Patents by Inventor Hong Nie
Hong Nie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8354406Abstract: The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.Type: GrantFiled: October 14, 2011Date of Patent: January 15, 2013Assignee: GlaxoSmithKline LLCInventors: Jianghe Deng, Jeffrey K. Kerns, Qi Jin, Guoliang Lin, Xichen Lin, Michael Lindenmuth, Christopher Neipp, Hong Nie, Sonia M Thomas, Katherine L. Widdowson
-
Patent number: 8334231Abstract: The present invention provides a hydrocracking catalyst comprising a moulded composite support of a zeolite molecular sieve with alumina, at least one of VIII Group metal components, at least one of VIB Group metal components and an organic additive; said organic additive is one or more compounds selected from the group consisting of oxygen-containing or nitrogen-containing organic compounds; the content of said zeolite molecular sieve is 3˜60 wt %, the content of said alumina is 10˜80 wt %, and the content of said organic additive is 0.1˜40 wt % based on the weight of said catalyst; the content of said VIII Group metal component is 1˜15 wt % and the content of said VIB Group metal component is 5˜40 wt % as calculated on oxide and based on the weight of said catalyst. The present invention relates also to a preparation method of said hydrocracking catalyst and use of the catalyst in the hydrocracking process of hydrocarbon oil.Type: GrantFiled: April 26, 2006Date of Patent: December 18, 2012Assignees: China Petroleum and Chemical Corporation, Research Institute of Petroleum Processing, SINOPECInventors: Yichao Mao, Hong Nie, Jianwei Dong, Zhenlin Xiong, Zhihai Hu, Yahua Shi, Dadong Li
-
Publication number: 20120035164Abstract: The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.Type: ApplicationFiled: October 14, 2011Publication date: February 9, 2012Inventors: Jianghe DENG, Jeffrey K. KERNS, Qi JIN, Guoliang LIN, Xichen LIN, Michael LINDENMUTH, Christopher NEIPP, Hong NIE, Sonia M. THOMAS, Katherine L. WIDDOWSON
-
Patent number: 8023571Abstract: A method and apparatus are provided for implementing an impulse ultra-wideband communications system which combines the technique of transmitted reference (TR) with a code-sifted reference scheme that separates the reference and the data pulses with a sequence of codes such as a subset of Walsh codes. The combination of the two techniques in ultra-wideband (UWB) radio systems removes the wideband delay elements required by conventional TR UWB systems. The invention provides a system with no analog carriers and lower complexities than other UWB systems, and which has better performances, higher tolerance to nonlinearity, and larger capacities.Type: GrantFiled: April 15, 2008Date of Patent: September 20, 2011Inventors: Hong Nie, Zhizhang Chen
-
Publication number: 20110127192Abstract: The present invention relates to a hydrocracking catalyst comprising an acidic silica-alumina, an optional alumina, an effective quantity of at least one VIII Group metal component(s), an effective quantity of at least one VIB Group metal component(s) and an organic additive, wherein the organic additive is one or more selected from the group consisting of an oxygen-containing or nitrogen-containing organic compound, and the molar ratio of the organic additive to the VIII Group metal component(s) is 0.01-10. The present invention relates further to a process for producing the hydrocracking catalyst and use of the catalyst in a process for hydrocracking hydrocarbon oils. The hydrocracking catalyst provided according to the present invention shows a higher activity for aromatic hydrosaturating and ring-opening reaction, as compared with the prior art hydrocracking catalyst.Type: ApplicationFiled: December 3, 2010Publication date: June 2, 2011Applicants: CHINA PETROLEUM & CHEMICAL CORPORATION, Research Institute of Petroleum Processing, SinopecInventors: Yichao Mao, Hong Nie, Jianwei Dong, Zhenlin Xiong, Zhihai Hu, Yahua Shi, Dadong Li
-
