Abstract: In the preferred embodiment of the present invention, a patch of dissolving microneedles loaded with active ingredients to be applied to skin for treating skin conditions is provided. As seen in FIG. 1, the dissolving microneedle patch (10) comprises a substrate (12) and a plurality of microneedles (14) which extends from the substrate. The dissolving microneedle patch (10) is made of a matrix material and at least one active ingredient such as a corticosteroid, namely triamcinolone (TAC). The matrix material is made of bio-compatible materials such as hyaluronic acid (HA), polyvinylpyrrolidone (PVP), or mixture of them, which dissolve rapidly when they are in contact with the inner skin. The active ingredient is loaded onto individual patches with the desirable dosage ranging from 0.01 mg-1.0 mg.

Abstract: There is provided a pharmaceutical formulation comprising an anticholinergic agent and a ternary solvent comprising 5% to 15% v/v glycol, 60% to 70% v/v alcohol and 5% to 20% v/v water. There is also provided a method of preparing the pharmaceutical formulation as disclosed herein, comprising the step of mixing the anticholinergic agent to a mixture containing alcohol, glycol, water, humectant and pH buffering agent at room temperature. There is also provided a method of inhibiting non-pathological body malodour in a mammal. There is also provided a method of treating apocrine secretion causing odour and reduction of microbial overgrowth in a mammalian subject, and uses of a pharmaceutical formulation.

Abstract: The present invention provides antagonizing antibodies that bind to complement factor D (CFD), conjugates thereof, and methods of using same. The anti-CFD antibodies can be used therapeutically alone or in combination with other therapeutics to treat age related macular degeneration and other diseases.

Abstract: Provided is an aqueous composition comprising dispersed particles that comprise a polyurethane, wherein said polyurethane is a reaction product of a group of reactants (GR1), wherein GR1 comprises one or more aromatic polyisocyanates and, a polyol component, wherein said polyol component comprises (a) 50% to 99% by weight, based on the weight of said polyol component, one or more polyester polyols, (b) 0.1% to 10% by weight, based on the weight of said polyol component, one or more diols having a hydrophilic side chain, and (c) 0.9% to 40% by weight, based on the weight of said polyol component, one or more polyols different from (a) and (b). Also provided is a method of bonding a metal foil to a polymer film using such an aqueous composition.

Abstract: An imaging device testing system has a light receiver for receiving light from an imaging device under test, a light emitter for returning the light back to the imaging device under test, and first and second transceiver tables movable relative to each other. The first transceiver table has a first light redirecting module for receiving the light from the light receiver and the second transceiver table comprising a second light redirecting module for transmitting the light to the light emitter. The first and second light redirecting modules are positionable to simulate a distance travelled by the light from the light receiver, through the first and second light redirecting modules and a gap between the first and second light redirecting modules, to the light emitter.

Abstract: The present invention provides a new treatment for idiopathic hypohidrosis. In one embodiment, the said treatment comprises administering to a patient in need a pharmaceutically effective amount of a retinoid. Preferably, the retinoid is isotretinoin or acitretin.

Abstract: The invention relates to systems and techniques for manufacturing articles containing cellulosic material, a coupling agent, and a binder resin, and related processes of making and using the cellulosic articles. In particularly exemplary embodiments, the manufactured articles are door skins, sometimes known as door facings, and doors made from the door skins. The article contains a lipophilic cellulosic material, a coupling agent, and a binder. The coupling agent is believed to increase the hydrophilicity (wettability) of the lipophilic cellulosic material.

Abstract: A computer-implemented method for use with a database computer system including a database data set that includes machine readable data in the form of a plurality of records, the computer-implemented method comprising: (i) defining a plurality of sets of permission rule(s); (ii) receiving a first user profile for a first user; (iii) establishing a plurality of user identities to the first user; (iv) generating a plurality of tokens; and (v) for each given user identity of the first user, adding a given token of the plurality of tokens to the first user profile and associating the given user identity and the given token.

Abstract: The invention relates to systems and techniques for manufacturing articles containing cellulosic material, a coupling agent, and a binder resin, and related processes of making and using the cellulosic articles. In particularly exemplary embodiments, the manufactured articles are door skins, sometimes known as door facings, and doors made from the door skins. The article contains a lipophilic cellulosic material, a coupling agent, and a binder. The coupling agent is believed to increase the hydrophilicity (wetability) of the lipophilic cellulosic material.

Abstract: Embodiments of the present disclosure pertain to methods of altering a tooth by applying an object to the tooth, where the object includes a composition that is released from the object onto the tooth, and where the composition has an altering effect on the tooth, such as tooth whitening, tooth repair, tooth maintenance, or combinations thereof. Additional embodiments of the present disclosure pertain to the objects of the present disclosure. The objects of the present disclosure may be in a chewable form, such as in the form of a chew toy or a chewing gum. The objects of the present disclosure may also be in a form that is capable of being applied topically by rubbing or brushing. The objects of the present disclosure may also include a second composition that has effects other than tooth altering effects, such as enticing a chewing of the object.

