Abstract: Compositions include gene-editing complexes for the treatment of myopathies, cancer and neurodegenerative diseases. Specifically, the disclosure provides methods of identifying in a subject's biological sample, ‘at least one Bcl2-associated anthanogene 3 (BAGS) genetic mutation as compared to a control BAGS nucleic acid sequence, and administering to the subject a therapeutically effective amount of a gene-editing complex, wherein the gene-editing complex corrects the bag3 mutation to a wild-type bag3, thereby, treating the subject.

Abstract: An event-driven transmission method comprises converting at least one event to at least one corresponding pulse pair and transmitting the at least one pulse pair. In this context, a delay between each pulse pair represents a corresponding identifier with respect to the respective event or with respect to at least one corresponding object causing or experiencing the respective event.

Abstract: An antibody or an antigen-binding fragment thereof that binds to CD228, and an antibody-drug conjugate containing the antibody or antigen-binding fragment thereof. The antibody or antigen-binding fragment thereof has a high affinity to a CD228 protein and an ability to mediate ADCC. The antibody-drug conjugate exhibits an inhibitory effect on various tumors. A nucleic acid encoding the antibody or antigen-binding fragment thereof; a cell containing the nucleic acid; a pharmaceutical composition containing the antibody or antigen-binding fragment thereof, the nucleic acid, the cell or the antibody-drug conjugate; and a kit. The use of the antibody or antigen-binding fragment thereof, the nucleic acid, the antibody-drug conjugate or the pharmaceutical composition in the prevention, treatment, detection or diagnosis of diseases related to CD228.

Abstract: The present disclosure includes methods for evaluating the bending stiffness of high aspect ratio nanosized structures. One example method for evaluating a bending stiffness of high aspect ratio nanosized structures arranged in a plurality of test patterns produced by lithography and etching in a respective plurality of different areas of a semiconductor substrate, where each test pattern includes a regular array of the high aspect ratio nanosized structures, includes scanning the regular arrays in the plurality of test patterns by an electron beam produced according to a same set of beam conditions for each array. The method also includes deriving images of the regular arrays in the respective test patterns by electron beam microscopy. Additionally, the method includes determining from each of the images an e-beam induced collapse rate representative of a percentage of structures in each array that have collapsed under an influence of the electron beam scanning.

Abstract: An ultrasound image processing apparatus includes an image processor arrangement that receives a plurality of ultrasound images. Each ultrasound image shows an invasive medical device relative to an anatomical feature during a cardiac cycle. At different phases of the cardiac cycle, the anatomical feature has a different shape. The ultrasound processing apparatus compiles groups of the ultrasound images with ultrasound images in each group belonging to the same phase of the cardiac cycle. The ultrasound image processing apparatus generates an augmented ultrasound image from one of the ultrasound images by removing a shadow region on the anatomical feature of interest caused by the invasive medical device based on a displacement of the invasive medical device.

Abstract: Coherent optical communications technology for recovery of 1D and 2D formatted optical signals. For example, 1D or 2D formatted signals that travel through fiber optic media may be recovered by separating the light into X- and Y-polarization components, rotating one polarization component (e.g., Y-component) into the polarization space of the other component (e.g., Y-component into the X-polarization space), delaying the rotated component enough to avoid destructive interference and combining the delayed component with the undelayed component to form a folded optical signal, which may then be processed as a X-polarized signal.

Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

Abstract: An array base plate and a display apparatus are provided by the present application. The array base plate includes a substrate, an active area and a binding area that are located on the substrate, wherein the binding area is located at one side of the active area; the array base plate further includes: an alignment layer extending from the active area to the binding area; and binding terminals located in the binding area, wherein an orthographic projection of the alignment layer on the substrate does not overlap with orthographic projections of the binding terminals on the substrate; wherein in a direction parallel to a plane where the substrate is located and pointing from the active area to the binding area.

Abstract: A display device and a manufacturing method thereof are provided. The display device includes a substrate, a shielding layer, a semiconductor layer, and a first gate electrode layer. The shielding layer is disposed on a side of the substrate. The semiconductor layer is disposed on a side of the shielding layer away from the substrate. The shielding layer is at least partially overlapped with the semiconductor layer. The first gate electrode layer is disposed on a side of the semiconductor layer away from the substrate. The first gate electrode layer is at least partially overlapped with the semiconductor layer and is electrically connected to the shielding layer. The manufacturing method of the display device is used to manufacture the display device.

Abstract: Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.

Abstract: The present disclosure relates to a power conversion module, a control method, and a power conversion system. An interconnecting branch is connected between a first power unit and a second power unit. The interconnecting branch includes a resonant capacitor and a switching unit that are electrically connected. The resonant inductor is connected between the midpoint of a first bridge arm and the midpoint of a second bridge arm, or in series with the resonant capacitor. In the present disclosure, by controlling the on and off of the interconnecting branch, a current opposite to the power grid current is generated on the branch connecting the first bridge arm and the second bridge arm, thereby realizing the soft switching of the switching transistors of the power conversion module.