Publication number: 20110062054Abstract: Disclosed is a combination process for improved hydrotreating and catalytic cracking of hydrocarbon oils, including: contacting residual oil, catalytic cracking cycle oil, and optional distillate oil with a hydrotreating catalyst under hydrotreating conditions in the presence of hydrogen followed by separation of the reaction products to obtain gas, hydrogenated naphtha, hydrogenated diesel oil, and hydrogenated tail oil; contacting the hydrogenated tail oil and optional normal catalytic cracking feedstock oil with a cracking catalyst under catalytic cracking conditions followed by separation of the reaction products to obtain dry gas, hydrogenated naphtha, liquefied petroleum gas, catalytic cracked gasoline, catalytic cracked diesel oil, and catalytic cracking cycle oil; wherein the hydrogenated tail oil and/or normal catalytic cracking feedstock oil are separated into at least two fractions, the light and the heavy fractions or normal catalytic cracking heavy feedstock oil and normal catalytic cracking lighType: ApplicationFiled: December 19, 2008Publication date: March 17, 2011Inventors: Yongcan Gao, Chaogang Xie, Chuanfeng Niu, Jiushun Zhang, Lishun Dai, Hong Nie, Dadong Li, Jun Long, Jianguo Ma, Yan Cui
-
Publication number: 20110000818Abstract: A catalytic conversion process can convert inferior feedstock to high quality fuel oil and propylene. A inferior feedstock is introduced into first and second reactor zone, wherein the feedstock carry out first step and second step reactions by contacting with catalytic conversion catalyst. Product vapors separate from spent catalyst by gas-solid separation. The spent catalyst is stripped, regenerated by burning off coke and then returns to reactor. The product vapors are introduced into separation system to obtain propylene, gasoline, diesel, fluid catalytic cracking gas oil (FGO) and other products. The FGO is introduced into hydrotreating unit and/or extraction unit to obtain hydrotreated FGO and/or extracted FGO. Said hyrotreated FGO and/or extracted FGO return to the first reactor zone and/or another catalytic cracking unit to obtain propylene and gasoline. The extracted oil of said FGO is rich in double ring aromatics which are good chemical materials.Type: ApplicationFiled: March 13, 2009Publication date: January 6, 2011Applicants: CHINA PETROLEUM & CHEMICAL CORPORATION, RESEARCH INSTITUTE OF PETROLEUM PROCESSINGInventors: Youhao Xu, Lishun Dai, Zhigang Zhang, Shouye Cui, Jianhong Gong, Chaogang Xie, Jun Long, Hong Nie, Zhijian Da, Jiushun Zhang, Tao Liu, Anguo Mao
-
Patent number: 7858796Abstract: The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.Type: GrantFiled: September 21, 2005Date of Patent: December 28, 2010Assignee: Glaxo Group LimitedInventors: Jeffrey K. Kerns, Michael Lindenmuth, Xichen Lin, Hong Nie, Sonia M. Thomas
-
Publication number: 20100314287Abstract: Disclosed is a combined process for hydrotreating and catalytic cracking of residue, wherein the residue, catalytic cracking heavy cycle oil with acidic solid impurity being removed, optional distillate oil and adistillate of catalytic cracking slurry oil from which the acidic solid impurity is removed are fed into residue hydrotreating unit, the hydrogenated residue obtained and optional vacuum gas oil are fed into catalytic cracking unit to obtain various products; the catalytic cracking heavy cycle oil from which the acidic solid impurity is removed is circulated to the residue hydrotreating unit; the catalytic cracking slurry oil is separated by distilling, the distillate of the catalytic cracking slurry oil after removing off the acidic solid impurity is circulated to the residue hydrotreating unit.Type: ApplicationFiled: December 27, 2007Publication date: December 16, 2010Inventors: Chuanfeng Niu, Lishun Dai, Yongcan Gao, Dadong Li, Yahua Shi, Hong Nie, Qinghe Yang
-
