Patents by Inventor Hisahiko Iwamoto

Hisahiko Iwamoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170131274
    Abstract: An object is to provide an immunochromatography detection method and an immunochromatography kit in which, a prozone phenomenon occurring in a sandwich method when using an analyte ire which an antigen is present in a large excess amount is suppressed/excluded. The object was achieved by retaining a nonionic and hydrophilic surfactant having an HLB value of 13 to 18 in a sample addition part of immunochromatography device, and also using a membrane having a fast flow speed as a membrane to be used for a chromatograph medium.
    Type: Application
    Filed: June 4, 2015
    Publication date: May 11, 2017
    Inventors: Keita SUZUKI, Hisahiko IWAMOTO
  • Publication number: 20170023559
    Abstract: An object is to provide an immunochromatographic analysis method capable of shortening the developing time without decreasing the detection sensitivity, and also capable of reducing the return of the liquid of a developed component, and a method for detecting a detection target contained in an analyte using an immunochromatographic analysis device including an absorption part composed of glass fiber, wherein the analyte and a labeling substance are developed in a chromatography medium part as a mobile phase in the presence of a nonionic surfactant, and the detection target is detected in a detection part is provided.
    Type: Application
    Filed: March 31, 2015
    Publication date: January 26, 2017
    Inventors: Hisahiko IWAMOTO, Kazuyoshi MOCHIDUKI, Daisuke ITO, Yuya KATO
  • Publication number: 20160370368
    Abstract: Disclosed herein is an immunoassay method for detecting the detection target antigen in an analyte through extraction with an extraction agent. The method is characterized in that the detection is performed in the presence of a cyclic oligosaccharide. The method is also characterized in the use of an immunochromatography kit for detecting gram-positive bacteria in an analyte, and that is configured from an analyte dilution solution, a sample dropping part, an antigen extracting part, a labeling substance retaining part, an immunochromatography medium having a detection part, and an absorption part, and in which an organic acid is retained in the antigen extracting part. The immunochrornatography kit contains a cyclic oligosaccharide and a nitrite compound by containing at least one of a cyclic oligosaccharide, a nitrite compound, and a mixture thereof in the analyte dilution solution and/or the sample dropping part.
    Type: Application
    Filed: August 8, 2014
    Publication date: December 22, 2016
    Applicant: Tranaka Kikinzoku Kogyo K.K.
    Inventors: Yuya KATO, Hisahiko IWAMOTO
  • Publication number: 20160139125
    Abstract: The present invention provides an easy-to-use and higher-sensitivity immunochromatography device for an RSV, the device using an antibody that binds specifically to F protein of the RSV in a determination region of a chromatography medium, a test kit by an immunochromatography method, and a method for detecting an RSV using these device and kit. The present invention relates to an immunochromatography device in which not only an antibody that binds specifically to F protein of an RSV but also an antibody that binds specifically to N protein of the RSV is solid-phased in a determination region of a chromatography medium. The present invention also relates to a test kit by an immunochromatography method, and a method for detecting an RSV using these device and kit.
    Type: Application
    Filed: June 20, 2014
    Publication date: May 19, 2016
    Inventors: Mieko KOSAKA, Hiromi TAGUCHI, Noboru SAKAI, Daisuke ITOH, Hisahiko IWAMOTO
  • Publication number: 20150079581
    Abstract: The present invention is a test kit for rapidly diagnosing influenza according to the principles of immunochromatography, and the purpose thereof is to provide a test kit for the influenza A virus in which the sensitivity in detecting the influenza A virus is greater than in conventional test kits, and a determination of “positive” is obtained stably and with high precision at an earlier time during the onset of influenza symptoms. The present invention pertains to a kit for detecting influenza A virus, in which an antibody that is in solid phase in the chromatographic medium enters into an antigen-antibody reaction with native nuclear proteins of the influenza A virus, but in Western blots the antibody does not enter into antigen-antibody reactions with full-length nuclear proteins of the influenza A virus that have been separated using SDS-polyacrylamide gel electrophoresis.
