Patents by Inventor Hitoshi Endo
Hitoshi Endo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230220331Abstract: Provided is a temporary treatment medium for inhibiting embryo developmental arrest due to manipulation of an embryo or the like. A temporary treatment medium according to the present invention reduces damage to an in-vitro culture due to manipulation thereof, said in-vitro culture containing one of pluripotent stem cells, reproductive cells, a fertilized egg, and an embryo or any combination thereof. For this purpose, the temporary treatment medium contains a cytoskeleton regulator and/or an apoptosis inhibitor. The cytoskeleton regulator and/or the apoptosis inhibitor is preferably an Rho kinase inhibitor. Specifically, a Rock inhibitor can be used as the Rho kinase inhibitor. The Rock inhibitor is, for example, Y-27632. The temporary treatment medium is used for treating an in-vitro culture for a specific period before and/or after manipulation involving damage thereto.Type: ApplicationFiled: March 23, 2021Publication date: July 13, 2023Applicant: JICHI MEDICAL UNIVERSITYInventors: Yasumitsu NAGAO, Hitoshi ENDO, Eiji SAKASHITA, Tsukasa OHMORI, Morisada HAYAKAWA
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Patent number: 11441125Abstract: The present application relates to a method for reestablishing stem cells capable of forming chimeras, and cells obtained by the method. The method of the present invention is a technique for monocloning stem cells, for example, capable of forming chimeras from a heterogeneous cell population to obtain high-quality stem cells.Type: GrantFiled: October 2, 2015Date of Patent: September 13, 2022Assignee: JICHI MEDICAL UNIVERSITYInventors: Hitoshi Endo, Yasumitsu Nagao, Yutaka Hanazono, Kaoru Tominaga, Tsukasa Ohmori
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Publication number: 20170306296Abstract: The present application relates to a method for reestablishing stem cells capable of forming chimeras, and cells obtained by the method. The method of the present invention is a technique for monocloning stem cells, for example, capable of forming chimeras from a heterogeneous cell population to obtain high-quality stem cells.Type: ApplicationFiled: October 2, 2015Publication date: October 26, 2017Inventors: Hitoshi ENDO, Yasumitsu NAGAO, Yutaka HANAZONO, Kaoru TOMINAGA, Tsukasa OHMORI
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Patent number: 9077197Abstract: A battery residual amount measurement system including includes a current detection section that detects a current value of current discharged from a battery that is an object of measurement; a first storage section that stores reference undischargeable amounts that are determined in advance in accordance with ambient temperatures of the battery and current values of current discharged from the battery; and a calculating section that, when a discharging operation is carried out at the battery, acquires, from the first storage section, the reference undischargeable amount that corresponds to an ambient temperature of the battery and the current value detected by the current detection section, and calculates a battery residual amount on the basis of a undischargeable amount that is calculated and computed on the basis of the acquired reference undischargeable amount and a nominal battery capacity of the battery.Type: GrantFiled: December 31, 2012Date of Patent: July 7, 2015Assignee: LAPIS SEMICONDUCTOR CO., LTD.Inventors: Hitoshi Endo, Kentaro Kotota
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Patent number: 8465913Abstract: The present invention relates to a PHB2 gene regulator and a therapeutic drug for mitochondrial-function-related disease containing the same, for example.Type: GrantFiled: February 23, 2012Date of Patent: June 18, 2013Assignee: Jichi Medical UniversityInventors: Hitoshi Endo, Katsumi Kasashima
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Publication number: 20120202215Abstract: The present invention relates to a PHB2 gene regulator and a therapeutic drug for mitochondrial-function-related disease containing the same, for example.Type: ApplicationFiled: February 23, 2012Publication date: August 9, 2012Applicant: JICHI MEDICAL UNIVERSITYInventors: Hitoshi Endo, Katsumi Kasashima
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Publication number: 20120196298Abstract: The present invention relates to a PHB2 gene regulator and a therapeutic drug for mitochondrial-function-related disease containing the same, for example.Type: ApplicationFiled: February 23, 2012Publication date: August 2, 2012Applicant: JICHI MEDICAL UNIVERSITYInventors: Hitoshi Endo, Katsumi Kasashima
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Patent number: 8153362Abstract: The present invention relates to a PHB2 gene regulator and a therapeutic drug for mitochondrial-function-related disease containing the same, for example.Type: GrantFiled: November 16, 2006Date of Patent: April 10, 2012Assignee: Jichi Medical UniversityInventors: Hitoshi Endo, Katsumi Kasashima
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Publication number: 20100069462Abstract: The present invention relates to a PHB2 gene regulator and a therapeutic drug for mitochondrial-function-related disease containing the same, for example.Type: ApplicationFiled: November 16, 2006Publication date: March 18, 2010Applicant: JICHI MEDICAL UNIVERSITYInventors: Hitoshi Endo, Katsumi Kasashima