Publication number: 20100213102Abstract: A catalytic conversion process which comprises catalytic cracking reaction of a hydrocarbon feedstock contacting with a medium pore size zeolite enriched catalyst in a reactor, characterized in that reaction temperature, weight hourly space velocity and catalyst/feedstock ratio by weight are sufficient to achieve a yield of fluid catalytic cracking gas oil between 12% and 60% by weight of said feedstock, wherein said weight hourly space velocity is between 25 h?1 and 100 h?1, said reaction temperature is between 450° C. and 600° C., and said catalyst/feedstock ratio by weight is between 1 and 30. This invention relates to a catalytic conversion process, especially for heavy feedstock oil to produce higher octane gasoline and an enhanced yield of propylene. More particularly, the invention relates to a process to utilize petroleum oil resources efficiently for decreasing the yield of dry gas and coke significantly.Type: ApplicationFiled: August 7, 2008Publication date: August 26, 2010Inventors: Youhao Xu, Lishun Dai, Longsheng Tian, Shouye Cui, Jianhong Gong, Chaogang Xie, Jiushun Zhang, Jun Long, Zhijian Da, Hong Nie, Jinbiao Guo, Zhigang Zhang
-
Patent number: 7745372Abstract: A catalyst for the selective hydrogenation of olefins especially dienes, its preparation and use, said catalyst comprising an alumina support and cobalt and/or nickel selected from Group VIII, molybdenum and/or tungsten from Group VIB and alkali metal components supported on said support, characterized in that the catalyst contains 0.5-8% by weight of cobalt and/or nickel selected from Group VIII, 2-15% by weight of molybdenum and/or tungsten from Group VIB, over 2-8% by weight of alkali metals, and a balanced amount of alumina support calculated for oxides and based on the catalyst. Compared to the prior catalysts, the activity and selectivity for olefins especially dienes of the catalyst are higher when used in the hydrogenation of a gasoline distillate.Type: GrantFiled: December 21, 2004Date of Patent: June 29, 2010Assignees: China Petroleum & Chemical Corporation, Research Institute of Petroleum Processing, SINOPECInventors: Mingfeng Li, Yang Chu, Yunjian Hu, Guofu Xia, Hong Nie, Yahua Shi, Dadong Li
-
Publication number: 20100111982Abstract: Described herein is an activated synovial autoreactive T cell and compositions thereof. Methods or preparing T cell compositions that may be used for treating rheumatoid arthritis are also described.Type: ApplicationFiled: June 27, 2007Publication date: May 6, 2010Applicant: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCESInventors: Jingwu Zhang Zang, Guangjie Chen, Hong Nie, Ningli Li
-
Publication number: 20100032341Abstract: The present invention provides a hydrocracking catalyst comprising a moulded composite support of a zeolite molecular sieve with alumina, at least one of VIII Group metal components, at least one of VIB Group metal components and an organic additive; said organic additive is one or more compounds selected from the group consisting of oxygen-containing or nitrogen-containing organic compounds; the content of said zeolite molecular sieve is 3˜60 wt %, the content of said alumina is 10˜80 wt %, and the content of said organic additive is 0.1˜40 wt % based on the weight of said catalyst; the content of said VIII Group metal component is 1˜15 wt % and the content of said VIB Group metal component is 5˜40 wt % as calculated on oxide and based on the weight of said catalyst. The present invention relates also to a preparation method of said hydrocracking catalyst and use of the catalyst in the hydrocracking process of hydrocarbon oil.Type: ApplicationFiled: April 26, 2006Publication date: February 11, 2010Inventors: Yichao Mao, Hong Nie, Jianwei Dong, Zhenlin Xiong, Zhihai Hu, Dadong Li
-
Publication number: 20090288985Abstract: A process for producing light olefins and aromatics, which comprises reacting a feedstock with a catalytic cracking catalyst in at least two reaction zones, wherein the reaction temperature of at least one reaction zone downstream of the first reaction zone is higher than that of the first reaction zone and its weight hourly space velocity is lower than that of the first reaction zone. The spent catalyst is separated from the reaction product vapor, regenerated and then returned to the reactor. The reaction product vapor is separated to obtain the desired products, light olefins and aromatics. This process efficiently produces light olefins such as propylene, ethylene, etc. from heavy feedstocks, wherein the yield of propylene exceeds 20% by weight, and produces aromatics such as toluene, xylene, etc. at the same time.Type: ApplicationFiled: March 8, 2005Publication date: November 26, 2009Inventors: Jun Long, Zhijian Da, Dadong Li, Xieqing Wang, Xingtian Shu, Jiushun Zhang, Hong Nie, Chaogang Xie, Zhigang Zhang, Wei Wang
