Abstract: The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said foreign chromosome(s) or a fragment(s) into a cell with high homologous recombination efficiency through its fusion with said microcell; (b) in said cell with high homologous recombination efficiency, inserting a targeting vector by homologous recombination into a desired site of said foreign chromosome(s) or a fragment(s) thereof, and/or a desired site of a chromosome(s) derived from said cell with high homologous recombination efficiency, thereby marking said desired site; and (c) in said cell with high homologous recombination efficiency, causing deletion and/or translocation to occur at the marked site of said foreign chromosome(s) or a fragment(s) thereof.

Abstract: An acceleration sensor includes: a rectangular moving electrode; a pair of beams which connect to centers of two opposite sides of the moving electrode, and support the moving electrode freely swingably; and first and second fixed electrodes which are provided on one side and other side of a boundary line, respectively, and are arranged to be opposed to a front surface of the moving electrode at a predetermined interval. A straight line that connects the pair of beams to each other is taken as the boundary line. Then, on a back surface of the moving electrode, first and second recessed portions are formed on one side of the boundary line and the other side thereof, respectively.

Abstract: The present invention provides an electrocasting method by which the shape of the surface opposite to the surface to be electrodeposited on the mold can be controlled. A molded metal article is electrocast by forming an insulating layer on the side wall faces of a cavity and the outer wall face of a conductive mold in which the cavity is formed, placing the mold in an electrolysis tank and applying voltage, electrodepositing metal on the bottom face of the cavity, and growing the metal layer in the cavity so as to leave a space having a height of at least one-third the width of the cavity.

Abstract: A host device is connected to at least one printer through a network. Before printing, the host device broadcasts a query on the network, selects a printer that replies to the query, and sends printer setting information to the printer. The printer includes a setting switch that can be set to different states to accept or reject the printer setting information. A printer replies to the query only if its setting switch is set to the state that accepts the printer setting information. The setting switch avoids the generation of unnecessary replies and thereby simplifies the selection of the printer, as well as protecting the printer from unwanted alteration of its settings.

Abstract: Embodiments of the present invention provide a magnetic disk drive in which the error correction capability of ECC is improved without sacrificing the storage capacity. In one embodiment, a data track adopts a format structure in which no data-to-data gap area is formed in data sectors. When one of the data sectors is updated in a state in which the rotational speed of a magnetic disk does not satisfy specified conditions, a leading end area of a succeeding data sector or a trailing end area of a preceding data sector is overwritten by the data sector. If a read error occurs in the overwritten data sector, ERP steps are executed to perform read retry so that the read error is recovered by means of on-the-fly ECC or erasure correction. In the case of the erasure correction, an erasure pointer equivalent to the maximum number of overwritten bytes is set.

Abstract: To provide an antibody against FGF23 and a pharmaceutical composition such as a preventive or therapeutic agent which can prevent or treat by suppressing an action of FGF23 by using the antibody. An antibody or its functional fragment against human FGF23 produced by hybridoma C10 (Accession No. FERM BP-10772).

Abstract: The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said foreign chromosome(s) or a fragment(s) into a cell with high homologous recombination efficiency through its fusion with said microcell; (b) in said cell with high homologous recombination efficiency, inserting a targeting vector by homologous recombination into a desired site of said foreign chromosome(s) or a fragment(s) thereof, and/or a desired site of a chromosome(s) derived from said cell with high homologous recombination efficiency, thereby marking said desired site; and (c) in said cell with high homologous recombination efficiency, causing deletion and/or translocation to occur at the marked site of said foreign chromosome(s) or a fragment(s) thereof.

Abstract: A host device is connected to at least one printer through a network. Before printing, the host device broadcasts a query on the network, selects a printer that replies to the query, and sends printer setting information to the printer. The printer includes a setting switch that can be set to different states to accept or reject the printer setting information. A printer replies to the query only if its setting switch is set to the state that accepts the printer setting information. The setting switch avoids the generation of unnecessary replies and thereby simplifies the selection of the printer, as well as protecting the printer from unwanted alteration of its settings.

Abstract: Erroneous detection of a failure in spite of the absence of failure on the route on account of a communication delay is to be prevented. A node device detects a failure on the route to a remote node device is detected by a failure to receive a packet from the remote node device after the elapse of a determined detection time. The node device sets “remote system transmission interval×detection multiplier” to be a first detecting time on the basis of a packet transmission interval determined by negotiation with the remote node device. It also sets the sum of “remote system actual transmission interval ×detection multiplier” and “tolerable delay time” to be a second detecting time. The first detecting time and the second detecting time are compared, and what is longer is determined as the detecting time to be applied to actual operation.

