Abstract: The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody ? light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.

Abstract: There are provided an apparatus and a method of manufacturing the apparatus. The apparatus includes: a plate-shaped base; a cover plate; and a curable resin adhering the plate-shaped base and the cover plate together. At least one of the plate-shaped base and the cover plate includes a light-shielding member covering a peripheral part of the at least one of the plate-shaped base and the cover plate. In an area which is shielded by the light-shielding member, a part of the curable resin at a side of an inner edge of the light shielding member is lower in one of an elastic modulus, a curing degree, and an adhesion strength than another part of the curable resin at a side of an outer edge of the light shielding member.

Abstract: A connection assembly includes a sensor substrate, a layer substrate coupled to the sensor substrate so as to face an upper surface of the sensor substrate, and a wire connected between the sensor substrate and the layer substrate. The sensor substrate includes first and second projections provide on the upper surface of the sensor substrate and extending in an extension direction along the upper surface of the sensor substrate. The wire has a first end sandwiched between the layer substrate and the first projection, and a second end sandwiched between the layer substrate and the second projection. The connection assembly provides reliable connection.

Abstract: A wiring-buried glass substrate includes a glass substrate and a first wiring. The glass substrate includes a first surface, a second surface perpendicular to the first surface, and a third surface facing the first surface. The first wiring includes a first pillar portion and a first beam portion. The first pillar portion extends in a first direction perpendicular to the first surface of the glass substrate. The first beam portion is connected to a first surface of the first pillar portion and extends to a second direction perpendicular to a second surface of the glass substrate. The first wiring is buried in the glass substrate. The first surface of the first beam portion is exposed from a third surface of the glass substrate.

Abstract: By a QTL analysis and so forth using 4-HPPD inhibitor-susceptible rice and 4-HPPD inhibitor-resistant rice, a hypothetical gene (HIS1 gene) of an iron/ascorbate-dependent oxidoreductase gene located on a short arm of chromosome 2 of rice has been identified as a 4-HPPD inhibitor-resistance gene. Further, it has also been revealed that a homologous gene (HSL1 gene) of the HIS1 gene is located on chromosome 6 of rice. Furthermore, it has been found out that utilizations of these genes make it possible to efficiently produce a plant having increased resistance or susceptibility to a 4-HPPD inhibitor and to efficiently determine whether a plant has resistance or susceptibility to a 4-HPPD inhibitor.

Abstract: The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody ? light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.

Abstract: A display device includes a display panel disposed in front of a chassis, a front surface plate disposed in front of the display panel and holding the display panel in a suspended state via an optical elasticity resin layer, and a bracket fixed to a side face of the chassis and bonded to a rear surface of the front surface plate by an adhesive portion. The bracket includes a side wall portion that is fixed to the side face of the chassis, rises from rear to front, and extends along a side of the front surface plate, and a beam portion in front of the side wall portion. The beam portion extends along the side of the front surface plate, and protrudes along the rear surface of the front surface plate, from the side wall portion to a space between the display panel and the front surface plate.

Abstract: To provide a tuning-fork type quartz crystal vibrating element capable of decreasing changes in oscillation frequencies before and after being mounted. The tuning fork element includes: a base part; a pair of vibration arm parts extended in a same longitudinal direction from the base part; and respective weight parts located at the tips of the vibration arm parts. Provided that, on a plan view, a measurement in the longitudinal direction is length, and a measurement in a direction perpendicular to the longitudinal direction is width, Expression (1) ?100?x?100, ?30?y?30, and ?0.3x?15?y??0.3x+15 applies, where a difference between the length of the vibration arm parts together with the respective weight parts and the reference value x0 is x, a difference between the width of the weight parts and the reference value y0 is y, and the unit is ?m.

Abstract: There are provided an apparatus and a method of manufacturing the apparatus. The apparatus includes: a plate-shaped base; a cover plate; and a curable resin adhering the plate-shaped base and the cover plate together. At least one of the plate-shaped base and the cover plate includes a light-shielding member covering a peripheral part of the at least one of the plate-shaped base and the cover plate. In an area which is shielded by the light-shielding member, a part of the curable resin at a side of an inner edge of the light shielding member is lower in one of an elastic modulus, a curing degree, and an adhesion strength than another part of the curable resin at a side of an outer edge of the light shielding member.

Abstract: To provide an antibody against FGF23 and a pharmaceutical composition such as a preventive or therapeutic agent which can prevent or treat by suppressing an action of FGF23 by using the antibody. An antibody or its functional fragment against human FGF23 produced by hybridoma C10 (Accession No. FERM BP-10772).

Abstract: There are provided an apparatus and a method of manufacturing the apparatus. The apparatus includes: a plate-shaped base; a cover plate; and a curable resin adhering the plate-shaped base and the cover plate together. At least one of the plate-shaped base and the cover plate includes a light-shielding member covering a peripheral part of the at least one of the plate-shaped base and the cover plate. In an area which is shielded by the light-shielding member, a part of the curable resin at a side of an inner edge of the light shielding member is lower in one of an elastic modulus, a curing degree, and an adhesion strength than another part of the curable resin at a side of an outer edge of the light shielding member.

