Abstract: Disclosed is a serum albumin-thioredoxin fusion body which is improved in the activity thereof and is stable with respect to the activity. The serum albumin-thioredoxin fusion body is provided, which is characterized in that the thioredoxin is a modified from in which at least a cysteine residue located at position 73 from the N-terminal of an amino acid sequence for the thioredoxin or located at a position equivalent to the position 73 is substituted by another amino acid residue. the modified serum albumin-thioredoxin fusion body is superior in the activity and stability thereof, is reduced in immunogenicity and has superior safety compared with a fusion body in which the thioredoxin is non-modified form.

Abstract: A particle size distribution measurement device includes a cell holding body 31 that holds a measurement cell 2 containing a measurement sample and a dispersion medium and a reference cell 6 containing a reference sample and is rotated by a motor 322, and a cell discrimination mechanism 7 that discriminates the cells 2, 6 passing through a predetermined rotation position by using a magnetic force or electrostatic capacitance.

Abstract: The present invention relates to a medicament for treating or preventing central nervous system disease whose cause is related to abnormal aggregation of proteins in the brain, which comprises as an active ingredient a compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are hydrogen, etc., R3 and R4 are hydrogen, C1-6 alkyl, etc., R5 is halogen, C1-6 alkyl, etc., R6 is hydrogen, halogen, etc., X is oxygen, etc., Y is carbon, etc., m and n are an integer of 0, 1, etc., r and s are 0, 1, 2, etc., Hy is pyridine ring, etc., which has an action of suppressing or reducing the accumulation of abnormal aggregation of proteins in the brain.

Abstract: The present invention provides a compound of the formula (1): wherein X, R1, R2, R3, R4, R5, R6, Y1, Y2, L, and m are as defined in the description, and a pharmaceutically acceptable salt thereof, which are useful as a vaccine adjuvant.

Abstract: An ID management unit allocates a first connection ID to a first vehicle in a first period and allocates the first connection ID to a second vehicle in a second period. A correction information acquisition unit connects to a distribution device using the first connection ID and receives correction information for the first vehicle from the distribution device in the first period. The correction information acquisition unit connects to the distribution device using the first connection ID and receives the correction information for the second vehicle from the distribution device in the second period. With the system, it is possible to reduce waste of connection IDs necessary for connection to the distribution device that distributes correction information for realizing high-accuracy positioning.

Abstract: The present invention provides an amine derivative having a DYRK-inhibiting activity and represented by formula (1): wherein A1, A2, L1, L2, X, Z, R1 and R4 are as defined in the description, or a pharmaceutically acceptable salt thereof.

Abstract: A video encoding method includes adding, to a bitstream, an indicator of whether a frame resolution is to be reduced. The method also includes, when said indicator indicates that the frame resolution is to be reduced, encoding a block of video data on a current video frame without motion compensation. A video decoding method includes receiving, as a syntax element from a bitstream, an indicator of whether a frame resolution is to be reduced. The method also includes, when said indicator indicates that the frame resolution is to be reduced, decoding a block of video data on a video frame without motion compensation.

Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X?Y—Z, X—Y?Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.

Abstract: A video encoding method includes (i) determining a current bit rate of a communication channel between a destination device and a source device that stores an input video frame, and (ii) generating a current reconstructed frame and an encoded bitstream at least in part via inter-frame coding of a current input video frame of a sequence of input video frames using a previously-generated reconstructed frame generated at least in part via inter-frame coding of a previous input video frame. The current reconstructed frame is a compressed version of the current input video frame. When both (i) a subsequent bit rate, determined after said inter-frame coding, is less than a threshold and (ii) the current bit rate exceeds the threshold, the method includes: (a) generating a downscaled reconstructed frame at least in part by downscaling the current reconstructed frame; and (b) appending the encoded bitstream with a bit sequence representing the downscaled reconstructed frame.

