclic compound having at least one skeleton selected from the group consisting of a cyclic ester, a cyclic amide, and a cyclic imide.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: March 17, 2020
    Assignee: TANAKA KIKINZOKU KOGYO K.K.
    Inventors: Yuya Kato, Hisahiko Iwamoto
  • Patent number: 10591470
    Abstract: An object is to provide an immunochromatographic analysis method capable of shortening the developing time without decreasing the detection sensitivity, and also capable of reducing the return of the liquid of a developed component, and a method for detecting a detection target contained in an analyte using an immunochromatographic analysis device including an absorption part composed of glass fiber, wherein the analyte and a labeling substance are developed in a chromatography medium part as a mobile phase in the presence of a nonionic surfactant, and the detection target is detected in a detection part is provided.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: March 17, 2020
    Assignee: TANAKA KIKINZOKU KOGYO K.K.
    Inventors: Hisahiko Iwamoto, Kazuyoshi Mochiduki, Daisuke Ito, Yuya Kato
  • Publication number: 20200057055
    Abstract: The invention relates to a nonspecific reaction inhibitor for an immunoassay containing an anti-mammal-derived IgM antibody in which, in ELISA assay, a ratio A2/A1 of an absorbance A2 which is obtained when a reaction of the anti-mammal-derived IgM antibody with cat IgM is carried out to an absorbance A1 which is obtained when a reaction of the anti-mammal-derived IgM antibody with dog IgM is carried out is 0.1 or more and 1.5 or less and in which, in ELISA assay, a ratio A3/A1 of an absorbance A3 which is obtained when a reaction of the anti-mammal-derived IgM antibody with human IgM is carried out to the absorbance A1 which is obtained when the reaction of the anti-mammal-derived IgM antibody with dog IgM is carried out is 0.5 or more, which can sufficiently inhibit a nonspecific reaction.
    Type: Application
    Filed: May 2, 2018
    Publication date: February 20, 2020
    Applicant: TANAKA KIKINZOKU KOGYO K.K.
    Inventors: Keita SUZUKI, Hisahiko IWAMOTO
  • Patent number: 10466237
    Abstract: An object is to provide an immunochromatography detection method and an immunochromatography kit in which a prozone phenomenon occurring in a sandwich method when using an analyte in which an antigen is present in a large excess amount is suppressed/excluded. The object was achieved by retaining a nonionic and hydrophilic surfactant having an HLB value of 13 to 18 in a sample addition part of an immunochromatography device, and also using a membrane having a fast flow speed as a membrane to be used for a chromatograph medium.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: November 5, 2019
    Assignee: TANAKA KIKINZOKU KOGYO K.K.
    Inventors: Keita Suzuki, Hisahiko Iwamoto
  • Publication number: 20190162727
    Abstract: The invention relates to an immunochromatography analysis device which enables simple and rapid diagnosis of Zika virus infection, and an object thereof is to provide an immunochromatography analysis device which can reduce a cross-reaction with a virus belonging to Flaviviridae other than Zika virus and which can specifically detect Zika virus. The invention relates to an immunochromatography analysis device for detecting Zika virus including a sample addition part, a labeling substance retaining part, a chromatography medium part having a detection part and an absorption part, wherein the labeling substance retaining part and the detection part each contain an antibody recognizing Zika virus nonstructural protein NS1 of SEQ ID NO: 1.
    Type: Application
    Filed: May 17, 2017
    Publication date: May 30, 2019
    Inventors: Keita SUZUKI, Hisahiko IWAMOTO
  • Publication number: 20190094218
    Abstract: An object of the present invention is to provide an immunochromatography analysis device for detecting gliadin in which a cross-reaction with an antigen in a food other than gliadin is inhibited and which has improved specificity and the invention relates to an immunochromatography analysis device for detecting gliadin including a sample addition part, a labeling substance retaining part, a chromatography medium part having a detection part and an absorption part, wherein the labeling substance retaining part and the detection part contains an antibody recognizing ?-gliadin.
    Type: Application
    Filed: February 22, 2017
    Publication date: March 28, 2019
    Inventors: Keita SUZUKI, Hiroko MOCHIZUKI, Hisahiko IWAMOTO
  • Patent number: 10234456
    Abstract: The present invention provides an easy-to-use and higher-sensitivity immunochromatography device for an RSV, the device using an antibody that binds specifically to F protein of the RSV in a determination region of a chromatography medium, a test kit by an immunochromatography method, and a method for detecting an RSV using these device and kit. The present invention relates to an immunochromatography device in which not only an antibody that binds specifically to F protein of an RSV but also an antibody that binds specifically to N protein of the RSV is solid-phased in a determination region of a chromatography medium. The present invention also relates to a test kit by an immunochromatography method, and a method for detecting an RSV using these device and kit.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: March 19, 2019
    Assignees: TANAKA KIKINZOKU KOGYO K.K., ALFERESA PHARMA CORPORATION
    Inventors: Mieko Kosaka, Hiromi Taguchi, Noboru Sakai, Daisuke Itoh, Hisahiko Iwamoto
  • Publication number: 20180372745
    Abstract: A method for specifically detecting Varicella-Zoster Virus (VZV) is provided by an immunochromatographic analysis device of the present invention which is an immunochromatographic analysis device for detecting Varicella-Zoster Virus (VZV) including a sample addition part, a labeling substance retaining part, a chromatographic medium part having a detection part, and an absorption part, wherein at least one of the labeling substance retaining part and the detection part contains an antibody which recognizes the amino acid sequence at positions 1 to 188 of glycoprotein E of the Varicella-Zoster Virus (VZVgE) composed of the amino acid sequence of SEQ ID NO: 1.