-
Publication number: 20090258669Abstract: A method and apparatus are provided for implementing an impulse ultra-wideband communications system which combines the technique of transmitted reference (TR) with a code-sifted reference scheme that separates the reference and the data pulses with a sequence of codes such as a subset of Walsh codes. The combination of the two techniques in ultra-wideband (UWB) radio systems removes the wideband delay elements required by conventional TR UWB systems.Type: ApplicationFiled: April 15, 2008Publication date: October 15, 2009Inventors: Hong Nie, Zhizhang Chen
-
Publication number: 20090139898Abstract: The present invention provides a hydrogenation catalyst, containing a carrier, metal components of nickel, molybdenum and tungsten supported thereon, and an adjuvant component selected from the group consisting of fluorine and phosphor and combination thereof. In another embodiment, the present invention provides a hydrogenation catalyst, containing a carrier and metal components of nickel, molybdenum and tungsten supported thereon, wherein said carrier contains a molecular sieve. The present invention provides further use of said catalyst in the process for hydrogenating hydrocarbon oil. In comparison with a hydrogenation catalyst according to the prior art, the catalyst according to the present invention has a much higher activity.Type: ApplicationFiled: April 20, 2006Publication date: June 4, 2009Inventors: Xiangyun Long, Xuefen Liu, Hong Nie, Kui Wang, Jing Xin, Qinghe Liu, Xiaodong Gao, Zhihai Hu, Yahua Shi, Dadong Li
-
Publication number: 20090143372Abstract: The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.Type: ApplicationFiled: October 31, 2007Publication date: June 4, 2009Inventors: Jianghe Deng, Jeffrey K. Kerns, Qi Jin, Guoliang Lin, Xichen Lin, Michael Lindenmuth, Christopher Neipp, Hong Nie, Sonia M. Thomas, Katherine L. Widdowson
-
Publication number: 20080269291Abstract: The invention is directed to novel indolecarboxamide derivatives. Specifically, the invention is directed to compounds according to formula (I): where R1, R2, R3 and X are defined below. These compounds are useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, in particular in the treatment and prevention of disorders mediated by IKK2 mechanisms including inflammatory and tissue repair disorders. Such disorders include rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease).Type: ApplicationFiled: November 17, 2006Publication date: October 30, 2008Inventors: Jeffrey K. Kerns, Jakob Busch-Petersen, Huijie Li, Jeffrey Charles Boehm, Hong Nie, John J. Taggart
-
Publication number: 20080190811Abstract: The present invention relates to a hydrocracking catalyst comprising an acidic silica-alumina, an optional alumina, an effective quantity of at least one VIII Group metal component(s), an effective quantity of at least one VIB Group metal component(s) and an organic additive, wherein the organic additive is one or more selected from the group consisting of an oxygen-containing or nitrogen-containing organic compound, and the molar ratio of the organic additive to the VIII Group metal component(s) is 0.01-10. The present invention relates further to a process for producing the hydrocracking catalyst and use of the catalyst in a process for hydrocracking hydrocarbon oils. The hydrocracking catalyst provided according to the present invention shows a higher activity for aromatic hydrosaturating and ring-opening reaction, as compared with the prior art hydrocracking catalyst.Type: ApplicationFiled: April 26, 2006Publication date: August 14, 2008Applicants: CHINA PETROLEUM & CHEMICAL CORPORATION, RESEARCH INSTITUTE OF PETROLEUM PROCESSING, SINOPEInventors: Yichao Mao, Hong Nie, Jianwei Dong, Zhenlin Xiong, Zhihai Hu, Yahua Shi, Dadong Li
-
Publication number: 20070254873Abstract: The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.Type: ApplicationFiled: September 21, 2005Publication date: November 1, 2007Applicant: Glaxo Group LimitedInventors: Jeffrey Kerns, Michael Lindenmuth, Xichen Lin, Hong Nie, Sonia Thomas