Abstract: Provided are a compound represented by formula (III) or pharmaceutically acceptable salts, solvates, active metabolites, polymorphs, esters, tautomers or prodrugs thereof, pharmaceutical compositions containing the compound represented by formula (III), and the application of the pharmaceutical compositions as selective inreversible inhibitor of Bruton's tyrosine kinase for the prevention and treatment of inflammation, autoimmune diseases (such as rheumatoid arthritis) associated with aberrant B cell proliferation and cancers.

Abstract: The disclosure provides a compilation method and system for heterogeneous computing platform, and a runtime method and system for supporting program execution on the heterogeneous computing platform. Inputting a trained neural network model to a Neural Network (NN) optimizing compiler to generate an NN assembly file corresponding to the neural network; inputting the NN assembly file to an NN assembler to generate an NN binary file corresponding to the neural network; compilation and assembling a neural network application developed by users in a high-level language using a host compiler toolchain to generate a corresponding host assembly file and a host binary file in sequence; and linking the NN binary file and the host binary file using a host linker to generate a single hybrid linking executable file. The technical solution of the present disclosure has the advantages such as good computing performance, strong scalability, strong compatibility and high flexibility.

Abstract: The present application relates to compounds represented by general formula (I), general formula (II) or general formula (III), and pharmaceutically acceptable salts or hydrates thereof, preparation methods thereof, and pharmaceutical compositions thereof. The compounds represented by general formula (I), general formula (II) or general formula (III) have inhibitory activities against isocitrate dehydrogenase 2 (IDH2), thereby being capable of treating IDH2 mutation-induced cancers.

Abstract: The present disclosure relates to aniline pyrimidine derivatives or pharmaceutically acceptable salts thereof as EGFR inhibitors, specifically relates to compounds represented by formula (I) or pharmaceutically acceptable salts, pharmaceutical compositions, the method and uses thereof for treating EGFR mediated diseases.

Abstract: The present invention provides transgenic plants having increased tolerance to cold and altered flowering characteristics. Also provided are methods and compositions for producing said transgenic plants.

Abstract: The present invention provides methods and compositions for regulation of gene expression in plants. In particular, the invention provides nucleic acids that can confer tissue specific and constitutive expression to operably linked polynucleotides of interest.

Abstract: The present application relates to a substituted amino six-membered saturated heteroalicycle represented by formula I as a long-acting DPP-IV inhibitor, a method for preparing the same, a pharmaceutical composition comprising the same, and a use of the same in treating and/or preventing diseases and disorders benefitting from DPP-IV inhibition.

Abstract: The present invention provides transgenic plants having increased tolerance to abiotic stress comprising a recombinant nucleic acid molecule, said recombinant nucleic acid molecule comprising a nucleotide sequence encoding miR319 operatively associated with a promoter, a nucleotide sequence that is antisense to a portion of consecutive nucleotides of a nucleotide sequence encoding PCF5, and/or a nucleotide sequence that encodes a portion of consecutive nucleotides of a nucleotide sequence encoding PCF5, which when expressed produces an antisense nucleotide sequence, wherein expression of the nucleotide sequence confers increased tolerance to abiotic stress. Also provided are methods and compositions for making said transgenic plants.

Abstract: A multi-channel laser device with a fiber array includes a housing and a ferrule. In the housing, laser components are arranged side by side, and each of the laser components is connected to a fiber array module through an optical isolator. The fiber array module includes thermal expanded fibers, and fibers out of the fiber array module are collected by the ferrule. The laser components are disposed on the same module board, and laser light radiated from the front end of a laser chip in each of the laser components is projected onto the optical isolator through a convex lens and then enters into the thermal expanded fiber. Such a structure may reach a relatively-high coupling efficiency and implement the coupling of arrayed laser components.

Abstract: The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic peptide toxins. In a preferred embodiment, the present invention also relates to methods for making small peptides and small cyclic peptides including peptides similar to amanitin. Further, the present inventions relate to providing kits for making small peptides.

Abstract: The invention provides novel poly-substituted 5-membered heterocyclic compounds represented by Formula (IV), or a pharmaceutically acceptable salt, solvate, metabolite, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as selective irreversible bruton's tyrosine kinase (Btk) inhibitors and are further useful to treat inflammatory, auto immune diseases associated with aberrant B-cell proliferation such as RA (rheumatoid arthritis) and cancers. This invention also provides the preparation of a medicament using of Formula (IV), and methods of preventing or treating diseases associated with excessive Btk activity in mammals, especially humans.

