Abstract: A pyrrolopyrimidine comprising a cyclopentyi substituent. The present invention specifically relates to a compound represented by formula. A and a stereoisomer and pharmaceutically acceptable salt thereof. The invention further relates to a method for manufacturing the pyrrolopyrimidine comprising the cyclopentyl substituent represented by formula A, a pharmaceutical composition, and an application of the compound in treating a disease induced by Janus kinase.

Abstract: A voltage regulator and method applied thereto are provided. The voltage regulator generates a regulated voltage in response to a reference voltage and a control code. The voltage regulator includes a voltage divider circuit, an amplifier circuit, and a power MOS array. The voltage divider circuit is configured to divide the regulated voltage to generate a feedback voltage. The amplifier circuit is configured to amplify a voltage difference between the reference voltage and the feedback voltage to generate a bias voltage. The power MOS array includes multiple transistors. Each transistor has a first terminal coupled to a power rail, a second terminal coupled to the regulated voltage, and a control terminal selectively coupled to either the power rail or the bias voltage in response to the control code.

Abstract: The present invention belongs to the field of pharmaceutical chemistry, and relates to a substituted pyrrolopyrimidine CDK inhibitor, in particular to a compound as shown in formula I or a pharmaceutically acceptable salt or solvate thereof, as well as a preparation method thereof and a pharmaceutical composition thereof. The present invention also relates to the use of the compound and the pharmaceutical composition thereof in the preparation of a drug for treating diseases associated with CDK inhibition. The compound according to the present invention has a marked inhibitory effect on CDK, excellent drug absorption and significantly superior oral absorption effect.

Abstract: The present application relates to the field of pharmaceutical chemistry, and in particular, to a pyrrolopyrimidine compound represented by general formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The present invention further relates to a method for preparing the pyrrolopyrimidine compound represented by general formula (I), pharmaceutical compositions and an application of the pyrrolopyrimidine compound in treating diseases mediated by Janus Kinase.

Abstract: Provided is an amino pyrazolopyrimidine compound as represented by the following structural formula used as a neurotrophic factor tyrosine kinase receptor inhibitor. The compound can inhibit the activity of Trk kinase and can treat diseases mediated by a Trk tyrosine kinase receptor in mammals.

Abstract: An acoustic emission source expansion apparatus integrated hydraulic engineering construction behavior fiber sensing device includes a base plate, a first side plate and a second side plate fixedly connected with two sides of the base plate, the top portion of the first side plate is connected with the top portion of the second side plate through an arc-shaped fiber-carrying channel, and a main common cavity is formed by the base plate, the first side plate, the second side plate and the arc-shaped fiber-carrying channel; a pair of sensing fibers is arranged in the arc-shaped fiber-carrying channel, the sensing fibers are tightly pressed in the arc-shaped fiber-carrying channel through a pressing block, the pressing block is provided with a plurality of springs, the springs tightly press the pressing block through a cover plate, and the cover plate is arranged on the first side plate and the second side plate.

Abstract: The present disclosure discloses a high speed optical module having a PCBA component and a passive optical element. The PCBA component includes a receiver and a transmitter. The transmitter includes an amplifier chip and a photodiode array connected to pins of the amplifier chip. The transmitter includes a laser driving chip and a base. Multiple lasers are arranged side by side in the base. The lasers are connected to the laser driving chip. A plurality of fiber interfaces are arranged on output light paths corresponding to the plurality of lasers. The passive optical element includes ferrules corresponding to the plurality of fiber interfaces, and the ferrules are correspondingly inserted into the plurality of fiber interfaces in a one-to-one relationship. The passive optical element is inserted into the PCBA component by fiber interfaces arranged on the PCBA component.

Abstract: The present invention belongs to the field of pharmaceutical chemistry, and relates to a substituted pyrrolopyrimidine CDK inhibitor, in particular to a compound as shown in formula I or a pharmaceutically acceptable salt or solvate thereof, as well as a preparation method thereof and a pharmaceutical composition thereof. The present invention also relates to the use of the compound and the pharmaceutical composition thereof in the preparation of a drug for treating diseases associated with CDK inhibition. The compound according to the present invention has a marked inhibitory effect on CDK, excellent drug absorption and significantly superior oral absorption effect.

Abstract: A glove for use in collecting data for sign language recognition comprises: multiple azimuth sensors arranged on the glove at positions corresponding to the phalanges and metacarpal bones of the hand and used for sensing postures of the hand. The azimuth sensors are only arranged on the glove at positions corresponding to the phalanges of the hand other than the distal phalange in proximity to the fingertip of at least one finger among the middle finger, the index finger, the ring finger, and the little finger. The glove reduces the number of the azimuth sensors arranged on the glove at positions corresponding to the phalanges of the hand, thus reducing costs while not affecting detection performance.