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Patent number: 7341740Abstract: The invention of the present application provides an isolated and purified human mitochondrial protein comprising the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4, which is a novel human protein promoting aggregation and fusion of mitochondria. The present invention also provides a polynucleotide encoding such a mitochondrial protein, antibody against such a mitochondrial protein, and a proteoliposome composed of such a mitochondrial protein and lipid. Mitochondrial proteins are useful for clarifying causes of mitochondrial diseases as well as for developing preventive and therapeutic methods thereof. Furthermore, antibodies and probes derived from genes encoding such proteins are potentially useful materials for diagnosis of condition of mitochondria in particular diseases. Furthermore, proteoliposomes provide measures for specific transfer of foreign genes or drugs targeted toward mitochondria.Type: GrantFiled: February 1, 2006Date of Patent: March 11, 2008Assignee: Japan Science and Technology CorporationInventor: Hitoshi Endo
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Patent number: 7319881Abstract: An example information delivering device includes a conversation relaying section for relaying conversation data between users of two or more information terminals. The conversation data corresponds to a conversation between the respective users of the information terminals. An additional information delivering section adds audio data such as advertisements and music to the conversation data so that the audio data and the conversation data can be reproduced simultaneously by one or more of the information terminals, while the conversation relaying section relays the conversation data between the information terminals. This allows the information delivering device to deliver additional information such as advertisements and music during a telephone conversation.Type: GrantFiled: April 9, 2003Date of Patent: January 15, 2008Assignee: Sharp Kabushiki KaishaInventor: Hitoshi Endo
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Patent number: 7181340Abstract: An engine control circuit includes a battery voltage detector, a signal supervisor, and a processor that operates in a normal mode and a power-down mode. The battery voltage detector senses the output voltage of a battery that supplies current to the engine, and asserts a detection signal when the voltage is below a predetermined value. The signal supervisor measures the length of time for which the detection signal remains asserted. The processor switches from the normal mode to the power-down mode when the measured length of time reaches a predetermined value. This scheme avoids loss of engine control when the battery voltage drops briefly and then recovers.Type: GrantFiled: June 14, 2005Date of Patent: February 20, 2007Assignee: Oki Electric Industry Co., Ltd.Inventor: Hitoshi Endo
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Publication number: 20060246125Abstract: The invention of the present application provides an isolated and purified human mitochondrial protein comprising the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4, which is a novel human protein promoting aggregation and fusion of mitochondria. The present invention also provides a polynucleotide encoding such a mitochondrial protein, antibody against such a mitochondrial protein, and a proteoliposome composed of such a mitochondrial protein and lipid. Mitochondrial proteins are useful for clarifying causes of mitochondrial diseases as well as for developing preventive and therapeutic methods thereof. Furthermore, antibodies and probes derived from genes encoding such proteins are potentially useful materials for diagnosis of condition of mitochondria in particular diseases. Furthermore, proteoliposomes provide measures for specific transfer of foreign genes or drugs targeted toward mitochondria.Type: ApplicationFiled: February 1, 2006Publication date: November 2, 2006Inventor: Hitoshi Endo
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Patent number: 7026452Abstract: The invention of the present application provides an isolated and purified human mitochondrial protein comprising the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4, which is a novel human protein promoting aggregation and fusion of mitochondria. The present invention also provides a polynucleotide encoding such a mitochondrial protein, antibody against such a mitochondrial protein, and a proteoliposome composed of such a mitochondrial protein and lipid. Mitochondrial proteins are useful for clarifying causes of mitochondrial diseases as well as for developing preventive and therapeutic methods thereof. Furthermore, antibodies and probes derived from genes encoding such proteins are potentially useful materials for diagnosis of condition of mitochondria in particular diseases. Furthermore, proteoliposomes provide measures for specific transfer of foreign genes or drugs targeted toward mitochondria.Type: GrantFiled: November 8, 2001Date of Patent: April 11, 2006Assignee: Japan Science and Technology CorporationInventor: Hitoshi Endo
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Patent number: 6988046Abstract: In a test method of a memory IC function, memory ICs of different types are prepared after a memory tester is prepared. The data related to each test method of these memory ICs is transmitted to the memory tester. Further, after a random number is generated, a test of a predetermined memory IC is executed in reply to the generated random number. It is checked whether the tests of all the memory ICs are finished or not: and the generation of the random number and the execution of the test are repeated when they are not finished, while the processing is finished when they are finished.Type: GrantFiled: September 24, 2003Date of Patent: January 17, 2006Assignee: Oki Electric Industry Co., Ltd.Inventors: Hitoshi Endo, Tomohiro Kamiyama