    Type: Application
    Filed: March 29, 2013
    Publication date: March 19, 2015
    Inventors: Hisahiko Iwamoto, Hiroko Kawamoto, Shinichi Kato
  • Publication number: 20130137192
    Abstract: When an immunochromatography reagent composition containing a nonionic surfactant, an N,N-bis(2-hydroxyethyl)glycine buffer, and casein is used as a specimen treatment solution or developing solution in detecting a detection object in a specimen according to an immunochromatographic method, an immunochromatography reagent composition which suppresses a non-specific reaction; does not cause aggregation of antibody-immobilized colloidal gold; and has a high developing rate, in comparison with conventional technology which detects a detection object by using an immunochromatographic device; and a high-performance and highly-sensitivity immunochromatographic method and a detection kit capable of rapid, simple and easy virus detection, which use the immunochromatography reagent composition are provided.
    Type: Application
    Filed: August 3, 2011
    Publication date: May 30, 2013
    Applicant: TANAKA KIKINZOKU KOGYO K.K.
    Inventors: Hisahiko Iwamoto, Yuhiro Sakakibara, Satoru Nakajima
  • Publication number: 20120329073
    Abstract: [Object] To provide preparation of an ingredient derived from a specimen optimal for detecting by immunoassay pork in heated food with high performance and high sensitivity without causing non-specific reaction, a convenient and high-accuracy detection method using a polyclonal antibody obtained by using the ingredient, and a detection kit therefor. [Solution] When a target to be detected in a sample, pork-derived protein in heat-processed food, is detected by immunochromatography, a polyclonal antibody specifically recognizing a protein of approximately 23 kD (molecular weight: 23000) contained in heat-treated pork is used as at least one or both detection antibodies.
    Type: Application
    Filed: February 18, 2011
    Publication date: December 27, 2012
    Applicant: Tanaka Kikinzoku Kogyo K.K
    Inventors: Yuhiro Sakakibara, Tatsuya Shuto, Hisahiko Iwamoto
  • Publication number: 20120288962
    Abstract: [Object] To provide preparation of a detection antibody optimal for detecting by immunoassay raw pork in non-heated food with high performance and high sensitivity without causing non-specific reaction, a convenient and high-accuracy detection process using the detection antibody, and a detection kit therefor. [Solution] Provided is an immunochromatographic detection process of a protein derived from raw pork in non-heated food using an antibody specifically recognizing immunoglobulin G contained in raw pork in non-heated food as a detection antibody, an immunochromatography detection apparatus for conducting the detection process, and an immunochromatographic detection kit.
    Type: Application
    Filed: February 24, 2011
    Publication date: November 15, 2012
    Inventors: Yuhiro Sakakibara, Kazuyoshi Mochiduki, Yusuke Shibai, Hisahiko Iwamoto
  • Publication number: 20120028246
    Abstract: Disclosed by the invention are an immunoassay kit and an immunoassay method for detecting highly pathogenic avian influenza virus subtype H5N1 rapidly, conveniently and specifically. Also disclosed are an immunochromatographic detection kit and an immunochromatographic detection method for detecting the virus subtype H5N1 rapidly, conveniently and specifically. It is found that a monoclonal antibody 4G6 produced by using the virus subtype H5N1 as an immunogen does not react with the subtype H5N2 virus or a subtype H5N3 virus and reacts only with a subtype H5N1 virus specifically. It is also found that only an avian influenza virus subtype H5N1 can be detected specifically by an immunoassay utilizing the monoclonal antibody 4G6.
    Type: Application
    Filed: October 1, 2009
    Publication date: February 2, 2012
    Applicants: TANAKA KIKINZOKU KOGYO K.K., OSAKA UNIVERSITY
    Inventors: Takaaki Nakaya, Anariwa Du, Yusuke Shibai, Daisuke Itoh, Hisahiko Iwamoto
  • Publication number: 20110003320
    Abstract: An immunoassay method and a kit which comprises a combination of a test piece for immunochromatography and a developing solvent, by which a target substance is detected accurately in a short period of time while a preventing a nonspecific reaction. The above method is to immunologically measure the target substance by using the test piece for immunochromatography which comprises a membrane carrier having a first antibody or a first antigen capable of binding specifically to the target substance immobilized thereon, an insoluble carrier having a second antibody or a second antigen capable of binding specifically to the target substance immobilized thereon and a porous separation matrix capable of cell separation, wherein the porous separation matrix is impregnated with a surfactant in advance, and the insoluble carrier bound specifically to the target substance through the second antibody or the second antigen is developed with a developing solvent containing mannitol.