Abstract: In an embodiment, the present disclosure pertains to a method of creating a supercapacitor. The method includes forming an anode and a cathode, each composed of a substrate having at least one of a lignin, a lignin-based composite, activated carbon, a plant extract, a cellulose by-product, biofuel waste, one or more metals, a metal oxide, a monometallic tungstate, or a bimetallic tungstate, and sandwiching an electrolyte coated separator between the anode and the cathode. In an addition embodiment, the present disclosure pertains to an electrode composed of a particle-decorated lignin. In some embodiments, the particle-decorated lignin includes particles that can include, without limitation, MnO2, NiWO4, MnO2, NiCoWO4, CoWO4, and combinations thereof. In a further embodiment, the present disclosure pertains to a supercapacitor made via the methods of the present disclosure.

Abstract: The invention relates to systems and techniques for manufacturing articles containing cellulosic material, a tackifier, and a binder, and related processes of making and using the cellulosic articles. In particularly exemplary embodiments, the manufactured articles are door skins, sometimes known as door facings, and doors made from the door skins. The article contains a lipophilic cellulosic material, a tackifier, and a binder.

Abstract: Provided herein are anti-VEGF-A antibodies and antibody conjugates thereof. Some embodiments of the antibodies can be conjugated to a moiety, such as a HEMA-PC polymer. Some embodiments of the antibody conjugates can retain or enhance antibody activity. The antibody and conjugate thereof can be particularly useful for treating diabetic retinopathy. Further provided are methods for conjugation of a polymer to a protein such as an antibody, such as IgG1.

Abstract: Disclosed are a gas sampling system and a gas sampling method for a fuel cell, a current density distribution estimation method for the fuel cell, a calibration method and a calibration device for an internal state model for the fuel cell, and a computer equipment. The gas sampling method for a fuel cell includes arranging a plurality of sampling pipelines and a plurality of sampling points, the plurality of sampling points being arranged at a cathode inlet, an anode outlet, an anode inlet, a cathode outlet, and in an anode flow channel, and a cathode flow channel of the fuel cell, the sampling points arranged in the anode flow channel and the cathode flow channel being located in central regions of cross sections of the flow channels, and the sampling pipelines being connected to the plurality of sampling points, respectively, and configured to guide gas inside the fuel cell out.

Abstract: An anisotropic conductive adhesive includes a conductive layer including a first surface and a second surface opposite the first surface. The conductive layer defines at least one air guide hole penetrating the first surface and the second surface.

Abstract: [Problem] To develop a technique that can stabilize the higher-order structure of a nucleic acid and can be used in analysis of nucleic acid structure. [Solution] This guanosine derivative compound is represented by formula 1. In the formula, one of R1 and R2 represents H, and the other represents any of H, OH, OCH3, and F, R3 represents a functional group that is for detection and that has 19F, R4 represents an amine-protecting group, R5 represents a hydroxy group-protecting group, and R6 represents an introduction group that is to be introduced into a nucleic acid oligomer. This guanosine derivative compound can be introduced as a part of a nucleic acid sequence, and the introduced nucleic acid oligomer stabilizes the higher-order structure in a nucleic acid, and enables dynamic detection by 19F NMR.

Abstract: Provided herein are anti-VEGF-A antibodies and antibody conjugates thereof. Some embodiments of the antibodies can be conjugated to a moiety, such as a HEMA-PC polymer. Some embodiments of the antibody conjugates can retain or enhance antibody activity. The antibody and conjugate thereof can be particularly useful for treating diabetic retinopathy. Further provided are methods for conjugation of a polymer to a protein such as an antibody, such as IgG1.

Abstract: The invention relates to systems and techniques for manufacturing articles containing cellulosic material, a tackifier, and a binder, and related processes of making and using the cellulosic articles. In particularly exemplary embodiments, the manufactured articles are door skins, sometimes known as door facings, and doors made from the door skins. The article contains a lipophilic cellulosic material, a tackifier, and a binder.

Abstract: A wireless charging device and a warning signal generating method are provided in this disclosure. The warning signal generating method includes: determining whether the smart key of the vehicle is in an operating mode according to a wireless unlock signal when a vehicle is turned off; determining whether a door of the vehicle is opened when the smart key is not in the operating mode; determining whether a portable electronic device is on a wireless charging base of the wireless charging device when the door is opened; and generating a warning signal when the portable electronic device is on the wireless charging base.

Abstract: In an approach to predicting issue development trends based on generated ordered association rules, one or more computer processors subdivide an issue into a set of one or more subproblems. The one or more computer processors generate ordered association rules by inputting the set of one or more subproblems into a model trained with historical subproblems, historical solutions, and historical ordered association rules. The one or more computer processors determine one or more solutions for each subproblem in the set of one or more subproblems utilizing the generated ordered association rules. The one or more computer processors present the one or more determined solutions.