Abstract: A light emission module includes a base, a laser diode driver, a laser diode and a monitor photodiode. The laser diode driver, the laser diode and the monitor photodiode are disposed on the base. The monitor photodiode and the laser diode are located close to a front end of the laser diode driver. A rear side of the laser diode facing the front end of the laser diode driver. A end surface at the front end of the laser diode driver, a side surface at the rear side of the laser diode and a light receiving surface of the monitor photodiode are arranged in a triangle shape for reflecting a light emitted from the rear side of the laser diode to the light receiving surface of the monitor photodiode by the end surface of the laser diode driver.

Abstract: Method and apparatus for electronic detection and determination includes detecting a signal T0 in a detection zone and a signal R0 in a reference zone before a sample is added; adding a sample and detecting the signals in each of the detection zone and the reference zone at an interval of a second preset period; calculating a judgement value based on 2k immediately previous signals in each of the detection zone and the reference zone, the signal T0 in the detection zone before the sample is added, and the signal R0 in the reference zone before the sample is added, each time when k successive signals are detected in each of the detection zone and the reference zone; and determining a judgement result based on m successive judgement values and a preset result threshold corresponding to a current detection time.

Abstract: The present disclosure provides a multi-channel parallel optical receiving device, including a carrier, a light receiving chip, a plurality of optoelectronic diodes disposed on a top surface of an end of the carrier, an optical fiber connector disposed in another end of the carrier, and an arrayed waveguide grating disposed on the top surface of the carrier. The plurality of optoelectronic diodes is electrically connected to the light receiving chip, and an input end of the arrayed waveguide grating is connected to the optical fiber connector for receiving an optical signal from the optical fiber. The optical signals are divided into multi-channel optical signals in parallel. The top surface of an output end of the arrayed waveguide grating is at a predetermined angle, causing the multi-channel optical signals to be reflected by the top surface and to photosensitive surfaces of the optoelectronic diodes arranged in parallel.

Abstract: A voltage regulator and method applied thereto are provided. The voltage regulator generates a regulated voltage in response to a reference voltage and a control code. The voltage regulator includes a voltage divider circuit, an amplifier circuit, and a power MOS array. The voltage divider circuit is configured to divide the regulated voltage to generate a feedback voltage. The amplifier circuit is configured to amplify a voltage difference between the reference voltage and the feedback voltage to generate a bias voltage. The power MOS array includes multiple transistors. Each transistor has a first terminal coupled to a power rail, a second terminal coupled to the regulated voltage, and a control terminal selectively coupled to either the power rail or the bias voltage in response to the control code.

Abstract: A light emission module includes a base, a laser diode driver, a laser diode, a monitor photodiode and a reflecting mirror. The laser diode driver, the laser diode and the monitor photodiode are disposed on the base. The monitor photodiode and the laser diode are located close to a front end of the laser diode driver. A rear side of the laser diode faces the laser diode driver. The reflecting mirror is disposed between the rear side of the laser diode and the monitor photodiode for reflecting a light emitted from the rear side of the laser diode to a light receiving surface of the monitor photodiode.

Abstract: The data serialization circuit includes a delay circuit, a data serializer, a first data sampler and a second data sampler. The delay circuit receives an input clock signal and generates a plurality of delayed clock signals. The delayed clock signals includes a first delayed clock signal generated by a first delay stage and a second delayed clock signal generated by a second delay stage. The data serializer receives parallel data and a final stage delayed clock signal of the delayed clock signals, and converts the parallel data into serial data according to the final stage delayed clock signal. Wherein, the first data sampler samples the serial data according to the first delayed clock signal to generate a first output serial data, and the second data sampler samples the first output serial data according to the second delayed clock signal to generate a second output serial data.

Abstract: A method, terminal, server and system for implementing information self-registration, and a computer storage medium. When a terminal starts for the first time or registration information of the terminal changes, the terminal sends to a server a self-registration session operation packet carrying current registration information of the terminal (S10); the server receives and parses the self-registration session operation packet to acquire the current registration information of the terminal (S20); determine whether the current registration information is new registration information according to pre-stored registration information of the terminal (S21); and if the current registration information is new registration information, save the new registration information and send a response message of successful self-registration session operation to the terminal (S22).

Abstract: The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic peptide toxins. In a preferred embodiment, the present invention also relates to methods for making small peptides and small cyclic peptides including peptides similar to amanitin. Further, the present inventions relate to providing kits for making small peptides.

Abstract: The data serialization circuit includes a delay circuit, a data serializer, a first data sampler and a second data sampler. The delay circuit receives an input clock signal and generates a plurality of delayed clock signals. The delayed clock signals includes a first delayed clock signal generated by a first delay stage and a second delayed clock signal generated by a second delay stage. The data serializer receives parallel data and a final stage delayed clock signal of the delayed clock signals, and converts the parallel data into serial data according to the final stage delayed clock signal. Wherein, the first data sampler samples the serial data according to the first delayed clock signal to generate a first output serial data, and the second data sampler samples the first output serial data according to the second delayed clock signal to generate a second output serial data.