Abstract: The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.

Abstract: The present invention provides a two-stage stiffness type elastomer combined device, including at least one small-stiffness elastic element and a large-stiffness elastic element, wherein the small-stiffness elastic element is arranged in an elastomer pre-compression device and is serially arranged with the large-stiffness elastic element under the action of a pre-compression load F1. The device has combined stiffness being hard at first and then becoming soft and is used as an elastic axle box suspension device of a railway vehicle, effectively solving the contradiction that a linear snaking critical operation speed of the vehicle and curve passing performance of the vehicle cannot be compromised.

Abstract: The present invention relates to new fatty acid analogues and to their use in cancer therapy, including antimetastatic therapy.

Abstract: The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.

Abstract: The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.

Abstract: The invention provides a method and apparatus, in a network device, for forking a calling request to a first registered called user address among a plurality of registered called user addresses. The method comprises: obtaining forking-related information, the forking-related information corresponding to the public user identity code and representing a forking order relationship between at least one calling number and the plurality of registered called user addresses; receiving the calling request from a calling user equipment; determining the first registered called user address among the plurality of registered called user addresses according to the number of the calling user equipment and the forking-related information corresponding to the public user identity code; and forking the calling request to the first registered called user address.

Abstract: A power neti pot has a mini pump, batteries, a detachable electric cord and plug, an AC/DC switch in the bottom of the base and an on/off switch on the side of the base. There is a cup with a lid seated on top of the base. An outlet tube connected to the pump is connected to a tapered spout on top of the cup. The pump delivers the liquid in the cup through the tube, exiting the spout into the sinus cavities to promote healing of sinus problems.

Abstract: A dynamically adjustable digital gyrator device for a telephone line interface (e.g., a DAA) utilizing extended feedback and a dynamically adjustable filter to achieve stable convergence in the control of DC line current on a telephone line a short period of time. The low pass filter of the digital gyrator includes at least two (2) different fast filter settings and at least two (2) different slow filter settings based on possible load terminations (e.g., PBX, TAS, etc.), which can be determined based on the dynamic detection of an oscillation on the line. For instance, in a disclosed example, a voice band modem system is allowed to go off-hook with a 1 Hz cutoff low pass filter, and then the output of the low pass filter is checked for an oscillation. If an oscillation is detected, then the poles and/or zeroes of the low pass filter cutoff are changed to a slower convergence rate cutoff frequency (e.g., to 0.1 Hz). As a result, the exemplary voice band modem will converge stably and quickly (e.g.

Abstract: The bicycle trainer includes a frame having a head tube, a top tube, and a rear fork, wherein a foot bar and a front fork are mounted at a lower part of the head tube, a front part of the top tube is pivotally connected to the head tube, and the rear fork is connected to the top tube; a handle connected to the front fork of the frame and properly connected to the front fork; a front wheel and a rear wheel pivotally connected to front wheel and rear wheel; and a flexible device connecting the frame with a rear pivot shaft at one side of the rear wheel, wherein the flexible device drive the rear wheel to rotate and is recovered by using a swirling spring installed at the other side of the rear wheel.

Abstract: The bicycle trainer includes a frame having a head tube, a top tube, and a rear fork, wherein a foot bar and a front fork are mounted at a lower part of the head tube, a front part of the top tube is pivotally connected to the head tube, and the rear fork is connected to the top tube; a handle connected to the front fork of the frame and properly connected to the front fork; a front wheel and a rear wheel pivotally connected to front wheel and rear wheel; and a flexible device connecting the frame with a rear pivot shaft at one side of the rear wheel, wherein the flexible device drive the rear wheel to rotate and is recovered by using a swirling spring installed at the other side of the rear wheel.

Abstract: A dynamically adjustable digital gyrator device for a telephone line interface (e.g., a DAA) utilizing extended feedback and a dynamically adjustable filter to achieve stable convergence in the control of DC line current on a telephone line a short period of time. The low pass filter of the digital gyrator includes at least two (2) different fast filter settings and at least two (2) different slow filter settings based on possible load terminations (e.g., PBX, TAS, etc.), which can be determined based on the dynamic detection of an oscillation on the line. For instance, in a disclosed example, a voice band modem system is allowed to go off-hook with a 1 Hz cutoff low pass filter, and then the output of the low pass filter is checked for an oscillation. If an oscillation is detected, then the poles and/or zeroes of the low pass filter cutoff are changed to a slower convergence rate cutoff frequency (e.g., to 0.1 Hz). As a result, the exemplary voice band modem will converge stably and quickly (e.g.