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Publication number: 20050283304Abstract: An engine control circuit includes a battery voltage detector, a signal supervisor, and a processor that operates in a normal mode and a power-down mode. The battery voltage detector senses the output voltage of a battery that supplies current to the engine, and asserts a detection signal when the voltage is below a predetermined value. The signal supervisor measures the length of time for which the detection signal remains asserted. The processor switches from the normal mode to the power-down mode when the measured length of time reaches a predetermined value. This scheme avoids loss of engine control when the battery voltage drops briefly and then recovers.Type: ApplicationFiled: June 14, 2005Publication date: December 22, 2005Applicant: Oki Electric Industry Co., Ltd.Inventor: Hitoshi Endo
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Publication number: 20050119256Abstract: 1. An aromatic amino acid derivative represented by the formula (I) or its pharmacologically acceptable salt: wherein, R1 is a hydrogen atom or an amino-protecting group, R2 is a halogen atom or an alkyl, aralkyl or aryl group, R3 is {circle over (1)} a hydrogen atom, {circle over (2)} an aroylamino group, {circle over (3)} a phenyl group substituted with lower alkyl, phenyl, phenoxy, etc. {circle over (4)} a naphthyl or tetrahydronaphthyl group optionally substituted with hydroxy, lower alkoxy or di(lower)alkylamino, {circle over (5)} an unsaturated mono-cyclic heterocyclic group containing N, O and/or S substituted with lower alkyl, phenyl, naphthyl or tetrahydroquinolyl, {circle over (6)} an unsaturated or partially saturated condensed heterocyclic group containing N, O and/or S, optionally substituted with oxo, carboxy, amino, lower alkyl, etc.; X is a halogen atom, an alkyl group or an alkoxy group; Y is oxygen atom or nitrogen atom; I is 0 or 1; m is 0, 1 or 2; n is an integer of 0-5.Type: ApplicationFiled: February 3, 2003Publication date: June 2, 2005Applicant: Hitoshi EndouInventors: Hitoshi Endo, Yoshikatsu Kanai, Kenji Tsujihara, Kunio Saito
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Publication number: 20050107648Abstract: The invention relates to a gas hydrate dewatering cooling and outputting apparatus which dewaters and solidifies gas hydrate slurry and takes out the solidified gas hydrate under ambient pressure. The apparatus comprises an output apparatus body 31 having a supply port 32 for the gas hydrate slurry on an upper part of a pressure vessel, a screw extruder 33 provided at a lower part inside the output apparatus body 31 and having a drain 37 and an outlet sealing device, and a cooling device 41 which cools the vicinity of the outlet 39 of the screw extruder 33. According to such a construction, slurry gas hydrate can be efficiently and continuously dewatered, cooled and solidified, and gas hydrate powder can be consolidated into blocks and taken out to the atmosphere.Type: ApplicationFiled: March 28, 2002Publication date: May 19, 2005Inventors: Takahiro Kimura, Shojiro Iwasaki, Katsuo Itoh, Satoru Uehara, Kozo Yoshikawa, Hiromitsu Nagayasu, Haruhiko Ema, Masaharu Watabe, Yuichi Kondo, Hisayoshi Fujita, Hitoshi Endo, Yoshihiro Kita
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Patent number: 6895519Abstract: A system LSI dynamically and speedily controls clocks of various frequencies as used in a wide range of operation modes from high-speed to low-speed operation modes, enabling user selection of a system of power consumption type most suitable. The system LSI includes a ROM that stores a clock control library for carrying out clock state transitions between ordinary operation modes; and a system control circuit having a register for carrying out clock state transitions between ordinary operation modes and special modes responsive to changes in value of the register, and also carrying out clock state transitions among ordinary operation modes responsive to the clock control library. Calling of the clock control library and changing of the register value are controlled by an application program. The main library of the clock control library is described and called using C language.Type: GrantFiled: September 23, 2002Date of Patent: May 17, 2005Assignee: Oki Electric Industry Co., Ltd.Inventor: Hitoshi Endo
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Publication number: 20040110934Abstract: The invention of the present application provides an isolated and purified human mitochondrial protein comprising the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4, which is a novel human protein promoting aggregation and fusion of mitochondria. The present invention also provides a polynucleotide encoding such a mitochondrial protein, antibody against such a mitochondrial protein, and a proteoliposome composed of such a mitochondrial protein and lipid. Mitochondrial proteins are useful for clarifying causes of mitochondrial diseases as well as for developing preventive and therapeutic methods thereof. Furthermore, antibodies and probes derived from genes encoding such proteins are potentially useful materials for diagnosis of condition of mitochondria in particular diseases. Furthermore, proteoliposomes provide measures for specific transfer of foreign genes or drugs targeted toward mitochondria.Type: ApplicationFiled: October 20, 2003Publication date: June 10, 2004Inventor: Hitoshi Endo