Abstract: The present disclosure provides a multi-channel parallel optical receiving device, including a carrier, a light receiving chip, a plurality of optoelectronic diodes disposed on a top surface of an end of the carrier, an optical fiber connector disposed in another end of the carrier, and an arrayed waveguide grating disposed on the top surface of the carrier. The plurality of optoelectronic diodes is electrically connected to the light receiving chip, and an input end of the arrayed waveguide grating is connected to the optical fiber connector for receiving an optical signal from the optical fiber. The optical signals are divided into multi-channel optical signals in parallel. The top surface of an output end of the arrayed waveguide grating is at a predetermined angle, causing the multi-channel optical signals to be reflected by the top surface and to photosensitive surfaces of the optoelectronic diodes arranged in parallel.

Abstract: The present invention discloses a dynamic diagnosis system and method for concrete damage based on a distributed sensing optical fiber.

Abstract: The present application relates to the field of pharmaceutical chemistry, and in particular, to a pyrrolopyrimidine compound represented by general formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The present invention further relates to a method for preparing the pyrrolopyrimidine compound represented by general formula (I), pharmaceutical compositions and an application of the pyrrolopyrimidine compound in treating diseases mediated by Janus Kinase.

Abstract: The present disclosure relates to aniline pyrimidine derivatives or pharmaceutically acceptable salts thereof as EGFR inhibitors, specifically relates to compounds represented by formula (I) or pharmaceutically acceptable salts, pharmaceutical compositions, the method and uses thereof for treating EGFR mediated diseases.

Abstract: A pyrrolopyrimidine comprising a cyclopentyi substituent. The present invention specifically relates to a compound represented by formula. A and a stereoisomer and pharmaceutically acceptable salt thereof. The invention further relates to a method for manufacturing the pyrrolopyrimidine comprising the cyclopentyl substituent represented by formula A, a pharmaceutical composition, and an application of the compound in treating a disease induced by Janus kinase.

Abstract: An acoustic emission source expansion apparatus integrated hydraulic engineering construction behavior fiber sensing device includes a base plate, a first side plate and a second side plate fixedly connected with two sides of the base plate, the top portion of the first side plate is connected with the top portion of the second side plate through an arc-shaped fiber-carrying channel, and a main common cavity is formed by the base plate, the first side plate, the second side plate and the arc-shaped fiber-carrying channel; a pair of sensing fibers is arranged in the arc-shaped fiber-carrying channel, the sensing fibers are tightly pressed in the arc-shaped fiber-carrying channel through a pressing block, the pressing block is provided with a plurality of springs, the springs tightly press the pressing block through a cover plate, and the cover plate is arranged on the first side plate and the second side plate.

Abstract: Disclosed are compounds having formulae I and II or pharmaceutically acceptable salts or hydrates thereof, a preparation method thereof and pharmaceutical compositions thereof. The compounds having formulae I and II possesses an isocitrate dehydrogenase 2 (IDH2) inhibitory activity and are capable of treating IDH2 mutation-induced cancers.

Abstract: The present disclosure discloses a high speed optical module having a PCBA component and a passive optical element. The PCBA component includes a receiver and a transmitter. The transmitter includes an amplifier chip and a photodiode array connected to pins of the amplifier chip. The transmitter includes a laser driving chip and a base. Multiple lasers are arranged side by side in the base. The lasers are connected to the laser driving chip. A plurality of fiber interfaces are arranged on output light paths corresponding to the plurality of lasers. The passive optical element includes ferrules corresponding to the plurality of fiber interfaces, and the ferrules are correspondingly inserted into the plurality of fiber interfaces in a one-to-one relationship. The passive optical element is inserted into the PCBA component by fiber interfaces arranged on the PCBA component.

Abstract: The present disclosure provides a multi-channel parallel optical transceiver module. The disclosed optical transceiver module/device may include a shell body and a circuit board located in the shell body, and an optical emitter base soldered to a first end of the circuit board. A notch located on the base, for engaging the first end of the circuit board, and the optical emitter base engaged with the first end of the circuit board may be soldered to two sides of the circuit board. The optical emitters may be disposed in parallel on the base, and separated from each other by a block. A lens and a laser may be disposed at a first side of each of the optical emitters that is adjacent to the circuit board, and an optical monitor may be disposed on a second end of the circuit board adjacent to the laser.

Abstract: The present application relates to a substituted amino six-membered saturated heteroalicycle represented by formula I as a long-acting DPP-IV inhibitor, a method for preparing the same, a pharmaceutical composition comprising the same, and a use of the same in treating and/or preventing diseases and disorders benefitting from DPP-IV inhibition.

Abstract: The present application relates to compounds represented by general formula (I), general formula (II) or general formula (III), and pharmaceutically acceptable salts or hydrates thereof, preparation methods thereof, and pharmaceutical compositions thereof. The compounds represented by general formula (I), general formula (II) or general formula (III) have inhibitory activities against isocitrate dehydrogenase 2 (IDH2), thereby being capable of treating IDH2 mutation-induced cancers.