Abstract: A video encoding method includes (i) determining a current bit rate of a communication channel between a destination device and a source device that stores an input video frame, and (ii) generating a current reconstructed frame and an encoded bitstream at least in part via inter-frame coding of a current input video frame of a sequence of input video frames using a previously-generated reconstructed frame generated at least in part via inter-frame coding of a previous input video frame. The current reconstructed frame is a compressed version of the current input video frame. When both (i) a subsequent bit rate, determined after said inter-frame coding, is less than a threshold and (ii) the current bit rate exceeds the threshold, the method includes: (a) generating a downscaled reconstructed frame at least in part by downscaling the current reconstructed frame; and (b) appending the encoded bitstream with a bit sequence representing the downscaled reconstructed frame.

Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X=Y-Z, X-Y=Z, or X-Y-Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.

Abstract: An electronic device having slots into each of which a circuit board is inserted includes faceplates attached respectively to the circuit boards on the side of an extraction direction. The faceplates each include two handle portions that are disposed respectively at both ends of a main body in the width direction and that extend in the extraction direction. The handle portion of one of two faceplates adjacent in the width direction that is located closer to the other of the faceplates, and the handle portion of the other faceplate that is located closer to the one faceplate, have respective distal ends shifted from each other in a thickness direction.

Abstract: A motion-detection method includes for a motion-detection region in a first image of a scene, (i) determining a respective first pixel-value gradient at each of a plurality of pixel-coordinates within the motion-detection region, and (ii) determining a first feature-descriptor value as a function of the first pixel-value gradients and position vectors defined by the plurality of pixel-coordinates. The method also includes, for the motion-detection region in a second image of the scene, (i) determining a respective second pixel-value gradient at each of the plurality of pixel-coordinates, and (ii) determining a second feature-descriptor value as a function of the second pixel-value gradients and the position vectors. The method also includes determining a difference-parameter that varies in direct relationship to a difference between the first feature-descriptor value and the second feature-descriptor value.

Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X?Y—Z, X—Y?Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.

Abstract: An image processing apparatus that is capable of preventing an additional image from being arranged at a position that overruns from a displayed base image when a user carelessly designates such a position. The image processing apparatus including an instruction unit that instructs a composition position by a user's operation at which an additional image selected by a user is combined with a base image displayed on a display, and a controller that controls so as to combine the additional image with the base image at a composition position instructed by the instruction unit. When the composition position where at least a part of the additional image overruns from the base image is instructed by the instruction unit, the controller changes the composition position so that the additional image will fit into the base image and combines the additional image at the changed composition position.

Abstract: The present invention provides a compound of the formula (1): wherein X, R1, R2, R3, R4, R5, R6, Y1, Y2, L, and m are as defined in the description, and a pharmaceutically acceptable salt thereof, which are useful as a vaccine adjuvant.

Abstract: An on-demand predefined route automated driving vehicle comprising a vehicle-mounted controller configured to cause the vehicle to run toward a planned riding location such that the vehicle automatically runs along a predefined route which is determined in advance and in a runnable area. The vehicle-mounted controller communicates with an on-demand predefined route automated driving vehicle fleet controller. Based on route information and an in-advance vehicle dispatch command signal received from the vehicle fleet controller, the vehicle-mounted controller controls the vehicle so that the vehicle runs toward an anticipated riding location based on the in-advance vehicle dispatch command signal.

Abstract: An on-demand predefined route automated driving vehicle automatically travels, regardless of whether a passenger is on board, along a annular-connecting predefined route which has a annular predefined route and a connecting predefined route.

Abstract: In a small massaging tool, numbness in fingers, strangeness, fatigue, and other discomfort, which are caused due to vibration of a grip part that is caused by vibration of a vibration motor, are eliminated to maintain comfortable use and vibration noise is reduced. The massaging tool includes a head unit 30 including vibrating parts 50 and 52 and a vibration motor 40 that vibrates the vibrating parts, a battery that is a power source of the vibration motor, and a body 10 having the vibration motor and the battery accommodated therein and having the grip part, wherein the head unit is supported in a floating state with respect to the body by a cushioning member made of gel-like resin and fixed to the body.