    Type: Application
    Filed: November 25, 2016
    Publication date: December 27, 2018
    Inventors: Keita SUZUKI, Hisahiko IWAMOTO, Hiroko MOCHIZUKI
  • Publication number: 20180284115
    Abstract: The present invention provides a chromatographic analysis device capable of increasing the detection sensitivity to a detection target while suppressing a nonspecific reaction. The present invention relates to a chromatographic analysis device which includes at least a chromatographic medium part (3) on which a detection part (4) for detecting a detection target contained in an analyte is supported, wherein the chromatographic medium part (3) has a structure in which a membrane is provided on a support, the average film thickness of the membrane is from 110 ?m to 130 ?m, and the developing flow rate of the membrane is from 30 to 45 sec/40 mm.
    Type: Application
    Filed: June 29, 2016
    Publication date: October 4, 2018
    Inventors: Keita SUZUKI, Hisahiko IWAMOTO
  • Publication number: 20180209970
    Abstract: The present invention is intended to provide an immunoassay method that enables an immunoassay with high sensitivity at a high development rate without causing aggregation of insoluble carriers or non-specific reaction while improving test efficiency and reducing labor. The present invention relates to an immunoassay method that uses a test device, and the method includes: extracting an antigen of a detection target in an analyte with an extraction agent; and detecting the detection target with a detection reagent capable of binding the antigen. The extraction agent is a nitrous acid generated on the test device by a contact reaction between a nitrite salt and a heterocyclic compound having at least one skeleton selected from the group consisting of a cyclic ester, a cyclic amide, and a cyclic imide.
    Type: Application
    Filed: July 15, 2016
    Publication date: July 26, 2018
    Inventors: Yuya KATO, Hisahiko IWAMOTO
  • Publication number: 20180172684
    Abstract: The present invention is intended to provide an immunochromatographic analyzer that enables a quick and easy, high-sensitivity detection of Mycoplasma pneumoniae, and thus more reliable and faster diagnosis of mycoplasma pneumonia. The immunochromatographic analyzer according to the present invention is for detecting Mycoplasma pneumoniae, and includes a sample adding section, a label-substance retaining section, a chromatographic medium section having a detection section, and an absorbing section. The label-substance retaining section and the detection section contain an antibody that strongly recognizes domain III of P30 protein of Mycoplasma pneumoniae consisting of the amino acid sequence of SEQ ID NO: 2.
    Type: Application
    Filed: June 1, 2016
    Publication date: June 21, 2018
    Inventors: Keita SUZUKI, Hisahiko IWAMOTO
  • Patent number: 9952207
    Abstract: When an immunochromatography reagent composition containing a nonionic surfactant, an N,N-bis(2-hydroxyethyl)glycine buffer, and casein is used as a specimen treatment solution or developing solution in detecting a detection object in a specimen according to an immunochromatographic method, an immunochromatography reagent composition which suppresses a non-specific reaction; does not cause aggregation of antibody-immobilized colloidal gold; and has a high developing rate, in comparison with conventional technology which detects a detection object by using an immunochromatographic device; and a high-performance and highly-sensitivity immunochromatographic method and a detection kit capable of rapid, simple and easy virus detection, which use the immunochromatography reagent composition are provided.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: April 24, 2018
    Assignee: TANAKA KIKINZOKU KOGYO K.K.
    Inventors: Hisahiko Iwamoto, Yuhiro Sakakibara, Satoru Nakajima
  • Patent number: 9863943
    Abstract: A method for detecting pork in heated food by immunochromatographic detection with high performance and high sensitivity without causing non-specific reaction. The method provides a convenient and high-accuracy detection method using a polyclonal antibody. When a target to be detected in a sample, pork-derived protein in heat-processed food, is detected by immunochromatography, a polyclonal antibody specifically recognizing a protein of approximately 23 kD (molecular weight: 23000) contained in heat-treated pork is used as at least one or both detection antibodies.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: January 9, 2018
    Assignee: TANAKA KIKINZOKU KOGYO K.K.
    Inventors: Yuhiro Sakakibara, Tatsuya Shuto, Hisahiko Iwamoto
  • Publication number: 20170131274
    Abstract: An object is to provide an immunochromatography detection method and an immunochromatography kit in which, a prozone phenomenon occurring in a sandwich method when using an analyte ire which an antigen is present in a large excess amount is suppressed/excluded. The object was achieved by retaining a nonionic and hydrophilic surfactant having an HLB value of 13 to 18 in a sample addition part of immunochromatography device, and also using a membrane having a fast flow speed as a membrane to be used for a chromatograph medium.
    Type: Application
    Filed: June 4, 2015
    Publication date: May 11, 2017
    Inventors: Keita SUZUKI, Hisahiko IWAMOTO