Abstract: The present disclosure provides a method of determining a leakage of a semiconductor manufacturing tool. The method includes: placing a substrate including a material layer on the substrate into a chamber of the semiconductor manufacturing tool; delivering a gas into the chamber to react with the material layer; obtaining a gas composition inside the chamber; and comparing the gas composition to a referential gas composition. The leakage is determined to exist if the gas composition is substantially different from the referential gas composition.

Abstract: The present disclosure provides a gate driving circuit and a display panel. The display panel includes a display area and a peripheral area surrounding the display area. At least one gate driving circuit is arranged in the peripheral area. The at least one gate driving circuit includes a plurality of shift register units cascaded in sequence. The plurality of shift register units include first shift register units and second shift register units. The first shift register units and the second shift register units are spaced apart from each other. The number of transistors in the first shift register units is smaller than the number of transistors in the second shift register units.

Abstract: In an embodiment, a system includes: a gas distributor assembly configured to dispense gas into a chamber; and a chuck assembly configured to secure a wafer within the chamber, wherein at least one of the gas distributor assembly and the chuck assembly includes: a first portion comprising a convex protrusion, and a second portion comprising a concave opening, wherein the convex protrusion is configured to engage the concave opening.

Abstract: The invention provides a low-power wide area network integrated sensing and communication method based on channel sensing and reinforcement learning, and the method comprises the steps: receiving an uplink signal transmitted by a terminal node through a gateway receiver, demodulating the uplink signal through employing a soft demodulation algorithm, and obtaining a bit log-likelihood ratio; the deep reinforcement learning model completes channel reconstruction of the corresponding link during communication according to the bit log-likelihood ratio; and calculating the current optimal network configuration according to the reconstructed channel so as to distribute the current optimal network configuration to each terminal node during next downlink transmission.

Abstract: The present disclosure provides a mechanism for filtering an etching byproduct during semiconductor fabrication. The mechanism includes: an etching tool, configured to etch a portion of a material layer and having an outlet for discharging the etching byproduct formed from the etched portion of the material layer; a pipeline, for allowing the etching byproduct to flow through, the pipeline having a first end connected to the outlet of the etching tool and a second end distal to the first end and the etching tool; and a filter, disposed between the first end and the second end and configured to filter the etching byproduct. The filter includes a solidifier configured to solidify the etching byproduct by freezing or heating, and a medium configured to retain the etching byproduct solidified by the solidifier.

Abstract: The disclosed technology allows for 1+1 optical protection and may improve coherent module output optical power by 3 dB over similar transmitter (Tx) and receiver (Rx) implementation complexity, as well as allow for integration into existing datacenter formats.

Abstract: A method and a device for measuring a temperature of a wire rod, a storage medium, and a computer device are disclosed. The method includes: determining an effective temperature measurement area according to the infrared thermal image and feature information of the wire rod; projecting preset light onto the wire rod geometric model, tracing a light propagation path of the preset light, and calculating an effective emissivity based on a tracing result of the light propagation path; and correcting temperature measurements in the effective temperature measurement area based on the effective emissivity to obtain a corrected temperature measurement result. The infrared thermal image is acquired, and is analyzed by image processing, thereby dynamically capturing the effective temperature measurement area. The effective emissivity between wire rods is calculated, and then the measured temperature of the wire rod is corrected, thereby improving the accuracy and stability of temperature measurement on wire rods.

Abstract: A label-free cell classification and screening system based on hybrid transfer learning, including a data preprocessing module for acquiring 2D light scattering video data and for digital cell filtering, is made public here; the data preprocessing module includes the label-free high-content video flow cytometry, which has the optical excitation module, the sheath flow control module, and the data acquisition and processing module; the image archiving module is used to sort and set labels for cells; in the feature extraction module, the first convolutional neural network is used to obtain image data feature vectors; in the cell classification and screening module, a support vector machine model is used to obtain the cell screening results.

Abstract: A method for generating a 3D printing file includes: layering a 3D model into a plurality of sliced layers, and obtaining contour data of each of the sliced layers; determining a straight line X=X0 corresponding to an abscissa X0 of an intersection point of a preset seamline on the current layer of the sliced layers; determining coordinates of a seam point in accordance with the straight line X=X0 and contour data of the current layer, adding the coordinates of the seam point into the contour data of the current layer to update the contour data of the current layer, and setting the seam point as a start printing point of the current layer; and generating the 3D printing file of the 3D model in accordance with updated contour data of each of the plurality of layers. A 3D printing device, a computer device, and a storage medium are also provided.