Abstract: The present invention relates to sustained release drug delivery systems, medical devices incorporating said systems, and methods of use and manufacture thereof. The inventive systems feature bioerodible drug delivery devices that include biocompatible solid and biocompatible fluid compositions to achieve desired sustained release drug delivery.

Abstract: Systems and methods for associating geographic coordinates with one or more points in a digital geographic image, such as a satellite image, aerial image, ground based image, street level image or other suitable geographic image are provided. More particularly, a digital geographic image can be analyzed to identify one or more features that may be suitable as measurement points for collecting measured ground truth data. The one or more features can be described as a mathematical model that defines image coordinates along the feature depicted in the digital geographic image with sub-pixel accuracy. Image coordinates can be assigned to the measurement points with sub-pixel accuracy using the mathematical model. Collected ground truth data can then be associated with the identified image coordinates to allow for the more precise association of geographic coordinate information to points in the digital geographic imagery.

Abstract: An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as “coatings,” “skins,” or “outer layers”). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles.

Abstract: This application provides a device for delivering a beneficial substance to a patient. The device comprises a shell enclosing a plurality of carrier particles. The carrier particles are porous, and a beneficial substance, such as a drug, is disposed in the pores. The drug can diffuse out of the pores, into the interior of the device, and then through at least one permeable portion of the shell. This application also provides methods of making and using these devices.

Abstract: Materials and Methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.

Abstract: This invention discloses bioerodible delivery compositions for delivering peptide therapeutic agents. The delivery compositions comprise a porous silicon-based carrier material loaded with the therapeutic agent. The delivery compositions may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The delivery compositions may be used for treating or preventing conditions of a patient such as chronic diseases.

Abstract: The present invention relates to sustained release drug delivery systems, medical devices incorporating said systems, and methods of use and manufacture thereof. The inventive systems feature bioerodible drug delivery devices that include biocompatible solid and biocompatible fluid compositions to achieve desired sustained release drug delivery.

Abstract: Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.

Abstract: A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.

Abstract: The system and method of use are provided for correcting digital images based on the notions of local black points. The system and method are based on determining local black points in a digital image and correcting the intensities of nearby pixels so as to remove bias in the image introduced by atmospheric conditions. By sampling only localized land imagery the claimed method computes black points that are more robust against the localized effects of atmospheric and land reflection effects than black points computed from wider areas. The result of the method is that images corrected by this method are robust to atmospheric conditions that vary with time and viewing angle.

Abstract: Disclosed is a sustained release system that includes a polymer and a pharmaceutically active agent dispersed in the polymer. The agent is in granular or particulate form, and has a rate of release from the system that is limited primarily by the rate at which the agent dissolves from the granules into the polymer matrix. Advantageously, the polymer is permeable to the agent and is non-release-rate-limiting with respect to the rate of release of the agent from the polymer.

Abstract: An automatic aligning apparatus for aligning aligning components of a first object with aligning components of a second object includes first and second aligning mechanisms. The first aligning mechanism carries the first object and has a guiding groove. The second aligning mechanism has a carrying component that carries the second object, two rear holding plates, and two connecting components, each extending through a through hole in a corresponding rear holding plate and having two clamping parts that clamp a corresponding rear holding plate. The carrying component is movable between an initial position and an aligning position where a guiding stud of the carrying component extends into the guiding groove.

Abstract: A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.

Abstract: A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.

Abstract: Materials and methods are provided for producing patterned multi-array, multi-specific surfaces which are electronically excited for use in electrochemiluminescence based tests. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use in flat panel displays and multiply specific testing procedures.

Abstract: Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.

Abstract: A push button assembly for use in an electronic device includes a plate, a circuit board, an elongated button and an elastic element. The plate is arranged within the electronic device. The circuit board is fixed to the plate. The circuit board includes a switch. The elastic element is fixed to the plate. The elastic element includes an elongated depressible portion arranged between the circuit board and the button. The depressible portion extends along a lengthwise direction of the button and is deformable by depression of elongated button. The disclosure also provides an electronic device having the push button assembly.

Abstract: A power supply system with an electronic high-voltage transformer includes an input module for receiving a current and eliminating disturbance in the current, a transformer module for transforming the received current into a low-voltage direct current, a power supply module for transforming the low-voltage direct current into a high-frequency alternating current, and a magnetic processing module comprising one or more magnetic elements and one or more high-voltage resistant wires connecting with the magnetic elements so as to transform the high-frequency alternating current into a high-voltage alternating current.

Abstract: An access authentication method includes pre-establishing a security channel between the authentication server of the access point and the authentication server of the user terminal and performing the authentication process at user terminal and access point. The authentication process includes 1) the access point sending the authentication_activating message; 2) the user terminal sending the authentication server of user terminal request message; 3) the authentication server of the user terminal sending to the user terminal response message; and 4) completing the authentication.