Abstract: An antibody or a functional fragment thereof, acting agonistically or antagonistically on CD40.

Abstract: The invention provides antibodies that specifically bind to OX40 (CD134), referred to as OX40 antibodies, anti-OX40 or anti-OX40 antibodies. Invention antibodies that specifically bind to OX40 include mammalian (human, primate, etc.), humanized and chimeric anti-OX40 antibodies. Invention antibodies and antibody subsequences (fragments) that specifically bind to OX40 include purified and isolated antibodies, as well as pharmaceutical formulations thereof, are useful in various methods including treatment, screening and detection methods.

Abstract: Embodiments in accordance with the present invention relate to detecting a micro-relief that exists on surfaces of a magnetic disk. A phase or frequency of a read signal obtained when data written to a minute projection or a minute concavity on a recording surface of a magnetic disk is read out, differs from that of a read signal obtained when data written to a flat recording surface is read out. The phase progresses in the minute projection, whereas the phase is delayed in the minute concavity. A micro-relief is detected by measuring a deviation value of this frequency, and then defect registration is performed. Embodiments in accordance with the present invention are configured to detect a minute projection whose level does not cause TA. Embodiments in accordance with the present invention may also be configured to provide a highly reliable magnetic disk drive by controlling the flying height in response to a state of a minute projection and that of a minute concavity.

Abstract: The specification relates to a method for producing a chimeric non-human animal, which comprises preparing a microcell containing a foreign chromosome(s) or a fragment(s) thereof and transferring the foreign chromosome(s) or fragment(s) thereof into a pluripotent cell by fusion with the microcell; a chimeric non-human animal which can be produced by the above method and its progeny; tissues and cells derived therefrom; and a method for using the same. Further, a pluripotent cell containing a foreign chromosome(s) or a fragment(s) thereof, a method for producing the same, and a method for using the same are also provided. Moreover, a pluripotent cell in which at least two endogenous genes are disrupted, and a method for producing the same by homologous recombination are provided.

Abstract: Embodiments of the invention provide a magnetic disk drive capable of reducing an area used for a preamble of each data sector to increase the storage capacity. The magnetic disk drive adopts a data-surface servo system. In one embodiment, main preambles are written on a magnetic disk at a frequency of a data clock. Each of data sectors is written with a write clock that is synchronized with a signal obtained by reading the main preamble. The data sectors include sub preambles respectively. When the data sector which has been written in this manner is read, a read clock is synchronized by use of a signal obtained by reading the main preamble, and a signal obtained by reading the sub preamble included in a data sector to be read. The bit length of the sub preamble is shorter than that of the conventional preamble that is used to independently achieve the synchronization.

Abstract: Embodiments of the invention provide a magnetic disk drive and its control method capable of effectively using the unrecordable area which is caused due to the composite magnetic head's gap between the read head and the write head. In one embodiment, a disk drive comprises a composite magnetic head structured in such a manner that during write the write head WH reaches each servo area earlier than the read head RH, and a read write control unit to control the write and read done by the composite magnetic head. On the disk, common servo data SP to be used both during read and during write, write servo data SW to be used during write and read servo data SR to be used during read are recorded in this order in each servo area. During write, the read write control unit starts the write head recording data at the timing when reading write servo data SW from the servo area is completed.

Abstract: To provide an antibody against FGF23 and a pharmaceutical composition such as a preventive or therapeutic agent which can prevent or treat by suppressing an action of FGF23 by using the antibody. An antibody or its functional fragment against human FGF23 produced by hybridoma C10 (Accession No. FERM BP-10772).

Abstract: An antibody or a functional fragment thereof, acting agonistically or antagonistically on CD40.

Abstract: An antibody or a functional fragment thereof, acting agonistically or antagonistically on CD40.

Abstract: An image processing apparatus is connected to a specific network for processing an image according to image information input to the image processing apparatus. The image processing apparatus includes an apparatus information storage unit for storing apparatus information of other apparatus connected to the network; an inquiry unit for inquiring an operational state of the other apparatus according to the apparatus information stored in the apparatus information storage unit; a determining unit for determining the operational state of the other apparatus according to an inquiry result of the inquiry unit; and a switching control unit for switching an operational state of the image processing apparatus between an active state and a power save state according to a number of apparatus that the determining unit determines as being in the active state.

Abstract: According to one embodiment, an information reproducing device comprises a file creation module creating an application file, a decision module deciding whether a reading of the application is completed at a specified playback end time of the video object, a comparator module comparing in size between non-played back portion of the video object and the stored application file, a playback continuing module playing back the non-played back portion when it is smaller in size, and a readout module reading the stored application file when it is smaller in size.