    Type: Application
    Filed: February 27, 2009
    Publication date: January 6, 2011
    Inventors: Daisuke Ito, Hisahiko Iwamoto, Kazuyoshi Mochiduki, Riku Tsuge, Yoshiko Kitani
  • Patent number: 7700531
    Abstract: There is provided a cleaning agent comprising a lactone represented by the following formula (1): wherein R1 is an alkylene group having 3 to 6 carbon atoms. The cleaning agent is useful for cleaning an organic electroluminescence material, photosensitive resin, liquid crystal or wax.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: April 20, 2010
    Assignee: Tokuyama Corporation
    Inventors: Hisahiko Iwamoto, Yoshifumi Inoue, Masaaki Nakashima, Masafumi Kasai
  • Publication number: 20080153732
    Abstract: There is provided a cleaning agent comprising a lactone represented by the following formula (1): wherein R1 is an alkylene group having 3 to 6 carbon atoms. The cleaning agent is useful for cleaning an organic electroluminescence material, photosensitive resin, liquid crystal or wax.
    Type: Application
    Filed: December 14, 2005
    Publication date: June 26, 2008
    Inventors: Hisahiko Iwamoto, Yoshifumi Inoue, Masaaki Nakashima, Masafumi Kasai
  • Publication number: 20080003692
    Abstract: An immunoassay for measuring the concentration of a ligand contained in a solid-phase complex prepared by immobilizing said ligand, comprising the steps (1) and (2) or the steps (1?) and (2?): (1) contacting a ligand, a first labeled substance binding specifically to said ligand and a second labeled substance binding specifically to said ligand with one another in a solvent to form a complex of said first labeled specifically binding substance, said ligand and said second labeled specifically binding substance; and (2) contacting said complex with carrier solid-phase particles supporting a substance binding specifically to the first marker of said first labeled specifically binding substance to form a solid-phase complex in which said complex and said carrier solid-phase particles are bound to each other by the first marker, or (1?) contacting a ligand, a first labeled substance binding specifically to said ligand and a second labeled substance binding specifically to said first labeled specifically binding s
    Type: Application
    Filed: April 1, 2005
    Publication date: January 3, 2008
    Inventors: Mitsuyasu Kawano, Hisahiko Iwamoto
  • Patent number: 6033862
    Abstract: There are provided: an immunological reagent for diagnosis of or the evaluation of the effect of a medicine for dialysis-related amyloidosis, which includes an antibody which reacts specifically with a carboxymethylated .alpha.-amino acid, a carboxymethylated protein, or a carboxymethylated peptide; or, an immunological reagent for diagnosis of or the evaluation of the effect of a medicine for diabetes mellitus and diabetes mellitus complications, which includes an antibody which reacts specifically with an N.sup..alpha. -carboxymethylated .alpha.-amino acid, an N.sup..alpha. -carboxymethylated protein, or an N.sup..alpha. -carboxymethylated peptide. Methods using the immunological reagents are provided: for determination of carboxymethylated hemoglobin as a marker for dialysis-related amyloidosis; or, for determination of N.sup..alpha. -carboxymethylated hemoglobin as a marker for diabetes mellitus or diabetes mellitus complications.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: March 7, 2000
    Assignee: Tokuyama Corporation
    Inventors: Noriko Matsuda, Hisahiko Iwamoto, Naohiro Hanyu
  • Patent number: 5811242
    Abstract: N.sup..epsilon. -carboxymethyllysine, a carboxymethylated protein in which at least part of the side-chain amino groups of amino acid residues constituting the protein is carboxymethylated, or a carboxymethylated peptide in which at least part of the side-chain amino groups of amino acid residues constituting the peptide is carboxymethylated can be used as a marker for diabetes mellitus or diabetes mellitus complications.
    Type: Grant
    Filed: October 22, 1996
    Date of Patent: September 22, 1998
    Assignee: Tokuyama Corporation
    Inventors: Hisahiko Iwamoto, Masato Okada