Abstract: To provide an antibody against FGF23 and a pharmaceutical composition such as a preventive or therapeutic agent which can prevent or treat by suppressing an action of FGF23 by using the antibody. An antibody or its functional fragment against human FGF23 produced by hybridoma C10 (Accession No. FERM BP-10772).

Abstract: A display device includes: a display panel including a display region where a user image is displayed and a measurement region; a transparent front panel disposed on a front side of the display panel; a bonding layer provided between the display panel and the front panel to avoid a first space and cover the display region, and bonding the display panel and the front panel together; and a component placed in the first space, the component including a detector configured to detect a physical property of the measurement region in the first space and flexible print circuits with the detector mounted thereon, and the flexible print circuits extending from the first space to an outside of an interspace between the display panel and the front panel.

Abstract: An acceleration sensor includes a weight portion having a recess section and a solid section, beam portions, a movable electrode provided on the opposite surface of the weight portion from an open surface of the recess section to extend over the recess section and the solid section, a first fixed electrode arranged at the opposite side of the movable electrode from the recess section, and a second fixed electrode arranged at the opposite side of the movable electrode from the solid section. The acceleration sensor detects acceleration using a change in capacitance between the movable electrode and the fixed electrodes caused by rotation of the weight portion. The beam portions are shifted toward the recess section such that an angle between a perpendicular line extending from a gravity center position of the weight portion to the rotation axis and a surface of the movable electrode becomes equal to 45 degrees.

Abstract: The invention provides antibodies that specifically bind to OX40 (CD134), referred to as OX40 antibodies, anti-OX40 or anti-OX40 antibodies. Invention antibodies that specifically bind to OX40 include mammalian (human, primate, etc.), humanized and chimeric anti-OX40 antibodies. Invention antibodies and antibody subsequences (fragments) that specifically bind to OX40 include purified and isolated antibodies, as well as pharmaceutical formulations thereof, are useful in various methods including treatment, screening and detection methods.

Abstract: An acceleration sensor includes a CV conversion circuit, an AD conversion circuit, and first and second registers. The CV conversion circuit outputs a voltage corresponding to the capacitance changes between a movable electrode and each of first and second fixed electrodes disposed to face the movable electrode. The AD conversion circuit is connected to the CV conversion circuit and has a first detection range and a second detection range. The first register is connected to the AD conversion circuit and holds a first value. The second register is connected to the AD conversion circuit and holds a second value. The first value contains information about an acceleration in the first detection range, and the second value contains information about an acceleration in the second detection range. The first and second values indicate accelerations in the same direction.

Abstract: A connection assembly includes a sensor substrate, a layer substrate coupled to the sensor substrate so as to face an upper surface of the sensor substrate, and a wire connected between the sensor substrate and the layer substrate. The sensor substrate includes first and second projections provide on the upper surface of the sensor substrate and extending in an extension direction along the upper surface of the sensor substrate. The wire has a first end sandwiched between the layer substrate and the first projection, and a second end sandwiched between the layer substrate and the second projection. The connection assembly provides reliable connection.

Abstract: A wiring-buried glass substrate includes a glass substrate and a first wiring. The glass substrate includes a first surface, a second surface perpendicular to the first surface, and a third surface facing the first surface. The first wiring includes a first pillar portion and a first beam portion. The first pillar portion extends in a first direction perpendicular to the first surface of the glass substrate. The first beam portion is connected to a first surface of the first pillar portion and extends to a second direction perpendicular to a second surface of the glass substrate. The first wiring is buried in the glass substrate. The first surface of the first beam portion is exposed from a third surface of the glass substrate.

Abstract: An illumination apparatus includes: a light-guiding portion including a light-introducing opening through which light is introduced from a light-emitting portion of an image pickup apparatus, a reflective surface that reflects light introduced from the light-introducing opening toward an image pickup optical axis of the image pickup apparatus, and a diffusion portion that diffuses the light reflected by the reflective surface toward an object as diffused light; and a reflective body including an opening portion allowing an image pickup opening of the image pickup apparatus to be exposed, and a reflective portion provided around the opening portion and including a reflective surface formed to expand from the opening portion toward the object, wherein the diffusion portion is disposed at a part of the reflective portion and the reflective body includes a wall portion extending to the object side at a boundary between the opening portion and the diffusion portion.

Abstract: The invention provides antibodies that specifically bind to OX40 (CD134), referred to as OX40 antibodies, anti-OX40 or anti-OX40 antibodies. Invention antibodies that specifically bind to OX40 include mammalian (human, primate, etc.), humanized and chimeric anti-OX40 antibodies. Invention antibodies and antibody subsequences (fragments) that specifically bind to OX40 include purified and isolated antibodies, as well as pharmaceutical formulations thereof, are useful in various methods including treatment, screening and detection methods.